Current Appointments & Affiliations
Rollie Assistant Professorship of Correlative Pathology
·
2019 - Present
Pathology,
Clinical Science Departments
Assistant Professor in Pathology
·
2021 - Present
Pathology,
Clinical Science Departments
Assistant Research Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
Journal Article Proc Natl Acad Sci U S A · December 3, 2024 Adenocarcinomas from multiple tissues can converge to treatment-resistant small cell neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 subtypes. We investigated how mitochondrial metabolism influences SCN cancer (SCNC) progression. ... Full text Link to item CiteTemporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Journal Article Cancer Cell · December 11, 2023 Trans-differentiation from an adenocarcinoma to a small cell neuroendocrine state is associated with therapy resistance in multiple cancer types. To gain insight into the underlying molecular events of the trans-differentiation, we perform a multi-omics ti ... Full text Link to item CiteILUSTRO: Phase II Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma.
Journal Article Clin Cancer Res · October 2, 2023 PURPOSE: Zolbetuximab, an IgG1 monoclonal antibody, binds to claudin 18.2 (CLDN18.2) and mediates tumor cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. We sought to examine zolbetuximab combinations in CLD ... Full text Link to item CiteRecent Grants
Understanding the molecular communication between prostate cancer cell types
ResearchPrincipal Investigator · Awarded by Department of Defense · 2025 - 2027Identifying essential molecular mechanisms for advanced prostate cancer growth by a new chemical compound
ResearchPrincipal Investigator · Awarded by Department of Defense · 2024 - 2027Duke ACS Institutional Research Grant
ResearchSignificant Contributor · Awarded by American Cancer Society, Inc. · 2024 - 2026View All Grants
Education, Training & Certifications
University of Wisconsin, Madison ·
2013
Ph.D.