Kafui Dzirasa
Associate Professor of Psychiatry and Behavioral Sciences
Current Appointments & Affiliations
- Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2017
- Associate Professor in Neurobiology, without tenure, Neurobiology, Basic Science Departments 2017
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2018
- Investigator in the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2013
Contact Information
- Box 3209 Medctr, Durham, NC 27710
- Bryan Research Bldg, Room 361, Durham, NC 27710
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kafui.dzirasa@duke.edu
(919) 613-2832
- Background
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Education, Training, & Certifications
- Resident in Psychiatry, Psychiatry, Duke University School of Medicine 2010 - 2016
- M.D., Duke University School of Medicine 2009
- Ph.D., Duke University 2007
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Duke Appointment History
- Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2013 - 2017
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2013 - 2017
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2014 - 2017
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2017
- Assistant Research Professor in Neurobiology, Neurobiology, Basic Science Departments 2012 - 2013
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2013
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Geriatric Behavioral Health, Psychiatry & Behavioral Sciences 2009 - 2013
- Instructor, Temporary in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Geriatric Behavioral Health, Psychiatry & Behavioral Sciences 2009
- Recognition
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In the News
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APR 18, 2019 -
DEC 14, 2018 -
AUG 6, 2018 Duke Medicine Alumni Magazine -
MAR 1, 2018 Duke University -
JUN 23, 2017 -
FEB 15, 2017 -
OCT 18, 2016 -
AUG 9, 2016 -
JUN 23, 2016 -
MAY 9, 2016 -
APR 14, 2016 PBS “Ride the Tiger” documentary -
FEB 19, 2016 -
JUN 26, 2015 -
JUL 30, 2014 USA Today -
JUL 29, 2014
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- Research
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Selected Grants
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by National Institutes of Health 2019 - 2023
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Network Dynamics of Negative and Positive Valence Systems in Decision Making awarded by National Institutes of Health 2019 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Acculturation Stress, Biomarkers, and Psychopathology Among Hispanic Immigrants awarded by National Institutes of Health 2017 - 2022
- Neuromuscular Control of Primate Eye Movements awarded by National Institutes of Health 2019 - 2021
- Akt/GSK-3 Signaling Cascade and the Actions of Dopamine awarded by National Institutes of Health 2005 - 2020
- A fully biological platform for monitoring mesoscale neural activity awarded by National Institutes of Health 2018 - 2020
- Unmasking a Role for Cortical Dopamine D4 Receptors in Controlling Circuit Dynamics and Behavior awarded by National Institutes of Health 2018 - 2020
- Hartwell Fellowship awarded by Hartwell Foundation 2018 - 2020
- The neurophysiology of impulsive sensation seeking awarded by University of Pittsburgh 2018 - 2020
- Simultaneous and Bidirectional Chemogenetic Control of Mesolimbic and Nigrostriatal Circuits awarded by National Institutes of Health 2018 - 2020
- Engineering gap junctions for the study and treatment of Autism Spectrum Disorders awarded by Burroughs Wellcome Fund 2018 - 2019
- Environmental Toxins and Microglia-Synapse Interactions in Autism awarded by Massachusetts General Hospital 2016 - 2019
- Network Dynamics of Positive and Negative Valence Systems in Decision Making awarded by Ruth K. Broad Biomedical Research Foundation 2018 - 2019
- Unraveling the neural gate to consciousness awarded by W.M. Keck Foundation 2016 - 2019
- Enabling Stress Resistance awarded by National Institutes of Health 2012 - 2018
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- A novel neural circuit analysis paradigm to model autism in mice awarded by National Institutes of Health 2014 - 2017
- BRAIN EAGER: Bayesian Models of Translational Neural Networks: Motivation and Reward awarded by National Science Foundation 2014 - 2017
- The 5-HT theory of depression tested in a naturalistic model of 5-HT deficiency awarded by National Institutes of Health 2006 - 2017
- Characterizing sensorimotor gaiting dysfunction in mouse models of schizophrenia awarded by National Institutes of Health 2013 - 2016
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Hultman, R, Ulrich, K, Sachs, BD, Blount, C, Carlson, DE, Ndubuizu, N, Bagot, RC, Parise, EM, Vu, M-AT, Gallagher, NM, Wang, J, Silva, AJ, Deisseroth, K, Mague, SD, Caron, MG, Nestler, EJ, Carin, L, and Dzirasa, K. "Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability." Cell 173, no. 1 (March 2018): 166-180.e14. Full Text
- Vu, M-AT, Adalı, T, Ba, D, Buzsáki, G, Carlson, D, Heller, K, Liston, C, Rudin, C, Sohal, VS, Widge, AS, Mayberg, HS, Sapiro, G, and Dzirasa, K. "A Shared Vision for Machine Learning in Neuroscience." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 38, no. 7 (February 2018): 1601-1607. Full Text
- Dzirasa, K. "Neuronal suppression causing depression?." Science Translational Medicine 10, no. 425 (January 24, 2018): eaar7520-eaar7520. Full Text
- Dzirasa, K. "Brain leak, mind bleak." Science Translational Medicine 9, no. 419 (December 6, 2017). Full Text
- Carlson, D, David, LK, Gallagher, NM, Vu, M-AT, Shirley, M, Hultman, R, Wang, J, Burrus, C, McClung, CA, Kumar, S, Carin, L, Mague, SD, and Dzirasa, K. "Dynamically Timed Stimulation of Corticolimbic Circuitry Activates a Stress-Compensatory Pathway." Biological Psychiatry 82, no. 12 (December 2017): 904-913. Full Text
- Dzirasa, K. "The new stars of synaptic regulation." Science Translational Medicine 9, no. 413 (October 25, 2017). Full Text
- Dzirasa, K. "In the mood for food." Science Translational Medicine 9, no. 407 (September 13, 2017). (Review) Full Text
- Dzirasa, K. "A brilliant approach to study the basis of intelligence?." Science Translational Medicine 9, no. 401 (August 2, 2017). (Review) Full Text
- Dzirasa, K. "When they go low, we go high." Science translational medicine 9, no. 395 (June 2017). Full Text
- Schaich Borg, J, Srivastava, S, Lin, L, Heffner, J, Dunson, D, Dzirasa, K, and de Lecea, L. "Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts." Brain and Behavior 7, no. 6 (June 2017): e00710-null. Full Text Open Access Copy
- Dzirasa, K. "Working memory: The real VIP." Science translational medicine 9, no. 389 (May 2017). Full Text
- Dzirasa, K. "The neural substrates of super memory." Science Translational Medicine 9, no. 383 (March 2017). Full Text
- Ade, KK, Wan, Y, Hamann, HC, O'Hare, JK, Guo, W, Quian, A, Kumar, S, Bhagat, S, Rodriguiz, RM, Wetsel, WC, Conn, PJ, Dzirasa, K, Huber, KM, and Calakos, N. "Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice." Biological Psychiatry 80, no. 7 (October 2016): 522-533. Full Text
- Hultman, R, Mague, SD, Li, Q, Katz, BM, Michel, N, Lin, L, Wang, J, David, LK, Blount, C, Chandy, R, Carlson, D, Ulrich, K, Carin, L, Dunson, D, Kumar, S, Deisseroth, K, Moore, SD, and Dzirasa, K. "Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology." Neuron 91, no. 2 (July 2016): 439-452. Full Text
- Wang, X, Bey, AL, Katz, BM, Badea, A, Kim, N, David, LK, Duffney, LJ, Kumar, S, Mague, SD, Hulbert, SW, Dutta, N, Hayrapetyan, V, Yu, C, Gaidis, E, Zhao, S, Ding, J-D, Xu, Q, Chung, L, Rodriguiz, RM, Wang, F, Weinberg, RJ, Wetsel, WC, Dzirasa, K, Yin, H, and Jiang, Y-H. "Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism." Nature Communications 7 (May 10, 2016): 11459-null. Full Text Open Access Copy
- Gordon, JA, and Dzirasa, K. "Animal models of psychiatric disorders." Neuroscience 321 (May 2016): 1-2. Full Text
- Sidor, MM, Spencer, SM, Dzirasa, K, Parekh, PK, Tye, KM, Warden, MR, Arey, RN, Enwright, JF, Jacobsen, JPR, Kumar, S, Remillard, EM, Caron, MG, Deisseroth, K, and McClung, CA. "Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice." Molecular psychiatry 20, no. 11 (November 2015): 1406-1419. Full Text
- Sidor, MM, Spencer, SM, Dzirasa, K, Parekh, PK, Tye, KM, Warden, MR, Arey, RN, Enwright, JF, Jacobsen, JPR, Kumar, S, Remillard, EM, Caron, MG, Deisseroth, K, and McClung, CA. "Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice." Molecular psychiatry 20, no. 11 (November 2015): 1479-1480. Full Text
- Borg, JS, Vu, M-A, Badea, C, Badea, A, Johnson, GA, and Dzirasa, K. "Localization of Metal Electrodes in the Intact Rat Brain Using Registration of 3D Microcomputed Tomography Images to a Magnetic Resonance Histology Atlas." Eneuro 2, no. 4 (July 2015). Full Text Open Access Copy
- Hultman, R, Sidor, MM, and Dzirasa, K. "Tuning the Brain-Gut Axis in Health and Disease." Current Stem Cell Reports 1, no. 1 (March 2015): 60-66. Full Text
- Dzirasa, K, Krishnan, RR, and Williams, RS. "Incubating the research independence of a medical scientist training program graduate: A case study." Academic Medicine 90, no. 2 (February 6, 2015): 176-179. Full Text
- Dzirasa, K, Krishnan, RR, and Williams, RS. "Incubating the research independence of a medical scientist training program graduate: a case study." Academic Medicine 90, no. 2 (February 2015): 176-179. Full Text
- Kumar, S, Hultman, R, Hughes, D, Michel, N, Katz, BM, and Dzirasa, K. "Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress." Nature Communications 5 (July 29, 2014): 4537-null. Full Text
- Dzirasa, K, Kumar, S, Sachs, BD, Caron, MG, and Nicolelis, MAL. "Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 33, no. 10 (March 2013): 4505-4513. Full Text
- Kumar, S, Black, SJ, Hultman, R, Szabo, ST, DeMaio, KD, Du, J, Katz, BM, Feng, G, Covington, HE, and Dzirasa, K. "Cortical control of affective networks." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 33, no. 3 (January 2013): 1116-1129. Full Text
- Dzirasa, K, and Lisanby, SH. "How does deep brain stimulation work?." Biological Psychiatry 72, no. 11 (December 2012): 892-894. Full Text
- Dzirasa, K, and Covington, HE. "Increasing the validity of experimental models for depression." Ann N Y Acad Sci 1265 (August 2012): 36-45. (Review) Full Text Link to Item
- Dzirasa, K, McGarity, DL, Bhattacharya, A, Kumar, S, Takahashi, JS, Dunson, D, McClung, CA, and Nicolelis, MAL. "Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 17 (April 2011): 6449-6456. Full Text
- Dzirasa, K, Fuentes, R, Kumar, S, Potes, JM, and Nicolelis, MAL. "Chronic in vivo multi-circuit neurophysiological recordings in mice." J Neurosci Methods 195, no. 1 (January 30, 2011): 36-46. Full Text Link to Item
- Dzirasa, K, Coque, L, Sidor, MM, Kumar, S, Dancy, EA, Takahashi, JS, McClung, CA, and Nicolelis, MAL. "Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 48 (December 2010): 16314-16323. Full Text
- Fuentes, R, Dzirasa, K, and Nicolelis, MAL. "Acute Effects of Spinal Cord Stimulation in Large-Scale Brain Circuits in a Transgenic Mouse Parkinson's Model." MOVEMENT DISORDERS 25 (September 15, 2010): S630-S630. Link to Item
- Dzirasa, K, Phillips, HW, Sotnikova, TD, Salahpour, A, Kumar, S, Gainetdinov, RR, Caron, MG, and Nicolelis, MAL. "Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 18 (May 2010): 6387-6397. Full Text
- Dzirasa, K, Ramsey, AJ, Takahashi, DY, Stapleton, J, Potes, JM, Williams, JK, Gainetdinov, RR, Sameshima, K, Caron, MG, and Nicolelis, MAL. "Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 25 (June 2009): 8215-8224. Full Text
- Dzirasa, K, Santos, LM, Ribeiro, S, Stapleton, J, Gainetdinov, RR, Caron, MG, and Nicolelis, MAL. "Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep." PLoS One 4, no. 4 (2009): e5238-. Full Text Link to Item
- Santos, LM, Dzirasa, K, Kubo, R, Silva, MTA, Ribeiro, S, Sameshima, K, Valle, AC, and Timo-Iaria, C. "Baseline hippocampal theta oscillation speeds correlate with rate of operant task acquisition." Behavioural Brain Research 190, no. 1 (June 2008): 152-155. Full Text
- Dzirasa, K, Ribeiro, S, Costa, R, Santos, LM, Lin, S-C, Grosmark, A, Sotnikova, TD, Gainetdinov, RR, Caron, MG, and Nicolelis, MAL. "Dopaminergic control of sleep-wake states." J Neurosci 26, no. 41 (October 11, 2006): 10577-10589. Full Text Link to Item
- Dzirasa, K, Ribeiro, S, Costa, R, Santos, LM, Lin, S-C, Grosmark, A, Sotnikova, TD, Gainetdinov, RR, Caron, MG, and Nicolelis, MAL. "Erratum: Dopaminergic Control of Sleep-Wake States (Journal of Neuroscience (October 11, 2006) (10577-10589))." Journal of Neuroscience 26, no. 47 (2006).
- Semple, KT, Lee, PH, Reid, BJ, and Dzirasa, K. "Bioavailability of cable insulating oil to soil biota." Battelle Memorial Institute International in Situ and on Site Bioreclamation Symposium Proceedings 5 (December 1, 1999).
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Book Sections
- Dzirasa, K. "Chronic recordings in transgenic mice." In Methods for Neural Ensemble Recordings, Second Edition, 83-96. January 1, 2007.
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Conference Papers
- Gallagher, NM, Ulrich, K, Talbot, A, Dzirasa, K, Carin, L, and Carlson, DE. "Cross-spectral factor analysis." January 1, 2017.
- Li, Y, Murias, M, Major, S, Dawson, G, Dzirasa, K, Carin, L, and Carlson, DE. "Targeting EEG/LFP synchrony with neural nets." January 1, 2017.
- Ulrich, K, Carlson, DE, Dzirasa, K, and Carin, L. "GP kernels for cross-spectrum analysis." January 1, 2015.
- Carlson, DE, Borg, JS, Dzirasa, K, and Carin, L. "On the relationship between LFP & spiking data." January 1, 2014.
- Ulrich, K, Carlson, DE, Lian, W, Borg, JS, Dzirasa, K, and Carin, L. "Analysis of brain states from multi-region LFP time-series." January 1, 2014.
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- Teaching & Mentoring
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Recent Courses
- NEUROBIO 393: Research Independent Study 2019
- NEUROBIO 793: Research in Neurobiology 2019
- NEUROSCI 493: Research Independent Study 1 2019
- NEUROSCI 495: Research Independent Study 3 2019
- NEUROSCI 494: Research Independent Study 2 2018
- NEUROSCI 150: Research Practicum 2017
- NEUROSCI 496: Research Independent Study 4 2017
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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