Journal ArticleNature communications · May 2025
Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine and a common cause of chronic diarrhea in older adults. Here, we use single-cell RNA sequencing analysis of colonic mucosal tissue to build a cellular and molecular model for ...
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Journal ArticleDig Dis Sci · January 2025
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a leading cause of morbidity and mortality, and health disparities have been shown to influence disease burden. AI ...
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Journal ArticleDigestive diseases and sciences · July 2022
BackgroundMicroscopic colitis (MC) primarily affects older adults; thus, data in younger patients are scarce.AimsTo compare clinical characteristics and treatment response by age at diagnosis.MethodsThis retrospective cohort stud ...
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Journal ArticleJournal of medical microbiology · April 2022
Introduction. Evidence has linked exogenous and endogenous sex hormones with the human microbiome.Hypothesis/Gap statement. The longitudinal effects of oral contraceptives (OC) on the human gut microbiome have not previously been studied.A ...
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Journal ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · May 2021
Background and aimsDespite reported adverse effects of opioids in patients with inflammatory bowel disease (IBD), the burden of opioid use in this population appears to be high. We performed a systematic review and meta-analysis of prior studies t ...
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Journal ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · April 2020
The critical role of the gut microbiome in microscopic colitis (MC) is evident by the observation that fecal diversion is associated with resolution of mucosal inflammation while restoration of fecal stream is associated with recurrence of disease.1
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