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Karen Christine Baker

Associate Professor of Urology
Urology
40 Duke Medicine Circle, Clinic 1G, Durham, NC 27710

Selected Publications


Minding the Bathwater: Fertility and Reproductive Toxicity in the Age of Immuno-Oncology.

Journal Article JCO Oncol Pract · December 2022 Immune checkpoint inhibition has resulted in significant efficacy across many cancer types, including melanoma. Melanoma is the second most common cancer among those of reproductive age, yet the reproductive toxicities of adjuvant and first-line immunother ... Full text Link to item Cite

Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation.

Journal Article Bone Marrow Transplant · July 2022 Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolon ... Full text Link to item Cite

Male-Specific Late Effects in Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation.

Journal Article Transplant Cell Ther · June 2022 Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GVHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies, such as prostate, penile, and testicular cancer. ... Full text Link to item Cite

Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria.

Journal Article F S Rep · June 2022 OBJECTIVE: To determine the reproducibility of the World Health Organization Fifth Edition (WHO5) strict grading methodology by comparing the percentage of morphologically normal sperm (PNS) recorded by the core laboratory with results obtained at the fert ... Full text Link to item Cite

Impact of surgical volume and resident involvement on patency rates after vasectomy reversal-A 14-year experience in an open access system.

Journal Article Asian J Urol · April 2021 OBJECTIVE: Evaluate the influence of fellowship training, resident participation, reconstruction type, and patient factors on outcomes after vasectomy reversals in a high volume, open access system. METHODS: Retrospective review of all vasectomy reversals ... Full text Link to item Cite

Could Nonenhanced Computer Tomography Suffice as the Imaging Study of Choice for the Screening of Asymptomatic Microscopic Hematuria?

Journal Article Urology · October 2018 OBJECTIVE: To compare the diagnostic accuracy of the noncontrast and contrast-enhanced phases of computed tomographic urography for detection of upper urinary tract findings in adults undergoing initial evaluation of newly diagnosed asymptomatic microscopi ... Full text Link to item Cite

Reduction in Opioid Prescribing Using a Postoperative Pain Management Protocol following Scrotal and Subinguinal Surgery

Journal Article Urology Practice · May 1, 2018 Introduction: Excess prescribing of opioid pain medication increases medical costs and the potential for abuse by patients and others. We sought to improve our understanding of postoperative pain and opioid use after scrotal and subinguinal urological surg ... Full text Cite

Analysis of semen parameters in male referrals: impact of reference limits, stratification by fertility categories, predictors of change, and comparison of normal semen parameters in subfertile couples.

Journal Article Fertil Steril · January 2015 OBJECTIVE: To [1] determine the impact of semen reference limits on referrals for male fertility evaluations, [2] analyze the stratification of subjects based on published "normal" thresholds, [3] analyze the odds of changing fertility categories during se ... Full text Link to item Cite

The economic burden of genetic tests for the infertile male: a pilot algorithm to improve test predictive value.

Journal Article J Urol · April 2014 PURPOSE: We developed a model to optimize genetic testing in infertile men with nonobstructive azoospermia and severe oligospermia. We also assessed the optimal cutoff value of the predicted probability of advising genetic testing and evaluated the direct ... Full text Link to item Cite

Sperm Surgical Retrieval Techniques: Critical Review

Chapter · August 31, 2013 This book is a comprehensive guide to recent advances in the diagnosis and management of male infertility. ... Cite

Pregnancy after varicocelectomy: impact of postoperative motility and DFI.

Journal Article Urology · April 2013 OBJECTIVE: To examine clinical and laboratory variables to determine which, if any, predict improved semen parameters and pregnancy after varicocelectomy. METHODS: Surgical logs were reviewed for men who underwent varicocele ligation for a fertility concer ... Full text Link to item Cite

The role of microsurgical reconstruction in the era of ICSI

Chapter · January 1, 2013 Even in the era of advanced assisted reproductive techniques, microsurgical reconstruction is an important and relevant treatment for obstructive azoospermia. Microsurgical reconstruction provides couples the opportunity to create a spontaneous pregnancy a ... Full text Cite

Obstructive azoospermia: reconstructive techniques and results.

Journal Article Clinics (Sao Paulo) · 2013 Obstructive azoospermia is a common cause of male infertility and can result from infection, congenital anomalies, or iatrogenic injury. Microsurgical vasal reconstruction is a suitable treatment for many cases of obstructive azoospermia, although some cou ... Full text Link to item Cite

Epidemiology of nephrolithiasis in personnel returning from Operation Iraqi Freedom.

Journal Article Urology · July 2009 OBJECTIVES: To examine the epidemiology of urolithiasis in personnel returning from deployment to Southwest Asia. METHODS: A survey-based study of personnel returning from deployment to Southwest Asia was performed. The demographics were compared between t ... Full text Link to item Cite

Effect of flexible cystoscopy on serum prostate-specific antigen values.

Journal Article Urology · February 2009 OBJECTIVES: To determine the effect of flexible cystoscopy on the total, free, and percent-free prostate-specific antigen (PSA) values in male volunteers. Flexible cystoscopy is the standard method of evaluation of the bladder and urethra. PSA measurement ... Full text Link to item Cite

Reply

Journal Article Urology · January 1, 2009 Full text Cite

An unusual presentation: renal tuberculosis.

Journal Article ScientificWorldJournal · December 23, 2008 Genitourinary tuberculosis (TB) is the second most common form of extrapulmonary TB after peripheral lymphadenopathy. We report the case of a 44-year-old woman referred for hydronephrosis discovered on ultrasound performed due to flank pain. Contrast compu ... Full text Link to item Cite

Demographics, stone characteristic, and treatment of urinary calculi at the 47th Combat Support Hospital during the first 6 months of Operation Iraqi Freedom.

Journal Article Mil Med · May 2007 There are few publications describing urolithiasis in deployed military personnel. Renal colic was the most common urologic indication for air evacuation from the 47th Combat Support Hospital during the first 6 months of Operation Iraqi Freedom and we desc ... Full text Link to item Cite

Thrombosed urethral prolapse in a premenopausal woman

Journal Article Journal of Pelvic Medicine and Surgery · May 1, 2006 BACKGROUND: Urethral prolapse is a rare condition and thrombosis is an infrequent complication of urethral prolapse. Urethral prolapse is seen almost exclusively in children and the elderly. Suspicion of urethral prolapse is essential for the correct diagn ... Full text Cite

Minding the Bathwater: Fertility and Reproductive Toxicity in the Age of Immuno-Oncology.

Journal Article JCO Oncol Pract · December 2022 Immune checkpoint inhibition has resulted in significant efficacy across many cancer types, including melanoma. Melanoma is the second most common cancer among those of reproductive age, yet the reproductive toxicities of adjuvant and first-line immunother ... Full text Link to item Cite

Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation.

Journal Article Bone Marrow Transplant · July 2022 Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolon ... Full text Link to item Cite

Male-Specific Late Effects in Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation.

Journal Article Transplant Cell Ther · June 2022 Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GVHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies, such as prostate, penile, and testicular cancer. ... Full text Link to item Cite

Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria.

Journal Article F S Rep · June 2022 OBJECTIVE: To determine the reproducibility of the World Health Organization Fifth Edition (WHO5) strict grading methodology by comparing the percentage of morphologically normal sperm (PNS) recorded by the core laboratory with results obtained at the fert ... Full text Link to item Cite

Impact of surgical volume and resident involvement on patency rates after vasectomy reversal-A 14-year experience in an open access system.

Journal Article Asian J Urol · April 2021 OBJECTIVE: Evaluate the influence of fellowship training, resident participation, reconstruction type, and patient factors on outcomes after vasectomy reversals in a high volume, open access system. METHODS: Retrospective review of all vasectomy reversals ... Full text Link to item Cite

Could Nonenhanced Computer Tomography Suffice as the Imaging Study of Choice for the Screening of Asymptomatic Microscopic Hematuria?

Journal Article Urology · October 2018 OBJECTIVE: To compare the diagnostic accuracy of the noncontrast and contrast-enhanced phases of computed tomographic urography for detection of upper urinary tract findings in adults undergoing initial evaluation of newly diagnosed asymptomatic microscopi ... Full text Link to item Cite

Reduction in Opioid Prescribing Using a Postoperative Pain Management Protocol following Scrotal and Subinguinal Surgery

Journal Article Urology Practice · May 1, 2018 Introduction: Excess prescribing of opioid pain medication increases medical costs and the potential for abuse by patients and others. We sought to improve our understanding of postoperative pain and opioid use after scrotal and subinguinal urological surg ... Full text Cite

Analysis of semen parameters in male referrals: impact of reference limits, stratification by fertility categories, predictors of change, and comparison of normal semen parameters in subfertile couples.

Journal Article Fertil Steril · January 2015 OBJECTIVE: To [1] determine the impact of semen reference limits on referrals for male fertility evaluations, [2] analyze the stratification of subjects based on published "normal" thresholds, [3] analyze the odds of changing fertility categories during se ... Full text Link to item Cite

The economic burden of genetic tests for the infertile male: a pilot algorithm to improve test predictive value.

Journal Article J Urol · April 2014 PURPOSE: We developed a model to optimize genetic testing in infertile men with nonobstructive azoospermia and severe oligospermia. We also assessed the optimal cutoff value of the predicted probability of advising genetic testing and evaluated the direct ... Full text Link to item Cite

Sperm Surgical Retrieval Techniques: Critical Review

Chapter · August 31, 2013 This book is a comprehensive guide to recent advances in the diagnosis and management of male infertility. ... Cite

Pregnancy after varicocelectomy: impact of postoperative motility and DFI.

Journal Article Urology · April 2013 OBJECTIVE: To examine clinical and laboratory variables to determine which, if any, predict improved semen parameters and pregnancy after varicocelectomy. METHODS: Surgical logs were reviewed for men who underwent varicocele ligation for a fertility concer ... Full text Link to item Cite

The role of microsurgical reconstruction in the era of ICSI

Chapter · January 1, 2013 Even in the era of advanced assisted reproductive techniques, microsurgical reconstruction is an important and relevant treatment for obstructive azoospermia. Microsurgical reconstruction provides couples the opportunity to create a spontaneous pregnancy a ... Full text Cite

Obstructive azoospermia: reconstructive techniques and results.

Journal Article Clinics (Sao Paulo) · 2013 Obstructive azoospermia is a common cause of male infertility and can result from infection, congenital anomalies, or iatrogenic injury. Microsurgical vasal reconstruction is a suitable treatment for many cases of obstructive azoospermia, although some cou ... Full text Link to item Cite

Epidemiology of nephrolithiasis in personnel returning from Operation Iraqi Freedom.

Journal Article Urology · July 2009 OBJECTIVES: To examine the epidemiology of urolithiasis in personnel returning from deployment to Southwest Asia. METHODS: A survey-based study of personnel returning from deployment to Southwest Asia was performed. The demographics were compared between t ... Full text Link to item Cite

Effect of flexible cystoscopy on serum prostate-specific antigen values.

Journal Article Urology · February 2009 OBJECTIVES: To determine the effect of flexible cystoscopy on the total, free, and percent-free prostate-specific antigen (PSA) values in male volunteers. Flexible cystoscopy is the standard method of evaluation of the bladder and urethra. PSA measurement ... Full text Link to item Cite

Reply

Journal Article Urology · January 1, 2009 Full text Cite

An unusual presentation: renal tuberculosis.

Journal Article ScientificWorldJournal · December 23, 2008 Genitourinary tuberculosis (TB) is the second most common form of extrapulmonary TB after peripheral lymphadenopathy. We report the case of a 44-year-old woman referred for hydronephrosis discovered on ultrasound performed due to flank pain. Contrast compu ... Full text Link to item Cite

Demographics, stone characteristic, and treatment of urinary calculi at the 47th Combat Support Hospital during the first 6 months of Operation Iraqi Freedom.

Journal Article Mil Med · May 2007 There are few publications describing urolithiasis in deployed military personnel. Renal colic was the most common urologic indication for air evacuation from the 47th Combat Support Hospital during the first 6 months of Operation Iraqi Freedom and we desc ... Full text Link to item Cite

Thrombosed urethral prolapse in a premenopausal woman

Journal Article Journal of Pelvic Medicine and Surgery · May 1, 2006 BACKGROUND: Urethral prolapse is a rare condition and thrombosis is an infrequent complication of urethral prolapse. Urethral prolapse is seen almost exclusively in children and the elderly. Suspicion of urethral prolapse is essential for the correct diagn ... Full text Cite

Time to development of symptomatic urinary calculi in a high risk environment.

Journal Article J Urol · March 2005 PURPOSE: While seasonal variation of stone disease is well described, the time to formation of urinary calculi is unknown. Because southwestern Asia is a high risk environment for stone disease, the date of entry into this region is a definitive beginning ... Full text Link to item Cite

Use of oral ketoconazole to prevent postoperative erections following penile surgery.

Journal Article Int J Impot Res · August 2004 Analgesics and topical agents ineffectively inhibit painful erections after penile and urethral surgery. Oral ketoconazole reversibly inhibits testosterone production and has been used empirically at our institution to decrease postoperative erections. We ... Full text Link to item Cite