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Karen Patton Alexander

Professor of Medicine
Medicine, Cardiology
Duke Box 3411, Durham, NC 27710
200 Morris St, Durham, NC 27701

Overview


My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Current Appointments & Affiliations


Professor of Medicine · 2015 - Present Medicine, Cardiology, Medicine
Member in the Duke Clinical Research Institute · 1995 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published August 22, 2022
Could a Common Heart Medication Prevent Dementia?
Published November 10, 2015
Angioplasty Procedure Reduces Need for Additional Drug Even When Blockages Remain

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Recent Publications


Clinical practice patterns among older multimorbid adults presenting with suspected ischemic symptoms: A multi-center survey

Journal Article American Heart Journal Plus: Cardiology Research and Practice · April 1, 2025 Background: When patients with suspected or known coronary artery disease (CAD) present with new or worsening ischemic symptoms, initial referral to imaging or optimization of guideline directed medical therapy (GDMT) with deferral of testing are both acce ... Full text Cite

Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.

Journal Article Circ Cardiovasc Interv · December 2024 BACKGROUND: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, ... Full text Link to item Cite

Apixaban and Limiting Aspirin for Patients With Atrial Fibrillation, Percutaneous Coronary Intervention, and Multimorbidity.

Journal Article JACC Adv · November 2024 BACKGROUND: Patients with atrial fibrillation (AF) after an acute coronary syndrome (ACS) and/or undergoing percutaneous coronary intervention (PCI) with multiple comorbidities are at increased risk for bleeding and ischemic events. OBJECTIVES: This post-h ... Full text Link to item Cite
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Recent Grants


PREVENTABLE

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2027

PREVENTABLE Trial Partnership and Meeting Support

ConferencePrincipal Investigator · Awarded by Alzheimer's Association · 2024 - 2025

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Education, Training & Certifications


Duke University · 1992 M.D.