Jung Wook Park | Scholars@Duke

Jung Wook Park
Rollie Assistant Professorship of Correlative Pathology

Current Research Interests

Park laboratory is interested in

1. Understanding prostate cancer progression using our novel human epithelial cell transformation system.

2. Investigating the pathogenesis of prostate and other epithelial cancers using primary human cells with organoid culture, which will create novel pre-clinical disease models.

3. Identifying vulnerabilities in treatment-resistant cancers.

4. Developing novel therapies targeting oncogenic drivers and other disease vulnerabilities.

Current Appointments & Affiliations

Rollie Assistant Professorship of Correlative Pathology, Pathology, Clinical Science Departments 2019 - 2024
Assistant Professor in Pathology, Pathology, Clinical Science Departments 2021
Assistant Research Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

Duke Box 103872, 905 South Lasalle Street, Durham, NC 27710
Duke Box 103872, 905 South Lasalle Street, Durham, NC 27710
jungwook.park@duke.edu (919) 684-0985
Park laboratory

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin - Madison 2013
Previous Appointments & Affiliations
- Assistant Professor Track V in Pathology, Pathology, Clinical Science Departments 2019 - 2020
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- Targeting NUAK2 in neuroendocrine prostate cancer awarded by Department of Defense 2023 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Targeting oncogenomic function of N-Myc to inhibit neuroendocrine prostate cancer visceral metastasis awarded by Department of Defense 2023 - 2026
- Defining Cellular and Genetic Factors for Renal Cell Carcinoma Subtypes awarded by Department of Defense 2022 - 2025
- Transcriptional reprogramming of lethal small cell prostate cancer awarded by Department of Defense 2021 - 2024
- Interrupting the aberrant cancer development sequence in epithelial cancer progression awarded by Prostate Cancer Foundation 2021 - 2024
- Defining the Essential Determinants of Prostate Cancer Differentiation States awarded by National Institutes of Health 2019 - 2022
- Unveiling the roles of neuroendocrine cells in prostate cancer development awarded by Mike Slive Foundation 2020 - 2021
Publications & Artistic Works
Selected Publications
- Academic Articles
  - VanDeusen, Halena R., Johnny R. Ramroop, Katherine L. Morel, Song Yi Bae, Anjali V. Sheahan, Zoi Sychev, Nathan A. Lau, et al. “Targeting RET Kinase in Neuroendocrine Prostate Cancer.” Mol Cancer Res 18, no. 8 (August 2020): 1176–88. https://doi.org/10.1158/1541-7786.MCR-19-1245.
    Full Text Link to Item
  - Wang, Liang, Bryan A. Smith, Nikolas G. Balanis, Brandon L. Tsai, Kim Nguyen, Michael W. Cheng, Matthew B. Obusan, et al. “A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.” Proc Natl Acad Sci U S A 117, no. 1 (January 7, 2020): 563–72. https://doi.org/10.1073/pnas.1915770117.
    Full Text Link to Item
  - Li, Yanjing, Yiping He, William Butler, Lingfan Xu, Yan Chang, Kefeng Lei, Hong Zhang, et al. “Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer.” Sci Transl Med 11, no. 521 (December 4, 2019). https://doi.org/10.1126/scitranslmed.aax0428.
    Full Text Link to Item
  - Balanis, Nikolas G., Katherine M. Sheu, Favour N. Esedebe, Saahil J. Patel, Bryan A. Smith, Jung Wook Park, Salwan Alhani, et al. “Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies.” Cancer Cell 36, no. 1 (July 8, 2019): 17-34.e7. https://doi.org/10.1016/j.ccell.2019.06.005.
    Full Text Link to Item
  - Park, Jung Wook, John K. Lee, Katherine M. Sheu, Liang Wang, Nikolas G. Balanis, Kim Nguyen, Bryan A. Smith, et al. “Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.” Science 362, no. 6410 (October 5, 2018): 91–95. https://doi.org/10.1126/science.aat5749.
    Full Text Link to Item
  - Smith, Bryan A., Nikolas G. Balanis, Avinash Nanjundiah, Katherine M. Sheu, Brandon L. Tsai, Qingfu Zhang, Jung Wook Park, et al. “A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.” Cell Rep 24, no. 12 (September 18, 2018): 3353-3366.e5. https://doi.org/10.1016/j.celrep.2018.08.062.
    Full Text Link to Item
  - Lee, John K., Nathanael J. Bangayan, Timothy Chai, Bryan A. Smith, Tiffany E. Pariva, Sangwon Yun, Ajay Vashisht, et al. “Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer.” Proc Natl Acad Sci U S A 115, no. 19 (May 8, 2018): E4473–82. https://doi.org/10.1073/pnas.1802354115.
    Full Text Link to Item
  - Park, Jung Wook, John K. Lee, Owen N. Witte, and Jiaoti Huang. “FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.” Mod Pathol 30, no. 9 (September 2017): 1262–72. https://doi.org/10.1038/modpathol.2017.44.
    Full Text Link to Item
  - Liu, Xian, Tristan R. Grogan, Haley Hieronymus, Takao Hashimoto, Jack Mottahedeh, Donghui Cheng, Lijun Zhang, et al. “Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.” Cell Rep 17, no. 10 (December 6, 2016): 2596–2606. https://doi.org/10.1016/j.celrep.2016.11.010.
    Full Text Link to Item
  - Park, Soyeong, Jung Wook Park, Henry C. Pitot, and Paul F. Lambert. “Loss of Dependence on Continued Expression of the Human Papillomavirus 16 E7 Oncogene in Cervical Cancers and Precancerous Lesions Arising in Fanconi Anemia Pathway-Deficient Mice.” Mbio 7, no. 3 (May 17, 2016). https://doi.org/10.1128/mBio.00628-16.
    Full Text Link to Item
  - Park, J. W., J. K. Lee, J. W. Phillips, P. Huang, D. Cheng, J. Huang, and O. N. Witte. “Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay.” Proceedings of the National Academy of Sciences of Usa 113, no. 16 (April 19, 2016): 4482–87.
    Link to Item
  - Park, Jung Wook, John K. Lee, John W. Phillips, Patrick Huang, Donghui Cheng, Jiaoti Huang, and Owen N. Witte. “Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay.” Proc Natl Acad Sci U S A 113, no. 16 (April 19, 2016): 4482–87. https://doi.org/10.1073/pnas.1603645113.
    Full Text Link to Item
  - Lee, John K., John W. Phillips, Bryan A. Smith, Jung Wook Park, Tanya Stoyanova, Erin F. McCaffrey, Robert Baertsch, et al. “N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.” Cancer Cell 29, no. 4 (April 11, 2016): 536–47. https://doi.org/10.1016/j.ccell.2016.03.001.
    Full Text Link to Item
  - Park, Jung Wook, Kwangok P. Nickel, Alexandra D. Torres, Denis Lee, Paul F. Lambert, and Randall J. Kimple. “Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage.” Radiother Oncol 113, no. 3 (December 2014): 337–44. https://doi.org/10.1016/j.radonc.2014.08.026.
    Full Text Link to Item
  - Park, J. W., M. -. K. Shin, and P. F. Lambert. “High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.” Oncogene 33, no. 26 (June 26, 2014): 3383–91. https://doi.org/10.1038/onc.2013.327.
    Full Text Link to Item
  - Son, Jieun, Jung Wook Park, Paul F. Lambert, and Sang-Hyuk Chung. “Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice.” Carcinogenesis 35, no. 2 (February 2014): 489–96. https://doi.org/10.1093/carcin/bgt350.
    Full Text Link to Item
  - Park, Jung Wook, Myeong-Kyun Shin, Henry C. Pitot, and Paul F. Lambert. “High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.” Plos One 8, no. 9 (2013): e75056. https://doi.org/10.1371/journal.pone.0075056.
    Full Text Link to Item
  - Park, Jung Wook, Henry C. Pitot, Katerina Strati, Nicole Spardy, Stefan Duensing, Markus Grompe, and Paul F. Lambert. “Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.” Cancer Res 70, no. 23 (December 1, 2010): 9959–68. https://doi.org/10.1158/0008-5472.CAN-10-1291.
    Full Text Link to Item
  - Park, Jung Wook, Seyoon Kim, and Young Yil Bahk. “A proteomic approach for dissecting H-Ras signaling networks in NIH/3T3 mouse embryonic fibroblast cells.” Proteomics 6, no. 8 (April 2006): 2433–43. https://doi.org/10.1002/pmic.200500688.
    Full Text Link to Item
  - Park, Jung Wook, Seyoon Kim, Kook Jin Lim, Richard J. Simpson, Yu Sam Kim, and Young Yil Bahk. “A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells.” Proteomics 6, no. 4 (February 2006): 1175–86. https://doi.org/10.1002/pmic.200500405.
    Full Text Link to Item
- Conference Papers
  - Park, Jung Wook, Nikolas Balanis, Katherine M. Sheu, Kim Nguyen, John K. Lee, Jiaoti Huang, Thomas Graeber, and Owen N. Witte. “Oncogenic convergence of normal human prostate epithelial cells to a small cell neuroendocrine phenotype.” In Cancer Research, 78:108–108. AMER ASSOC CANCER RESEARCH, 2018.
    Link to Item
  - Smith, Bryan A., Nikolas G. Balanis, Avinash Nanjundiah, Katherine M. Sheu, Qingfu Zhang, Jung Wook Park, Michael Thompson, Jiaoti Huang, Thomas G. Graeber, and Owen N. Witte. “Stem cell-directed pan-cancer analysis reveals a human adult stem cell signature that defines aggressive epithelial cancer subtypes.” In Cancer Research, 78:119–119. AMER ASSOC CANCER RESEARCH, 2018.
    Link to Item
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses