Karen Chiswell | Scholars@Duke

Karen Chiswell
Statistical Scientist

Ph.D., North Carolina State University - 2007

I work closely with clinical and quantitative colleagues to provide statistical leadership, guidance and mentoring on the design, execution, and analysis of clinical research studies. My work includes design and analysis of observational studies (including large cardiovascular registries, and clinical care databases linked with electronic health record data) and early-phase trials in pediatric populations. My statistical interests include study design, linear and non-linear mixed effects models, survival analysis, biology- and mechanism-based models, and statistical thinking and learning.

Current Appointments & Affiliations

Statistical Scientist, Duke Clinical Research Institute, Institutes and Centers

Contact Information

2400 Pratt Street, NP.4144, Durham, NC 27705
karen.chiswell@duke.edu +1 919 668 8395

Expertise
Subject Headings
Research
Selected Grants
- North Carolina Congenital Heart Defects Surveillance Network awarded by Centers for Disease Control and Prevention 2015 - 2019
- Using AACT - to answer Oncology landscape portfolio of open trials awarded by American Cancer Society Cancer Action Network 2017 - 2018
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Shavadia, J, Chiswell, K, White, R, Stephens, L, Schikorr, T, Bhounsule, P, and Krucoff, M. "Prevalence and treatment patterns for in-stent restenosis: A single center report from the Duke Databank for Cardiovascular Disease." October 31, 2017. Link to Item
  - Sullivan, LT, Mulder, H, Chiswell, K, Shaw, L, Wang, T, and Thomas, K. "DUAL ANTIPLATELET THERAPY UTILIZATION AND CARDIOVASCULAR OUTCOMES AMONG BLACK AND WHITE PATIENTS TREATED WITH DRUG ELUTING STENTS." March 21, 2017. Link to Item
  - Kragholm, K, Lu, D, Chiswell, K, Al-Khalidi, H, Roettig, ML, Roe, M, Jollis, J, and Granger, CB. "Improvement in Care and Outcomes for Ambulance-Transported ST-Elevation Myocardial Infarction Patients With and Without Out-of-Hospital Cardiac Arrest: A Mission: Lifeline STEMI ACCELERATOR Study." November 11, 2016. Link to Item
  - Patel, PA, Phelan, M, MacKenzie, M, Chiswell, K, Van Dyke, MK, Tomfohr, J, Alenezi, FA, Honarpour, N, and Velazquez, EJ. "Shorter Left Ventricular Ejection Time is Associated With Adverse Outcomes in Heart Failure Patients With Reduced Ejection Fraction." November 11, 2016. Link to Item
  - Patel, PA, Phelan, M, MacKenzie, M, Chiswell, K, Van Dyke, MK, Tomfohr, J, Alenezi, FA, Honarpour, N, and Velazquez, EJ. "Shorter Left Ventricular Ejection Time is Associated With Adverse Outcomes in Heart Failure Patients With Reduced Ejection Fraction." November 11, 2016. Link to Item
  - Siddiqui, I, Rajagopal, S, Brucker, A, Chiswell, K, Al Enezi, F, Rivera, D, Mandawat, A, Arges, K, Velazquez, E, Douglas, P, and Samad, Z. "Clinical and Echocardiographic Predictors of Clinical Outcomes in Pulmonary Arterial Hypertension." November 11, 2016. Link to Item
  - Badri, M, Abdelbaky, A, Li, S, Chiswell, K, and Wang, T. "ASSOCIATION BETWEEN PRE-CATHETERIZATION USE OF P2Y12 INHIBITORS WITH TIMING OF CABG AND CABG-RELATED OUTCOMES IN PATIENTS PRESENTING WITH NSTEMI AND SURGICAL CORONARY DISEASE: INSIGHTS FROM NCDR ®." April 2016. Full Text
  - Basra, SS, Wang, T, Simon, D, Chiswell, K, Virani, S, Alam, M, Nambi, V, Denktas, A, Deswal, A, Bozkurt, B, Ballantyne, C, Peterson, E, and Jneid, H. "ASPIRIN DOSING IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION TREATED WITH TICAGRELOR: INSIGHT FROM THE NATIONAL CARDIOVASCULAR DATA REGISTRY (NCDR)." April 2016. Full Text
  - Douglas, PS, De Bruyne, B, Pontone, G, Patel, M, Norgaard, B, Byrne, R, Curzen, N, Purcell, I, Gutberlet, M, Rioufol, G, Hink, U, Schuchlenz, H, Feuchtner, G, Gilard, M, Chiswell, K, Cyr, D, Wilk, A, Rogers, C, and Hlatky, M. "LONG-TERM OUTCOMES OF AN FFRCT DIAGNOSTIC STRATEGY VERSUS USUAL CARE IN SUSPECTED CORONARY ARTERY DISEASE: RESULTS FROM THE PLATFORM (PROSPECTIVE LONGITUDINAL TRIAL OF FFRCT: OUTCOME AND RESOURCE IMPACTS) STUDY." April 2016. Full Text
  - Hansen, CM, Wang, T, Chen, A, Chiswell, K, Bhatt, D, Enriquez, J, Henry, T, and Roe, M. "HOSPITAL-LEVEL VARIATION IN THE USE OF EARLY CATHETERIZATION FOR PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION: INSIGHTS FROM THE NCDR ACTION REGISTRY-GWTG." April 2016. Full Text
  - Kontos, MC, Fordyce, C, Enriquez, J, Roe, M, Chiswell, K, Chen, AY, and Garvey, L. "ASSOCIATION OF ACUTE MYOCARDIAL INFARCTION CARDIAC ARREST PATIENT VOLUME AND IN-HOSPITAL MORTALITY." April 2016. Full Text
  - Pagidipati, NJ, Mudrick, D, Chiswell, K, Brucker, A, Mackenzie, M, Zhu, S, Peterson, E, and Douglas, P. "SEX DIFFERENCES IN LONG-TERM OUTCOMES OF PATIENTS WITH NON-OBSTRUCTIVE CORONARY ARTERY DISEASE." April 2016. Full Text
  - Pi, Y, Roe, M, Simon, D, Chiswell, K, Garvey, L, Fonarow, G, de Lemos, J, and Xian, Y. "UTILIZATION, CHARACTERISTICS, AND IN-HOSPITAL OUTCOMES FOR PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION UNDERGOING IN-HOSPITAL CORONARY ARTERY BYPASS GRAFTING (CABG)." April 2016. Full Text
  - Smilowitz, NR, Mahajan, A, Roe, M, Hellkamp, A, Chiswell, K, Gulati, M, and Reynolds, H. "IN-HOSPITAL MORTALITY OF MYOCARDIAL INFARCTION BY SEX, AGE, AND OBSTRUCTIVE CORONARY ARTERY DISEASE STATUS IN THE ACTION REGISTRY-GWTG." April 2016. Full Text
  - Green, JL, Jacobs, AK, Simon, DN, Chiswell, K, Blanco, R, Bates, ER, French, W, Kupas, DF, Mears, G, Roe, M, and Nallamothu, BK. "Are State Policies to Permit Pre-hospital Bypass Associated With Better Treatment Patterns Among Patients With ST-Elevation Myocardial Infarction? A Report From AHA's Mission: Lifeline Program." November 10, 2015. Link to Item
  - Harskamp, RE, Chiswell, K, Halim, S, Rymer, J, Shaw, L, and Newby, LK. "Revascularization versus Optimal Medical Therapy for Patients With Prior Coronary Artery Bypass Surgery: An Analysis From the Duke Databank for Cardiovascular Disease." November 10, 2015. Link to Item
  - Riley, I, Boulware, LE, Sun, J-L, Chiswell, K, Que, L, Califf, R, Kraft, M, and Anderson, M. "Race/Ethnicity Reporting for Pulmonary Clinical Trials in ClinicalTrials.gov." October 2015. Full Text
  - Held, C, White, HD, Stewart, RAH, Davies, R, Sampson, SH, Chiswell, K, Boden, U, Mahaffey, KW, and Wallentin, L. "Characterization of cardiovascular endpoints, impact of event adjudication and effects of darapladib in the STABILITY trial." August 1, 2015. Link to Item
  - Psotka, MA, Teerlink, JR, Chiswell, K, Cleland, JG, Cotter, G, Davison, BA, Givertz, MM, Metra, M, Ponikowski, P, Voors, AA, Bloomfield, DM, and O'Connor, CM. "Prediction of Post-Discharge Outcomes for Patients Hospitalized with Heart Failure: Results from PROTECT." August 2015. Full Text
  - Stewart, RAH, Armstrong, PW, Chiswell, K, Hagstrom, E, Held, C, Krug-Gourley, S, Ryan, CM, Stebbins, A, Wallentin, L, and White, HD. "Effect of ivabradine on heart rate variability in patients with stable coronary artery disease." August 1, 2015. Link to Item
  - Kakkar, AK, Accetta, G, Agnelli, G, Angchaisuksiri, P, Bassand, J-P, Chiswell, K, Cools, F, Fitzmaurice, DA, Gibbs, H, Goldhaber, SZ, Goto, S, Haas, S, Jacobson, B, Jerjes-Sanchez, C, Kayani, G, Mantovani, LG, Misselwitz, F, ten Cate, H, Turpie, AG, van Eickels, M, Verheugt, FW, Camm, J, and Investigators, GARFIELD-AF. "Risk profiles and 1-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF." June 2015. Link to Item
  - Randolph, T, Broderick, S, Shaw, L, Mentz, R, Chiswell, K, Gilliam, F, and Thomas, K. "RACE AND SEX DIFFERENCES IN THE QRS INTERVAL AMONG PATIENTS WITH LEFT VENTRICULAR SYSTOLIC DYSFUNCTION." March 2015. Full Text
  - DeVore, AD, Yow, E, Krucoff, MW, Shaw, LK, Chiswell, K, O'Connor, CM, Ohman, EM, and Velazquez, EJ. "Outcomes After Percutaneous Coronary Intervention for Patients With Stable Coronary Disease and Left Ventricular Systolic Dysfunction." November 25, 2014. Link to Item
  - Subherwal, S, Patel, MR, Chiswell, K, Tidemann-Miller, BA, Jones, WS, Conte, MS, White, CJ, Bhatt, DL, Laird, JR, Hiatt, WR, Tasneem, A, and Califf, RM. "Clinical trials in peripheral vascular disease: pipeline and trial designs: an evaluation of the ClinicalTrials.gov database." November 2014. Full Text
  - Holmqvist, F, Thomas, KL, Broderick, S, Ersboll, M, Singh, D, Chiswell, K, Shaw, LK, Hegland, DD, Velazquez, EJ, and Daubert, JP. "Heart Rhythm Disorders and Resuscitation Science." November 26, 2013. Link to Item
  - Mentz, RJ, Broderick, S, Shaw, LK, Chiswell, K, Fiuzat, M, and O'Connor, CM. "Clinical Characteristics and Outcomes of Patients With Ischemic Cardiomyopathy and Persistent Angina Pectoris: From the Duke Databank for Cardiovascular Disease." November 26, 2013. Link to Item
  - Shah, A, Broderick, S, Chiswell, K, Tasneem, A, and Sundy, JS. "Status of the Allergy and Immunology Clinical Trials Portfolio: Data From Clinicaltrials.Gov." February 2013. Full Text
  - Shah, A, Broderick, S, Chiswell, K, Tasneem, A, and Sundy, JS. "Status of the Rheumatology Clinical Trials Portfolio: Data From Clinicaltrials.Gov." October 2012. Link to Item
  - Metra, M, Chiswell, K, Fiuzat, M, Lazzarini, V, Horton, J, Davison, B, Cleland, J, Ponikowski, P, Teerlink, J, Voors, A, Givertz, M, Mansoor, G, Massie, B, Cotter, G, and O'Connor, C. "Age, Clinical Characteristics and Outcomes of Patients With Acute Decompensated Heart Failure: Insights from the PROTECT Trial." August 2012. Full Text
  - Cleland, J, Chiswell, K, Filippatos, G, Givertz, M, Massie, B, Cotter, G, Davison, B, Fiuzat, M, Voors, A, Mansoor, G, Ponikowski, P, Teerlink, J, O', andConnor, C. "QUALITY OF LIFE 60 DAYS AFTER AN ACUTE HEART FAILURE EVENT: INSIGHTS FROM THE PROTECT TRIAL." March 2012. Full Text
  - Mentz, RJ, Wojdyla, D, Fiuzat, M, Chiswell, K, Ahmad, T, Fonarow, G, O', andConnor, C. "THE ASSOCIATION OF BETA-BLOCKER USE AND SELECTIVITY WITH OUTCOMES IN HEART FAILURE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: FINDINGS FROM THE ORGANIZED PROGRAM TO INITIATE LIFE-SAVING TREATMENT IN HOSPITALIZED PATIENTS WITH HEART FAILURE." March 2012. Full Text
  - Fiuzat, M, Wojdyla, D, Whellan, D, Chiswell, K, Kitzman, D, Kraus, W, Keteyian, S, Patterson, H, Adams, K, Fleg, J, Pina, I, and O'Connor, CM. "Relationship of Beta-Blocker (BB) Dose with Outcomes in Ambulatory Heart Failure (HF) Patients with Systolic Dysfunction: Results from the HF-ACTION Trial." November 22, 2011. Link to Item
  - Fiuzat, M, Massie, B, Chiswell, K, Givertz, M, Davison, B, Cotter, G, Cleland, J, Dittrich, H, Mansoor, G, Ponikowski, P, Voors, A, Teerlink, J, Mentz, R, Metra, M, and O'Connor, C. "International Differences in Acute Heart Failure (AHF) Patients: Insight from the PROTECT Trial." August 2011. Full Text
  - Mentz, R, Fiuzat, M, Chiswell, K, Wojdyla, D, Davison, B, Cleland, J, Dittrich, H, Givertz, M, Mansoor, G, Ponikowski, P, Teerlink, J, Voors, A, Cotter, G, Metra, M, Massie, B, and O'Connor, C. "The PROTECT In-Hospital Risk Model: 7-Day Outcome in Patients Hospitalized with Acute Heart Failure (AHF) and Renal Dysfunction." August 2011. Full Text
  - Mentz, R, Fiuzat, M, Wojdyla, D, Chiswell, K, Pieper, K, Gheorghiade, M, Fonarow, G, and O'Connor, C. "Clinical Characteristics and Outcomes for Hospitalized Heart Failure (HF) Patients with Chronic Obstructive Pulmonary Disease (COPD): Findings from OPTIMIZE-HF." August 2011. Full Text
  - Hirsch, BR, Califf, RM, Tasneem, A, Chiswell, K, Bolte, J, Schulman, KA, and Abernethy, AP. "Assessment of clinical trials in oncology: An evaluation of 40,696 trials on ClinicalTrials.gov." May 20, 2011. Full Text
  - Harigaya, Y, Chiswell, KE, Hoover, JL, and Fossler, MJ. "USE OF MONTE CARLO SIMULATION (MCS) TO EVALUATE TOXICITY AND EFFICACY BREAKPOINTS OF A NOVEL ANTIBIOTIC." January 2009. Link to Item
  - Goodman, SG, Mahaffey, KW, Chiswell, K, Cohen, M, Kontos, MC, Antman, EM, Ferguson, JJ, Califf, RM, and Becker, R. "Activated partial thromboplastin time measurement is not associated with clinical outcomes in patients with high-risk non-ST-segment elevation acute coronary syndromes treated with unfractionated heparin." March 6, 2007. Link to Item
  - Albert, NM, Fonarow, G, Abraham, W, Chiswell, K, Stough, WG, Gheorghiade, M, Greenberg, B, O'Connor, C', Yancy, C, and Young, J. "Do hospitals that provide heart failure patient education prior to discharge also promote continuity of care? A report from OPTIMIZE-HF." August 2006. Link to Item
  - Abraham, WT, Greenberg, B, Fonarow, GC, Albert, NM, Chiswell, K, Stough, WG, Gheorghiade, M, O'Connor, C, Sun, JL, Yancy, C, and Young, JB. "Cardiac resynchronization device placement during hospitalization for heart failure is associated with a significant improvement in early clinical outcomes." February 21, 2006. Link to Item
  - Albert, NM, Fonarow, GC, Abraham, WT, Chiswell, K, Stough, WG, Gheorghiade, M, Greenberg, B, O'Connor, CM, Yancy, C, Young, JB, and Investigators, OPTIMIZEHF. "Do hospitals that provide heart failure patient education prior to discharge also promote continuity of care? - A report from OPTIMIZE-HF." February 21, 2006. Link to Item
  - Ferrarow, GC, Abraham, WT, Albert, NM, Chiswell, K, Stough, WG, Gheorghiade, M, Greenberg, B, O'Connor, C, Sun, JL, Yancy, C, and Young, JB. "ACC/AHA performance measures for patients hospitalized with HF: Are they predictive of clinical outcomes?." February 21, 2006. Link to Item
  - Levine, GN, Lokhnygina, Y, White, HD, Chiswell, K, Kleiman, NS, Mahaffey, KW, Gulba, DC, Cohen, M, Harrington, RA, Petersen, JL, Aylward, PE, Ferguson, JJ, and Califf, RM. "Percutaneous coronary intervention in patients receiving only a single subcutaneous dose of enoxaparin: Results from the SYNERGY trial." February 21, 2006. Link to Item
  - Moser, D, Chiswell, K, Yamokoski, L, Conway, G, Hartman, KA, Binanay, C, and Stevenson, LW. "Lack of improvement in quality of life post-hospitalization predicts mortality in patients with advanced heart failure." February 1, 2005. Link to Item
- Journal Articles
  - Riley, IL, Boulware, LE, Sun, J-L, Chiswell, K, Que, LG, Kraft, M, Todd, JL, Palmer, SM, and Anderson, ML. "Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov." Clinical trials (London, England) 15, no. 1 (February 2018): 87-94. Full Text
  - Doll, JA, Li, S, Chiswell, K, Roe, MT, Kosiborod, M, Scirica, BM, and Wang, TY. "Clopidogrel reloading for patients with acute myocardial infarction already on clopidogrel therapy." European heart journal 39, no. 3 (January 2018): 193-200. Full Text
  - Hagström, E, Norlund, F, Stebbins, A, Armstrong, PW, Chiswell, K, Granger, CB, López-Sendón, J, Pella, D, Soffer, J, Sy, R, Wallentin, L, White, HD, Stewart, RAH, and Held, C. "Psychosocial stress and major cardiovascular events in patients with stable coronary heart disease." Journal of internal medicine 283, no. 1 (January 2018): 83-92. Full Text
  - Mody, P, Wang, T, McNamara, R, Das, S, Li, S, Chiswell, K, Tsai, T, Kumbhani, D, Wiviott, S, Goyal, A, Roe, M, and de Lemos, JA. "Association of acute kidney injury and chronic kidney disease with processes of care and long-term outcomes in patients with acute myocardial infarction." European heart journal. Quality of care & clinical outcomes 4, no. 1 (January 2018): 43-50. Full Text
  - Krishnamoorthy, A, DeVore, AD, Sun, J-L, Barnett, AS, Samsky, MD, Shaw, LK, Chiswell, K, Patel, CB, and Patel, MR. "The impact of a failing right heart in patients supported by intra-aortic balloon counterpulsation." European heart journal. Acute cardiovascular care 6, no. 8 (December 2017): 709-718. Full Text
  - Smilowitz, NR, Mahajan, AM, Roe, MT, Hellkamp, AS, Chiswell, K, Gulati, M, and Reynolds, HR. "Mortality of Myocardial Infarction by Sex, Age, and Obstructive Coronary Artery Disease Status in the ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines)." Circulation. Cardiovascular quality and outcomes 10, no. 12 (December 2017): e003443-. Full Text
  - Sze, E, Dunning, A, Loring, Z, Atwater, BD, Chiswell, K, Daubert, JP, Kisslo, JA, Mark, DB, Velazquez, EJ, and Samad, Z. "Comparison of Incidence of Left Ventricular Systolic Dysfunction Among Patients With Left Bundle Branch Block Versus Those With Normal QRS Duration." The American journal of cardiology 120, no. 11 (December 2017): 1990-1997. Full Text
  - Kragholm, K, Lu, D, Chiswell, K, Al-Khalidi, HR, Roettig, ML, Roe, M, Jollis, J, and Granger, CB. "Improvement in Care and Outcomes for Emergency Medical Service-Transported Patients With ST-Elevation Myocardial Infarction (STEMI) With and Without Prehospital Cardiac Arrest: A Mission: Lifeline STEMI Accelerator Study." Journal of the American Heart Association 6, no. 10 (October 11, 2017). Full Text
  - Vidal-Petiot, E, Stebbins, A, Chiswell, K, Ardissino, D, Aylward, PE, Cannon, CP, Ramos Corrales, MA, Held, C, López-Sendón, JL, Stewart, RAH, Wallentin, L, White, HD, Steg, PG, and STABILITY Investigators, . "Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial." European heart journal 38, no. 37 (October 2017): 2813-2822. Full Text
  - Badri, M, Abdelbaky, A, Li, S, Chiswell, K, and Wang, TY. "Precatheterization Use of P2Y12 Inhibitors in Non-ST-Elevation Myocardial Infarction Patients Undergoing Early Cardiac Catheterization and In-Hospital Coronary Artery Bypass Grafting: Insights From the National Cardiovascular Data Registry®." Journal of the American Heart Association 6, no. 9 (September 22, 2017). Full Text
  - Guimarães, PO, Granger, CB, Stebbins, A, Chiswell, K, Held, C, Hochman, JS, Krug-Gourley, S, Lonn, E, Lopes, RD, Stewart, RAH, Vinereanu, D, Wallentin, L, White, HD, Hagström, E, and Danchin, N. "Sex Differences in Clinical Characteristics, Psychosocial Factors, and Outcomes Among Patients With Stable Coronary Heart Disease: Insights from the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial." Journal of the American Heart Association 6, no. 9 (September 14, 2017). Full Text
  - Vora, AN, Wang, TY, Li, S, Chiswell, K, Hess, C, Lopes, RD, Rao, SV, and Peterson, ED. "Selection of Stent Type in Patients With Atrial Fibrillation Presenting With Acute Myocardial Infarction: An Analysis From the ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry-Get With the Guidelines." Journal of the American Heart Association 6, no. 8 (August 21, 2017). Full Text
  - Pi, Y, Roe, MT, Holmes, DN, Chiswell, K, Garvey, JL, Fonarow, GC, de Lemos, JA, Garratt, KN, and Xian, Y. "Utilization, Characteristics, and In-Hospital Outcomes of Coronary Artery Bypass Grafting in Patients With ST-Segment-Elevation Myocardial Infarction: Results From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines." Circulation. Cardiovascular quality and outcomes 10, no. 8 (August 2017). Full Text
  - Pandey, A, Golwala, H, Hall, HM, Wang, TY, Lu, D, Xian, Y, Chiswell, K, Joynt, KE, Goyal, A, Das, SR, Kumbhani, D, Julien, H, Fonarow, GC, and de Lemos, JA. "Association of US Centers for Medicare and Medicaid Services Hospital 30-Day Risk-Standardized Readmission Metric With Care Quality and Outcomes After Acute Myocardial Infarction: Findings From the National Cardiovascular Data Registry/Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines." JAMA cardiology 2, no. 7 (July 2017): 723-731. Full Text
  - Banks, A, Broderick, S, Chiswell, K, Shaw, L, Devore, A, Fiuzat, M, O'Connor, C, Felker, GM, Velazquez, E, and Mentz, R. "Comparison of Clinical Characteristics and Outcomes of Patients With Versus Without Diabetes Mellitus and With Versus Without Angina Pectoris (from the Duke Databank for Cardiovascular Disease)." The American journal of cardiology 119, no. 11 (June 2017): 1703-1709. Full Text
  - Randolph, TC, Broderick, S, Shaw, LK, Chiswell, K, Mentz, RJ, Kutyifa, V, Velazquez, EJ, Gilliam, FR, and Thomas, KL. "Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction." Journal of the American Heart Association 6, no. 3 (March 20, 2017). Full Text Open Access Copy
  - Roswell, RO, Kunkes, J, Chen, AY, Chiswell, K, Iqbal, S, Roe, MT, and Bangalore, S. "Impact of Sex and Contact-to-Device Time on Clinical Outcomes in Acute ST-Segment Elevation Myocardial Infarction-Findings From the National Cardiovascular Data Registry." Journal of the American Heart Association 6, no. 1 (January 11, 2017). Full Text
  - Shah, R, Clare, RM, Chiswell, K, Jones, WS, Kumar, AS, Thiele, H, Smalling, RW, Chandra, P, Cohen, M, Perera, D, Chew, DP, French, JK, Blaxill, J, Ohman, EM, and Patel, MR. "Impact of Non-Infarct-Related Artery Disease on Infarct Size and Outcomes (from the CRISP-AMI Trial)." The American journal of medicine 129, no. 12 (December 2016): 1307-1315. Full Text
  - Douglas, PS, De Bruyne, B, Pontone, G, Patel, MR, Norgaard, BL, Byrne, RA, Curzen, N, Purcell, I, Gutberlet, M, Rioufol, G, Hink, U, Schuchlenz, HW, Feuchtner, G, Gilard, M, Andreini, D, Jensen, JM, Hadamitzky, M, Chiswell, K, Cyr, D, Wilk, A, Wang, F, Rogers, C, Hlatky, MA, and PLATFORM Investigators, . "1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study." Journal of the American College of Cardiology 68, no. 5 (August 2016): 435-445. Full Text
  - Stewart, RAH, Wallentin, L, Benatar, J, Danchin, N, Hagström, E, Held, C, Husted, S, Lonn, E, Stebbins, A, Chiswell, K, Vedin, O, Watson, D, White, HD, and STABILITY Investigators, . "Dietary patterns and the risk of major adverse cardiovascular events in a global study of high-risk patients with stable coronary heart disease." European heart journal 37, no. 25 (July 2016): 1993-2001. Full Text
  - Kohl, LP, Leimberger, JD, Chiswell, K, Jones, WS, Thiele, H, Smalling, RW, Chandra, P, Cohen, M, Perera, D, Chew, DP, French, JK, Blaxil, J, Kumar, AS, Ohman, EM, and Patel, MR. "Clinical characteristics and outcomes after unplanned intraaortic balloon counterpulsation in the Counterpulsation to Reduce Infarct Size Pre-PCI Acute Myocardial Infarction trial." American heart journal 174 (April 2016): 7-13. Full Text
  - Barnard, K, Lakey, WC, Batch, BC, Chiswell, K, Tasneem, A, and Green, JB. "Recent Clinical Trials in Osteoporosis: A Firm Foundation or Falling Short?." PloS one 11, no. 5 (January 2016): e0156068-. Full Text Open Access Copy
  - Douglas, PS, Pontone, G, Hlatky, MA, Patel, MR, Norgaard, BL, Byrne, RA, Curzen, N, Purcell, I, Gutberlet, M, Rioufol, G, Hink, U, Schuchlenz, HW, Feuchtner, G, Gilard, M, Andreini, D, Jensen, JM, Hadamitzky, M, Chiswell, K, Cyr, D, Wilk, A, Wang, F, Rogers, C, De Bruyne, B, and PLATFORM Investigators, . "Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR(CT): outcome and resource impacts study." European heart journal 36, no. 47 (December 2015): 3359-3367. Full Text
  - Ruopp, M, Chiswell, K, Thaden, JT, Merchant, K, and Tsalik, EL. "Respiratory Tract Infection Clinical Trials from 2007 to 2012. A Systematic Review of ClinicalTrials.gov." Annals of the American Thoracic Society 12, no. 12 (December 2015): 1852-1863. (Review) Full Text
  - Mentz, RJ, Velazquez, EJ, Metra, M, McKendry, C, Chiswell, K, Fiuzat, M, Givertz, MM, Voors, AA, Teerlink, JR, and O'Connor, CM. "Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial." Future cardiology 11, no. 5 (September 25, 2015): 585-595. Full Text
  - Pontone, G, Patel, MR, Hlatky, MA, Chiswell, K, Andreini, D, Norgaard, BL, Byrne, RA, Curzen, N, Purcell, I, Gutberlet, M, Rioufol, G, Hink, U, Schuchlenz, HW, Feuchtner, G, Gilard, M, de Bruyne, B, Rogers, C, and Douglas, PS. "Rationale and design of the Prospective LongitudinAl Trial of FFRCT: Outcome and Resource IMpacts study." American heart journal 170, no. 3 (September 2015): 438-46.e44. Full Text
  - Hess, CN, Roe, MT, Clare, RM, Chiswell, K, Kelly, J, Tcheng, JE, Hagstrom, E, James, SK, Khouri, MG, Hirsch, BR, Kong, DF, Abernethy, AP, and Krucoff, MW. "Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention." Journal of the American Heart Association 4, no. 7 (July 6, 2015). Full Text Open Access Copy
  - Mentz, RJ, Metra, M, Cotter, G, Milo, O, McKendry, C, Chiswell, K, Davison, BA, Cleland, JGF, Bloomfield, DM, Dittrich, HC, Fiuzat, M, Ponikowski, P, Givertz, MM, Voors, AA, Teerlink, JR, and O'Connor, CM. "Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial." European journal of heart failure 17, no. 7 (July 2015): 697-706. Full Text
  - Holmqvist, F, Thomas, KL, Broderick, S, Ersbøll, M, Singh, D, Chiswell, K, Shaw, LK, Hegland, DD, Velazquez, EJ, and Daubert, JP. "Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease." Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 17, no. 6 (June 2015): 978-985. Full Text
  - Subherwal, S, Patel, M, and Chiswell, K. "Clinical Trials in Peripheral Vascular Disease Pipeline and Trial Designs: An Evaluation of the Clinical Trials.gov Database." Journal of Vascular Surgery 61, no. 4 (April 2015): 1099-1099. Full Text
  - Anderson, ML, Chiswell, K, Peterson, ED, Tasneem, A, Topping, J, and Califf, RM. "Compliance with results reporting at ClinicalTrials.gov." The New England journal of medicine 372, no. 11 (March 2015): 1031-1039. Full Text
  - Jones, WS, Clare, RM, Chiswell, K, Perera, D, French, JK, Kumar, AS, Blaxill, J, Pijls, N, Mills, J, Ohman, EM, and Patel, MR. "The impact of processes of care on myocardial infarct size in patients with ST-segment elevation myocardial infarction: observations from the CRISP-AMI trial." Clinical cardiology 38, no. 1 (January 2015): 25-31. Full Text
  - Jones, WS, Clare, RM, Chiswell, K, Perera, D, French, JK, Kumar, AS, Blaxill, J, Pijls, N, Mills, J, Ohman, EM, and Patel, MR. "The impact of processes of care on myocardial infarct size in patients with ST-segment elevation myocardial infarction: Observations from the CRISPAMI trial." Clinical Cardiology 38, no. 1 (January 1, 2015): 25-31. Full Text
  - Metra, M, Mentz, RJ, Chiswell, K, Bloomfield, DM, Cleland, JGF, Cotter, G, Davison, BA, Dittrich, HC, Fiuzat, M, Givertz, MM, Lazzarini, V, Mansoor, GA, Massie, BM, Ponikowski, P, Teerlink, JR, Voors, AA, and O'Connor, CM. "Acute heart failure in elderly patients: worse outcomes and differential utility of standard prognostic variables. Insights from the PROTECT trial." European journal of heart failure 17, no. 1 (January 2015): 109-118. Full Text
  - Mentz, RJ, Broderick, S, Shaw, LK, Chiswell, K, Fiuzat, M, and O'Connor, CM. "Persistent angina pectoris in ischaemic cardiomyopathy: increased rehospitalization and major adverse cardiac events." European journal of heart failure 16, no. 8 (August 2014): 854-860. Full Text
  - Hill, KD, Chiswell, K, Califf, RM, Pearson, G, and Li, JS. "Characteristics of pediatric cardiovascular clinical trials registered on ClinicalTrials.gov." American heart journal 167, no. 6 (June 2014): 921-9.e2. Full Text
  - Mentz, RJ, Cotter, G, Cleland, JGF, Stevens, SR, Chiswell, K, Davison, BA, Teerlink, JR, Metra, M, Voors, AA, Grinfeld, L, Ruda, M, Mareev, V, Lotan, C, Bloomfield, DM, Fiuzat, M, Givertz, MM, Ponikowski, P, Massie, BM, and O'Connor, CM. "International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short-term outcomes in patients enrolled in Eastern Europe and Russia in the PROTECT trial." European journal of heart failure 16, no. 6 (June 2014): 614-624. Full Text
  - Inrig, JK, Califf, RM, Tasneem, A, Vegunta, RK, Molina, C, Stanifer, JW, Chiswell, K, and Patel, UD. "The landscape of clinical trials in nephrology: a systematic review of Clinicaltrials.gov." American journal of kidney diseases : the official journal of the National Kidney Foundation 63, no. 5 (May 2014): 771-780. (Review) Full Text
  - Cleland, JG, Chiswell, K, Teerlink, JR, Stevens, S, Fiuzat, M, Givertz, MM, Davison, BA, Mansoor, GA, Ponikowski, P, Voors, AA, Cotter, G, Metra, M, Massie, BM, and O'Connor, CM. "Predictors of postdischarge outcomes from information acquired shortly after admission for acute heart failure: a report from the Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function (PROTECT) Study." Circ Heart Fail 7, no. 1 (January 2014): 76-87. Full Text Link to Item
  - Hill, KD, Chiswell, K, Califf, RM, Pearson, G, and Li, JS. "Characteristics of pediatric cardiovascular clinical trials registered on ClinicalTrials.gov." American Heart Journal 167, no. 6 (January 1, 2014). Full Text
  - Inrig, JK, Califf, RM, Tasneem, A, Vegunta, RK, Molina, C, Stanifer, JW, Chiswell, K, and Patel, UD. "The landscape of clinical trials in nephrology: A systematic review of clinicaltrials.gov." American Journal of Kidney Diseases 63, no. 5 (January 1, 2014): 771-780. Full Text
  - Subherwal, S, Patel, MR, Chiswell, K, Tidemann-Miller, BA, Jones, WS, Conte, MS, White, CJ, Bhatt, DL, Laird, JR, Hiatt, WR, Tasneem, A, and Califf, RM. "Clinical trials in peripheral vascular disease: Pipeline and trial designs: An evaluation of the ClinicalTrials.gov database." Circulation 130, no. 20 (January 1, 2014): 1812-1819. Full Text
  - Witsell, DL, Schulz, KA, Lee, WT, and Chiswell, K. "An analysis of registered clinical trials in otolaryngology from 2007 to 2010: ClinicalTrials.gov." Otolaryngol Head Neck Surg 149, no. 5 (November 2013): 692-699. Full Text Link to Item
  - Goswami, ND, Pfeiffer, CD, Horton, JR, Chiswell, K, Tasneem, A, and Tsalik, EL. "The State of Infectious Diseases Clinical Trials: A Systematic Review of ClinicalTrials.gov." PLoS ONE 8, no. 10 (October 16, 2013): e77086-. Full Text Link to Item
  - Todd, JL, White, KR, Chiswell, K, Tasneem, A, and Palmer, SM. "Using ClinicalTrials.gov to understand the state of clinical research in pulmonary, critical care, and sleep medicine." Ann Am Thorac Soc 10, no. 5 (October 2013): 411-417. Full Text Link to Item
  - Alexander, KP, Kong, DF, Starr, AZ, Kramer, J, Chiswell, K, Tasneem, A, and Califf, RM. "Portfolio of clinical research in adult cardiovascular disease as reflected in ClinicalTrials.gov. (Published online)" J Am Heart Assoc 2, no. 5 (September 26, 2013): e000009-. Full Text Link to Item
  - Vavalle, JP, Clare, R, Chiswell, K, Rao, SV, Petersen, JL, Kleiman, NS, Mahaffey, KW, and Wang, TY. "Prognostic significance of bleeding location and severity among patients with acute coronary syndromes." JACC Cardiovasc Interv 6, no. 7 (July 2013): 709-717. Full Text Link to Item
  - Hirsch, BR, Califf, RM, Cheng, SK, Tasneem, A, Horton, J, Chiswell, K, Schulman, KA, Dilts, DM, and Abernethy, AP. "Characteristics of oncology clinical trials: insights from a systematic analysis of ClinicalTrials.gov." JAMA Intern Med 173, no. 11 (June 10, 2013): 972-979. Full Text Link to Item
  - Lakey, WC, Barnard, K, Batch, BC, Chiswell, K, Tasneem, A, and Green, JB. "Are current clinical trials in diabetes addressing important issues in diabetes care?." Diabetologia 56, no. 6 (June 2013): 1226-1235. (Review) Full Text Link to Item
  - Rose, JJ, Newby, LK, Broderick, S, Chiswell, K, Van de Werf, F, Armstrong, PW, Mahaffey, KW, Harrington, RA, Ohman, EM, Giugliano, RP, Goodman, SG, White, HD, Califf, RM, Granger, CB, and Lopes, RD. "Left bundle branch block in non-ST-segment elevation acute coronary syndromes. Incidence, angiographic characteristics, and clinical outcomes." J Am Coll Cardiol 61, no. 13 (April 2, 2013): 1461-1463. (Letter) Full Text Link to Item
  - Berger, PB, Williams, JB, Hasselblad, V, Chiswell, K, Pieper, KS, and Califf, RM. "Would tirofiban have been shown non-inferior to abciximab had the TENACITY trial not been terminated for financial reasons?." J Interv Cardiol 26, no. 2 (April 2013): 123-130. Full Text Link to Item
  - Mentz, RJ, Wojdyla, D, Fiuzat, M, Chiswell, K, Fonarow, GC, and O'Connor, CM. "Association of beta-blocker use and selectivity with outcomes in patients with heart failure and chronic obstructive pulmonary disease (from OPTIMIZE-HF)." The American journal of cardiology 111, no. 4 (February 2013): 582-587. Full Text
  - Williams, ES, Thompson, VP, Chiswell, KE, Alexander, JH, White, HD, Ohman, EM, and Al-Khatib, SM. "Rate versus rhythm control and outcomes in patients with atrial fibrillation and chronic kidney disease: data from the GUSTO-III Trial." Cardiol J 20, no. 4 (2013): 439-446. Full Text Link to Item
  - Pasquali, SK, Lam, WK, Chiswell, K, Kemper, AR, and Li, JS. "Status of the pediatric clinical trials enterprise: an analysis of the US ClinicalTrials.gov registry." Pediatrics 130, no. 5 (November 2012): e1269-e1277. Full Text Link to Item
  - Green, JB, Lakey, W, Barnard, K, Batch, B, Bethel, M, Chiswell, K, and Tasneem, A. "State of diabetes-related trials in the clinicaltrials.gov dataset." DIABETOLOGIA 55 (October 2012): S90-S91. Link to Item
  - Thomas, MP, Mahaffey, KW, Chiswell, K, Cohen, M, Kontos, MC, Antman, EM, Ferguson, JJ, Califf, RM, Goodman, SG, and Becker, RC. "Activated partial thromboplastin time measurement is not associated with clinical outcomes in patients with high-risk non-ST-segment elevation acute coronary syndromes treated with unfractionated heparin." J Thromb Thrombolysis 34, no. 1 (July 2012): 114-119. Full Text Link to Item
  - O'Connor, CM, Mentz, RJ, Cotter, G, Metra, M, Cleland, JG, Davison, BA, Givertz, MM, Mansoor, GA, Ponikowski, P, Teerlink, JR, Voors, AA, Fiuzat, M, Wojdyla, D, Chiswell, K, and Massie, BM. "The PROTECT in-hospital risk model: 7-day outcome in patients hospitalized with acute heart failure and renal dysfunction." European journal of heart failure 14, no. 6 (June 2012): 605-612. Full Text
  - Mentz, RJ, Fiuzat, M, Wojdyla, DM, Chiswell, K, Gheorghiade, M, Fonarow, GC, and O'Connor, CM. "Clinical characteristics and outcomes of hospitalized heart failure patients with systolic dysfunction and chronic obstructive pulmonary disease: findings from OPTIMIZE-HF." Eur J Heart Fail 14, no. 4 (April 2012): 395-403. Full Text Link to Item
  - Novick, S, Chiswell, K, and Peterson, J. "A Bayesian Approach to Show Assay Equivalence with Replicate Measurements Over a Specified Response Range." Statistics in Biopharmaceutical Research 4, no. 2 (April 2012): 102-117. Full Text
  - Tasneem, A, Aberle, L, Ananth, H, Chakraborty, S, Chiswell, K, McCourt, BJ, and Pietrobon, R. "The database for aggregate analysis of Clinicaltrials.gov (AACT) and subsequent regrouping by clinical specialty." PLoS ONE 7, no. 3 (2012). Full Text
  - Hirsch, BR, Califf, RM, Tasneem, A, Chiswell, K, Bolte, J, Schulman, KA, and Abernethy, AP. "Assessment of clinical trials in oncology: An evaluation of 40,696 trials on ClinicalTrials.gov." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, no. 15_suppl (May 2011): 6095-.
  - Goffinet, C, Allespach, I, Oberbremer, L, Golden, PL, Foster, SA, Johns, BA, Weatherhead, JG, Novick, SJ, Chiswell, KE, Garvey, EP, and Keppler, OT. "Pharmacovirological impact of an integrase inhibitor on human immunodeficiency virus type 1 cDNA species in vivo." Journal of virology 83, no. 15 (August 2009): 7706-7717. Full Text
  - Muniz-Medina, VM, Jones, S, Maglich, JM, Galardi, C, Hollingsworth, RE, Kazmierski, WM, Ferris, RG, Edelstein, MP, Chiswell, KE, and Kenakin, TP. "The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?." Molecular pharmacology 75, no. 3 (March 2009): 490-501. Full Text
  - Rao, SV, Chiswell, K, Sun, J-L, Granger, CB, Newby, LK, Van de Werf, F, White, HD, Armstong, PW, Califf, RM, and Harrington, RA. "International variation in the use of blood transfusion in patients with non-ST-segment elevation acute coronary syndromes." Am J Cardiol 101, no. 1 (January 1, 2008): 25-29. Full Text Link to Item
  - Greenberg, BH, Abraham, WT, Albert, NM, Chiswell, K, Clare, R, Stough, WG, Gheorghiade, M, O'Connor, CM, Sun, JL, Yancy, CW, Young, JB, and Fonarow, GC. "Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: A report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) (vol 154, art no 277.e1, 2007)." AMERICAN HEART JOURNAL 154, no. 4 (October 2007): 646-646. Full Text Link to Item
  - Greenberg, BH, Abraham, WT, Albert, NM, Chiswell, K, Clare, R, Stough, WG, Gheorghiade, M, O'Connor, CM, Sun, JL, Yancy, CW, Young, JB, and Fonarow, GC. "Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: A report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)." AMERICAN HEART JOURNAL 154, no. 4 (October 2007): 647-654. Full Text Link to Item
  - Greenberg, BH, Abraham, WT, Albert, NM, Chiswell, K, Clare, R, Stough, WG, Gheorghiade, M, O'Connor, CM, Sun, JL, Yancy, CW, Young, JB, and Fonarow, GC. "Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: a report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)." Am Heart J 154, no. 2 (August 2007): 277.e1-277.e8. Full Text Link to Item
  - Albert, NM, Fonarow, GC, Abraham, WT, Chiswell, K, Stough, WG, Gheorghiade, M, Greenberg, BH, O'Connor, CM, Sun, JL, Yancy, CW, and Young, JB. "Predictors of delivery of hospital-based heart failure patient education: a report from OPTIMIZE-HF." J Card Fail 13, no. 3 (April 2007): 189-198. Full Text Link to Item
  - Greenberg, BH, Abraham, WT, Albert, NM, Chiswell, K, Clare, R, Stough, WG, Gheorghiade, M, O'Connor, CM, Sun, JL, Yancy, CW, Young, JB, and Fonarow, GC. "Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: A report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)." American Heart Journal 154, no. 4 (2007): 647-654. Full Text
  - White, HD, Kleiman, NS, Mahaffey, KW, Lokhnygina, Y, Pieper, KS, Chiswell, K, Cohen, M, Harrington, RA, Chew, DP, Petersen, JL, Berdan, LG, Aylward, PEG, Nessel, CC, Ferguson, JJ, and Califf, RM. "Efficacy and safety of enoxaparin compared with unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention in the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial." Am Heart J 152, no. 6 (December 2006): 1042-1050. Full Text Link to Item
  - Chandler, RE, Chiswell, KE, and Faulkner, GD. "Quantifying a possible miocene phyletic change in Hemipristis (Chondrichthyes) teeth." Palaeontologia Electronica 9, no. 1 (February 6, 2006).
  - Viero, P, Chiswell, K, and Theron, J. "The effect of a soil-amended hydrogel on the establishment of a Eucalyptus grandis clone on a sandy clay loam soil in Zululand during winter." The Southern African Forestry Journal 193, no. 1 (March 2002): 65-75. Full Text
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