Overview
My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.
Current Appointments & Affiliations
Professor of Medicine
·
2015 - Present
Medicine, Cardiology,
Medicine
Member in the Duke Clinical Research Institute
·
1995 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Advancing Age and Risk From the Elevated Atherogenic Index: Triglyceride (TG) to High-Density Cholesterol (HDL-C) Ratio.
Journal Article J Am Geriatr Soc · June 29, 2025 BACKGROUND: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but this association diminishes with age. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio, also known as ... Full text Link to item CiteEffect of Frailty on In-Hospital Mortality and Complications of PCI: An NCDR Registry Report.
Journal Article J Am Coll Cardiol · June 24, 2025 Full text Link to item CiteDevelopment and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults.
Journal Article J Am Heart Assoc · June 3, 2025 BACKGROUND: Guidelines emphasize using atherosclerotic cardiovascular disease (ASCVD) risk prediction models for treatment decisions, but risk of cognitive impairment is an equally important concern in older adults. Current ASCVD risk prediction models wer ... Full text Link to item CiteRecent Grants
PREVENTABLE
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2027Coronary Artery Calcium in the PRagmatic EValuation of evENTs And Benefits of Lipid lowering in the Elderly: CAC PREVENTABLE Ancillary Study
ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2027PREVENTABLE Trial Partnership and Meeting Support
ConferencePrincipal Investigator · Awarded by Alzheimer's Association · 2024 - 2025View All Grants
Education, Training & Certifications
Duke University ·
1992
M.D.