Justin Solomon

Journal Article Eur Radiol · April 2021 OBJECTIVE: The purpose of this study was to determine how well radiologists could visually detect a change in lung nodule size on the basis of visual image perception alone. SUBJECTS AND METHODS: Under IRB approval, 109 standard chest CT image series were ... Full text Link to item Cite

Can Realistic Liver Tissue Surrogates Accurately Quantify the Impact of Reduced-kV Imaging on Attenuation and Contrast of Parenchyma and Lesions?

Journal Article Acad Radiol · May 2019 RATIONALE AND OBJECTIVES: To assess if a liquid tissue surrogate for the liver (LTSL) can emulate contrast-enhanced liver parenchyma and lesions and quantify the impact of reduced-kV imaging as a function of lesion contrast, phase of enhancement, and phant ... Full text Link to item Cite

How accurate and precise are CT based measurements of iodine concentration? A comparison of the minimum detectable concentration difference among single source and dual source dual energy CT in a phantom study.

Journal Article Eur Radiol · April 2019 OBJECTIVES: To assess the impact of scan- and patient-related factors on the error and the minimum detectable difference in iodine concentration among different generations of single-source (SS) fast kV-switching and dual-source (DS) dual-energy CT (DECT). ... Full text Link to item Cite

Validation of lesion simulations in clinical CT data for anonymized chest and abdominal CT databases.

Journal Article Med Phys · April 2019 PURPOSE: To make available to the medical imaging community a computed tomography (CT) image database composed of hybrid datasets (patient CT images with digitally inserted anthropomorphic lesions) where lesion ground truth is known a priori. It is envisio ... Full text Link to item Cite

High-Pitch Wide-Coverage Fast-Kilovoltage-Switching Dual-Energy CT: Impact of Pitch on Noise, Spatial Resolution, and Iodine Quantification in a Phantom Study.

Journal Article AJR Am J Roentgenol · March 2019 OBJECTIVE: The purpose of this study was to assess the impact of high pitch values on image noise, spatial resolution, and iodine quantification in single-source wide-coverage fast-kilovoltage-switching dual-energy CT (DECT). MATERIALS AND METHODS: Two pha ... Full text Link to item Cite

Systematic analysis of bias and variability of morphologic features for lung lesions in computed tomography.

Journal Article J Med Imaging (Bellingham) · January 2019 We propose to characterize the bias and variability of quantitative morphology features of lung lesions across a range of computed tomography (CT) imaging conditions. A total of 15 lung lesions were simulated (five in each of three spiculation classes: low ... Full text Link to item Cite

A Data-Centric Strategy for Developing CT Dose and Noise Reference Levels from Clinical Patient Populations

Conference · November 27, 2018 PURPOSE To develop a data-centric strategy solution for developing CT dose and noise reference levels across large clinical patient populations and in CT scanners. METHOD AND MATERIALS This IRB-exempt study evaluated CT abdominopelvic (AP)-related examin ... Cite

3D task-transfer function representation of the signal transfer properties of low-contrast lesions in FBP- and iterative-reconstructed CT.

Journal Article Med Phys · November 2018 PURPOSE: The purpose of this study was to investigate how accurately the task-transfer function (TTF) models the signal transfer properties of low-contrast features in a non-linear commercial CT system. METHODS: A cylindrical phantom containing 24 anthropo ... Full text Link to item Cite

Local complexity metrics to quantify the effect of anatomical noise on detectability of lung nodules in chest CT imaging.

Journal Article J Med Imaging (Bellingham) · October 2018 The purpose of this study is to (1) develop metrics to characterize the regional anatomical complexity of the lungs, and (2) relate these metrics with lung nodule detection in chest CT. A free-scrolling reader-study with virtually inserted nodules (13 radi ... Full text Link to item Cite

Estimating detectability index in vivo: development and validation of an automated methodology.

Journal Article J Med Imaging (Bellingham) · July 2018 This study's purpose was to develop and validate a method to estimate patient-specific detectability indices directly from patients' CT images (i.e., in vivo). The method extracts noise power spectrum (NPS) and modulation transfer function (MTF) resolution ... Full text Link to item Cite

Inter-laboratory comparison of channelized hotelling observer computation.

Journal Article Med Phys · July 2018 PURPOSE: The task-based assessment of image quality using model observers is increasingly used for the assessment of different imaging modalities. However, the performance computation of model observers needs standardization as well as a well-established t ... Full text Link to item Cite

Interchangeability between real and three-dimensional simulated lung tumors in computed tomography: an interalgorithm volumetry study.

Journal Article J Med Imaging (Bellingham) · July 2018 Using hybrid datasets consisting of patient-derived computed tomography (CT) images with digitally inserted computational tumors, we establish volumetric interchangeability between real and computational lung tumors in CT. Pathologically-confirmed malignan ... Full text Link to item Cite

A Third-Generation Adaptive Statistical Iterative Reconstruction Technique: Phantom Study of Image Noise, Spatial Resolution, Lesion Detectability, and Dose Reduction Potential.

Journal Article AJR Am J Roentgenol · June 2018 OBJECTIVE: The purpose of this study was to assess image noise, spatial resolution, lesion detectability, and the dose reduction potential of a proprietary third-generation adaptive statistical iterative reconstruction (ASIR-V) technique. MATERIALS AND MET ... Full text Link to item Cite

3D printed anthropomorphic physical phantom for mammography and DBT with high contrast custom materials, lesions, and uniform chest wall region

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Anthropomorphic breast phantoms mimic anatomy to evaluate the performance of clinical mammography and digital breast tomosynthesis (DBT) systems. Our goal is to make a phantom that mimics clinically relevant appearance of a patient to allow for improved im ... Full text Cite

How reliable are texture measurements?

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 The purpose of this study was to assess the bias (objectivity) and variability (robustness) of computed tomography (CT) texture features (internal heterogeneities) across a series of image acquisition settings and reconstruction algorithms. We simulated a ... Full text Cite

Realistic lesion simulation: Application of hyperelastic deformation to lesion-local environment in lung CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Lesion simulation programs can be used to insert realistic, generated lesions into anatomical images for further study. Most lesion simulation programs rely on insertion of a mask within an otherwise unchangeable, i.e., static surrounding - in reality, les ... Full text Cite

Bias and variability in morphology features of lung lesions across CT imaging conditions

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 CT imaging method can influence radiomic features. The purpose of this study was to characterize the intra-protocol and inter-protocol variability and bias of quantitative morphology features of lung lesions across a range of CT imaging conditions. A total ... Full text Cite

Can a 3D task transfer function accurately represent the signal transfer properties of low-contrast lesions in non-linear CT systems?

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 The purpose of this study was to investigate how accurately the task-transfer function (TTF) models the signal transfer properties of low-contrast features in a non-linear CT system. A cylindrical phantom containing 24 anthropomorphic liver lesions (modele ... Full text Cite

Quantifying quality: correlation phantom and clinical scan CT noise levels to contruct a Quality Reference Level

Conference · November 26, 2017 Conclusion This study represents a proof of concept method to develop and refine a Noise Reference Level for a given protocol and scanner. This represents a first step in establishing an automated Performance Reference Level for a given scan protocol that ... Cite

Optimizing window settings for improved presentation of virtual monoenergetic images in dual-energy computed tomography.

Journal Article Med Phys · November 2017 PURPOSE: Dual-energy computed tomography virtual monoenergetic imaging (VMI) at 40 keV exhibits superior contrast-to-noise ratio (CNR), although practicing radiologists do not consistently prefer it over VMI at 70 keV due to high perceivable noise. We hypo ... Full text Link to item Cite

Effect of Radiation Dose Reduction and Reconstruction Algorithm on Image Noise, Contrast, Resolution, and Detectability of Subtle Hypoattenuating Liver Lesions at Multidetector CT: Filtered Back Projection versus a Commercial Model-based Iterative Reconstruction Algorithm.

Journal Article Radiology · September 2017 Purpose To determine the effect of radiation dose and iterative reconstruction (IR) on noise, contrast, resolution, and observer-based detectability of subtle hypoattenuating liver lesions and to estimate the dose reduction potential of the IR algorithm in ... Full text Link to item Cite

Techniques for virtual lung nodule insertion: volumetric and morphometric comparison of projection-based and image-based methods for quantitative CT.

Journal Article Phys Med Biol · August 22, 2017 Virtual nodule insertion paves the way towards the development of standardized databases of hybrid CT images with known lesions. The purpose of this study was to assess three methods (an established and two newly developed techniques) for inserting virtual ... Full text Link to item Cite

From DRL to NRL: A First Step Toward Quality-Based Reference Level

Conference Medical Physics · June 30, 2017 Purpose: Radiologic procedures are optimized based on a benefit-to-risk. However, risk has been the primary focus of radiology optimization and dose monitoring. Such programs are typically based on the concept of Diagnostic Reference Level (DRL). The term ... Cite

Dual-Source Single-Energy Multidetector CT Used to Obtain Multiple Radiation Exposure Levels within the Same Patient: Phantom Development and Clinical Validation.

Journal Article Radiology · May 2017 Purpose To develop, in a phantom environment, a method to obtain multidetector computed tomographic (CT) data sets at multiple radiation exposure levels within the same patient and to validate its use for potential dose reduction by using different image r ... Full text Link to item Cite

Third generation anthropomorphic physical phantom for mammography and DBT: Incorporating voxelized 3D printing and uniform chest wall QC region

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 Physical breast phantoms provide a standard method to test, optimize, and develop clinical mammography systems, including new digital breast tomosynthesis (DBT) systems. In previous work, we produced an anthropomorphic phantom based on 500x500x500 μm breas ... Full text Cite

Accuracy and variability of texture-based radiomics features of lung lesions across CT imaging conditions

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 Texture analysis for lung lesions is sensitive to changing imaging conditions but these effects are not well understood, in part, due to a lack of ground-truth phantoms with realistic textures. The purpose of this study was to explore the accuracy and vari ... Full text Cite

Development of local complexity metrics to quantify the effect of anatomical noise on detectability of lung nodules in chest CT imaging

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 The purpose of this study was to develop metrics of local anatomical complexity and compare them with detectability of lung nodules in CT. Data were drawn retrospectively from a published perception experiment in which detectability was assessed in cases e ... Full text Cite

In-vivo detectability index: Development and validation of an automated methodology

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 The purpose of this study was to develop and validate a method to estimate patient-specific detectability indices directly from patients' CT images (i.e., "in vivo"). The method works by automatically extracting noise (NPS) and resolution (MTF) properties ... Full text Cite

Inter-algorithm lesion volumetry comparison of real and 3D simulated lung lesions in CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 The purpose of this study was to establish volumetric exchangeability between real and computational lung lesions in CT. We compared the overall relative volume estimation performance of segmentation tools when used to measure real lesions in actual patien ... Full text Cite

Comparison of low-contrast detectability between two CT reconstruction algorithms using voxel-based 3D printed textured phantoms.

Journal Article Med Phys · December 2016 PURPOSE: To use novel voxel-based 3D printed textured phantoms in order to compare low-contrast detectability between two reconstruction algorithms, FBP (filtered-backprojection) and SAFIRE (sinogram affirmed iterative reconstruction) and determine what im ... Full text Link to item Cite

Impact of breast structure on lesion detection in breast tomosynthesis, a simulation study.

Journal Article J Med Imaging (Bellingham) · July 2016 This study aims to characterize the effect of background tissue density and heterogeneity on the detection of irregular masses in breast tomosynthesis, while demonstrating the capability of the sophisticated tools that can be used in the design, implementa ... Full text Link to item Cite

Correlation between human detection accuracy and observer model-based image quality metrics in computed tomography.

Journal Article J Med Imaging (Bellingham) · July 2016 The purpose of this study was to compare computed tomography (CT) low-contrast detectability from human readers with observer model-based surrogates of image quality. A phantom with a range of low-contrast signals (five contrasts, three sizes) was imaged o ... Full text Link to item Cite

Quantitative Features of Liver Lesions, Lung Nodules, and Renal Stones at Multi-Detector Row CT Examinations: Dependency on Radiation Dose and Reconstruction Algorithm.

Journal Article Radiology · April 2016 PURPOSE: To determine if radiation dose and reconstruction algorithm affect the computer-based extraction and analysis of quantitative imaging features in lung nodules, liver lesions, and renal stones at multi-detector row computed tomography (CT). MATERIA ... Full text Link to item Cite

Design, fabrication, and implementation of voxel-based 3D printed textured phantoms for task-based image quality assessment in CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 In x-ray computed tomography (CT), task-based image quality studies are typically performed using uniform background phantoms with low-contrast signals. Such studies may have limited clinical relevancy for modern non-linear CT systems due to possible influ ... Full text Cite

Second generation anthropomorphic physical phantom for mammography and DBT: Incorporating voxelized 3D printing and inkjet printing of iodinated lesion inserts

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Physical phantoms are needed for the evaluation and optimization of new digital breast tomosynthesis (DBT) systems. Previously, we developed an anthropomorphic phantom based on human subject breast CT data and fabricated using commercial 3D printing. We no ... Full text Cite

Development of a Hausdorff distance based 3D quantification technique to evaluate the CT imaging system impact on depiction of lesion morphology

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 The purpose of this study was to develop a 3D quantification technique to assess the impact of imaging system on depiction of lesion morphology. Regional Hausdorff Distance (RHD) was computed from two 3D volumes: virtual mesh models of synthetic nodules or ... Full text Cite

Development and comparison of projection and image space 3D nodule insertion techniques

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 This study aimed to develop and compare two methods of inserting computerized virtual lesions into CT datasets. 24 physical (synthetic) nodules of three sizes and four morphologies were inserted into an anthropomorphic chest phantom (LUNGMAN, KYOTO KAGAKU) ... Full text Cite

Synthesized interstitial lung texture for use in anthropomorphic computational phantoms

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 A realistic model of the anatomical texture from the pulmonary interstitium was developed with the goal of extending the capability of anthropomorphic computational phantoms (e.g., XCAT, Duke University), allowing for more accurate image quality assessment ... Full text Cite

Characteristic image quality of a third generation dual-source MDCT scanner: Noise, resolution, and detectability.

Journal Article Med Phys · August 2015 PURPOSE: The purpose of this work was to assess the inherent image quality characteristics of a new multidetector computed tomography system in terms of noise, resolution, and detectability index as a function of image acquisition and reconstruction for a ... Full text Link to item Cite

Diagnostic Performance of an Advanced Modeled Iterative Reconstruction Algorithm for Low-Contrast Detectability with a Third-Generation Dual-Source Multidetector CT Scanner: Potential for Radiation Dose Reduction in a Multireader Study.

Journal Article Radiology · June 2015 PURPOSE: To assess the effect of radiation dose reduction on low-contrast detectability by using an advanced modeled iterative reconstruction (ADMIRE; Siemens Healthcare, Forchheim, Germany) algorithm in a contrast-detail phantom with a third-generation du ... Full text Link to item Cite

A multireader diagnostic performance study of low-contrast detectability on a third-generation dual-source CT scanner: Filtered back projection versus advanced modeled iterative reconstruction

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 The purpose of this work was to compare CT low-contrast detectability between two reconstruction algorithms, filtered back-projection (FBP) and advanced modeled iterative reconstruction (ADMIRE). A phantom was designed with a range of low-contrast circular ... Full text Cite

What observer models best reflect low-contrast detectability in CT?

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 The purpose of this work was to compare CT low-contrast detectability as measured via human perception experiments with observer model surrogates of image quality measured directly from the images. A phantom was designed with a range of low-contrast circul ... Full text Cite

Evaluating iterative reconstruction performance in computed tomography.

Journal Article Med Phys · December 2014 PURPOSE: Iterative reconstruction (IR) offers notable advantages in computed tomography (CT). However, its performance characterization is complicated by its potentially nonlinear behavior, impacting performance in terms of specific tasks. This study aimed ... Full text Link to item Cite

A generic framework to simulate realistic lung, liver and renal pathologies in CT imaging.

Journal Article Phys Med Biol · November 7, 2014 Realistic three-dimensional (3D) mathematical models of subtle lesions are essential for many computed tomography (CT) studies focused on performance evaluation and optimization. In this paper, we develop a generic mathematical framework that describes the ... Full text Link to item Cite

Quantum noise properties of CT images with anatomical textured backgrounds across reconstruction algorithms: FBP and SAFIRE.

Journal Article Med Phys · September 2014 PURPOSE: Quantum noise properties of CT images are generally assessed using simple geometric phantoms with uniform backgrounds. Such phantoms may be inadequate when assessing nonlinear reconstruction or postprocessing algorithms. The purpose of this study ... Full text Link to item Cite

Design of anthropomorphic Textured phantoms for CT performance evaluation

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 Commercially available computed Tomography (CT) Technologies such as iterative reconstruction (IR) have The potential To enable reduced patient doses while maintaining diagnostic image quality. However, systematically determining safe dose reduction levels ... Full text Cite

Are uniform phantoms sufficient to characterize the performance of iterative reconstruction in CT?

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 3, 2013 The evaluation of dose reduction potential from iterative reconstruction (IR) algorithms is an area of ongoing research in CT. The non-linearity of IR algorithms poses challenges to using traditional image quality metrics. Past attempts to evaluate iterati ... Full text Cite

WE-C-103-06: An Automated CT Quality Control Program.

Journal Article Med Phys · June 2013 PURPOSE: Daily image quality assessment is an essential part of a rigorous quality control program. Time constraints; however, make it difficult to fully analyze image quality daily. Therefore, the goal of this work was to develop a robust automated CT qua ... Full text Link to item Cite

Relating noise to image quality indicators in CT examinations with tube current modulation.

Journal Article AJR Am J Roentgenol · March 2013 OBJECTIVE: Modern CT systems use surrogates of noise-noise index (NI) and quality reference effective tube current-time product (Q)-to infer the quality of images acquired using tube current modulation. This study aimed to determine the relationship betwee ... Full text Link to item Cite

TU‐C‐103‐01: A Framework for 3D Modeling of Anthropomorphic Lesions in CT

Conference Medical Physics · January 1, 2013 Purpose: Realistic three‐dimensional mathematical models of subtle lesions are essential for many CT studies focused on performance evaluation and optimization. The purpose of this work was to develop and apply a generic framework for creating such models ... Full text Cite

Quantitative comparison of noise texture across CT scanners from different manufacturers.

Journal Article Med Phys · October 2012 PURPOSE: To quantitatively compare noise texture across computed tomography (CT) scanners from different manufacturers using the noise power spectrum (NPS). METHODS: The American College of Radiology CT accreditation phantom (Gammex 464, Gammex, Inc., Midd ... Full text Link to item Cite

Defining Performance-Based, Size-Specific, Optimized Protocols for Pediatric CT

Conference MEDICAL PHYSICS · 2012 Full text Cite

Quantitative Comparison of Noise Texture Across CT Scanners From Different Vendors

Conference MEDICAL PHYSICS · 2012 Full text Cite