Overview
1) Characterization of the oligomeric interactions of the receptor, and elucidation of their role in toxin mediated receptor activation. We have engineered dominant negative mutants that have permitted us to elucidate the receptor's novel mode of activation.
2) Elucidation of the mechanisms by which a negative regulatory domain regulates signalling. We have demonstrated that a kinaselike domain within the receptor acts as an autoinhibitor domain.
3) Examination of post-translational processing events modulate receptor signalling. We have preliminary data demonstrating that the receptor exists in multiple forms in vivo. We are currently elucidating where in the cells these different forms are generated, and how they interact with toxin.
4) To characteize the cellular response of receptors to prolonged toxin stimulation: We have preliminary data demonstrating that the receptor undergoes toxin-mediated desensitization, and are currently characterizing these mechanisms.
Current Appointments & Affiliations
Consulting Professor in the Department of Medicine
·
2012 - Present
Medicine, Infectious Diseases,
Medicine
Education, Training & Certifications
Icahn School of Medicine at Mount Sinai ·
1985
M.D.
Icahn School of Medicine at Mount Sinai ·
1983
Ph.D.