Kafui Dzirasa
K. Ranga Rama Krishnan Associate Professor
Current Appointments & Affiliations
- K. Ranga Rama Krishnan Associate Professor, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2018
- Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2019
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2014
- Associate Professor in Neurobiology, without tenure, Neurobiology, Basic Science Departments 2017
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2018
- Investigator in the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2013
Contact Information
- Box 3209 Medctr, Durham, NC 27710
- Bryan Research Bldg, Room 361, Durham, NC 27710
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kafui.dzirasa@duke.edu
(919) 681-7371
- Background
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Education, Training, & Certifications
- Resident in Psychiatry, Psychiatry, Duke University School of Medicine 2010 - 2016
- M.D., Duke University School of Medicine 2009
- Ph.D., Duke University 2007
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Duke Appointment History
- Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2017 - 2019
- Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2013 - 2017
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2013 - 2017
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2017
- Assistant Research Professor in Neurobiology, Neurobiology, Basic Science Departments 2012 - 2013
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2013
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Geriatric Behavioral Health, Psychiatry & Behavioral Sciences 2009 - 2013
- Instructor, Temporary in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Geriatric Behavioral Health, Psychiatry & Behavioral Sciences 2009
- Recognition
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In the News
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AUG 30, 2019 Graduate School -
APR 18, 2019 -
DEC 14, 2018 -
AUG 6, 2018 Duke Medicine Alumni Magazine -
MAR 1, 2018 Duke University -
JUN 23, 2017 -
FEB 15, 2017 -
OCT 18, 2016 -
AUG 9, 2016 -
JUN 23, 2016 -
MAY 9, 2016 -
APR 14, 2016 PBS “Ride the Tiger” documentary -
FEB 19, 2016 -
JUN 26, 2015 -
JUL 30, 2014 USA Today -
JUL 29, 2014
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- Research
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Selected Grants
- Dissecting and modifying temporal dynamics underlying major depressive disorder awarded by National Institutes of Health 2019 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Network Dynamics of Negative and Positive Valence Systems in Decision Making awarded by National Institutes of Health 2019 - 2023
- Uncovering Population-Level Cellular Relationships to Behavior via Mesoscale Networks awarded by National Institutes of Health 2019 - 2022
- Engineering Gap Junctions for the Study and Treatment of Autism Spectrum Disorders 2019 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- Acculturation Stress, Biomarkers, and Psychopathology Among Hispanic Immigrants awarded by National Institutes of Health 2017 - 2022
- Network Dynamics of Negative and Positive Valence Systems in Decision Making awarded by Burroughs Wellcome Fund 2019 - 2021
- Engineering gap junctions for the study and treatment of Autism Spectrum Disorders awarded by Burroughs Wellcome Fund 2018 - 2021
- Environmental Toxins and Microglia-Synapse Interactions in Autism awarded by National Institutes of Health 2016 - 2021
- Neuromuscular Control of Primate Eye Movements awarded by National Institutes of Health 2019 - 2021
- A FULLY BIOLOGICAL PLATFORM FOR MONITORING MESOSCALE NEURAL ACTIVITY awarded by Burroughs Wellcome Fund 2019 - 2020
- Akt/GSK-3 Signaling Cascade and the Actions of Dopamine awarded by National Institutes of Health 2005 - 2020
- A fully biological platform for monitoring mesoscale neural activity awarded by National Institutes of Health 2018 - 2020
- Unmasking a Role for Cortical Dopamine D4 Receptors in Controlling Circuit Dynamics and Behavior awarded by National Institutes of Health 2018 - 2020
- Hartwell Fellowship 2018 - 2020
- Multilevel integration to understand, treat, and prevent depression 2019 - 2020
- Unraveling the neural gate to consciousness awarded by W.M. Keck Foundation 2016 - 2020
- The neurophysiology of impulsive sensation seeking awarded by University of Pittsburgh 2018 - 2020
- Simultaneous and Bidirectional Chemogenetic Control of Mesolimbic and Nigrostriatal Circuits awarded by National Institutes of Health 2018 - 2020
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by Yale University 2019
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by National Institutes of Health 2019
- Network Dynamics of Positive and Negative Valence Systems in Decision Making 2018 - 2019
- Environmental Toxins and Microglia-Synapse Interactions in Autism awarded by Massachusetts General Hospital 2016 - 2019
- Enabling Stress Resistance awarded by National Institutes of Health 2012 - 2018
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- A novel neural circuit analysis paradigm to model autism in mice awarded by National Institutes of Health 2014 - 2017
- BRAIN EAGER: Bayesian Models of Translational Neural Networks: Motivation and Reward awarded by National Science Foundation 2014 - 2017
- The 5-HT theory of depression tested in a naturalistic model of 5-HT deficiency awarded by National Institutes of Health 2006 - 2017
- Characterizing sensorimotor gaiting dysfunction in mouse models of schizophrenia awarded by National Institutes of Health 2013 - 2016
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Grossman, Yael, and Kafui Dzirasa. “Is depression a disorder of electrical brain networks?.” Neuropsychopharmacology 45, no. 1 (January 2020): 230–31. https://doi.org/10.1038/s41386-019-0511-8.Full Text Link to Item
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Hish, Alexander J., Gabriela A. Nagy, Caitlin M. Fang, Lisalynn Kelley, Christopher V. Nicchitta, Kafui Dzirasa, and M Zachary Rosenthal. “Applying the Stress Process Model to Stress-Burnout and Stress-Depression Relationships in Biomedical Doctoral Students: A Cross-Sectional Pilot Study..” Cbe Life Sci Educ 18, no. 4 (December 2019). https://doi.org/10.1187/cbe.19-03-0060.Full Text Link to Item
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Jiang-Xie, Li-Feng, Luping Yin, Shengli Zhao, Vincent Prevosto, Bao-Xia Han, Kafui Dzirasa, and Fan Wang. “A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep..” Neuron 102, no. 5 (June 5, 2019): 1053-1065.e4. https://doi.org/10.1016/j.neuron.2019.03.033.Full Text Link to Item
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Nagy, Gabriela A., Caitlin M. Fang, Alexander J. Hish, Lisalynn Kelly, Christopher V. Nicchitta, Kafui Dzirasa, and M Zachary Rosenthal. “Burnout and Mental Health Problems in Biomedical Doctoral Students..” Cbe Life Sci Educ 18, no. 2 (June 2019). https://doi.org/10.1187/cbe.18-09-0198.Full Text Link to Item
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Hultman, Rainbo, Kyle Ulrich, Benjamin D. Sachs, Cameron Blount, David E. Carlson, Nkemdilim Ndubuizu, Rosemary C. Bagot, et al. “Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability..” Cell 173, no. 1 (March 22, 2018): 166-180.e14. https://doi.org/10.1016/j.cell.2018.02.012.Full Text Link to Item
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Vu, Mai-Anh T., Tülay Adalı, Demba Ba, György Buzsáki, David Carlson, Katherine Heller, Conor Liston, et al. “A Shared Vision for Machine Learning in Neuroscience..” J Neurosci 38, no. 7 (February 14, 2018): 1601–7. https://doi.org/10.1523/JNEUROSCI.0508-17.2018.Full Text Link to Item
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Dzirasa, K. “Neuronal suppression causing depression?.” Science Translational Medicine 10, no. 425 (January 24, 2018). https://doi.org/10.1126/scitranslmed.aar7520.Full Text
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Carlson, David, Lisa K. David, Neil M. Gallagher, Mai-Anh T. Vu, Matthew Shirley, Rainbo Hultman, Joyce Wang, et al. “Dynamically Timed Stimulation of Corticolimbic Circuitry Activates a Stress-Compensatory Pathway..” Biol Psychiatry 82, no. 12 (December 15, 2017): 904–13. https://doi.org/10.1016/j.biopsych.2017.06.008.Full Text Link to Item
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Dzirasa, K. “Brain leak, mind bleak.” Science Translational Medicine 9, no. 419 (December 6, 2017). https://doi.org/10.1126/scitranslmed.aar4429.Full Text
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Dzirasa, K. “The new stars of synaptic regulation.” Science Translational Medicine 9, no. 413 (October 25, 2017). https://doi.org/10.1126/scitranslmed.aap8174.Full Text
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Dzirasa, K. “In the mood for food.” Science Translational Medicine 9, no. 407 (September 13, 2017). https://doi.org/10.1126/scitranslmed.aao6124.Full Text
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Dzirasa, K. “A brilliant approach to study the basis of intelligence?.” Science Translational Medicine 9, no. 401 (August 2, 2017). https://doi.org/10.1126/scitranslmed.aao0978.Full Text
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Dzirasa, Kafui. “When they go low, we go high..” Sci Transl Med 9, no. 395 (June 21, 2017). https://doi.org/10.1126/scitranslmed.aan6193.Full Text Link to Item
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Schaich Borg, Jana, Sanvesh Srivastava, Lizhen Lin, Joseph Heffner, David Dunson, Kafui Dzirasa, and Luis de Lecea. “Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts..” Brain Behav 7, no. 6 (June 2017). https://doi.org/10.1002/brb3.710.Full Text Open Access Copy Link to Item
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Dzirasa, Kafui. “Working memory: The real VIP..” Sci Transl Med 9, no. 389 (May 10, 2017). https://doi.org/10.1126/scitranslmed.aan3779.Full Text Link to Item
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Dzirasa, Kafui. “The neural substrates of super memory..” Sci Transl Med 9, no. 383 (March 29, 2017). https://doi.org/10.1126/scitranslmed.aan0770.Full Text Link to Item
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Ade, Kristen K., Yehong Wan, Harold C. Hamann, Justin K. O’Hare, Weirui Guo, Anna Quian, Sunil Kumar, et al. “Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice..” Biol Psychiatry 80, no. 7 (October 1, 2016): 522–33. https://doi.org/10.1016/j.biopsych.2016.04.023.Full Text Link to Item
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Hultman, Rainbo, Stephen D. Mague, Qiang Li, Brittany M. Katz, Nadine Michel, Lizhen Lin, Joyce Wang, et al. “Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology..” Neuron 91, no. 2 (July 20, 2016): 439–52. https://doi.org/10.1016/j.neuron.2016.05.038.Full Text Link to Item
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Wang, Xiaoming, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, et al. “Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism..” Nat Commun 7 (May 10, 2016). https://doi.org/10.1038/ncomms11459.Full Text Open Access Copy Link to Item
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Gordon, Joshua A., and Kafui Dzirasa. “Animal models of psychiatric disorders..” Neuroscience 321 (May 3, 2016): 1–2. https://doi.org/10.1016/j.neuroscience.2016.02.004.Full Text Link to Item
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Sidor, M. M., S. M. Spencer, K. Dzirasa, P. K. Parekh, K. M. Tye, M. R. Warden, R. N. Arey, et al. “Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice..” Mol Psychiatry 20, no. 11 (November 2015): 1406–19. https://doi.org/10.1038/mp.2014.167.Full Text Link to Item
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Sidor, M. M., S. M. Spencer, K. Dzirasa, P. K. Parekh, K. M. Tye, M. R. Warden, R. N. Arey, et al. “Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice..” Mol Psychiatry 20, no. 11 (November 2015): 1479–80. https://doi.org/10.1038/mp.2015.8.Full Text Link to Item
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Borg, Jana Schaich, Mai-Anh Vu, Cristian Badea, Alexandra Badea, G Allan Johnson, and Kafui Dzirasa. “Localization of Metal Electrodes in the Intact Rat Brain Using Registration of 3D Microcomputed Tomography Images to a Magnetic Resonance Histology Atlas..” Eneuro 2, no. 4 (July 2015). https://doi.org/10.1523/ENEURO.0017-15.2015.Full Text Open Access Copy Link to Item
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Hultman, R., M. M. Sidor, and K. Dzirasa. “Tuning the Brain-Gut Axis in Health and Disease.” Current Stem Cell Reports 1, no. 1 (March 1, 2015): 60–66. https://doi.org/10.1007/s40778-014-0004-y.Full Text
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Dzirasa, Kafui, Ranga R. Krishnan, and R Sanders Williams. “Incubating the research independence of a medical scientist training program graduate: a case study..” Acad Med 90, no. 2 (February 2015): 176–79. https://doi.org/10.1097/ACM.0000000000000568.Full Text Link to Item
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Kumar, Sunil, Rainbo Hultman, Dalton Hughes, Nadine Michel, Brittany M. Katz, and Kafui Dzirasa. “Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress..” Nat Commun 5 (July 29, 2014). https://doi.org/10.1038/ncomms5537.Full Text Link to Item
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Dzirasa, Kafui, Sunil Kumar, Benjamin D. Sachs, Marc G. Caron, and Miguel A. L. Nicolelis. “Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency..” J Neurosci 33, no. 10 (March 6, 2013): 4505–13. https://doi.org/10.1523/JNEUROSCI.4891-12.2013.Full Text Link to Item
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Kumar, Sunil, Sherilynn J. Black, Rainbo Hultman, Steven T. Szabo, Kristine D. DeMaio, Jeanette Du, Brittany M. Katz, Guoping Feng, Herbert E. Covington, and Kafui Dzirasa. “Cortical control of affective networks..” J Neurosci 33, no. 3 (January 16, 2013): 1116–29. https://doi.org/10.1523/JNEUROSCI.0092-12.2013.Full Text Link to Item
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Dzirasa, Kafui, and Sarah H. Lisanby. “How does deep brain stimulation work?.” Biol Psychiatry 72, no. 11 (December 1, 2012): 892–94. https://doi.org/10.1016/j.biopsych.2012.09.013.Full Text Link to Item
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Dzirasa, Kafui, and Herbert E. Covington. “Increasing the validity of experimental models for depression..” Ann N Y Acad Sci 1265 (August 2012): 36–45. https://doi.org/10.1111/j.1749-6632.2012.06669.x.Full Text Link to Item
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Dzirasa, Kafui, DeAnna L. McGarity, Anirban Bhattacharya, Sunil Kumar, Joseph S. Takahashi, David Dunson, Colleen A. McClung, and Miguel A. L. Nicolelis. “Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania..” J Neurosci 31, no. 17 (April 27, 2011): 6449–56. https://doi.org/10.1523/JNEUROSCI.6144-10.2011.Full Text Link to Item
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Dzirasa, Kafui, Romulo Fuentes, Sunil Kumar, Juan M. Potes, and Miguel A. L. Nicolelis. “Chronic in vivo multi-circuit neurophysiological recordings in mice..” J Neurosci Methods 195, no. 1 (January 30, 2011): 36–46. https://doi.org/10.1016/j.jneumeth.2010.11.014.Full Text Link to Item
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Dzirasa, Kafui, Laurent Coque, Michelle M. Sidor, Sunil Kumar, Elizabeth A. Dancy, Joseph S. Takahashi, Colleen A. McClung, and Miguel A. L. Nicolelis. “Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania..” J Neurosci 30, no. 48 (December 1, 2010): 16314–23. https://doi.org/10.1523/JNEUROSCI.4289-10.2010.Full Text Link to Item
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Fuentes, R., K. Dzirasa, and M. A. L. Nicolelis. “Acute Effects of Spinal Cord Stimulation in Large-Scale Brain Circuits in a Transgenic Mouse Parkinson's Model.” Movement Disorders 25 (September 15, 2010): S630–S630.Link to Item
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Dzirasa, Kafui, H Westley Phillips, Tatyana D. Sotnikova, Ali Salahpour, Sunil Kumar, Raul R. Gainetdinov, Marc G. Caron, and Miguel A. L. Nicolelis. “Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony..” J Neurosci 30, no. 18 (May 5, 2010): 6387–97. https://doi.org/10.1523/JNEUROSCI.0764-10.2010.Full Text Link to Item
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Dzirasa, Kafui, Amy J. Ramsey, Daniel Yasumasa Takahashi, Jennifer Stapleton, Juan M. Potes, Jamila K. Williams, Raul R. Gainetdinov, Koichi Sameshima, Marc G. Caron, and Miguel A. L. Nicolelis. “Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling..” J Neurosci 29, no. 25 (June 24, 2009): 8215–24. https://doi.org/10.1523/JNEUROSCI.1773-09.2009.Full Text Link to Item
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Dzirasa, Kafui, Lucas M. Santos, Sidarta Ribeiro, Jennifer Stapleton, Raul R. Gainetdinov, Marc G. Caron, and Miguel A. L. Nicolelis. “Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep..” Plos One 4, no. 4 (2009). https://doi.org/10.1371/journal.pone.0005238.Full Text Link to Item
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Santos, Lucas M., Kafui Dzirasa, Rodrigo Kubo, M Teresa A. Silva, Sidarta Ribeiro, Koichi Sameshima, Angela C. Valle, and Cesar Timo-Iaria. “Baseline hippocampal theta oscillation speeds correlate with rate of operant task acquisition..” Behav Brain Res 190, no. 1 (June 26, 2008): 152–55. https://doi.org/10.1016/j.bbr.2008.02.032.Full Text Link to Item
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Dzirasa, K., S. Ribeiro, R. Costa, L. M. Santos, S. C. Lin, A. Grosmark, T. D. Sotnikova, R. R. Gainetdinov, M. G. Caron, and M. A. L. Nicolelis. “Erratum: Dopaminergic Control of Sleep-Wake States (Journal of Neuroscience (October 11, 2006) (10577-10589)).” Journal of Neuroscience 26, no. 47 (November 22, 2006).
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Dzirasa, Kafui, Sidarta Ribeiro, Rui Costa, Lucas M. Santos, Shih-Chieh Lin, Andres Grosmark, Tatyana D. Sotnikova, Raul R. Gainetdinov, Marc G. Caron, and Miguel A. L. Nicolelis. “Dopaminergic control of sleep-wake states..” J Neurosci 26, no. 41 (October 11, 2006): 10577–89. https://doi.org/10.1523/JNEUROSCI.1767-06.2006.Full Text Link to Item
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Semple, K. T., P. H. Lee, B. J. Reid, and K. Dzirasa. “Bioavailability of cable insulating oil to soil biota.” Battelle Memorial Institute International in Situ and on Site Bioreclamation Symposium Proceedings 5 (December 1, 1999).
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Book Sections
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Dzirasa, K. “Chronic recordings in transgenic mice.” In Methods for Neural Ensemble Recordings, Second Edition, 83–96, 2007.
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Conference Papers
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Gallagher, N. M., K. Ulrich, A. Talbot, K. Dzirasa, L. Carin, and D. E. Carlson. “Cross-spectral factor analysis.” In Advances in Neural Information Processing Systems, 2017-December:6843–53, 2017.
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Li, Y., M. Murias, S. Major, G. Dawson, K. Dzirasa, L. Carin, and D. E. Carlson. “Targeting EEG/LFP synchrony with neural nets.” In Advances in Neural Information Processing Systems, 2017-December:4621–31, 2017.
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Ulrich, K., D. E. Carlson, K. Dzirasa, and L. Carin. “GP kernels for cross-spectrum analysis.” In Advances in Neural Information Processing Systems, 2015-January:1999–2007, 2015.
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Carlson, D. E., J. S. Borg, K. Dzirasa, and L. Carin. “On the relationship between LFP & spiking data.” In Advances in Neural Information Processing Systems, 3:2060–68, 2014.
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Ulrich, K., D. E. Carlson, W. Lian, J. S. Borg, K. Dzirasa, and L. Carin. “Analysis of brain states from multi-region LFP time-series.” In Advances in Neural Information Processing Systems, 3:2483–91, 2014.
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- Teaching & Mentoring
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Recent Courses
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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