Karthik Raghunathan | Scholars@Duke

Karthik Raghunathan
Associate Professor of Anesthesiology

Dr. Karthik Raghunathan, MD is a board certified anesthesiologist affiliated with Duke University and with the Durham Veterans Affairs Healthcare System in Durham, North Carolina.

Office Hours

Available by appointment, call Staff Assistant at 919-286-6938.

Current Appointments & Affiliations

Associate Professor of Anesthesiology, Anesthesiology, VA Anesthesiology Service, Anesthesiology 2017
Associate Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2019

Contact Information

D5005 VAMC, Durham, NC 27710
DUMC Box 3094, Durham, NC 27710
karthik.raghunathan@duke.edu (919) 286-6938
Google Scholar Profile

Background
Education, Training, & Certifications
- M.B.B.S., Tamilnadu Dr. M.G.R. Medical University (India) 1997
Duke Appointment History
- Assistant Professor of Anesthesiology, Anesthesiology, VA Anesthesiology Service, Anesthesiology 2012 - 2017
Research
Selected Grants
- Utilization and Outcomes of Peptide-based versus other Tube Feeding Formulae among Surgical Critical Care Patients in the United States awarded by Abbott Nutrition 2020 - 2021
- PSA Tetsu Ohnuma awarded by Institute for Medical Research, Inc. 2020 - 2021
- The Impact of Race and Socioeconomic Status on Malnutrition in Surgical Patients awarded by American Society for Parenteral and Enteral Nutrition 2020
- PSA Tetsu Ohnuma awarded by Institute for Medical Research, Inc. 2019 - 2020
- Comparative effectiveness in Perioperative and Critical Care Medicine: Crystalloid Fluid Therapy awarded by Baxter Healthcare Corporation 2013 - 2014
External Relationships
- Boston Strategic Partners
- Grifols SSNA
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Krishnamoorthy, Vijay, Danny J. N. Wong, Matt Wilson, Karthik Raghunathan, Tetsu Ohnuma, Duncan McLean, S Ramani Moonesinghe, and Steve K. Harris. “Causal inference in perioperative medicine observational research: part 1, a graphical introduction.” Br J Anaesth 125, no. 3 (September 2020): 393–97. https://doi.org/10.1016/j.bja.2020.03.031.
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  - Krishnamoorthy, Vijay, Duncan McLean, Tetsu Ohnuma, Steve K. Harris, Danny J. N. Wong, Matt Wilson, Ramani Moonesinghe, and Karthik Raghunathan. “Causal inference in perioperative medicine observational research: part 2, advanced methods.” Br J Anaesth 125, no. 3 (September 2020): 398–405. https://doi.org/10.1016/j.bja.2020.03.032.
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  - Krishnamoorthy, Vijay, Raquel Bartz, and Karthik Raghunathan. “Rational perioperative utilisation and management during the COVID-19 pandemic.” Br J Anaesth 125, no. 2 (August 2020): e248–51. https://doi.org/10.1016/j.bja.2020.04.017.
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  - Haines, Krista L., Matthew Fuller, Justin G. Vaughan, Vijay Krishnamoorthy, Karthik Raghunathan, George Kasotakis, Suresh Agarwal, and Tetsu Ohnuma. “The Impact of Nonsteroidal Anti-inflammatory Drugs on Older Adult Trauma Patients With Hip Fractures.” J Surg Res 255 (July 7, 2020): 583–93. https://doi.org/10.1016/j.jss.2020.05.064.
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  - Chen, Fangyu, Mohammad R. Rasouli, Alan R. Ellis, Tetsu Ohnuma, Raquel R. Bartz, Vijay Krishnamoorthy, Krista L. Haines, and Karthik Raghunathan. “Associations Between Perioperative Crystalloid Volume and Adverse Outcomes in Five Surgical Populations.” J Surg Res 251 (July 2020): 26–32. https://doi.org/10.1016/j.jss.2019.12.013.
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  - Williams, David G. A., Tetsu Ohnuma, Vijay Krishnamoorthy, Karthik Raghunathan, Suela Sulo, Bridget A. Cassady, Refaat Hegazi, and Paul E. Wischmeyer. “Postoperative Utilization of Oral Nutritional Supplements in Surgical Patients in US Hospitals.” Jpen J Parenter Enteral Nutr, June 3, 2020. https://doi.org/10.1002/jpen.1862.
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  - Cobert, Julien, Paul M. Lantos, Mark M. Janko, David G. A. Williams, Karthik Raghunathan, Vijay Krishnamoorthy, Eric A. JohnBull, Atilio Barbeito, and Padma Gulur. “Geospatial Variations and Neighborhood Deprivation in Drug-Related Admissions and Overdoses.” J Urban Health, May 4, 2020. https://doi.org/10.1007/s11524-020-00436-8.
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  - Stefan, Mihaela S., Quinn Pack, Meng-Shiou Shieh, Penelope S. Pekow, Steven L. Bernstein, Karthik Raghunathan, Katie S. Nason, and Peter K. Lindenauer. “The Association of Nicotine Replacement Therapy With Outcomes Among Smokers Hospitalized for a Major Surgical Procedure.” Chest 157, no. 5 (May 2020): 1354–61. https://doi.org/10.1016/j.chest.2019.10.054.
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  - Pyati, Srinivas, Julien Cobert, Joe F. Jabre, Alan D. Kaye, James H. Diaz, and Karthik Raghunathan. “Effects of Tourniquets in the Development of Pain States: a Novel Clinical Pilot Study and Review of Utilization of Tissue Oximetry to Measure Neural Ischemia.” Curr Pain Headache Rep 24, no. 6 (April 22, 2020): 25. https://doi.org/10.1007/s11916-020-00855-x.
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  - Ohnuma, Tetsu, Vijay Krishnamoorthy, Karthik Raghunathan, David G. A. Williams, Suela Sulo, Refaat Hegazi, and Paul E. Wischmeyer. “Overcoming confounding by indication in nutrition research using electronic healthcare data.” Clin Nutr 39, no. 4 (April 2020): 985–87. https://doi.org/10.1016/j.clnu.2020.01.024.
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  - Ohnuma, Tetsu, Karthik Raghunathan, Sean Moore, Soko Setoguchi, Alan R. Ellis, Matthew Fuller, John Whittle, et al. “Dose-Dependent Association of Gabapentinoids with Pulmonary Complications After Total Hip and Knee Arthroplasties.” J Bone Joint Surg Am 102, no. 3 (February 5, 2020): 221–29. https://doi.org/10.2106/JBJS.19.00889.
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  - Herzig, Shoshana J., Mihaela S. Stefan, Penelope S. Pekow, Meng-Shiou Shieh, William Soares, Karthik Raghunathan, and Peter K. Lindenauer. “Risk Factors for Severe Opioid-Related Adverse Events in a National Cohort of Medical Hospitalizations.” J Gen Intern Med 35, no. 2 (February 2020): 538–45. https://doi.org/10.1007/s11606-019-05490-w.
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  - Tan, D. J. A., B. A. Polascik, H. M. Kee, A. C. Hui Lee, R. Sultana, M. Kwan, K. Raghunathan, C. M. Belden, and B. L. Sng. “The Effect of Perioperative Music Listening on Patient Satisfaction, Anxiety, and Depression: A Quasiexperimental Study.” Anesthesiology Research and Practice 2020 (January 1, 2020). https://doi.org/10.1155/2020/3761398.
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  - Ohnuma, Tetsu, Vijay Krishnamoorthy, Alan R. Ellis, Rosalie Yan, Neil D. Ray, Hung-Lun Hsia, Srinivas Pyati, et al. “Association 'Between Gabapentinoids on the Day of Colorectal Surgery and Adverse Postoperative Respiratory Outcomes.” Ann Surg 270, no. 6 (December 2019): e65–67. https://doi.org/10.1097/SLA.0000000000003317.
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  - Raghunathan, Karthik, Neil Ray, William Bryan, Marc Pepin, Robert Overman, Atilio Barbeito, and Vijay Krishnamoorthy. “Trends in Chronic Opioid Use Around Inpatient Surgery Within the Veterans Health Administration.” Jama Surg 154, no. 12 (December 1, 2019): 1158–59. https://doi.org/10.1001/jamasurg.2019.2895.
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  - Chen, Qi, Hung-Lun Hsia, Robert Overman, William Bryan, Marc Pepin, Edward R. Mariano, Seshadri C. Mudumbai, et al. “Impact of an Opioid Safety Initiative on Patients Undergoing Total Knee Arthroplasty: A Time Series Analysis.” Anesthesiology 131, no. 2 (August 2019): 369–80. https://doi.org/10.1097/ALN.0000000000002771.
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  - Karamchandani, Kunal, Srinivas Pyati, William Bryan, Marc Pepin, Erik B. Lehman, Vijay Krishnamoorthy, and Karthik Raghunathan. “New Persistent Opioid Use After Postoperative Intensive Care in US Veterans.” Jama Surgery 154, no. 8 (August 2019): 778–80. https://doi.org/10.1001/jamasurg.2019.0899.
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  - Krishnamoorthy, Vijay, Catherine L. Hough, Monica S. Vavilala, Jordan Komisarow, Nophanan Chaikittisilpa, Abhijit V. Lele, Karthik Raghunathan, and Claire J. Creutzfeldt. “Tracheostomy After Severe Acute Brain Injury: Trends and Variability in the USA.” Neurocrit Care 30, no. 3 (June 2019): 546–54. https://doi.org/10.1007/s12028-019-00697-5.
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  - Kuo, Alfred C., Karthik Raghunathan, Alain M. Lartigue, William E. Bryan, Marc J. Pepin, Steven Takemoto, and Arthur W. Wallace. “Freedom From Opioids After Total Knee Arthroplasty.” J Arthroplasty 34, no. 5 (May 2019): 893–97. https://doi.org/10.1016/j.arth.2019.01.054.
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  - Kingeter, Adam J., Karthik Raghunathan, Sibyl H. Munson, David K. Hayashida, Xuan Zhang, Sloka Iyengar, Martin Bunke, and Andrew D. Shaw. “Association between albumin administration and survival in cardiac surgery: a retrospective cohort study.” Can J Anaesth 65, no. 11 (November 2018): 1218–27. https://doi.org/10.1007/s12630-018-1181-4.
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  - Nathanson, Brian H., and Karthik Raghunathan. “Response.” Am J Crit Care 27, no. 6 (November 2018): 443. https://doi.org/10.4037/ajcc2018759.
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  - Hsia, Hung-Lun, Steven Takemoto, Thomas van de Ven, Srinivas Pyati, Thomas Buchheit, Neil Ray, Samuel Wellman, Alfred Kuo, Arthur Wallace, and Karthik Raghunathan. “Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty.” Reg Anesth Pain Med 43, no. 7 (October 2018): 705–11. https://doi.org/10.1097/AAP.0000000000000831.
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  - Carter, Jessica E., Srinivas Pyati, Frances A. Kanach, Ann Miller W. Maxwell, Charles M. Belden, Christopher M. Shea, Thomas Van de Ven, Jillian Thompson, Helen Hoenig, and Karthik Raghunathan. “Implementation of Perioperative Music Using the Consolidated Framework for Implementation Research.” Anesth Analg 127, no. 3 (September 2018): 623–31. https://doi.org/10.1213/ANE.0000000000003565.
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  - Krishnamoorthy, Vijay, and Karthik Raghunathan. “Anesthesia Care Handovers and Risk of Adverse Outcomes.” Jama 319, no. 21 (June 5, 2018): 2235–36. https://doi.org/10.1001/jama.2018.4442.
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  - Raghunathan, Karthik, Mandeep Singh, Brian H. Nathanson, Elliott Bennett-Guerrero, and Peter K. Lindenauer. “Early Blood Transfusions in Sepsis: Unchanged Survival and Increased Costs.” Am J Crit Care 27, no. 3 (May 2018): 205–11. https://doi.org/10.4037/ajcc2018303.
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  - Scott, Michael J., Matthew D. McEvoy, Debra B. Gordon, Stuart A. Grant, Julie K. M. Thacker, Christopher L. Wu, Tong J. Gan, et al. “Correction to: American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) Joint Consensus Statement on Optimal Analgesia within an Enhanced Recovery Pathway for Colorectal Surgery: Part 2-From PACU to the Transition Home.” Perioper Med (Lond) 7 (2018): 4. https://doi.org/10.1186/s13741-018-0086-7.
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  - Thiele, Robert H., Karthik Raghunathan, C. S. Brudney, Dileep N. Lobo, Daniel Martin, Anthony Senagore, Maxime Cannesson, et al. “Correction to: American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery.” Perioper Med (Lond) 7 (2018): 5. https://doi.org/10.1186/s13741-018-0085-8.
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  - Holubar, Stefan D., Traci Hedrick, Ruchir Gupta, John Kellum, Mark Hamilton, Tong J. Gan, Monty G. Mythen, Andrew D. Shaw, Timothy E. Miller, and Timothy E. Perioperative Quality Initiative (POQI) I Workgroup. “American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on prevention of postoperative infection within an enhanced recovery pathway for elective colorectal surgery.” Perioper Med (Lond) 6 (2017): 4. https://doi.org/10.1186/s13741-017-0059-2.
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  - McEvoy, Matthew D., Michael J. Scott, Debra B. Gordon, Stuart A. Grant, Julie K. M. Thacker, Christopher L. Wu, Tong J. Gan, et al. “American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on optimal analgesia within an enhanced recovery pathway for colorectal surgery: part 1-from the preoperative period to PACU.” Perioper Med (Lond) 6 (2017): 8. https://doi.org/10.1186/s13741-017-0064-5.
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  - Moonesinghe, S Ramani, Michael P. W. Grocott, Elliott Bennett-Guerrero, Roberto Bergamaschi, Vijaya Gottumukkala, Thomas J. Hopkins, Stuart McCluskey, et al. “American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on measurement to maintain and improve quality of enhanced recovery pathways for elective colorectal surgery.” Perioper Med (Lond) 6 (2017): 6. https://doi.org/10.1186/s13741-017-0062-7.
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  - Scott, Michael J., Matthew D. McEvoy, Debra B. Gordon, Stuart A. Grant, Julie K. M. Thacker, Christopher L. Wu, Tong J. Gan, et al. “American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) Joint Consensus Statement on Optimal Analgesia within an Enhanced Recovery Pathway for Colorectal Surgery: Part 2-From PACU to the Transition Home.” Perioper Med (Lond) 6 (2017): 7. https://doi.org/10.1186/s13741-017-0063-6.
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  - Stefan, Mihaela S., Nicholas S. Hill, Karthik Raghunathan, Xiaoxia Liu, Penelope S. Pekow, Stavros G. Memtsoudis, Satya Krishna Ramachandran, and Peter K. Lindenauer. “Outcomes Associated with Early Postoperative Noninvasive Ventilation in Bariatric Surgical Patients with Sleep Apnea.” J Clin Sleep Med 12, no. 11 (November 15, 2016): 1507–16. https://doi.org/10.5664/jcsm.6278.
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  - Raghunathan, Karthik, J Bradley Layton, Tetsu Ohnuma, and Andrew D. Shaw. “Observational Research Using Propensity Scores.” Adv Chronic Kidney Dis 23, no. 6 (November 2016): 367–72. https://doi.org/10.1053/j.ackd.2016.11.010.
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  - Guinn, Nicole R., Nathan H. Waldron, Mary L. Cooter, Corinne L. Goldberg, Miklos D. Kertai, Karthik Raghunathan, Nicholas Bandarenko, Maureane Hoffman, and Elliott Bennett-Guerrero. “No association between donor age and recipient outcomes: transfusion of plasma in patients undergoing coronary artery bypass grafting surgery.” Transfusion 56, no. 7 (July 2016): 1723–29. https://doi.org/10.1111/trf.13616.
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  - Raghunathan, K., and X. S. Wang. “In support of 'usual' perioperative care.” Br J Anaesth 117, no. 1 (July 2016): 7–12. https://doi.org/10.1093/bja/aew067.
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  - Barbeito, Atilio, Karthik Raghunathan, and Ronald Albrecht. “Primus Inter Pares.” Anesth Analg 122, no. 5 (May 2016): 1719–20. https://doi.org/10.1213/ANE.0000000000000883.
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  - Barbeito, Atilio, Roberto A. Guerri-Guttenberg, Karthik Raghunathan, and Sunil Rao. “High-Velocity Jet in the Right Atrium: What Is the Diagnosis?” Anesth Analg 122, no. 3 (March 2016): 647–50. https://doi.org/10.1213/ANE.0000000000001076.
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  - Conlin, Frederick, Neil Roy Connelly, Karthik Raghunathan, Jennifer Friderici, and Adam Schwabauer. “Focused Transthoracic Cardiac Ultrasound: A Survey of Training Practices.” J Cardiothorac Vasc Anesth 30, no. 1 (January 2016): 102–6. https://doi.org/10.1053/j.jvca.2015.05.111.
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  - Heath, Michele, Atilio Barbeito, Ian Welsby, Cory Maxwell, Alexander Iribarne, and Karthik Raghunathan. “Using Zero-Balance Ultrafiltration With Dialysate as a Replacement Solution for Toxin and Eptifibatide Removal on a Dialysis-Dependent Patient During Cardiopulmonary Bypass.” J Cardiothorac Vasc Anesth 30, no. 1 (January 2016): 162–68. https://doi.org/10.1053/j.jvca.2014.12.007.
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  - Thiele, Robert H., Karthik Raghunathan, C. S. Brudney, Dileep N. Lobo, Daniel Martin, Anthony Senagore, Maxime Cannesson, et al. “American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery.” Perioper Med (Lond) 5 (2016): 24. https://doi.org/10.1186/s13741-016-0049-9.
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  - McGee, William T., Karthik Raghunathan, and Adam C. Adler. “Utility of Functional Hemodynamics and Echocardiography to Aid Diagnosis and Management of Shock.” Shock 44, no. 6 (December 2015): 535–41. https://doi.org/10.1097/SHK.0000000000000472.
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  - Raghunathan, Karthik, Anthony Bonavia, Brian H. Nathanson, Christopher A. Beadles, Andrew D. Shaw, M Alan Brookhart, Timothy E. Miller, and Peter K. Lindenauer. “Association between Initial Fluid Choice and Subsequent In-hospital Mortality during the Resuscitation of Adults with Septic Shock.” Anesthesiology 123, no. 6 (December 2015): 1385–93. https://doi.org/10.1097/ALN.0000000000000861.
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  - Raghunathan, Karthik, Patrick Nailer, and Ryan Konoske. “What is the ideal crystalloid?” Curr Opin Crit Care 21, no. 4 (August 2015): 309–14. https://doi.org/10.1097/MCC.0000000000000218.
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  - Raghunathan, Karthik, Timothy E. Miller, and Ali M. Rashid. “Confounders versus Mediators: An Important Distinction.” Anesthesiology 123, no. 1 (July 2015): 234. https://doi.org/10.1097/ALN.0000000000000702.
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  - Raghunathan, Karthik, and Ryan Konoske. “The authors reply.” Crit Care Med 43, no. 5 (May 2015): e156. https://doi.org/10.1097/CCM.0000000000000951.
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  - Raghunathan, Karthik, Mandeep Singh, and Dileep N. Lobo. “Fluid management in abdominal surgery: what, when, and when not to administer.” Anesthesiol Clin 33, no. 1 (March 2015): 51–64. https://doi.org/10.1016/j.anclin.2014.11.004.
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  - Krajewski, M. L., K. Raghunathan, S. M. Paluszkiewicz, C. R. Schermer, and A. D. Shaw. “Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation.” Br J Surg 102, no. 1 (January 2015): 24–36. https://doi.org/10.1002/bjs.9651.
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  - Raghunathan, K., P. T. Murray, W. S. Beattie, D. N. Lobo, J. Myburgh, R. Sladen, J. A. Kellum, M. G. Mythen, A. D. Shaw, and A. D. ADQI XII Investigators Group. “Choice of fluid in acute illness: what should be given? An international consensus.” Br J Anaesth 114, no. 1 (January 2015): 175. https://doi.org/10.1093/bja/aeu406.
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  - Raghunathan, Karthik, Christopher Beadles, Brian H. Nathanson, and Peter K. Lindenauer. “The authors reply.” Crit Care Med 43, no. 1 (January 2015): e27–28. https://doi.org/10.1097/CCM.0000000000000697.
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  - Beadles, Chris, Karthik Raghunathan, Brian H. Nathanson, and Peter K. Lindenauer. “The authors reply.” Crit Care Med 42, no. 12 (December 2014): e796–97. https://doi.org/10.1097/CCM.0000000000000651.
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  - Shaw, Andrew D., Karthik Raghunathan, Fred W. Peyerl, Sibyl H. Munson, Scott M. Paluszkiewicz, and Carol R. Schermer. “Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS.” Intensive Care Med 40, no. 12 (December 2014): 1897–1905. https://doi.org/10.1007/s00134-014-3505-3.
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  - Raghunathan, K., P. T. Murray, W. S. Beattie, D. N. Lobo, J. Myburgh, R. Sladen, J. A. Kellum, M. G. Mythen, A. D. Shaw, and A. D. ADQI XII Investigators Group. “Choice of fluid in acute illness: what should be given? An international consensus.” Br J Anaesth 113, no. 5 (November 2014): 772–83. https://doi.org/10.1093/bja/aeu301.
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  - Heath, Michele, Karthik Raghunathan, Ian Welsby, and Cory Maxwell. “Using Zero Balance Ultrafiltration with Dialysate as a Replacement Fluid for Hyperkalemia during Cardiopulmonary Bypass.” J Extra Corpor Technol 46, no. 3 (September 2014): 262–66.
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  - Miller, Timothy E., Karthik Raghunathan, and Tong J. Gan. “State-of-the-art fluid management in the operating room.” Best Pract Res Clin Anaesthesiol 28, no. 3 (September 2014): 261–73. https://doi.org/10.1016/j.bpa.2014.07.003.
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  - Raghunathan, Karthik, Timothy E. Miller, and Andrew D. Shaw. “Intravenous starches: is suspension the best solution?” Anesth Analg 119, no. 3 (September 2014): 731–36. https://doi.org/10.1213/ANE.0000000000000186.
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  - Raghunathan, Karthik, Andrew Shaw, Brian Nathanson, Til Stürmer, Alan Brookhart, Mihaela S. Stefan, Soko Setoguchi, Chris Beadles, and Peter K. Lindenauer. “Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis*.” Crit Care Med 42, no. 7 (July 2014): 1585–91. https://doi.org/10.1097/CCM.0000000000000305.
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  - Shaw, A. D., K. Raghunathan, F. W. Peyerl, S. H. Munson, S. M. Paluszkiewicz, and C. R. Schermer. “Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS.” Intensive Care Medicine 40, no. 12 (January 1, 2014): 1897–1905. https://doi.org/10.1007/s00134-014-3505-3.
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  - Steingrub, Jay S., Tara Lagu, Michael B. Rothberg, Brian H. Nathanson, Karthik Raghunathan, and Peter K. Lindenauer. “Treatment with neuromuscular blocking agents and the risk of in-hospital mortality among mechanically ventilated patients with severe sepsis.” Crit Care Med 42, no. 1 (January 2014): 90–96. https://doi.org/10.1097/CCM.0b013e31829eb7c9.
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  - Adler, Adam C., Brian H. Nathanson, Karthik Raghunathan, and William T. McGee. “Effects of body surface area-indexed calculations in the morbidly obese: a mathematical analysis.” J Cardiothorac Vasc Anesth 27, no. 6 (December 2013): 1140–44. https://doi.org/10.1053/j.jvca.2013.06.011.
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  - Karakala, Nithin, Karthik Raghunathan, and Andrew D. Shaw. “Intravenous fluids in sepsis: what to use and what to avoid.” Curr Opin Crit Care 19, no. 6 (December 2013): 537–43. https://doi.org/10.1097/MCC.0000000000000028.
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  - McGee, William T., and Karthik Raghunathan. “Physiologic goal-directed therapy in the perioperative period: the volume prescription for high-risk patients.” J Cardiothorac Vasc Anesth 27, no. 6 (December 2013): 1079–86. https://doi.org/10.1053/j.jvca.2013.04.019.
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  - Raghunathan, Karthik, Atilio Barbeito, and David MacLeod. “Goal-directed advanced cardiac life support: coronary perfusion pressure as a target during resuscitation.” Crit Care Med 41, no. 12 (December 2013): 2817–18. https://doi.org/10.1097/CCM.0b013e31829cb381.
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  - Marik, Paul E., Karthik Raghunathan, and Joshua Bloomstone. “Rebuttal from Dr Marik et al.” Chest 144, no. 2 (August 2013): 379–80. https://doi.org/10.1378/chest.13-0849.
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  - Marik, Paul E., Karthik Raghunathan, and Joshua Bloomstone. “Counterpoint: Are the best patient outcomes achieved when ICU bundles are rigorously adhered to? No.” Chest 144, no. 2 (August 2013): 374–78. https://doi.org/10.1378/chest.13-0848.
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  - Raghunathan, Karthik, Andrew D. Shaw, and Sean M. Bagshaw. “Fluids are drugs: type, dose and toxicity.” Curr Opin Crit Care 19, no. 4 (August 2013): 290–98. https://doi.org/10.1097/MCC.0b013e3283632d77.
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  - Adler, Adam C., Neil Roy Connelly, Abistanand Ankam, and Karthik Raghunathan. “Technical communication: inhaled anesthetic agent-vaporizer mismatch: management in settings with limited resources: don't try this at home.” Anesth Analg 116, no. 6 (June 2013): 1272–75. https://doi.org/10.1213/ANE.0b013e31828d6aeb.
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  - Shaw, Andrew, and Karthik Raghunathan. “Fluid management in cardiac surgery: colloid or crystalloid?” Anesthesiol Clin 31, no. 2 (June 2013): 269–80. https://doi.org/10.1016/j.anclin.2012.12.007.
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  - Raghunathan, Karthik, Neil Roy Connelly, Jennifer Friderici, Deborah Naglieri-Prescod, Ryan Joyce, Praveen Prasanna, and Nandakumar Ponnusamy. “Unwarranted variability in antibiotic prophylaxis for cesarean section delivery: a national survey of anesthesiologists.” Anesth Analg 116, no. 3 (March 2013): 644–48. https://doi.org/10.1213/ANE.0b013e318276cf72.
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  - Raghunathan, Karthik, and Andrew Shaw. “Hydroxyethyl starch or saline in intensive care.” N Engl J Med 368, no. 8 (February 21, 2013): 774–75. https://doi.org/10.1056/NEJMc1215977.
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  - Raghunathan, Karthik, and Srinivas Pyati. “Persistent postsurgical pain--need for better methods.” Reg Anesth Pain Med 38, no. 1 (January 2013): 73–74. https://doi.org/10.1097/AAP.0b013e318276651c.
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  - Adler, Adam C., Brian H. Nathanson, Karthik Raghunathan, and William T. McGee. “Misleading indexed hemodynamic parameters: the clinical importance of discordant BMI and BSA at extremes of weight.” Crit Care 16, no. 6 (December 28, 2012): 471. https://doi.org/10.1186/cc11876.
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  - Adler, Adam C., Brian H. Nathanson, Karthik Raghunathan, and William T. McGee. “Indexed hemodynamic measurements may be inappropriate at body surface area extremes.” Crit Care 16, no. 5 (September 4, 2012): 149. https://doi.org/10.1186/cc11452.
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  - Raghunathan, Karthik, William T. McGee, and Thomas Higgins. “Importance of intravenous fluid dose and composition in surgical ICU patients.” Curr Opin Crit Care 18, no. 4 (August 2012): 350–57. https://doi.org/10.1097/MCC.0b013e328355598c.
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  - Raghunathan, Karthik. “Checklists, safety, my culture and me.” Bmj Qual Saf 21, no. 7 (July 2012): 617–20. https://doi.org/10.1136/bmjqs-2011-000608.
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  - Raghunathan, Karthik, Joshua A. Bloomstone, and William T. McGee. “Cardiac output measured with both esophageal Doppler device and Vigileo-FloTrac device.” Anesth Analg 114, no. 5 (May 2012): 1141–42. https://doi.org/10.1213/ANE.0b013e3182501c5e.
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  - Bloomstone, Joshua A., Karthik Raghunathan, and William T. McGee. “Why the gray zone may shift within the fog.” Anesthesiology 116, no. 3 (March 2012): 739–40. https://doi.org/10.1097/ALN.0b013e3182472339.
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  - Connelly, Neil Roy, Jorge P. Freiman, Tanya Lucas, Robert K. Parker, Karthik Raghunathan, Charles Gibson, Brennan Katz, and Chad Iwashita. “Addition of epinephrine to epidural bupivacaine infusions following initiation of labor analgesia with epidural fentanyl.” J Clin Anesth 23, no. 4 (June 2011): 265–69. https://doi.org/10.1016/j.jclinane.2010.09.005.
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  - Raghunathan, Karthik, Hani Al-Najjar, and Adam Snavely. “Control charts and control limits.” Anesth Analg 112, no. 3 (March 2011): 736–37. https://doi.org/10.1213/ANE.0b013e31820685f0.
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  - Malik, Ashish, Eric R. Jenkins, Karthik Raghunathan, and Neil Roy Connelly. “General anesthesia is not defined by a BIS level.” J Clin Anesth 23, no. 1 (February 2011): 79–80. https://doi.org/10.1016/j.jclinane.2010.09.002.
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  - Raghunathan, Karthik, Neil Roy Connelly, and Gary J. Kanter. “ε-Aminocaproic acid and clinical value in cardiac anesthesia.” J Cardiothorac Vasc Anesth 25, no. 1 (February 2011): 16–19. https://doi.org/10.1053/j.jvca.2010.07.024.
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  - Schwartz, Donald A., Karthik Raghunathan, and Neil Roy Connelly. “Reply to 'Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate'.” Paediatr Anaesth 20, no. 12 (December 2010): 1136–37. https://doi.org/10.1111/j.1460-9592.2010.03455.x.
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  - Connelly, Neil Roy, and Karthik Raghunathan. “The value of the P-value.” J Clin Anesth 22, no. 2 (March 2010): 154–55. https://doi.org/10.1016/j.jclinane.2009.07.005.
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  - Raghunathan, Karthik, Neil Roy Connelly, Larry D. Robbins, Rose Ganim, Gary Hochheiser, and Rebecca DiCampli. “Inhaled epoprostenol during one-lung ventilation.” Ann Thorac Surg 89, no. 3 (March 2010): 981–83. https://doi.org/10.1016/j.athoracsur.2009.07.059.
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  - Raghunathan, Karthik, Donald A. Schwartz, and Neil Roy Connelly. “The need for perspective.” Anesthesiology 111, no. 6 (December 2009): 1386. https://doi.org/10.1097/ALN.0b013e3181c0d930.
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  - Raghunathan, Karthik, Karin L. Zuegge, Neil Roy Connelly, and Tanya Lucas. “Maternal hemodynamic monitoring and the Vigileo monitor.” Anesthesiology 111, no. 1 (July 2009): 211–12. https://doi.org/10.1097/ALN.0b013e3181a86320.
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  - Reuben, S. S., A. Buvenandran, J. S. Kroin, and K. Raghunathan. “Erratum: Analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery (Anesthesiology (2006) 105 (A1194)).” Anesthesiology 110, no. 3 (March 1, 2009): 689. https://doi.org/10.1097/01.anes.0000346772.12368.bc.
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  - Schwartz, Donald, and Karthik Raghunathan. “Difficult venous access.” Paediatr Anaesth 19, no. 1 (January 2009): 60. https://doi.org/10.1111/j.1460-9592.2008.02804.x.
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  - Schwartz, Donald, and Karthik Raghunathan. “Anesthesia and mitochondrial disorders.” Paediatr Anaesth 19, no. 1 (January 2009): 60–61. https://doi.org/10.1111/j.1460-9592.2008.02805.x.
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  - Raghunathan, K., D. Schwartz, and N. R. Connelly. “Determining the accuracy of caudal needle placement in children: A comparison of the swoosh test and ultrasonography (Pediatric Anesthesia (2008) 18, (606-612)).” Paediatric Anaesthesia 18, no. 11 (November 1, 2008): 1147. https://doi.org/10.1111/j.1460-9592.2008.02817.x.
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  - Raghunathan, Karthik, Donald Schwartz, and Neil Roy Connelly. “Determining the accuracy of caudal needle placement in children: a comparison of the swoosh test and ultrasonography.” Paediatr Anaesth 18, no. 7 (July 2008): 606–12. https://doi.org/10.1111/j.1460-9592.2008.02529.x.
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  - Schwartz, D., and K. Raghunathan. “Reply.” Paediatric Anaesthesia 18, no. 4 (April 1, 2008): 334–35. https://doi.org/10.1111/j.1460-9592.2008.02439.x.
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  - Schwartz, Donald, Karthik Raghunathan, Steven Dunn, and Neil Roy Connelly. “Ultrasonography and pediatric caudals.” Anesth Analg 106, no. 1 (January 2008): 97–99. https://doi.org/10.1213/01.ane.0000287681.41646.b8.
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  - Liang, Bryan A. “To tell the truth: potential liability for concealing physician impairment.” J Clin Anesth 19, no. 8 (December 2007): 638–39. https://doi.org/10.1016/j.jclinane.2007.10.001.
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  - Schwartz, Donald, Karthik Raghunathan, and David Han. “The 'Doppler-swoosh' test: a further modification to the 'swoosh' test.” Paediatr Anaesth 17, no. 6 (June 2007): 600–601. https://doi.org/10.1111/j.1460-9592.2006.02163.x.
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  - Connelly, N. R., and K. Raghunathan. “Commentary.” Journal of Clinical Anesthesia 19, no. 8 (January 1, 2007): 639–41. https://doi.org/10.1016/j.jclinane.2007.10.002.
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  - Reuben, Scott S., Asokumar Buvanendran, Jeffrey S. Kroin, and Karthik Raghunathan. “The analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery.” Anesth Analg 103, no. 5 (November 2006): 1271–77. https://doi.org/10.1213/01.ane.0000237279.08847.2d.
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  - Reuben, S. S., K. Raghunathan, and S. Roissing. “Evaluating the analgesic effect of the perioperative perineural infiltration of bupivacaine and clonidine at the site of injury following lower extremity amputation.” Acute Pain 8, no. 3 (October 1, 2006): 117–23. https://doi.org/10.1016/j.acpain.2006.07.001.
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  - Reuben, Scott S., Evan F. Ekman, Karthik Raghunathan, Robert B. Steinberg, Jordan L. Blinder, and John Adesioye. “The effect of cyclooxygenase-2 inhibition on acute and chronic donor-site pain after spinal-fusion surgery.” Reg Anesth Pain Med 31, no. 1 (January 2006): 6–13. https://doi.org/10.1016/j.rapm.2005.10.014.
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