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Karen Patton Alexander

Professor of Medicine
Medicine, Cardiology
Duke Box 3411, Durham, NC 27710
Durham Centre, Durham, NC 27701

Overview


My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Current Appointments & Affiliations


Professor of Medicine · 2015 - Present Medicine, Cardiology, Medicine
Member in the Duke Clinical Research Institute · 1995 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published August 22, 2022
Could a Common Heart Medication Prevent Dementia?
Published November 10, 2015
Angioplasty Procedure Reduces Need for Additional Drug Even When Blockages Remain

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Recent Publications


Representation of Older Adults and Women in Randomized Trials of Noninvasive Imaging for Chest Pain.

Journal Article Circ Cardiovasc Imaging · October 2025 BACKGROUND: Noninvasive imaging is widely used for both initial diagnosis and guided management of ischemic heart disease. Older adults and women with ischemic heart disease may have different responses to imaging and subsequent treatment outcomes compared ... Full text Link to item Cite

Advancing Age and Risk From the Elevated Atherogenic Index: Triglyceride (TG) to High-Density Cholesterol (HDL-C) Ratio.

Journal Article J Am Geriatr Soc · September 2025 BACKGROUND: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but this association diminishes with age. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio, also known as ... Full text Link to item Cite

Comparative Prognosis by Stress ECG and Stress Imaging: Results From the ISCHEMIA Trial.

Journal Article JACC Cardiovasc Imaging · September 2025 BACKGROUND: Limited contemporary evidence exists on risk prediction by stress imaging and exercise electrocardiography (ECG) among patients with chronic coronary syndromes (CCS). Objectives From the ISCHEMIA (International Study of Comparative Health Effec ... Full text Link to item Cite
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Recent Grants


PREVENTABLE

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2027

1/2 PREEMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2025 - 2027

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Education, Training & Certifications


Duke University · 1992 M.D.