Karen Patton Alexander | Scholars@Duke

Karen Patton Alexander
Professor of Medicine

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Cardiology, Medicine 2015
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1995

Contact Information

200 Morris St, Durham, NC 27701
Duke Box 3411, Durham, NC 27710
(919) 668-8871

Background
Education, Training, & Certifications
- Cardiology Fellow, Medicine, Duke University 1995 - 1998
- Resident, Internal Medicine, Brigham and Women's Hospital 1993 - 1995
- Intern, Internal Medicine, Brigham and Women's Hospital 1992 - 1993
- M.D., Duke University 1992
Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2010 - 2015
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2006 - 2010
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2000 - 2006
- Associate in the Department of Medicine, Medicine, Cardiology, Medicine 1998 - 2000
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 1998
Recognition
In the News
- AUG 22, 2022 Clinical and Translational Science Institute
  
  Could a Common Heart Medication Prevent Dementia?
- NOV 10, 2015 Duke Today
  
  Angioplasty Procedure Reduces Need for Additional Drug Even When Blockages Remain
- NOV 10, 2015
  
  Angioplasty Procedure Reduces Need for Additional Drug Even When Blockages Remain
Research
Selected Grants
- PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE) awarded by National Institutes of Health 2019 - 2027
- Coronary Artery Calcium in the PRagmatic EValuation of evENTs And Benefits of Lipid lowering in the Elderly: CAC PREVENTABLE Ancillary Study awarded by National Institutes of Health 2021 - 2026
- PREVENTABLE Trial Partnership and Meeting Support awarded by Alzheimer's Association 2022
- ISCHEMIA-CKD SDCC awarded by National Institutes of Health 2013 - 2022
- The ISCHEMIA Trial - SDCC awarded by National Institutes of Health 2011 - 2022
- The ISCHEMIA Trial - SDCC awarded by National Institutes of Health 2011 - 2019
- CABANA-AF Trial awarded by National Institutes of Health 2009 - 2017
- NCDR-ACTION awarded by American College of Cardiology Foundation 2008 - 2015
- Duke Cardiovascular CERTs awarded by Agency for Healthcare Research and Quality 2007 - 2012
- Transition of Care for Acute Stroke and Myocardial Infarction Patients awarded by Agency for Healthcare Research and Quality 2010 - 2011
- Safer Antithrombotic Therapy for Elderly ACS Patients awarded by National Institutes of Health 2005 - 2008
- Managed Care Features Affecting Quality for CAD Patients awarded by National Institutes of Health 1999 - 2003
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Damluji, Abdulla A., Daniel E. Forman, Tracy Y. Wang, Joanna Chikwe, Vijay Kunadian, Michael W. Rich, Bessie A. Young, et al. “Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association.” Circulation 147, no. 3 (January 17, 2023): e32–62. https://doi.org/10.1161/CIR.0000000000001112.
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  - Bagai, Akshay, Faeez M. Ali, John Gregson, Karen P. Alexander, Mauricio G. Cohen, Karolina Andersson Sundell, Tabassome Simon, et al. “Multimorbidity, functional impairment, and mortality in older patients stable after prior acute myocardial infarction: Insights from the TIGRIS registry.” Clin Cardiol 45, no. 12 (December 2022): 1277–86. https://doi.org/10.1002/clc.23915.
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  - Park, Dae Yong, Jiun-Ruey Hu, Karen P. Alexander, and Michael G. Nanna. “Readmission and adverse outcomes after percutaneous coronary intervention in patients with dementia.” J Am Geriatr Soc, November 21, 2022. https://doi.org/10.1111/jgs.18120.
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  - Chaitman, Bernard R., Derek D. Cyr, Karen P. Alexander, Radosław Pracoń, Kevin R. Bainey, Anoop Mathew, Anjali Acharya, et al. “Cardiovascular and Renal Implications of Myocardial Infarction in the ISCHEMIA-CKD Trial.” Circ Cardiovasc Interv 15, no. 8 (August 2022): e012103. https://doi.org/10.1161/CIRCINTERVENTIONS.122.012103.
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  - Udell, Jacob A., Di Lu, Akshay Bagai, John A. Dodson, Nihar R. Desai, Gregg C. Fonarow, Abhinav Goyal, et al. “Preexisting frailty and outcomes in older patients with acute myocardial infarction.” Am Heart J 249 (July 2022): 34–44. https://doi.org/10.1016/j.ahj.2022.03.007.
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  - Alexander, Karen P. “Meaningful Evidence for Anticoagulation in the Gray (Elder) Zone.” Jama Cardiol 7, no. 6 (June 1, 2022): 581–82. https://doi.org/10.1001/jamacardio.2022.0477.
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  - Wegermann, Zachary K., Michael J. Mack, Suzanne V. Arnold, Christin A. Thompson, Michael Ryan, Candace Gunnarsson, Susan Strong, David J. Cohen, Karen P. Alexander, and J Matthew Brennan. “Anxiety and Depression Following Aortic Valve Replacement.” J Am Heart Assoc 11, no. 9 (May 3, 2022): e024377. https://doi.org/10.1161/JAHA.121.024377.
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  - Lowenstern, Angela, Karen P. Alexander, Neha J. Pagidipati, C Larry Hill, Patricia A. Pellikka, Lawton S. Cooper, Brooke Alhanti, Udo Hoffmann, Daniel B. Mark, and Pamela S. Douglas. “Presenting Symptoms in Patients Undergoing Coronary Artery Disease Evaluation: Association With Noninvasive Test Results and Clinical Outcomes in the PROMISE Trial.” Circ Cardiovasc Qual Outcomes 15, no. 5 (May 2022): e008298. https://doi.org/10.1161/CIRCOUTCOMES.121.008298.
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  - Mark, Daniel B., John A. Spertus, Robert Bigelow, Sophia Anderson, Melanie R. Daniels, Kevin J. Anstrom, Khaula N. Baloch, et al. “Comprehensive Quality-of-Life Outcomes With Invasive Versus Conservative Management of Chronic Coronary Disease in ISCHEMIA.” Circulation 145, no. 17 (April 26, 2022): 1294–1307. https://doi.org/10.1161/CIRCULATIONAHA.121.057363.
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  - Sharma, Abhinav, Kenneth W. Mahaffey, Charles Michael Gibson, Karen A. Hicks, Karen P. Alexander, Maria Ali, Bernard R. Chaitman, et al. “Clinical events classification (CEC) in clinical trials: Report on the current landscape and future directions - proceedings from the CEC Summit 2018.” Am Heart J 246 (April 2022): 93–104. https://doi.org/10.1016/j.ahj.2021.12.012.
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  - Ekerstad, Niklas, Dariush Javadzadeh, Karen P. Alexander, Olle Bergström, Lars Eurenius, Mats Fredrikson, Gudny Gudnadottir, et al. “Clinical Frailty Scale classes are independently associated with 6-month mortality for patients after acute myocardial infarction.” Eur Heart J Acute Cardiovasc Care 11, no. 2 (February 8, 2022): 89–98. https://doi.org/10.1093/ehjacc/zuab114.
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  - Rasmussen, Peter Vibe, Jannik Langtved Pallisgaard, Morten Lock Hansen, Gunnar Hilmar Gislason, Christian Torp-Pedersen, Martin Ruwald, Karen P. Alexander, Renato D. Lopes, Sana M. Al-Khatib, and Frederik Dalgaard. “Treatment of older patients with atrial fibrillation by morbidity burden.” Eur Heart J Qual Care Clin Outcomes 8, no. 1 (January 5, 2022): 23–30. https://doi.org/10.1093/ehjqcco/qcaa070.
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  - Lopez-Sendon, Jose L., Derek D. Cyr, Daniel B. Mark, Sripal Bangalore, Zhen Huang, Harvey D. White, Karen P. Alexander, et al. “Effects of initial invasive vs. initial conservative treatment strategies on recurrent and total cardiovascular events in the ISCHEMIA trial.” European Heart Journal 43, no. 2 (January 2022): 148–49. https://doi.org/10.1093/eurheartj/ehab509.
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  - Sachs, B. C., S. R. Rapp, C. E. Kistler, N. Musi, M. A. Supiano, N. M. Pajewski, K. E. Callahan, et al. “The PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) trial: Study design and procedures for cognitive assessment and adjudication.” Alzheimer’S and Dementia 17, no. S9 (December 1, 2021). https://doi.org/10.1002/alz.054022.
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  - Alexander, Karen P., and Pamela S. Douglas. “Chest Pain Redux: Updated and Patient Centered.” Circulation 144, no. 22 (November 30, 2021): 1735–37. https://doi.org/10.1161/CIRCULATIONAHA.121.056714.
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  - White, Harvey D., Sean M. O’Brien, Karen P. Alexander, William E. Boden, Sripal Bangalore, Jianghao Li, Cholenahally N. Manjunath, et al. “Comparison of Days Alive Out of Hospital With Initial Invasive vs Conservative Management: A Prespecified Analysis of the ISCHEMIA Trial.” Jama Cardiol 6, no. 9 (September 1, 2021): 1023–31. https://doi.org/10.1001/jamacardio.2021.1651.
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  - Schwartz, Gregory G., Michael Szarek, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, J Wouter Jukema, Ulf Landmesser, et al. “Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.” J Am Coll Cardiol 78, no. 5 (August 3, 2021): 421–33. https://doi.org/10.1016/j.jacc.2021.04.102.
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  - Alexander, Karen P. “Late-life watercolors, a friendship, and a fall.” J Am Geriatr Soc 69, no. 7 (July 2021): 2021–22. https://doi.org/10.1111/jgs.17144.
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  - Greenland, Philip, Erin D. Michos, Nicole Redmond, Lawrence J. Fine, Karen P. Alexander, Walter T. Ambrosius, Kirsten Bibbins-Domingo, et al. “Primary Prevention Trial Designs Using Coronary Imaging: A National Heart, Lung, and Blood Institute Workshop.” Jacc Cardiovasc Imaging 14, no. 7 (July 2021): 1454–65. https://doi.org/10.1016/j.jcmg.2020.06.042.
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  - Lopes, Renato D., Karen P. Alexander, Judith S. Hochman, and David J. Maron. “Response by Lopes et al to Letter Regarding Article, "Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial".” Circulation 143, no. 20 (May 18, 2021): e961–62. https://doi.org/10.1161/CIRCULATIONAHA.121.053672.
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  - Chaitman, Bernard R., Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, et al. “Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.” Circulation 143, no. 8 (February 23, 2021): 790–804. https://doi.org/10.1161/CIRCULATIONAHA.120.047987.
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  - Dalgaard, Frederik, Haolin Xu, Roland A. Matsouaka, Andrea M. Russo, Anne B. Curtis, Peter Vibe Rasmussen, Martin H. Ruwald, et al. “Management of Atrial Fibrillation in Older Patients by Morbidity Burden: Insights From Get With The Guidelines-Atrial Fibrillation.” J Am Heart Assoc 9, no. 23 (December 2020): e017024. https://doi.org/10.1161/JAHA.120.017024.
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  - Krishnaswami, Ashok, Craig Beavers, Michael P. Dorsch, John A. Dodson, Ruth Masterson Creber, Spyros Kitsiou, Parag Goyal, et al. “Gerotechnology for Older Adults With Cardiovascular Diseases: JACC State-of-the-Art Review.” J Am Coll Cardiol 76, no. 22 (December 1, 2020): 2650–70. https://doi.org/10.1016/j.jacc.2020.09.606.
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  - Lowenstern, Angela, Karen P. Alexander, and Pamela S. Douglas. “Should We Simplify Computed Tomography Angiography Reporting as Black or White vs Describing All Shades of Gray?-Reply.” Jama Cardiol 5, no. 12 (December 1, 2020): 1450–51. https://doi.org/10.1001/jamacardio.2020.3733.
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  - Lopes, Renato D., Karen P. Alexander, Susanna R. Stevens, Harmony R. Reynolds, Gregg W. Stone, Ileana L. Piña, Frank W. Rockhold, et al. “Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial.” Circulation 142, no. 18 (November 3, 2020): 1725–35. https://doi.org/10.1161/CIRCULATIONAHA.120.050304.
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  - Bangalore, Sripal, David J. Maron, Sean M. O’Brien, Jerome L. Fleg, Evgeny I. Kretov, Carlo Briguori, Upendra Kaul, et al. “Management of Coronary Disease in Patients with Advanced Kidney Disease.” N Engl J Med 382, no. 17 (April 23, 2020): 1608–18. https://doi.org/10.1056/NEJMoa1915925.
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  - Fanaroff, Alexander C., Ghazala Haque, Betsy Thomas, Allegra E. Stone, Lynn M. Perkins, Matthew Wilson, W Schuyler Jones, et al. “Methods for safety and endpoint ascertainment: identification of adverse events through scrutiny of negatively adjudicated events.” Trials 21, no. 1 (April 9, 2020): 323. https://doi.org/10.1186/s13063-020-04254-w.
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  - Maron, David J., Judith S. Hochman, Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, William E. Boden, Bernard R. Chaitman, et al. “Initial Invasive or Conservative Strategy for Stable Coronary Disease.” N Engl J Med 382, no. 15 (April 9, 2020): 1395–1407. https://doi.org/10.1056/NEJMoa1915922.
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  - Spertus, John A., Philip G. Jones, David J. Maron, Sean M. O’Brien, Harmony R. Reynolds, Yves Rosenberg, Gregg W. Stone, et al. “Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease.” N Engl J Med 382, no. 15 (April 9, 2020): 1408–19. https://doi.org/10.1056/NEJMoa1916370.
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  - Lowenstern, Angela, Karen P. Alexander, C Larry Hill, Brooke Alhanti, Patricia A. Pellikka, Michael G. Nanna, Rajendra H. Mehta, et al. “Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease: Insights From the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Trial.” Jama Cardiol 5, no. 2 (February 1, 2020): 193–201. https://doi.org/10.1001/jamacardio.2019.4973.
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  - Wenger, Nanette K., and Karen P. Alexander. “Not your grandparents' cardiac care: The future of geriatric cardiology.” Clin Cardiol 43, no. 2 (February 2020): 90–91. https://doi.org/10.1002/clc.23270.
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  - Damluji, Abdulla A., Daniel E. Forman, Sean van Diepen, Karen P. Alexander, Robert L. Page, Scott L. Hummel, Venu Menon, et al. “Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association.” Circulation 141, no. 2 (January 14, 2020): e6–32. https://doi.org/10.1161/CIR.0000000000000741.
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  - Starks, Monique Anderson, and Karen Alexander. “In Anticipation of the Inevitable: Preparing Older Americans for Cardiac Arrest.” J Am Geriatr Soc 68, no. 1 (January 2020): 9–10. https://doi.org/10.1111/jgs.16269.
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  - Nanna, Michael G., Eric D. Peterson, Angie Wu, Tina Harding, Anthony N. Galanos, Lisa Wruck, and Karen P. Alexander. “Age, knowledge, preferences, and risk tolerance for invasive cardiac care.” Am Heart J 219 (January 2020): 99–108. https://doi.org/10.1016/j.ahj.2019.09.008.
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  - Goyal, Parag, Eiran Z. Gorodeski, Kelsey M. Flint, Deena S. Goldwater, John A. Dodson, Jonathan Afilalo, Mathew S. Maurer, Michael W. Rich, Karen P. Alexander, and Scott L. Hummel. “Perspectives on Implementing a Multidomain Approach to Caring for Older Adults With Heart Failure.” J Am Geriatr Soc 67, no. 12 (December 2019): 2593–99. https://doi.org/10.1111/jgs.16183.
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  - Newman, Jonathan D., Karen P. Alexander, Xiangqiong Gu, Sean M. O’Brien, William E. Boden, Sajeev C. Govindan, Roxy Senior, et al. “Baseline Predictors of Low-Density Lipoprotein Cholesterol and Systolic Blood Pressure Goal Attainment After 1 Year in the ISCHEMIA Trial.” Circ Cardiovasc Qual Outcomes 12, no. 11 (November 2019): e006002. https://doi.org/10.1161/CIRCOUTCOMES.119.006002.
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  - Nanna, Michael G., Alexandra M. Hajduk, Harlan M. Krumholz, Terrence E. Murphy, Rachel P. Dreyer, Karen P. Alexander, Mary Geda, et al. “Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction: The SILVER-AMI Study.” Circ Cardiovasc Qual Outcomes 12, no. 10 (October 2019): e005691. https://doi.org/10.1161/CIRCOUTCOMES.119.005691.
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  - Bagai, Akshay, Anita Y. Chen, Jacob A. Udell, John A. Dodson, David D. McManus, Mathew S. Maurer, Jonathan R. Enriquez, et al. “Association of Cognitive Impairment With Treatment and Outcomes in Older Myocardial Infarction Patients: A Report From the NCDR Chest Pain-MI Registry.” J Am Heart Assoc 8, no. 17 (September 3, 2019): e012929. https://doi.org/10.1161/JAHA.119.012929.
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  - Alexander, Karen P., and John H. Alexander. “Safe and Effective Anticoagulation: What Does Drug Concentration Add?” J Am Geriatr Soc 67, no. 9 (September 2019): 1772–73. https://doi.org/10.1111/jgs.15981.
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  - Ray, Kausik K., Helen M. Colhoun, Michael Szarek, Marie Baccara-Dinet, Deepak L. Bhatt, Vera A. Bittner, Andrzej J. Budaj, et al. “Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.” Lancet Diabetes Endocrinol 7, no. 8 (August 2019): 618–28. https://doi.org/10.1016/S2213-8587(19)30158-5.
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  - Krishnaswami, Ashok, Michael A. Steinman, Parag Goyal, Andrew R. Zullo, Timothy S. Anderson, Kim K. Birtcher, Sarah J. Goodlin, et al. “Deprescribing in Older Adults With Cardiovascular Disease.” J Am Coll Cardiol 73, no. 20 (May 28, 2019): 2584–95. https://doi.org/10.1016/j.jacc.2019.03.467.
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  - Dodson, John A., Alexandra M. Hajduk, Terrence E. Murphy, Mary Geda, Harlan M. Krumholz, Sui Tsang, Michael G. Nanna, et al. “Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction.” Circ Cardiovasc Qual Outcomes 12, no. 5 (May 2019): e005320. https://doi.org/10.1161/CIRCOUTCOMES.118.005320.
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  - Fanaroff, Alexander C., Kristi Prather, Amanda Brucker, Daniel Wojdyla, Linda Davidson-Ray, Daniel B. Mark, Redford B. Williams, et al. “Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris.” Am J Cardiol 123, no. 9 (May 1, 2019): 1399–1405. https://doi.org/10.1016/j.amjcard.2019.01.036.
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  - Kaul, Padma, Karen P. Alexander, E Magnus Ohman, Anamaria Savu, Matthew T. Roe, Shaun G. Goodman, Keith A. Fox, et al. “Sex And Prognostic Significance of Self-Reported Frailty in Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From the TRILOGY ACS Trial.” Can J Cardiol 35, no. 4 (April 2019): 430–37. https://doi.org/10.1016/j.cjca.2018.12.035.
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  - “Correction.” Jacc: Cardiovascular Interventions 12, no. 7 (April 2019): 695–96. https://doi.org/10.1016/j.jcin.2019.03.009.
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  - Hochman, Judith S., Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, Karen P. Alexander, Roxy Senior, William E. Boden, et al. “Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial.” Jama Cardiol 4, no. 3 (March 1, 2019): 273–86. https://doi.org/10.1001/jamacardio.2019.0014.
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  - Fanaroff, Alexander C., Robert Clare, Karen S. Pieper, Kenneth W. Mahaffey, Chiara Melloni, Jennifer B. Green, John H. Alexander, et al. “Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials.” Circulation 139, no. 7 (February 12, 2019): 863–73. https://doi.org/10.1161/CIRCULATIONAHA.118.037202.
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  - Alexander, Karen P., Marc A. Brouwer, Hillary Mulder, Dragos Vinereanu, Renato D. Lopes, Marco Proietti, Sana M. Al-Khatib, et al. “Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial.” Am Heart J 208 (February 2019): 123–31. https://doi.org/10.1016/j.ahj.2018.09.017.
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  - Afilalo, Jonathan, Abhinav Sharma, Shuaiqi Zhang, J Matthew Brennan, Fred H. Edwards, Michael J. Mack, James B. McClurken, et al. “Gait Speed and 1-Year Mortality Following Cardiac Surgery: A Landmark Analysis From the Society of Thoracic Surgeons Adult Cardiac Surgery Database.” J Am Heart Assoc 7, no. 23 (December 4, 2018): e010139. https://doi.org/10.1161/JAHA.118.010139.
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  - Schwartz, Gregory G., P Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Jay M. Edelberg, et al. “Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.” N Engl J Med 379, no. 22 (November 29, 2018): 2097–2107. https://doi.org/10.1056/NEJMoa1801174.
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  - Dodson, John A., Judith S. Hochman, Matthew T. Roe, Anita Y. Chen, Sarwat I. Chaudhry, Stuart Katz, Hua Zhong, et al. “The Association of Frailty With In-Hospital Bleeding Among Older Adults With Acute Myocardial Infarction: Insights From the ACTION Registry.” Jacc Cardiovasc Interv 11, no. 22 (November 26, 2018): 2287–96. https://doi.org/10.1016/j.jcin.2018.08.028.
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  - Bangalore, Sripal, David J. Maron, Jerome L. Fleg, Sean M. O’Brien, Charles A. Herzog, Gregg W. Stone, Daniel B. Mark, et al. “International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design.” Am Heart J 205 (November 2018): 42–52. https://doi.org/10.1016/j.ahj.2018.07.023.
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  - Ekerstad, Niklas, Staffan Pettersson, Karen Alexander, David Andersson, Sofia Eriksson, Magnus Janzon, Marcus Lindenberger, Eva Swahn, and Joakim Alfredsson. “Frailty as an instrument for evaluation of elderly patients with non-ST-segment elevation myocardial infarction: A follow-up after more than 5 years.” Eur J Prev Cardiol 25, no. 17 (November 2018): 1813–21. https://doi.org/10.1177/2047487318799438.
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  - Hernandez, Adrian F., Jennifer B. Green, Salim Janmohamed, Ralph B. D’Agostino, Christopher B. Granger, Nigel P. Jones, Lawrence A. Leiter, et al. “Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.” Lancet 392, no. 10157 (October 27, 2018): 1519–29. https://doi.org/10.1016/S0140-6736(18)32261-X.
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  - Krishnaswami, Ashok, Dae Hyun Kim, Charles E. McCulloch, Daniel E. Forman, Mathew S. Maurer, Karen P. Alexander, and Michael W. Rich. “Individual and Joint Effects of Pulse Pressure and Blood Pressure Treatment Intensity on Serious Adverse Events in the SPRINT Trial.” Am J Med 131, no. 10 (October 2018): 1220-1227.e1. https://doi.org/10.1016/j.amjmed.2018.05.027.
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  - Patel, Ashish, Shaun G. Goodman, Andrew T. Yan, Karen P. Alexander, Camilla L. Wong, Asim N. Cheema, Jacob A. Udell, et al. “Frailty and Outcomes After Myocardial Infarction: Insights From the CONCORDANCE Registry.” J Am Heart Assoc 7, no. 18 (September 18, 2018): e009859. https://doi.org/10.1161/JAHA.118.009859.
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  - ISCHEMIA Trial Research Group, Yves, David J. Maron, Judith S. Hochman, Sean M. O’Brien, Harmony R. Reynolds, William E. Boden, Gregg W. Stone, et al. “International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design.” Am Heart J 201 (July 2018): 124–35. https://doi.org/10.1016/j.ahj.2018.04.011.
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  - Miller, Andrew P., Mathew Maurer, and Karen P. Alexander. “Geriatric Cardiology: Two Decades of Progress and Strategy for the Future.” J Am Coll Cardiol 71, no. 25 (June 26, 2018): 2970–73. https://doi.org/10.1016/j.jacc.2018.05.014.
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  - Madhavan, Mahesh V., Bernard J. Gersh, Karen P. Alexander, Christopher B. Granger, and Gregg W. Stone. “Coronary Artery Disease in Patients ≥80 Years of Age.” J Am Coll Cardiol 71, no. 18 (May 8, 2018): 2015–40. https://doi.org/10.1016/j.jacc.2017.12.068.
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  - Bangalore, Sripal, David J. Maron, Harmony R. Reynolds, Gregg W. Stone, Sean M. O’Brien, Karen P. Alexander, and Judith S. Hochman. “ISCHEMIA: Establishing the Primary End Point.” Circ Cardiovasc Qual Outcomes 11, no. 5 (May 2018): e004791. https://doi.org/10.1161/CIRCOUTCOMES.118.004791.
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  - Gorodeski, Eiran Z., Parag Goyal, Scott L. Hummel, Ashok Krishnaswami, Sarah J. Goodlin, Linda L. Hart, Daniel E. Forman, et al. “Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future.” J Am Coll Cardiol 71, no. 17 (May 1, 2018): 1921–36. https://doi.org/10.1016/j.jacc.2018.02.059.
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  - Patel, Krishna K., Suzanne V. Arnold, Philip G. Jones, Mohammed Qintar, Karen P. Alexander, and John A. Spertus. “Relation of Age and Health-Related Quality of Life to Invasive Versus Ischemia-Guided Management of Patients with Non-ST Elevation Myocardial Infarction.” Am J Cardiol 121, no. 7 (April 1, 2018): 789–95. https://doi.org/10.1016/j.amjcard.2017.12.034.
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  - Cooper, Lauren B., Bradley G. Hammill, Larry A. Allen, JoAnn Lindenfeld, Robert J. Mentz, Joseph G. Rogers, Carmelo A. Milano, Chetan B. Patel, Karen P. Alexander, and Adrian F. Hernandez. “Assessing Frailty in Patients Undergoing Destination Therapy Left Ventricular Assist Device: Observations from Interagency Registry for Mechanically Assisted Circulatory Support.” Asaio J 64, no. 1 (2018): 16–23. https://doi.org/10.1097/MAT.0000000000000600.
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  - Neeland, Ian J., Sandeep R. Das, DaJuanicia N. Simon, Deborah B. Diercks, Karen P. Alexander, Tracy Y. Wang, and James A. de Lemos. “The obesity paradox, extreme obesity, and long-term outcomes in older adults with ST-segment elevation myocardial infarction: results from the NCDR.” Eur Heart J Qual Care Clin Outcomes 3, no. 3 (July 1, 2017): 183–91. https://doi.org/10.1093/ehjqcco/qcx010.
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  - Arnold, Suzanne V., Shu-Xia Li, Karen P. Alexander, John A. Spertus, Brahmajee K. Nallamothu, Jeptha P. Curtis, Mikhail Kosiborod, et al. “Hospital variability in use of anticoagulant strategies during acute myocardial infarction treated with an early invasive strategy.” J Am Heart Assoc 4, no. 6 (June 15, 2015): e002009. https://doi.org/10.1161/JAHA.115.002009.
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  - O’Brien, Emily C., DaJuanicia N. Simon, Matthew T. Roe, Tracy Y. Wang, Eric D. Peterson, and Karen P. Alexander. “Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry).” Am J Cardiol 115, no. 12 (June 15, 2015): 1655–60. https://doi.org/10.1016/j.amjcard.2015.03.007.
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  - Taha, Salma, Fabrizio D’Ascenzo, Claudio Moretti, Pierluigi Omedè, Antonio Montefusco, Richard G. Bach, Karen P. Alexander, et al. “Accuracy of bleeding scores for patients presenting with myocardial infarction: a meta-analysis of 9 studies and 13 759 patients.” Postepy Kardiol Interwencyjnej 11, no. 3 (2015): 182–90. https://doi.org/10.5114/pwki.2015.54011.
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  - Hall, Hurst M., James A. de Lemos, Jonathan R. Enriquez, Darren K. McGuire, S Andrew Peng, Karen P. Alexander, Matthew T. Roe, Nihar Desai, Stephen D. Wiviott, and Sandeep R. Das. “Contemporary patterns of discharge aspirin dosing after acute myocardial infarction in the United States: results from the National Cardiovascular Data Registry (NCDR).” Circ Cardiovasc Qual Outcomes 7, no. 5 (September 2014): 701–7. https://doi.org/10.1161/CIRCOUTCOMES.113.000822.
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  - Alexander, Karen P., L Kristin Newby, Christopher P. Cannon, Paul W. Armstrong, W Brian Gibler, Michael W. Rich, Frans Van de Werf, et al. “Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology.” Circulation 115, no. 19 (May 15, 2007): 2549–69. https://doi.org/10.1161/CIRCULATIONAHA.107.182615.
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  - Alexander, Karen P., L Kristin Newby, Paul W. Armstrong, Christopher P. Cannon, W Brian Gibler, Michael W. Rich, Frans Van de Werf, et al. “Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology.” Circulation 115, no. 19 (May 15, 2007): 2570–89. https://doi.org/10.1161/CIRCULATIONAHA.107.182616.
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  - Skolnick, Adam H., Karen P. Alexander, Anita Y. Chen, Matthew T. Roe, Charles V. Pollack, E Magnus Ohman, John S. Rumsfeld, W Brian Gibler, Eric D. Peterson, and David J. Cohen. “Characteristics, management, and outcomes of 5,557 patients age > or =90 years with acute coronary syndromes: results from the CRUSADE Initiative.” J Am Coll Cardiol 49, no. 17 (May 1, 2007): 1790–97. https://doi.org/10.1016/j.jacc.2007.01.066.
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  - Frazier, Camille G., Karen P. Alexander, L Kristin Newby, Susan Anderson, Erik Iverson, Milton Packer, Jay Cohn, Sidney Goldstein, and Pamela S. Douglas. “Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials.” J Am Coll Cardiol 49, no. 13 (April 3, 2007): 1450–58. https://doi.org/10.1016/j.jacc.2006.11.041.
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  - Ali, Robin, and Karen P. Alexander. “Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence.” Am J Geriatr Pharmacother 5, no. 1 (March 2007): 52–63. https://doi.org/10.1016/j.amjopharm.2007.03.008.
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  - Purser, Jama L., Maragatha N. Kuchibhatla, Gerda G. Fillenbaum, Tina Harding, Eric D. Peterson, and Karen P. Alexander. “Identifying frailty in hospitalized older adults with significant coronary artery disease.” J Am Geriatr Soc 54, no. 11 (November 2006): 1674–81. https://doi.org/10.1111/j.1532-5415.2006.00914.x.
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  - Alexander, Karen P., Anita Y. Chen, L Kristin Newby, Nancy M Allen LaPointe, E Magnus Ohman, Matthew T. Roe, William E. Boden, and Eric D. Peterson. “Blood transfusion and mortality among patients with non-ST-segment elevation acute coronary syndromes: Results from CRUSADE.” Circulation 114, no. 18 (October 31, 2006): 701–701.
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  - Mellori, Chiara, Eric D. Peterson, Anita Y. Chen, Lynda A. Szczech, L Kristin Newby, Robert A. Harrington, W Brian Gibler, et al. “Importance of glomerular filtration rate formula for determining chronic kidney disease and clinical care in patients with acute coronary syndromes.” Circulation 114, no. 18 (October 31, 2006): 406–406.
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  - Frazier, Camille G., Karen P. Alexander, L Kristin Newby, Milton Packer, Jay Cohn, Sidney Goldstein, Ake Hjalmarson, Susan Anderson, Erik Iverson, and Pamela S. Douglas. “Sex differences in heart failure with systolic dysfunction: A pooled analysis of five randomized control trials.” Circulation 114, no. 18 (October 31, 2006): 573–573.
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  - Alexander, Karen P., Anita Y. Chen, L Kristin Newby, Janice B. Schwartz, Rita F. Redberg, Judith S. Hochman, Matthew T. Roe, et al. “Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative.” Circulation 114, no. 13 (September 26, 2006): 1380–87. https://doi.org/10.1161/CIRCULATIONAHA.106.620815.
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  - Kraschnewski, J. L., K. P. Alexander, and E. D. Peterson. “Coronary artery disease in later life.” Generations 30, no. 3 (September 1, 2006): 17–23.
  - Alexander, Karen P., Laura Kristin Newby, Manju V. Bhapkar, Harvey D. White, Judith S. Hochman, Matthias E. Pfisterer, David J. Moliterno, et al. “International variation in invasive care of the elderly with acute coronary syndromes.” Eur Heart J 27, no. 13 (July 2006): 1558–64. https://doi.org/10.1093/eurheartj/ehl067.
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  - Gharacholou, S Michael, and Karen P. Alexander. “Issues with care in the elderly patient presenting with acute ischemia.” Curr Heart Fail Rep 3, no. 2 (June 2006): 51–56. https://doi.org/10.1007/s11897-006-0002-1.
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  - Alexander, K. P., and E. D. Peterson. “In reply [6].” Jama 295, no. 16 (April 26, 2006): 1897. https://doi.org/10.1001/jama.295.16.1897-b.
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  - Alexander, Karen P., and Eric D. Peterson. “Treatment of non-ST-elevation acute coronary syndrome in the elderly: current practice and future opportunities.” Am J Geriatr Cardiol 15, no. 1 (2006): 42–49. https://doi.org/10.1111/j.1076-7460.2006.04642.x.
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  - Kulkarni, Sonali P., Karen P. Alexander, Barbara Lytle, Gerardo Heiss, and Eric D. Peterson. “Long-term adherence with cardiovascular drug regimens.” Am Heart J 151, no. 1 (January 2006): 185–91. https://doi.org/10.1016/j.ahj.2005.02.038.
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  - Swaminathan, Rajesh V., and Karen P. Alexander. “Pulse pressure and vascular risk in the elderly: associations and clinical implications.” Am J Geriatr Cardiol 15, no. 4 (2006): 226–32. https://doi.org/10.1111/j.1076-7460.2006.04774.x.
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  - Alexander, Karen P., Anita Y. Chen, Matthew T. Roe, L Kristin Newby, C Michael Gibson, Nancy M. Allen-LaPointe, Charles Pollack, et al. “Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes.” Jama 294, no. 24 (December 28, 2005): 3108–16. https://doi.org/10.1001/jama.294.24.3108.
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  - Yang, Xin, Karen P. Alexander, Anita Y. Chen, Matthew T. Roe, Ralph G. Brindis, Sunil V. Rao, W Brian Gibler, E Magnus Ohman, Eric D. Peterson, and Eric D. CRUSADE Investigators. “The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative.” J Am Coll Cardiol 46, no. 8 (October 18, 2005): 1490–95. https://doi.org/10.1016/j.jacc.2005.06.072.
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  - Alexander, Karen P., Matthew T. Roe, Anita Y. Chen, Barbara L. Lytle, Charles V. Pollack, Joanne M. Foody, William E. Boden, et al. “Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative.” J Am Coll Cardiol 46, no. 8 (October 18, 2005): 1479–87. https://doi.org/10.1016/j.jacc.2005.05.084.
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  - Gharacholou, S Michael, and Karen P. Alexander. “Issues with care in the elderly patient presenting with acute ischemia.” Curr Cardiol Rep 7, no. 4 (July 2005): 270–75. https://doi.org/10.1007/s11886-005-0048-9.
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  - DeLong, E. R., B. L. Lytle, P. A. Cowper, K. P. Alexander, E. D. Peterson, and D. B. Mark. “Research, managed care, and patient privacy: Challenges to successful collaboration.” Journal of Clinical Outcomes Management 12, no. 3 (March 1, 2005): 151–56.
  - Mehta, Rajendra H., Christopher B. Granger, Karen P. Alexander, Eduardo Bossone, Harvey D. White, and Michael H. Sketch. “Reperfusion strategies for acute myocardial infarction in the elderly: benefits and risks.” J Am Coll Cardiol 45, no. 4 (February 15, 2005): 471–78. https://doi.org/10.1016/j.jacc.2004.10.065.
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  - Mehta, S. R., S. Yusuf, R. Díaz, J. Zhu, P. Pais, D. Xavier, E. Paolasso, et al. “Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: The CREATE-ECLA randomized controlled trial.” Journal of the American Medical Association 293, no. 4 (2005): 437–46. https://doi.org/10.1001/jama.293.4.437.
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  - Heitner, John F., Igor Klem, Karen Alexander, Louise Thomson, Trip J. Meine, Manesh R. Patel, Salman A. Haq, Dipan J. Shah, and Raymond J. Kim. “The case of the disappearing myxoma.” J Cardiovasc Magn Reson 7, no. 5 (2005): 841–43. https://doi.org/10.1080/10976640500288156.
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  - Parsons, Elizabeth, L Kristin Newby, Manjushri V. Bhapkar, Karen P. Alexander, Harvey D. White, Svati H. Shah, Cheryl D. Bushnell, Robert M. Califf, and Robert M. Symphony and 2nd Symphony Investigators. “Postmenopausal hormone use in women with acute coronary syndromes.” J Womens Health (Larchmt) 13, no. 8 (October 2004): 863–71. https://doi.org/10.1089/jwh.2004.13.863.
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  - Peterson, Eric D., Karen P. Alexander, David J. Malenka, Edward L. Hannan, Gerald T. O’Conner, Ben D. McCallister, William S. Weintraub, Fred L. Grover, and Fred L. American Heart Association Chronic CAD Working Group. “Multicenter experience in revascularization of very elderly patients.” Am Heart J 148, no. 3 (September 2004): 486–92. https://doi.org/10.1016/j.ahj.2004.03.039.
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  - Alexander, Karen P., and Mimi S. Biswas. “Heart failure and the elderly: disease diversity, data, and delivery of care.” Am Heart J 146, no. 2 (August 2003): 194–96. https://doi.org/10.1016/S0002-8703(03)00190-X.
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  - Jones, D. L., M. Ishii, A. LaPerriere, H. Stanley, M. Antoni, G. Ironson, N. Schneiderman, et al. “Influencing medication adherence among women with AIDS.” Aids Care 15, no. 4 (August 2003): 463–74. https://doi.org/10.1080/0954012031000134700.
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  - Alexander, Karen P., and Eric D. Peterson. “Evidence-based care for all patients.” Am J Med 114, no. 4 (March 2003): 333–35. https://doi.org/10.1016/s0002-9343(03)00069-x.
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  - Shah, S. H., K. P. Alexander, and E. D. Peterson. “PCI in women.” Cardiology Review 20, no. 3 (March 1, 2003): 24–29.
  - Pasquali, Sara K., Karen P. Alexander, Laura P. Coombs, Barbara L. Lytle, and Eric D. Peterson. “Effect of cardiac rehabilitation on functional outcomes after coronary revascularization.” Am Heart J 145, no. 3 (March 2003): 445–51. https://doi.org/10.1067/mhj.2003.172.
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  - Frazier, Camille, and Karen Alexander. “The finer points of race and hypertension.” Am Heart J 145, no. 2 (February 2003): 206–8. https://doi.org/10.1067/mhj.2003.108.
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  - Shah, Svati H., and Karen P. Alexander. “Hormone Replacement Therapy for Primary and Secondary Prevention of Heart Disease.” Curr Treat Options Cardiovasc Med 5, no. 1 (February 2003): 25–33. https://doi.org/10.1007/s11936-003-0012-1.
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  - Califf, Robert M., and Karen P. Alexander. “Cardiovascular research in the elderly: challenges, opportunities, and impact.” Postgraduate Medicine 112, no. 6 Suppl Heart (December 2002): 6–11. https://doi.org/10.3810/pgm.12.2002.suppl24.125.
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  - Alexander, K. P., M. V. Bhapkar, H. D. White, J. S. Hochman, M. E. Pfisterer, D. J. Moliterno, R. M. Califf, et al. “Paradoxical use of angiography with advancing age: Insights from an international trial population.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 152A-152A.
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  - Alexander, K. P., T. Harding, L. P. Coombs, K. Taylor, and E. D. Peterson. “Aging and patient preferences regarding invasive cardiac care.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 197A-197A.
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  - Pasquali, S. K., K. P. Alexander, L. P. Coombs, B. L. Lytle, and E. D. Peterson. “Effect of cardiac rehabilitation on functional outcomes following coronary revascularization.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 151A-151A.
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  - Pasquali, S. K., K. P. Alexander, B. L. Lytle, L. P. Coombs, and E. D. Peterson. “Testing an intervention to increase cardiac rehabilitation enrollment after coronary artery bypass grafting.” Am J Cardiol 88, no. 12 (December 15, 2001): 1415-A6. https://doi.org/10.1016/s0002-9149(01)02123-3.
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  - Pasquali, S. K., K. P. Alexander, and E. D. Peterson. “Cardiac rehabilitation in the elderly.” Am Heart J 142, no. 5 (November 2001): 748–55. https://doi.org/10.1067/mhj.2001.119134.
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  - Alexander, K. P., and E. D. Peterson. “Medical and surgical management of coronary artery disease in women.” Am J Manag Care 7, no. 10 (October 2001): 951–56.
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  - Lee, P. Y., K. P. Alexander, B. G. Hammill, S. K. Pasquali, and E. D. Peterson. “Representation of elderly persons and women in published randomized trials of acute coronary syndromes.” Jama 286, no. 6 (August 8, 2001): 708–13. https://doi.org/10.1001/jama.286.6.708.
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  - Alexander, K. P., A. N. Galanos, J. G. Jollis, J. A. Stafford, and E. D. Peterson. “Post-myocardial infarction risk stratification in elderly patients.” Am Heart J 142, no. 1 (July 2001): 37–42. https://doi.org/10.1067/mhj.2001.115589.
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  - Alexander, K. P., L. K. Newby, A. S. Hellkamp, R. A. Harrington, E. D. Peterson, S. Kopecky, A. Langer, et al. “Initiation of hormone replacement therapy after acute myocardial infarction is associated with more cardiac events during follow-up.” J Am Coll Cardiol 38, no. 1 (July 2001): 1–7. https://doi.org/10.1016/s0735-1097(01)01329-8.
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  - Alexander, J. H., K. P. Alexander, P. J. Joski, M. S. Cuffe, and R. H. Peter. “Morbidly obese patients undergoing cardiac catheterization: Less disease, less aggressive revascularization, and similar outcomes.” Journal of the American College of Cardiology 37, no. 2 (February 1, 2001): 367A-368A.
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  - Lee, P. Y., K. P. Alexander, B. G. Hammill, S. K. Pasquali, and E. D. Peterson. “Representation of the elderly in cardiovascular clinical trials.” Journal of the American College of Cardiology 37, no. 2 (February 1, 2001): 497A-497A.
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  - Alexander, K. P., D. J. Malenka, E. L. Hannan, B. D. McCallister, and E. D. Peterson. “Outcomes of PCI in the aged: Results from 6 large registries.” Circulation 102, no. 18 (October 31, 2000): 642–642.
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  - Alexander, K. P., L. L. Barbara, L. L. Choi, M. B. Daniel, and P. D. Eric. “Women have worse functional outcomes following bypass surgery.” Circulation 102, no. 18 (October 31, 2000): 839–839.
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  - Bahit, M. C., C. B. Granger, K. P. Alexander, J. Kramer, N. M. A. Lapointe, and R. M. Califf. “Applying the evidence: Opportunity in US for 80,000 additional lives saved per year.” Circulation 102, no. 18 (October 31, 2000): 873–873.
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  - Peterson, E. D., K. P. Alexander, G. T. O’Connor, F. L. Grover, E. L. Hannan, B. D. McCallister, and W. S. Weintraub. “The safety of coronary artery bypass surgery in the aged.” Circulation 102, no. 18 (October 31, 2000): 680-+.
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  - Alexander, K. P., K. J. Anstrom, L. H. Muhlbaier, R. D. Grosswald, P. K. Smith, R. H. Jones, and E. D. Peterson. “Outcomes of cardiac surgery in patients > or = 80 years: results from the National Cardiovascular Network.” J Am Coll Cardiol 35, no. 3 (March 1, 2000): 731–38. https://doi.org/10.1016/s0735-1097(99)00606-3.
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  - Alexander, K., L. J. Shaw, L. K. Shaw, E. DeLong, D. Mark, and E. Peterson. “Erratum: Value of exercise treadmill testing in women. Low dose dobutamine echocardiography predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy (Journal of the American College of Cardiology (1998) 32 (1657-1664)).” Journal of the American College of Cardiology 33, no. 1 (February 10, 1999): 289. https://doi.org/10.1016/S0735-1097(98)00655-X.
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  - Alexander, K. P., E. D. Peterson, C. B. Granger, A. C. Casas, F. Van de Werf, P. W. Armstrong, A. Guerci, E. J. Topol, and R. M. Califf. “Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.” J Am Coll Cardiol 32, no. 7 (December 1998): 2023–30. https://doi.org/10.1016/s0735-1097(98)00466-5.
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  - Alexander, K. P., L. J. Shaw, L. K. Shaw, E. R. Delong, D. B. Mark, and E. D. Peterson. “Value of exercise treadmill testing in women.” J Am Coll Cardiol 32, no. 6 (November 15, 1998): 1657–64. https://doi.org/10.1016/s0735-1097(98)00451-3.
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  - Peterson, E. D., and K. P. Alexander. “Learning to suspect the unexpected: evaluating women with cardiac syndromes.” Am Heart J 136, no. 2 (August 1998): 186–88. https://doi.org/10.1053/hj.1998.v136.89736.
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  - Alexander, J. H., K. Alexander, D. F. Kong, C. Y. Tung, and D. Whellan. “Session highlights from the American Heart Association Scientific Sessions: November 9-12, 1997.” Am Heart J 135, no. 1 (January 1998): 157–80. https://doi.org/10.1016/s0002-8703(98)70357-6.
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  - Alexander, K. P., and E. D. Peterson. “Coronary artery bypass grafting in the elderly.” Am Heart J 134, no. 5 Pt 1 (November 1997): 856–64. https://doi.org/10.1016/s0002-8703(97)80008-7.
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  - Alexander, K. P., E. D. Peterson, L. H. Muhlbaier, R. D. Grosswald, and M. J. Lanzilotta. “Cardiac surgery outcomes in 3,220 octogenarians: Results from the National Cardiovascular Network.” Circulation 96, no. 8 (October 21, 1997): 59–59.
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  - Alexander, K. P., E. D. Peterson, N. E. ClappChanning, L. C. Lam, R. B. Williams, and D. B. Mark. “Functional outcome of CABG in the elderly.” Circulation 96, no. 8 (October 21, 1997): 2066–2066.
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  - Alexander, K. P., E. D. Peterson, A. S. Hellkamp, C. B. Granger, E. J. Topol, and R. M. Califf. “Early catheterization is standard strategy in unstable angina/NQWMI: Results from GUSTO IIb.” Journal of the American College of Cardiology 29, no. 2 (February 1, 1997): 5614–5614.
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  - Alexander, K. P., E. D. Peterson, K. W. Mahaffey, A. C. Casas, C. B. Granger, F. VandeWerf, P. W. Armstrong, D. B. Mark, E. J. Topol, and R. M. Califf. “Medical interventions in unstable angina: Does international clinical practice match evidence-based guidelines?” Journal of the American College of Cardiology 29, no. 2 (February 1, 1997): 23138–23138.
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  - Alexander, K. P., and D. B. Mark. “Effect of gender on angioplasty outcome: are we closer to the answer?” Mayo Clin Proc 72, no. 1 (January 1997): 89–91. https://doi.org/10.4065/72.1.89.
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- Conference Papers
  - Sidhu, Mandeep S., Karen P. Alexander, Zhen Huang, Sean M. O’Brien, Bernard R. Chaitman, Gregg W. Stone, Jonathan D. Newman, et al. “Causes of cardiovascular and noncardiovascular death in the ISCHEMIA trial.” In Am Heart J, 248:72–83, 2022. https://doi.org/10.1016/j.ahj.2022.01.017.
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  - Rasmussen, P. V., M. L. Hansen, G. Gislason, J. Pallisgaard, M. Ruwald, C. B. Granger, R. D. Lopes, K. P. Alexander, S. M. Al-Khatib, and F. Dalgaard. “Older patients with atrial fibrillation and comorbidities are less likely to be treated with oral anticoagulation: insights from a nationwide study.” In European Heart Journal, 40:2978–2978. OXFORD UNIV PRESS, 2019.
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  - Melloni, Chiara, Karen P. Alexander, Angie Wu, W Schuyler Jones, Rajendra H. Mehta, Robert W. Harrison, David Kong, et al. “Type 2 Myocardial Infarction: Incidence, Risk Factors, and Outcomes Among 41,581 Patients Enrolled in 3 Large Randomized Clinical Trials.” In Circulation, Vol. 140, 2019.
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  - Dodson, John A., Terrence E. Murphy, Mary Geda, Harlan M. Krumholz, Sui Tsang, Alexandra Hajduk, Michael Nanna, et al. “A Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER-AMI Study.” In Circulation, Vol. 138, 2018.
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  - Alexander, Karen P., Kristi Prather, Kevin J. Anstrom, Daniel Mark, Ori Ben-Yehuda, Linda Davidson-Ray, Giora Weisz, Ramin Farzaneh-Far, Gregg Stone, and E Magnus Ohman. “Angina and Quality of Life Following PCI With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial.” In Circulation, 132:2273–2273. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Zimerman, Andre, Amanda L. Stebbins, Renato D. Lopes, Patricia O. Guimaraes, Stefan K. James, John H. Alexander, Pierluigi Tricoci, et al. “Adverse Event Reporting in > 48,000 Participants in Four Acute Coronary Syndrome Trials.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Dodson, J. A., Y. Wang, S. I. Chaudhry, K. P. Alexander, F. A. Masoudi, J. A. Spertus, B. Nallamothu, et al. “National trends in rehospitalization for bleeding after acute myocardial infarction in the oldest old.” In Journal of the American Geriatrics Society, 62:S41–S41. WILEY-BLACKWELL, 2014.
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  - Bagai, Akshay, Yongfei Wang, Tracy Y. Wang, Jeptha Curtis, Hitinder S. Gurm, Eric D. Peterson, Jorge F. Saucedo, et al. “In-Hospital ADP Receptor Inhibitor Switching in Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry (R).” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Dodson, John A., Yun Wang, Karen P. Alexander, Fred Masoudi, John A. Spertus, Sarwat I. Chaudhry, Iersey Chen, et al. “National Trends in Rehospitalization for Bleeding After Acute Myocardial Infarction in Older Patients, 1999-2010.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Shen, Lan, Shuang Li, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, Bimal Shah, Eric Peterson, and Matthew T. Roe. “The Association of Transfer-out Rates from Hospitals Without Revascularization Capabilities and Long-term Mortality Risk Among Older Nstemi Patients.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Dodson, John A., Kimberly J. Reid, Thomas M. Gill, Harlan M. Krumholz, Daniel E. Forman, John A. Spertus, Michael W. Rich, Suzanne V. Arnold, and Karen P. Alexander. “SLOW GAIT AMONG OLDER ADULTS POST-AMI AND RISK FOR HOSPITAL READMISSION.” In Journal of the American College of Cardiology, 59:E1914–E1914. Elsevier BV, 2012. https://doi.org/10.1016/s0735-1097(12)61915-9.
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  - Chin, Chee Tang, Tracy Y. Wang, Anita Y. Chen, Robin Mathews, Karen P. Alexander, Matthew T. Roe, and Eric D. Peterson. “COMPARISON OF TRENDS IN IN-HOSPITAL AND LONG-TERM OUTCOMES OVER TIME AMONG OLDER PATIENTS WITH NON-ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: INSIGHTS FROM THE CRUSADE QUALITY IMPROVEMENT REGISTRY.” In Journal of the American College of Cardiology, 57:E905–E905. Elsevier BV, 2011. https://doi.org/10.1016/s0735-1097(11)60905-4.
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  - Desai, Nihar, Anita Y. Chen, Stephen D. Wiviott, Marc S. Sabatine, Karen P. Alexander, Matthew T. Roe, Eric D. Peterson, and Bimal R. Shah. “CHALLENGES IN THE TREATMENT OF NSTEMI PATIENTS AT HIGH RISK FOR BOTH ISCHEMIC AND BLEEDING EVENTS: INSIGHTS FROM THE ACTION REGISTRY-GWTG.” In Journal of the American College of Cardiology, 57:E913–E913. Elsevier BV, 2011. https://doi.org/10.1016/s0735-1097(11)60913-3.
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  - Fosbøl, Emil L., Tracy Y. Wang, Jonathan Piccini, Renato D. Lopes, Bimal Shah, Karen P. Alexander, Shuang Li, Matthew T. Roe, and Eric D. Peterson. “LONG-TERM SAFETY OF ANTITHROMBOTIC THERAPY IN NON-ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS WITH ATRIAL FIBRILLATION.” In Journal of the American College of Cardiology, 57:E948–E948. Elsevier BV, 2011. https://doi.org/10.1016/s0735-1097(11)60948-0.
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  - Martin, Seth S., Kensey Gosch, Krishnaji Kulkarni, John A. Spertus, Robin Mathews, L Kristin Newby, Karen P. Alexander, and Tracy Y. Wang. “PATIENT AND PROVIDER FACTORS IN LIPID GOAL ATTAINMENT AFTER ACUTE MYOCARDIAL INFARCTION: INSIGHTS FROM THE TRANSLATIONAL RESEARCH INVESTIGATING UNDERLYING DISPARITIES IN ACUTE MYOCARDIAL INFARCTION PATIENTS' HEALTH STATUS (TRIUMPH) STUDY.” In Journal of the American College of Cardiology, 57:E573–E573. Elsevier BV, 2011. https://doi.org/10.1016/s0735-1097(11)60573-1.
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  - Subherwal, Sumeet, Shuang Li, Manesh R. Patel, Deepak L. Bhatt, Tracy Y. Wang, Karen P. Alexander, E Magnus Ohman, W Brian Gibler, Eric D. Peterson, and Matthew T. Roe. “IMPACT OF POLYVASCULAR DISEASE ON LONG-TERM MORTALITY IN OLDER PATIENTS WITH NON-ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION.” In Journal of the American College of Cardiology, 57:E992–E992. Elsevier BV, 2011. https://doi.org/10.1016/s0735-1097(11)60992-3.
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  - Afilalo, Jonathan, Mark J. Eisenberg, Jean-Francois Morin, Howard Bergman, Johanne Monette, Nicolas Noiseux, Louis P. Perrault, et al. “Gait Speed as a Predictor of Mortality and Major Morbidity in Older Adults Undergoing Cardiac Surgery: Preliminary Results From the FRAILTY ABC'S Study.” In Circulation, 120:S988–89. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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  - Shah, Bimal R., Matthew T. Roe, Anita Y. Chen, Karen P. Alexander, Tracy Y. Wang, E Magnus Ohman, W Brian Gibler, and Eric D. Peterson. “Association Between Hospital Process Performance and 1-Year Post-discharge Mortality in Patients With Non-ST-elevation Myocardial Infarction: Results From 36,262 Patients.” In Circulation, 120:S1086–S1086. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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  - Tsai, Thomas T., Thomas M. Maddox, Matthew T. Roe, David Dai, Karen P. Alexander, P Michael Ho, John C. Messenger, Brahmajee K. Nallamothu, Eric D. Peterson, and John S. Rumsfeld. “Use of Contraindicated Anti-Thrombotics in Dialysis Patients Undergoing Percutaneous Coronary Interventions: Insights From the NCDR Cath-PCI Registry.” In Circulation, 120:S414–S414. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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  - Wang, Tracy Y., Anita Y. Chen, Bimal R. Shah, Matthew T. Roe, Karen P. Alexander, E Magnus Ohman, W Brian Gibler, and Eric D. Peterson. “Readmission Rates Among Patients With Non-ST-Segment Elevation Myocardial Infarction: Results in 38,131 Patients From the CRUSADE Quality Improvement Initiative.” In Circulation, 120:S436–37. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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  - Alexander, Karen P., Chiara Melloni, A. Pappas, L Kristin Newby, Nancy M Allen LaPointe, E Magnus Ohman, W Brian Gibler, Matthew T. Roe, and Eric D. Peterson. “Potency of statins track with intensity of overall secondary prevention.” In Circulation, 117:E453–E453. LIPPINCOTT WILLIAMS & WILKINS, 2008.
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  - Melloni, Chiara, Karen P. Alexander, Fang-Shu Ou, Nancy M Allen LaPointe, Matthew T. Roe, and Eric D. Peterson. “Factors associated with patient reported self-discontinuation of prescribed medicine after non-ST-segment elevation acute coronary syndromes.” In Circulation, 117:E418–E418. LIPPINCOTT WILLIAMS & WILKINS, 2008.
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  - Alexander, Karen P., Richard G. Bach, Anita Y. Chen, Sumeet Subherwal, Brian F. Gage, Sunil V. Rao, W Brian Gibler, et al. “Bleeding and ischemic events run parallel in NSTEMI patients.” In Journal of the American College of Cardiology, 51:A207–8. ELSEVIER SCIENCE INC, 2008.
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  - Subherwal, Sumeet, Richard G. Bach, Anita Y. Chen, Brian F. Gage, Sunil V. Rao, Tracy Y. Wang, W Brian Gibler, et al. “The CRUSADE bleeding score to assess baseline risk of major bleeding in non-ST-segment elevation myocardial infarction.” In Journal of the American College of Cardiology, 51:A212–A212. ELSEVIER SCIENCE INC, 2008.
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  - Wang, Tracy Y., Anita Y. Chen, Eric D. Peterson, Karen P. Alexander, E Magnus Ohman, W Brian Gibler, and Matthew T. Roe. “Incidence and bleeding outcomes of excess unfractionated heparin dosing among patients with ST-Segment elevation myocardial infarction undergoing fibrinolysis.” In Journal of the American College of Cardiology, 51:A203–A203. ELSEVIER SCIENCE INC, 2008.
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  - Alexander, Karen P., Anita Y. Chen, Matthew T. Roe, L Kristin Newby, Brian Gibler, E Magnus Ohman, Charles V. Pollack, and Eric D. Peterson. “Decline in GP 2b3a inhibitor overdosing with site-specific feedback in CRUSADE.” In Circulation, 116:798–99. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Wang, Tracy Y., Anita Y. Chen, Magnus Ohman, Karen P. Alexander, Charles V. Pollack, Sidney C. Smith, W Brian Gibler, Matthew T. Roe, and Eric D. Peterson. “Contemporary patterns of reperfusion for elderly patients with ST-segment elevation myocardial infarction.” In Circulation, 115:E582–E582. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Alexander, Karen P., Patricia A. Cowper, Barbara L. Lylte, Judith A. Kempf, and Eric D. Peterson. “Predictors of persistent angina among coronary disease patients.” In Journal of the American College of Cardiology, 49:232A-232A. ELSEVIER SCIENCE INC, 2007.
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  - Alexander, Karen P., Patricia A. Cowper, Barbara L. Lytle, Judith A. Kempf, and Eric D. Peterson. “Less is better, none is best: Angina and health related quality of life.” In Journal of the American College of Cardiology, 49:229A-229A. ELSEVIER SCIENCE INC, 2007.
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  - Roe, Matthew T., Karen P. Alexander, Fang-Shou Ou, L Kristin Newby, W Brian Gibler, Charles V. Pollack, E Magnus Ohman, Sidney C. Smith, and Eric D. Peterson. “Patterns of HDL levels in patients with non-ST-segment elevation acute coronary syndromes and association with clinical outcomes.” In Journal of the American College of Cardiology, 49:366A-366A. ELSEVIER SCIENCE INC, 2007.
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  - Wang, Tracy Y., Anita Y. Chen, Matthew T. Roe, Karen P. Alexander, L Kristin Newby, Sidney C. Smith, Sripal Bangalore, W Brian Gibler, E Magnus Ohman, and Eric D. Peterson. “Increased bleeding risk among Asians with non-ST-segment elevation acute coronary syndromes: Insights from the CRUSADE quality improvement initiative.” In Journal of the American College of Cardiology, 49:208A-208A. ELSEVIER SCIENCE INC, 2007.
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  - Alexander, Karen P., E Magnus Ohman, Michel E. Bertrand, Frederic Feit, Charles V. Pollack, James Hoekstra, Bernard J. Gersh, Harvey D. White, and Gregg W. Stone. “Outcomes in elderly patients undergoing PCI treated with bivalirudin monotherapy versus glycoprotein IIb/IIIa inhibitors with hepaiin or LMWH: Results from the randomized ACUITY trial.” In American Journal of Cardiology, 98:18M-18M. EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2006.
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  - Mehta, R. H., E. D. Peterson, L. Liang, K. P. Alexander, W. B. Gibler, E. M. Ohman, C. V. Pollack, and M. T. Roe. “Contraindications to cardiac catheterization in non-ST-elevation acute coronary syndromes: Insights from the CRUSADE national quality improvement initiative.” In European Heart Journal, 27:183–183. OXFORD UNIV PRESS, 2006.
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  - Alexander, Karen P., Jyotsna Mulgund, Barbara Lytle, and Eric Peterson. “Long-term implications of discharge anemia in a cardiovascular population.” In Circulation, 113:E795–E795. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - Dunlay, Shannon M., Li Liang, Chiara Melloni, Jennifer L. Kraschnewski, Karen P. Alexander, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, and Eric D. Peterson. “Quality of medical record documentation in an acute coronary syndrome population: Results from CRUSADE.” In Circulation, 113:E802–3. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - LaPointe, N. M. A., K. P. Alexander, A. Y. Chen, M. T. Roe, C. V. Pollack, E. M. Ohman, W. B. Gibler, and E. D. Peterson. “Enoxaparin dosing and bleeding in real world practice: Results from CRUSADE.” In Journal of the American College of Cardiology, 47:235A-235A. ELSEVIER SCIENCE INC, 2006.
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  - Peterson, E. D., A. Y. Chen, K. P. Alexander, N. M. A. LaPointe, E. S. Fraulo, L. K. Newby, M. T. Roe, W. B. Gibler, and E. M. Ohman. “The association between hospital guideline adherence, dosing safety, and patient outcomes: Results from the CRUSADE quality improvement initiative.” In Journal of the American College of Cardiology, 47:255A-255A. ELSEVIER SCIENCE INC, 2006.
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  - Alexander, K. P., A. Y. Chen, M. T. Roe, L. K. Newby, C. M. Gibson, J. Schwartz, J. S. Hochman, et al. “Sex differences in glycoprotein 11b/111a inhibitor dosing and bleeding in acute coronary syndromes: Results from CRUSADE.” In Circulation, 112:U491–92. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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  - Melloni, C., M. T. Roe, S. Milford-Boland, K. P. Alexander, L. K. Newby, L. A. Szczech, C. V. Pollack, et al. “Renal insufficiency, troponin, and risk of death among patients with non-ST-segment elevation acute coronary syndromes.” In Circulation, 112:U587–88. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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  - Spinler, S., K. P. Alexander, A. Y. Chen, M. T. Roe, W. B. Gibler, M. Ohman, and E. D. Peterson. “Predictors of excess dosing of injectable antithrombotics in patients with non-ST-segment elevation acute coronary syndromes.” In Pharmacotherapy, 25:1437–38. PHARMACOTHERAPY PUBLICATIONS INC, 2005.
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  - Alexander, K. P., A. Y. Chen, M. T Roe, L. K. Newby, W. B. Gibler, E. M. Ohman, and E. D. Peterson. “Antiplatelet and antithrombin dose variation in patients with non-ST-segment elevation acute coronary syndromes.” In Circulation, 111:E312–13. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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  - Alexander, K. P., J. L. Sun, T. Harding, and B. Lee. “Who is right and what matters? Frailty in patients with cardiovascular disease.” In Circulation, 111:E339–40. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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  - Lytle, Barbara L., Gregory J. Shook, Karen P. Alexander, Patricia A. Cowper, Daniel B. Mark, and Elizabeth R. DeLong. “1153-74 Physician counseling can influence health-related quality of life.” In Journal of the American College of Cardiology, 43:A418–A418. Elsevier BV, 2004. https://doi.org/10.1016/s0735-1097(04)91763-9.
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  - Alexander, K. P., B. Lytle, Y. Li, and E. Peterson. “Elderly patients have better functioning, less angina at one year with coronary artery bypass graft.” In Journal of the American College of Cardiology, 41:220A-221A. ELSEVIER SCIENCE INC, 2003.
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  - Alexander, K. P., T. Harding, L. Coombs, and E. Peterson. “Are patients properly informed prior to revascularization decisions?” In Journal of the American College of Cardiology, 41:535A-535A. ELSEVIER SCIENCE INC, 2003.
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  - Lytle, B. L., L. P. Coombs, G. J. Shook, P. A. Cowper, K. P. Alexander, E. D. Peterson, D. B. Mark, and E. R. DeLong. “Home health care for coronary artery disease patients impacts quality of life.” In Journal of the American College of Cardiology, 41:521A-521A. ELSEVIER SCIENCE INC, 2003.
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  - Biswas, M. S., E. L. Eisenstein, and K. P. Alexander. “The right test for the right price.” In Circulation, 106:759–759. LIPPINCOTT WILLIAMS & WILKINS, 2002.
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