Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Boston University 2010
• 

  Duke Appointment History

  • Assistant Professor in Pediatrics, Pediatrics, Children's Health Discovery Institute, Pediatrics 2019 - 2021
  • Visiting Assistant Professor in Environmental Sciences and Policy, Environmental Sciences and Policy, Nicholas School of the Environment 2015 - 2017
• Research
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  Selected Grants

  • Flame retardant effects on thyroid hormone regulation at the fetal-maternal interface of the placenta awarded by National Institutes of Health 2020 - 2025
  • Children Exposure to SVOC Mixtures Indoors and Associations with Obesity awarded by National Institutes of Health 2017 - 2020
  • Immune function in children exposed to organophosphate flame retardants awarded by Gerber Foundation 2016 - 2019
  • Prenatal Exposure to Organophosphates and Associations with Child Growth awarded by University of North Carolina - Chapel Hill 2014 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Gardner, C. M., K. Hoffman, H. M. Stapleton, and C. K. Gunsch. “Exposures to Semivolatile Organic Compounds in Indoor Environments and Associations with the Gut Microbiomes of Children.” Environmental Science and Technology Letters 8, no. 1 (January 12, 2021): 73–79. https://doi.org/10.1021/acs.estlett.0c00776.
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    • Hammel, S. C., H. M. Stapleton, B. Eichner, and K. Hoffman. “Reconsidering an Appropriate Urinary Biomarker for Flame Retardant Tris(1-chloro-2-propyl) Phosphate (TCIPP) Exposure in Children.” Environmental Science and Technology Letters 8, no. 1 (January 12, 2021): 80–85. https://doi.org/10.1021/acs.estlett.0c00794.
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    • Kassotis, Christopher D., Nicholas J. Herkert, Stephanie C. Hammel, Kate Hoffman, Qianyi Xia, Seth W. Kullman, Julie Ann Sosa, and Heather M. Stapleton. “Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study.” Environmental Science & Technology 54, no. 23 (December 2020): 15296–312. https://doi.org/10.1021/acs.est.0c05972.
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    • Hall, Samantha M., Sharyle Patton, Myrto Petreas, Sharon Zhang, Allison L. Phillips, Kate Hoffman, and Heather M. Stapleton. “Per- and Polyfluoroalkyl Substances in Dust Collected from Residential Homes and Fire Stations in North America.” Environmental Science & Technology 54, no. 22 (November 4, 2020): 14558–67. https://doi.org/10.1021/acs.est.0c04869.
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    • Hammel, Stephanie C., Kate Hoffman, Allison L. Phillips, Jessica L. Levasseur, Amelia M. Lorenzo, Thomas F. Webster, and Heather M. Stapleton. “Comparing the Use of Silicone Wristbands, Hand Wipes, And Dust to Evaluate Children's Exposure to Flame Retardants and Plasticizers.” Environmental Science & Technology 54, no. 7 (April 2020): 4484–94. https://doi.org/10.1021/acs.est.9b07909.
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    • Herkert, N. J., J. Merrill, C. Peters, D. Bollinger, S. Zhang, K. Hoffman, P. L. Ferguson, D. R. U. Knappe, and H. M. Stapleton. “Assessing the effectiveness of point-of-use residential drinking water filters for perfluoroalkyl substances (pfass).” Environmental Science and Technology Letters 7, no. 3 (March 10, 2020): 178–84. https://doi.org/10.1021/acs.estlett.0c00004.
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    • Doherty, Brett T., Stephanie C. Hammel, Julie L. Daniels, Heather M. Stapleton, and Kate Hoffman. “Organophosphate Esters: Are These Flame Retardants and Plasticizers Affecting Children's Health?” Current Environmental Health Reports 6, no. 4 (December 2019): 201–13. https://doi.org/10.1007/s40572-019-00258-0.
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    • Hammel, Stephanie C., Jessica L. Levasseur, Kate Hoffman, Allison L. Phillips, Amelia M. Lorenzo, Antonia M. Calafat, Thomas F. Webster, and Heather M. Stapleton. “Children's exposure to phthalates and non-phthalate plasticizers in the home: The TESIE study.” Environment International 132 (November 2019): 105061. https://doi.org/10.1016/j.envint.2019.105061.
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    • Doherty, Brett T., Kate Hoffman, Alexander P. Keil, Stephanie M. Engel, Heather M. Stapleton, Barbara D. Goldman, Andrew F. Olshan, and Julie L. Daniels. “Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study.” Environmental Research 169 (February 2019): 33–40. https://doi.org/10.1016/j.envres.2018.10.033.
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    • Lantos, Paul M., Gabriela Maradiaga-Panayotti, Xavier Barber, Eileen Raynor, Debara Tucci, Kate Hoffman, Sallie R. Permar, et al. “Geographic and Racial Disparities in Infant Hearing Loss.” Otolaryngol Head Neck Surg, October 9, 2018, 194599818803305. https://doi.org/10.1177/0194599818803305.
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    • Hammel, Stephanie C., Allison L. Phillips, Kate Hoffman, and Heather M. Stapleton. “Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants.” Environmental Science & Technology 52, no. 20 (October 2, 2018): 11875–85. https://doi.org/10.1021/acs.est.8b03755.
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    • Hoffman, Kate, Stephanie C. Hammel, Allison L. Phillips, Amelia M. Lorenzo, Albert Chen, Antonia M. Calafat, Xiaoyun Ye, Thomas F. Webster, and Heather M. Stapleton. “Biomarkers of exposure to SVOCs in children and their demographic associations: The TESIE Study.” Environment International 119 (October 2018): 26–36. https://doi.org/10.1016/j.envint.2018.06.007.
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    • Kollitz, Erin M., Christopher D. Kassotis, Kate Hoffman, P Lee Ferguson, Julie Ann Sosa, and Heather M. Stapleton. “Chemical Mixtures Isolated from House Dust Disrupt Thyroid Receptor β Signaling.” Environmental Science & Technology 52, no. 20 (October 2018): 11857–64. https://doi.org/10.1021/acs.est.8b03283.
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    • Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, Amy Kind, and Geeta Swamy. “Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy.” J Racial Ethn Health Disparities 5, no. 4 (August 2018): 782–86. https://doi.org/10.1007/s40615-017-0423-4.
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    • Hoffman, Kate, Heather M. Stapleton, Amelia Lorenzo, Craig M. Butt, Linda Adair, Amy H. Herring, and Julie L. Daniels. “Prenatal exposure to organophosphates and associations with birthweight and gestational length.” Environment International 116 (July 2018): 248–54. https://doi.org/10.1016/j.envint.2018.04.016.
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    • Phillips, Allison L., Stephanie C. Hammel, Kate Hoffman, Amelia M. Lorenzo, Albert Chen, Thomas F. Webster, and Heather M. Stapleton. “Children's residential exposure to organophosphate ester flame retardants and plasticizers: Investigating exposure pathways in the TESIE study.” Environment International 116 (July 2018): 176–85. https://doi.org/10.1016/j.envint.2018.04.013.
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    • Hammel, Stephanie C., Kate Hoffman, Amelia M. Lorenzo, Albert Chen, Allison L. Phillips, Craig M. Butt, Julie Ann Sosa, Thomas F. Webster, and Heather M. Stapleton. “Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels.” Environment International 107 (October 2017): 181–89. https://doi.org/10.1016/j.envint.2017.07.015.
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    • Hoffman, Kate, Marc G. Weisskopf, Andrea L. Roberts, Raanan Raz, Jaime E. Hart, Kristen Lyall, Elin M. Hoffman, Francine Laden, and Verónica M. Vieira. “Geographic Patterns of Autism Spectrum Disorder Among Children of Participants in Nurses' Health Study II.” American Journal of Epidemiology 186, no. 7 (October 2017): 834–42. https://doi.org/10.1093/aje/kwx158.
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    • Siebenaler, Rebecca, Rochelle Cameron, Craig M. Butt, Kate Hoffman, Christopher P. Higgins, and Heather M. Stapleton. “Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes.” Chemosphere 184 (October 2017): 687–93. https://doi.org/10.1016/j.chemosphere.2017.06.023.
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    • Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, and Geeta K. Swamy. “Geographic Disparities in Cytomegalovirus Infection During Pregnancy.” J Pediatric Infect Dis Soc 6, no. 3 (September 1, 2017): e55–61. https://doi.org/10.1093/jpids/piw088.
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    • Hoffman, K., L. Gearhart-Serna, M. Lorber, T. F. Webster, and H. M. Stapleton. “Estimated Tris(1,3-dichloro-2-propyl) Phosphate Exposure Levels for U.S. Infants Suggest Potential Health Risks.” Environmental Science and Technology Letters 4, no. 8 (August 8, 2017): 334–38. https://doi.org/10.1021/acs.estlett.7b00196.
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    • Kassotis, Christopher D., Kate Hoffman, and Heather M. Stapleton. “Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells.” Environmental Science & Technology 51, no. 15 (August 2017): 8735–45. https://doi.org/10.1021/acs.est.7b01788.
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    • Jensen, Elizabeth T., Kate Hoffman, Cary C. Cotton, Daniel J. Green, Amanda Tapia, Kevin Turner, Robert M. Genta, and Evan S. Dellon. “Assessment of Proximity to Swine Farming Operations as a Risk Factor for Eosinophilic Esophagitis.” Gastroenterology 152, no. 5 (April 2017): S861–S861. https://doi.org/10.1016/s0016-5085(17)32961-x.
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    • Hoffman, Kate, Craig M. Butt, Thomas F. Webster, Emma V. Preston, Stephanie C. Hammel, Colleen Makey, Amelia M. Lorenzo, et al. “Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States.” Environ Sci Technol Lett 4, no. 3 (March 14, 2017): 112–18. https://doi.org/10.1021/acs.estlett.6b00475.
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    • Hoffman, Kate, Thomas F. Webster, Andreas Sjödin, and Heather M. Stapleton. “Toddler's behavior and its impacts on exposure to polybrominated diphenyl ethers.” Journal of Exposure Science & Environmental Epidemiology 27, no. 2 (March 2017): 193–97. https://doi.org/10.1038/jes.2016.11.
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    • Hoffman, Kate, Amelia Lorenzo, Craig M. Butt, Linda Adair, Amy H. Herring, Heather M. Stapleton, and Julie L. Daniels. “Predictors of urinary flame retardant concentration among pregnant women.” Environment International 98 (January 2017): 96–101. https://doi.org/10.1016/j.envint.2016.10.007.
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    • Hoffman, Kate, Julie A. Sosa, and Heather M. Stapleton. “Do flame retardant chemicals increase the risk for thyroid dysregulation and cancer?” Current Opinion in Oncology 29, no. 1 (January 2017): 7–13. https://doi.org/10.1097/cco.0000000000000335.
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    • Leonetti, Christopher, Craig M. Butt, Kate Hoffman, Stephanie C. Hammel, Marie Lynn Miranda, and Heather M. Stapleton. “Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints.” Environmental Health : A Global Access Science Source 15, no. 1 (November 25, 2016): 113. https://doi.org/10.1186/s12940-016-0199-8.
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    • Hoffman, Kate, Michelle Mendez, Anna Maria Siega-Riz, Amy H. Herring, Andreas Sjödin, and Julie L. Daniels. “Lactational Exposure to Polybrominated Diphenyl Ethers and Its Relation to Early Childhood Anthropometric Measurements.” Environmental Health Perspectives 124, no. 10 (October 2016): 1656–61. https://doi.org/10.1289/ehp201.
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    • Butt, Craig M., Kate Hoffman, Albert Chen, Amelia Lorenzo, Johanna Congleton, and Heather M. Stapleton. “Regional comparison of organophosphate flame retardant (PFR) urinary metabolites and tetrabromobenzoic acid (TBBA) in mother-toddler pairs from California and New Jersey.” Environment International 94 (September 2016): 627–34. https://doi.org/10.1016/j.envint.2016.06.029.
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    • Hammel, Stephanie C., Kate Hoffman, Thomas F. Webster, Kim A. Anderson, and Heather M. Stapleton. “Correction to Measuring Personal Exposure to Organophosphate Flame Retardants using Silicone Wristbands and Hand Wipes.” Environmental Science & Technology 50, no. 18 (September 2016): 10291. https://doi.org/10.1021/acs.est.6b04169.
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    • Gomes, Genna, Peyton Ward, Amelia Lorenzo, Kate Hoffman, and Heather M. Stapleton. “Characterizing Flame Retardant Applications and Potential Human Exposure in Backpacking Tents.” Environmental Science & Technology 50, no. 10 (May 2, 2016): 5338–45. https://doi.org/10.1021/acs.est.6b00923.
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    • Hammel, Stephanie C., Kate Hoffman, Thomas F. Webster, Kim A. Anderson, and Heather M. Stapleton. “Measuring Personal Exposure to Organophosphate Flame Retardants Using Silicone Wristbands and Hand Wipes.” Environmental Science & Technology 50, no. 8 (April 2016): 4483–91. https://doi.org/10.1021/acs.est.6b00030.
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    • Leonetti, Christopher, Craig M. Butt, Kate Hoffman, Marie Lynn Miranda, and Heather M. Stapleton. “Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues.” Environment International 88 (March 2016): 23–29. https://doi.org/10.1016/j.envint.2015.12.002.
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    • Mendelsohn, Emma, Audrey Hagopian, Kate Hoffman, Craig M. Butt, Amelia Lorenzo, Johanna Congleton, Thomas F. Webster, and Heather M. Stapleton. “Nail polish as a source of exposure to triphenyl phosphate.” Environment International 86 (January 2016): 45–51. https://doi.org/10.1016/j.envint.2015.10.005.
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    • Hoffman, Kate, Craig M. Butt, Albert Chen, Alexander T. Limkakeng, and Heather M. Stapleton. “High Exposure to Organophosphate Flame Retardants in Infants: Associations with Baby Products.” Environ Sci Technol 49, no. 24 (December 15, 2015): 14554–59. https://doi.org/10.1021/acs.est.5b03577.
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    • Lantos, Paul M., Sallie R. Permar, Kate Hoffman, and Geeta K. Swamy. “The Excess Burden of Cytomegalovirus in African American Communities: A Geospatial Analysis.” Open Forum Infect Dis 2, no. 4 (December 2015): ofv180. https://doi.org/10.1093/ofid/ofv180.
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    • Hoffman, Kate, Ann Aschengrau, Thomas F. Webster, Scott M. Bartell, and Verónica M. Vieira. “Associations between residence at birth and mental health disorders: a spatial analysis of retrospective cohort data.” Bmc Public Health 15 (July 21, 2015): 688. https://doi.org/10.1186/s12889-015-2011-z.
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    • Hoffman, Kate, Stavros Garantziotis, Linda S. Birnbaum, and Heather M. Stapleton. “Monitoring indoor exposure to organophosphate flame retardants: hand wipes and house dust.” Environmental Health Perspectives 123, no. 2 (February 2015): 160–65. https://doi.org/10.1289/ehp.1408669.
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    • Kalkbrenner, Amy E., Gayle C. Windham, Marc L. Serre, Yasuyuki Akita, Xuexia Wang, Kate Hoffman, Brian P. Thayer, and Julie L. Daniels. “Particulate matter exposure, prenatal and postnatal windows of susceptibility, and autism spectrum disorders.” Epidemiology (Cambridge, Mass.) 26, no. 1 (January 2015): 30–42. https://doi.org/10.1097/ede.0000000000000173.
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    • Stapleton, Heather M., John Misenheimer, Kate Hoffman, and Thomas F. Webster. “Flame retardant associations between children's handwipes and house dust.” Chemosphere 116 (December 2014): 54–60. https://doi.org/10.1016/j.chemosphere.2013.12.100.
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    • Butt, Craig M., Johanna Congleton, Kate Hoffman, Mingliang Fang, and Heather M. Stapleton. “Metabolites of organophosphate flame retardants and 2-ethylhexyl tetrabromobenzoate in urine from paired mothers and toddlers.” Environmental Science & Technology 48, no. 17 (September 2014): 10432–38. https://doi.org/10.1021/es5025299.
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    • Hoffman, Kate, Mingliang Fang, Brian Horman, Heather B. Patisaul, Stavros Garantziotis, Linda S. Birnbaum, and Heather M. Stapleton. “Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster® 550.” Environmental Health Perspectives 122, no. 9 (September 2014): 963–69. https://doi.org/10.1289/ehp.1308028.
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    • Jensen, Elizabeth T., Kate Hoffman, Nicholas J. Shaheen, Robert M. Genta, and Evan S. Dellon. “Esophageal eosinophilia is increased in rural areas with low population density: results from a national pathology database.” The American Journal of Gastroenterology 109, no. 5 (May 2014): 668–75. https://doi.org/10.1038/ajg.2014.47.
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    • Hoffman, Kate, Veronica M. Vieira, and Julie L. Daniels. “Brief report: diminishing geographic variability in autism spectrum disorders over time?” Journal of Autism and Developmental Disorders 44, no. 3 (March 2014): 712–18. https://doi.org/10.1007/s10803-013-1907-7.
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    • Hoffman, Kate, Julie L. Daniels, and Heather M. Stapleton. “Urinary metabolites of organophosphate flame retardants and their variability in pregnant women.” Environment International 63 (February 2014): 169–72. https://doi.org/10.1016/j.envint.2013.11.013.
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    • Taylor, Kyla W., Kate Hoffman, Kristina A. Thayer, and Julie L. Daniels. “Polyfluoroalkyl chemicals and menopause among women 20-65 years of age (NHANES).” Environmental Health Perspectives 122, no. 2 (February 2014): 145–50. https://doi.org/10.1289/ehp.1306707.
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    • Adgent, Margaret A., Kate Hoffman, Barbara Davis Goldman, Andreas Sjödin, and Julie L. Daniels. “Brominated flame retardants in breast milk and behavioural and cognitive development at 36 months.” Paediatric and Perinatal Epidemiology 28, no. 1 (January 2014): 48–57. https://doi.org/10.1111/ppe.12078.
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    • Vieira, Verónica M., Kate Hoffman, Hyeong-Moo Shin, Janice M. Weinberg, Thomas F. Webster, and Tony Fletcher. “Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis.” Environmental Health Perspectives 121, no. 3 (March 2013): 318–23. https://doi.org/10.1289/ehp.1205829.
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    • Balbus, John M., Robert Barouki, Linda S. Birnbaum, Ruth A. Etzel, Peter D. Gluckman, Philippe Grandjean, Christine Hancock, et al. “Early-life prevention of non-communicable diseases.” Lancet (London, England) 381, no. 9860 (January 2013): 3–4. https://doi.org/10.1016/s0140-6736(12)61609-2.
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    • Vieira, Verónica, Kate Hoffman, and Tony Fletcher. “Assessing the Spatial Distribution of Perfluorooctanoic Acid Exposure via Public Drinking Water Pipes Using Geographic Information Systems.” Environmental Health and Toxicology 28 (January 2013): e2013009. https://doi.org/10.5620/eht.2013.28.e2013009.
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    • Hoffman, Kate, Amy E. Kalkbrenner, Veronica M. Vieira, and Julie L. Daniels. “The spatial distribution of known predictors of autism spectrum disorders impacts geographic variability in prevalence in central North Carolina.” Environmental Health : A Global Access Science Source 11 (October 31, 2012): 80. https://doi.org/10.1186/1476-069x-11-80.
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    • Hoffman, Kate, Margaret Adgent, Barbara Davis Goldman, Andreas Sjödin, and Julie L. Daniels. “Lactational exposure to polybrominated diphenyl ethers and its relation to social and emotional development among toddlers.” Environmental Health Perspectives 120, no. 10 (October 2012): 1438–42. https://doi.org/10.1289/ehp.1205100.
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    • Hoffman, Kate, Thomas F. Webster, Scott M. Bartell, Marc G. Weisskopf, Tony Fletcher, and Verónica M. Vieira. “Private drinking water wells as a source of exposure to perfluorooctanoic acid (PFOA) in communities surrounding a fluoropolymer production facility.” Environmental Health Perspectives 119, no. 1 (January 2011): 92–97. https://doi.org/10.1289/ehp.1002503.
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    • Hoffman, Kate, Thomas Webster, Scott Bartell, Marc Weisskopf, Tony Fletcher, and Verónica Vieira. “Private Drinking Water Wells as a Source of Exposure to Perfluorooctanoic Acid in Communities Surrounding a Washington, West Virginia Fluoropolymer Production Facility.” Epidemiology 22 (January 2011): S85–86. https://doi.org/10.1097/01.ede.0000391926.69693.ca.
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    • Hoffman, Kate, Thomas F. Webster, Marc G. Weisskopf, Janice Weinberg, and Verónica M. Vieira. “Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age.” Environmental Health Perspectives 118, no. 12 (December 2010): 1762–67. https://doi.org/10.1289/ehp.1001898.
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    • Hoffman, Kate, Thomas F. Webster, Janice M. Weinberg, Ann Aschengrau, Patricia A. Janulewicz, Roberta F. White, and Verónica M. Vieira. “Spatial analysis of learning and developmental disorders in upper Cape Cod, Massachusetts using generalized additive models.” International Journal of Health Geographics 9 (February 12, 2010): 7. https://doi.org/10.1186/1476-072x-9-7.
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• Teaching & Mentoring
• 

  Recent Courses

  • ENVIRON 537: Environmental Health 2021
  • ENVIRON 899: Master's Project 2021
  • ENVIRON 537: Environmental Health 2020
  • ENVIRON 899: Master's Project 2020
  • ENVIRON 537: Environmental Health 2019
  • ENVIRON 899: Master's Project 2019

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