Kathryn Radabaugh Nightingale

Kathryn Radabaugh Nightingale
Theo Pilkington Distinguished Professor of Biomedical Engineering

The goals of our laboratory are to investigate and improve ultrasonic imaging methods for clinically-relevant problems. We do this through theoretical, experimental, and simulation methods. The main focus of our recent work is the development of novel, acoustic radiation force impulse (ARFI)-based elasticity imaging methods to generate images of the mechanical properties of tissue, involving interdisciplinary research in ultrasonics and tissue biomechanics. We have access to the engineering interfaces of several commercial ultrasound systems which allows us to design, rapidly prototype, and experimentally demonstrate custom sequences to explore novel beamforming and imaging concepts. We employ FEM modeling methods to simulate the behavior of tissues during mechanical excitation, and we have integrated these tools with ultrasonic imaging modeling tools to simulate the ARFI imaging process. We maintain strong collaborations with the Duke University Medical Center where we work to translate our technologies to clinical practice. The ARFI imaging technologies we have developed have served as the basis for commercial imaging technologies that are now being used in clinics throughout the world. We are also studying the risks and benefits of increasing acoustic output energy for specific clinical imaging scenarios, with the goal of improving ultrasonic image quality in the difficult-to-image patient.

Office Hours

Fridays, 1:30-3:00pm, 277 Hudson Hall Annex

Current Appointments & Affiliations

Theo Pilkington Distinguished Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2019
Professor in the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016
Bass Fellow, Biomedical Engineering, Pratt School of Engineering 2018

Contact Information

277 Hudson Hall Annex, Durham, NC 27708
Box 90281, Durham, NC 27708-0281
kathy.nightingale@duke.edu (919) 660-5175
Google Scholar
http://kathynightingalelab.pratt.duke.edu/

Background
Education, Training, & Certifications
- Ph.D., Duke University 1997
- B.S., Duke University 1989
Duke Appointment History
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2011 - 2016
- Member of Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2014 - 2015
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2004 - 2011
- Assistant Research Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1998 - 2004
Recognition
In the News
- DEC 6, 2019 Pratt School of Engineering
  
  Nightingale, Wilson Elected Fellows of the National Academy of Inventors
- MAY 7, 2019
  
  Duke Adds 21 Faculty to Distinguished Faculty Rank
- NOV 19, 2013
  
  Bringing Scholarship to the Classroom
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Duke Resident Physician-Scientist Program in Radiation Oncology and Radiology awarded by National Institutes of Health 2020 - 2024
- Image guided targeted biopsy of clinically significant prostate cancer with acoustic radiation force awarded by National Institutes of Health 2010 - 2022
- A Patient-Adaptive, High MI Abdominal Scanner awarded by National Institutes of Health 2018 - 2022
- Improved ultrasound imaging using elevated acoustic output awarded by National Institutes of Health 2016 - 2020
- Training in Medical Imaging awarded by National Institutes of Health 2003 - 2020
- Acoustic Radiation Force Impulse (ARFI) Imaging of Cardiac Tissue awarded by National Institutes of Health 2009 - 2020
- Early Detection of Clinically Significant Prostate Cancer using Ultrasonic Acoustic Radiation Force Impulse (ARFI) Imaging awarded by United States Army Medical Research Acquisition Activity 2016 - 2019
- Acoustic Radiation Force Based Hepatic Elasticity Quantification and Imaging awarded by National Institutes of Health 2001 - 2017
- Acoustic Radiation Force Impulse (ARFI) Imaging of Cardiac Tissue awarded by National Institutes of Health 2009 - 2014
- Assessing Use of Acoustic Radiation Force to Noninvasively Measure Liver Pressure awarded by National Institutes of Health 2012 - 2014
- Acoustic Radiation Force Impulse (AFRI) Imaging for Prostate Cancer awarded by United States Army Medical Research and Materiel Command 2008 - 2011
- Acoustic Radiation Force Imaging of Colorectal Tissues awarded by National Institutes of Health 2005 - 2011
- Laboratory Renovation for Teaching and Research in Tissue Engineering awarded by Lord Foundation of North Carolina 1998 - 1999
External Relationships
- MicroElastic Ultrasound Systems Inc
- Samsung
- Siemens Medical Solutions
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Caenen, Annette, Anna E. Knight, Ned C. Rouze, Nick B. Bottenus, Patrick Segers, and Kathryn R. Nightingale. “Analysis of multiple shear wave modes in a nonlinear soft solid: Experiments and finite element simulations with a tilted acoustic radiation force.” Journal of the Mechanical Behavior of Biomedical Materials 107 (July 2020): 103754. https://doi.org/10.1016/j.jmbbm.2020.103754.
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  - Rouze, Ned C., Mark L. Palmeri, and Kathryn R. Nightingale. “Tractable calculation of the Green's tensor for shear wave propagation in an incompressible, transversely isotropic material.” Physics in Medicine and Biology 65, no. 1 (January 13, 2020): 015014. https://doi.org/10.1088/1361-6560/ab5c2d.
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  - Rouze, Ned C., Yufeng Deng, Courtney A. Trutna, Mark L. Palmeri, and Kathryn R. Nightingale. “Characterization of Viscoelastic Materials Using Group Shear Wave Speeds.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 65, no. 5 (May 2018): 780–94. https://doi.org/10.1109/tuffc.2018.2815505.
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  - Lipman, Samantha L., Ned C. Rouze, Mark L. Palmeri, and Kathryn R. Nightingale. “Impact of Acoustic Radiation Force Excitation Geometry on Shear Wave Dispersion and Attenuation Estimates.” Ultrasound in Medicine & Biology 44, no. 4 (April 2018): 897–908. https://doi.org/10.1016/j.ultrasmedbio.2017.12.019.
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  - Deng, Yufeng, Mark L. Palmeri, Ned C. Rouze, Clare M. Haystead, and Kathryn R. Nightingale. “Evaluating the Benefit of Elevated Acoustic Output in Harmonic Motion Estimation in Ultrasonic Shear Wave Elasticity Imaging.” Ultrasound Med Biol 44, no. 2 (February 2018): 303–10. https://doi.org/10.1016/j.ultrasmedbio.2017.10.003.
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  - Deng, Yufeng, Mark L. Palmeri, Ned C. Rouze, Gregg E. Trahey, Clare M. Haystead, and Kathryn R. Nightingale. “Quantifying Image Quality Improvement Using Elevated Acoustic Output in B-Mode Harmonic Imaging.” Ultrasound Med Biol 43, no. 10 (October 2017): 2416–25. https://doi.org/10.1016/j.ultrasmedbio.2017.06.024.
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  - Rouze, Ned C., Yufeng Deng, Mark L. Palmeri, and Kathryn R. Nightingale. “Accounting for the Spatial Observation Window in the 2-D Fourier Transform Analysis of Shear Wave Attenuation.” Ultrasound in Medicine & Biology 43, no. 10 (October 2017): 2500–2506. https://doi.org/10.1016/j.ultrasmedbio.2017.06.006.
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  - Deng, Yufeng, Ned C. Rouze, Mark L. Palmeri, and Kathryn R. Nightingale. “Ultrasonic Shear Wave Elasticity Imaging Sequencing and Data Processing Using a Verasonics Research Scanner.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 64, no. 1 (January 2017): 164–76. https://doi.org/10.1109/tuffc.2016.2614944.
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  - Lipman, Samantha L., Ned C. Rouze, Mark L. Palmeri, and Kathryn R. Nightingale. “Evaluating the Improvement in Shear Wave Speed Image Quality Using Multidimensional Directional Filters in the Presence of Reflection Artifacts.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 63, no. 8 (August 2016): 1049–63. https://doi.org/10.1109/tuffc.2016.2558662.
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  - Palmeri, Mark L., Tyler J. Glass, Zachary A. Miller, Stephen J. Rosenzweig, Andrew Buck, Thomas J. Polascik, Rajan T. Gupta, Alison F. Brown, John Madden, and Kathryn R. Nightingale. “Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation.” Ultrasound Med Biol 42, no. 6 (June 2016): 1251–62. https://doi.org/10.1016/j.ultrasmedbio.2016.01.004.
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  - Deng, Yufeng, Ned C. Rouze, Mark L. Palmeri, and Kathryn R. Nightingale. “On System-Dependent Sources of Uncertainty and Bias in Ultrasonic Quantitative Shear-Wave Imaging.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 63, no. 3 (March 2016): 381–93. https://doi.org/10.1109/tuffc.2016.2524260.
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  - Lee, Seung Yun, Adela R. Cardones, Joshua Doherty, Kathryn Nightingale, and Mark Palmeri. “Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases.” Ultrasound Med Biol 41, no. 11 (November 2015): 2806–19. https://doi.org/10.1016/j.ultrasmedbio.2015.06.007.
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  - Rouze, Ned C., Mark L. Palmeri, and Kathryn R. Nightingale. “An analytic, Fourier domain description of shear wave propagation in a viscoelastic medium using asymmetric Gaussian sources.” The Journal of the Acoustical Society of America 138, no. 2 (August 2015): 1012–22. https://doi.org/10.1121/1.4927492.
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  - Deng, Yufeng, Mark L. Palmeri, Ned C. Rouze, Stephen J. Rosenzweig, Manal F. Abdelmalek, and Kathryn R. Nightingale. “Analyzing the Impact of Increasing Mechanical Index and Energy Deposition on Shear Wave Speed Reconstruction in Human Liver.” Ultrasound Med Biol 41, no. 7 (July 2015): 1948–57. https://doi.org/10.1016/j.ultrasmedbio.2015.02.019.
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  - Nightingale, Kathryn R., Charles C. Church, Gerald Harris, Keith A. Wear, Michael R. Bailey, Paul L. Carson, Hui Jiang, Kurt L. Sandstrom, Thomas L. Szabo, and Marvin C. Ziskin. “Conditionally Increased Acoustic Pressures in Nonfetal Diagnostic Ultrasound Examinations Without Contrast Agents: A Preliminary Assessment.” Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine 34, no. 7 (July 2015): 1–41. https://doi.org/10.7863/ultra.34.7.15.13.0001.
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  - Barr, Richard G., Kazutaka Nakashima, Dominique Amy, David Cosgrove, Andre Farrokh, Fritz Schafer, Jeffrey C. Bamber, et al. “WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 2: breast.” Ultrasound in Medicine & Biology 41, no. 5 (May 2015): 1148–60. https://doi.org/10.1016/j.ultrasmedbio.2015.03.008.
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  - Ferraioli, Giovanna, Carlo Filice, Laurent Castera, Byung Ihn Choi, Ioan Sporea, Stephanie R. Wilson, David Cosgrove, et al. “WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 3: liver.” Ultrasound in Medicine & Biology 41, no. 5 (May 2015): 1161–79. https://doi.org/10.1016/j.ultrasmedbio.2015.03.007.
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  - Shiina, Tsuyoshi, Kathryn R. Nightingale, Mark L. Palmeri, Timothy J. Hall, Jeffrey C. Bamber, Richard G. Barr, Laurent Castera, et al. “WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 1: basic principles and terminology.” Ultrasound in Medicine & Biology 41, no. 5 (May 2015): 1126–47. https://doi.org/10.1016/j.ultrasmedbio.2015.03.009.
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  - Hollender, Peter J., Stephen J. Rosenzweig, Kathryn R. Nightingale, and Gregg E. Trahey. “Single- and multiple-track-location shear wave and acoustic radiation force impulse imaging: matched comparison of contrast, contrast-to-noise ratio and resolution.” Ultrasound in Medicine & Biology 41, no. 4 (April 2015): 1043–57. https://doi.org/10.1016/j.ultrasmedbio.2014.11.006.
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  - Church, Charles C., Cecille Labuda, and Kathryn Nightingale. “A theoretical study of inertial cavitation from acoustic radiation force impulse imaging and implications for the mechanical index.” Ultrasound in Medicine & Biology 41, no. 2 (February 2015): 472–85. https://doi.org/10.1016/j.ultrasmedbio.2014.09.012.
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  - Rosenzweig, Stephen, Mark Palmeri, and Kathryn Nightingale. “Analysis of rapid multi-focal-zone ARFI imaging.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 62, no. 2 (February 2015): 280–89. https://doi.org/10.1109/tuffc.2014.006594.
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  - Nightingale, Kathryn R., Ned C. Rouze, Stephen J. Rosenzweig, Michael H. Wang, Manal F. Abdelmalek, Cynthia D. Guy, and Mark L. Palmeri. “Derivation and analysis of viscoelastic properties in human liver: impact of frequency on fibrosis and steatosis staging.” Ieee Trans Ultrason Ferroelectr Freq Control 62, no. 1 (January 2015): 165–75. https://doi.org/10.1109/TUFFC.2014.006653.
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  - Palmeri, Mark L., Zachary A. Miller, Tyler J. Glass, Kirema Garcia-Reyes, Rajan T. Gupta, Stephen J. Rosenzweig, Christopher Kauffman, et al. “B-mode and acoustic radiation force impulse (ARFI) imaging of prostate zonal anatomy: comparison with 3T T2-weighted MR imaging.” Ultrason Imaging 37, no. 1 (January 2015): 22–41. https://doi.org/10.1177/0161734614542177.
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  - Rouze, Ned C., Michael H. Wang, Mark L. Palmeri, and Kathy R. Nightingale. “Finite element modeling of impulsive excitation and shear wave propagation in an incompressible, transversely isotropic medium.” Journal of Biomechanics 46, no. 16 (November 2013): 2761–68. https://doi.org/10.1016/j.jbiomech.2013.09.008.
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  - Wang, Michael, Brett Byram, Mark Palmeri, Ned Rouze, and Kathryn Nightingale. “Imaging transverse isotropic properties of muscle by monitoring acoustic radiation force induced shear waves using a 2-D matrix ultrasound array.” Ieee Transactions on Medical Imaging 32, no. 9 (September 2013): 1671–84. https://doi.org/10.1109/tmi.2013.2262948.
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  - Doherty, Joshua R., Gregg E. Trahey, Kathryn R. Nightingale, and Mark L. Palmeri. “Acoustic radiation force elasticity imaging in diagnostic ultrasound.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 60, no. 4 (April 2013): 685–701. https://doi.org/10.1109/tuffc.2013.2617.
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  - Wang, Michael, Brett Byram, Mark Palmeri, Ned Rouze, and Kathryn Nightingale. “On the precision of time-of-flight shear wave speed estimation in homogeneous soft solids: initial results using a matrix array transducer.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 60, no. 4 (April 2013): 758–70. https://doi.org/10.1109/tuffc.2013.2624.
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  - Church, Charles C., Cecille Labuda, and Kathryn Nightingale. “Should the mechanical index be revised for ARFI imaging?” Ieee International Ultrasonics Symposium : [Proceedings]. Ieee International Ultrasonics Symposium 2012 (October 2012): 17–20. https://doi.org/10.1109/ultsym.2012.0005.
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  - Rouze, Ned C., Michael H. Wang, Mark L. Palmeri, and Kathryn R. Nightingale. “Parameters affecting the resolution and accuracy of 2-D quantitative shear wave images.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 59, no. 8 (August 2012): 1729–40. https://doi.org/10.1109/tuffc.2012.2377.
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  - Howles, Gabriel P., Yi Qi, Stephen J. Rosenzweig, Kathryn R. Nightingale, and G Allan Johnson. “Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI.” J Vis Exp, no. 65 (July 12, 2012): e4055. https://doi.org/10.3791/4055.
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  - Palmeri, M. L., M. F. Abdelmalek, and K. R. Nightingale. “Reply to: The use of acoustic radiation force-based shear stiffness in non-alcoholic fatty liver disease.” Journal of Hepatology 56, no. 4 (April 1, 2012): 996. https://doi.org/10.1016/j.jhep.2011.09.007.
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  - Rotemberg, V., M. Palmeri, R. Nightingale, N. Rouze, and K. Nightingale. “The impact of hepatic pressurization on liver shear wave speed estimates in constrained versus unconstrained conditions.” Physics in Medicine and Biology 57, no. 2 (January 2012): 329–41. https://doi.org/10.1088/0031-9155/57/2/329.
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  - Zhai, Liang, Thomas J. Polascik, Wen-Chi Foo, Stephen Rosenzweig, Mark L. Palmeri, John Madden, and Kathryn R. Nightingale. “Acoustic radiation force impulse imaging of human prostates: initial in vivo demonstration.” Ultrasound Med Biol 38, no. 1 (January 2012): 50–61. https://doi.org/10.1016/j.ultrasmedbio.2011.10.002.
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  - Rotemberg, V., M. L. Palmeri, N. C. Rouze, R. Nightingale, and K. R. Nightingale. “Comparison between Acoustic Radiation Force Impulse (ARFI)-based hepatic stiffness quantification in deformed and undeformed pressurized canine livers.” Ieee International Ultrasonics Symposium, Ius, December 1, 2011, 2090–93. https://doi.org/10.1109/ULTSYM.2011.0518.
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  - Wang, M. H., B. C. Byram, M. L. Palmeri, N. C. Rouze, and K. R. Nightingale. “Improving shear wave speed estimation precision in homogeneous media by tracking shear wave propagation in 3D using a real-time volumetric imaging transducer.” Ieee International Ultrasonics Symposium, Ius, December 1, 2011, 1262–65. https://doi.org/10.1109/ULTSYM.2011.0311.
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  - Nightingale, Kathy. “Acoustic Radiation Force Impulse (ARFI) Imaging: a Review.” Current Medical Imaging Reviews 7, no. 4 (November 2011): 328–39. https://doi.org/10.2174/157340511798038657.
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  - Bing, Kristin Frinkley, Ned C. Rouze, Mark L. Palmeri, Veronica M. Rotemberg, and Kathryn R. Nightingale. “Combined ultrasonic thermal ablation with interleaved ARFI image monitoring using a single diagnostic curvilinear array: a feasibility study.” Ultrasonic Imaging 33, no. 4 (October 2011): 217–32. https://doi.org/10.1177/016173461103300402.
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  - Palmeri, Mark L., Michael H. Wang, Ned C. Rouze, Manal F. Abdelmalek, Cynthia D. Guy, Barry Moser, Anna Mae Diehl, and Kathryn R. Nightingale. “Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease.” J Hepatol 55, no. 3 (September 2011): 666–72. https://doi.org/10.1016/j.jhep.2010.12.019.
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  - Palmeri, Mark L., and Kathryn R. Nightingale. “Acoustic radiation force-based elasticity imaging methods.” Interface Focus 1, no. 4 (August 2011): 553–64. https://doi.org/10.1098/rsfs.2011.0023.
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  - Palmeri, Mark L., and Kathryn R. Nightingale. “What challenges must be overcome before ultrasound elasticity imaging is ready for the clinic?” Imaging in Medicine 3, no. 4 (August 2011): 433–44. https://doi.org/10.2217/iim.11.41.
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  - Bouchard, Richard R., Stephen J. Hsu, Mark L. Palmeri, Ned C. Rouze, Kathryn R. Nightingale, and Gregg E. Trahey. “Acoustic radiation force-driven assessment of myocardial elasticity using the displacement ratio rate (DRR) method.” Ultrasound in Medicine & Biology 37, no. 7 (July 2011): 1087–1100. https://doi.org/10.1016/j.ultrasmedbio.2011.04.005.
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  - Rosenzweig, Stephen, Mark Palmeri, and Kathryn Nightingale. “GPU-based real-time small displacement estimation with ultrasound.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 58, no. 2 (February 2011): 399–405. https://doi.org/10.1109/tuffc.2011.1817.
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  - Rotemberg, Veronica, Mark Palmeri, Stephen Rosenzweig, Stuart Grant, David Macleod, and Kathryn Nightingale. “Acoustic Radiation Force Impulse (ARFI) imaging-based needle visualization.” Ultrason Imaging 33, no. 1 (January 2011): 1–16. https://doi.org/10.1177/016173461103300101.
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  - Rouze, N. C., M. H. Wang, M. L. Palmeri, and K. R. Nightingale. “Robust estimation of time-of-flight shear wave speed using a Radon sum transformation.” Proceedings Ieee Ultrasonics Symposium, December 1, 2010, 21–24. https://doi.org/10.1109/ULTSYM.2010.5935919.
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  - Rouze, Ned C., Michael H. Wang, Mark L. Palmeri, and Kathryn R. Nightingale. “Robust estimation of time-of-flight shear wave speed using a radon sum transformation.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 57, no. 12 (December 2010): 2662–70. https://doi.org/10.1109/tuffc.2010.1740.
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  - Howles, Gabriel P., Kristin F. Bing, Yi Qi, Stephen J. Rosenzweig, Kathryn R. Nightingale, and G Allan Johnson. “Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound.” Magn Reson Med 64, no. 4 (October 2010): 995–1004. https://doi.org/10.1002/mrm.22411.
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  - Zhai, Liang, John Madden, Wen-Chi Foo, Vladimir Mouraviev, Thomas J. Polascik, Mark L. Palmeri, and Kathryn R. Nightingale. “Characterizing stiffness of human prostates using acoustic radiation force.” Ultrason Imaging 32, no. 4 (October 2010): 201–13. https://doi.org/10.1177/016173461003200401.
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  - Zipparo, Michael J., Kristin F. Bing, and Kathryn R. Nightingale. “Imaging arrays with improved transmit power capability.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 57, no. 9 (September 2010): 2076–90. https://doi.org/10.1109/tuffc.2010.1655.
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  - Wang, Michael H., Mark L. Palmeri, Veronica M. Rotemberg, Ned C. Rouze, and Kathryn R. Nightingale. “Improving the robustness of time-of-flight based shear wave speed reconstruction methods using RANSAC in human liver in vivo.” Ultrasound in Medicine & Biology 36, no. 5 (May 2010): 802–13. https://doi.org/10.1016/j.ultrasmedbio.2010.02.007.
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  - Zhai, Liang, John Madden, Wen-Chi Foo, Mark L. Palmeri, Vladimir Mouraviev, Thomas J. Polascik, and Kathryn R. Nightingale. “Acoustic radiation force impulse imaging of human prostates ex vivo.” Ultrasound Med Biol 36, no. 4 (April 2010): 576–88. https://doi.org/10.1016/j.ultrasmedbio.2009.12.006.
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  - Palmeri, M. L., D. Xu, M. Wang, and K. Nightingale. “Quantitative images of elastic modulus using tissue dynamics in the region of impulsive acoustic radiation force excitation.” Asme International Mechanical Engineering Congress and Exposition, Proceedings 2 (January 1, 2010): 487–91. https://doi.org/10.1115/IMECE2009-12695.
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  - Wang, Michael H., Mark L. Palmeri, Cynthia D. Guy, Liu Yang, Laurence W. Hedlund, Anna Mae Diehl, and Kathryn R. Nightingale. “In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force.” Ultrasound Med Biol 35, no. 10 (October 2009): 1709–21. https://doi.org/10.1016/j.ultrasmedbio.2009.04.019.
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  - Bing, Kristin Frinkley, Gabriel P. Howles, Yi Qi, Mark L. Palmeri, and Kathryn R. Nightingale. “Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in Mice.” Ultrasound in Medicine & Biology 35, no. 8 (August 2009): 1298–1308. https://doi.org/10.1016/j.ultrasmedbio.2009.03.012.
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  - Palmeri, Mark L., Jeremy J. Dahl, David B. MacLeod, Stuart A. Grant, and Kathryn R. Nightingale. “On the feasibility of imaging peripheral nerves using acoustic radiation force impulse imaging.” Ultrason Imaging 31, no. 3 (July 2009): 172–82. https://doi.org/10.1177/016173460903100303.
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  - Palmeri, M. L., M. H. Wang, J. J. Dahl, K. D. Frinkley, and K. R. Nightingale. “Quantifying hepatic shear modulus in vivo using acoustic radiation force.” Ultrasound in Medicine & Biology 34, no. 4 (April 2008): 546–58. https://doi.org/10.1016/j.ultrasmedbio.2007.10.009.
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  - Zhai, Liang, Mark L. Palmeri, Richard R. Bouchard, Roger W. Nightingale, and Kathryn R. Nightingale. “An integrated indenter-ARFI imaging system for tissue stiffness quantification.” Ultrasonic Imaging 30, no. 2 (April 2008): 95–111. https://doi.org/10.1177/016173460803000203.
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  - Palmeri, M. L., M. H. Wang, K. D. Frinkley, K. R. Nightingale, M. F. Abdelmalek, and A. M. Diehl. “Dependence of in vivo, radiation force derived hepatic shear modulus estimates on imaging approach: Intercostal vs. subcostal.” Proceedings Ieee Ultrasonics Symposium, December 1, 2007, 566–69. https://doi.org/10.1109/ULTSYM.2007.147.
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  - Wang, M. H., L. W. Hedlund, M. L. Palmeri, C. D. Guy, L. Yang, A. M. Diehl, and K. R. Nightingale. “In-vivo staging of liver fibrosis in a rat model using acoustic radiation force.” Proceedings Ieee Ultrasonics Symposium, December 1, 2007, 562–65. https://doi.org/10.1109/ULTSYM.2007.146.
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  - Nightingale, K., B. Fahey, S. Hsu, K. Frinkley, J. Dahl, M. Palmeri, L. Zhai, G. Pinton, and G. Trahey. “On the potential for guidance of ablation therapy using acoustic radiation force impulse imaging.” 2007 4th Ieee International Symposium on Biomedical Imaging: From Nano to Macro Proceedings, November 27, 2007, 1116–19. https://doi.org/10.1109/ISBI.2007.357052.
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  - Dahl, Jeremy J., Gianmarco F. Pinton, Mark L. Palmeri, Vineet Agrawal, Kathryn R. Nightingale, and Gregg E. Trahey. “A parallel tracking method for acoustic radiation force impulse imaging.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 54, no. 2 (February 2007): 301–12. https://doi.org/10.1109/tuffc.2007.244.
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  - Nightingale, K. R., L. Zhai, J. J. Dahl, K. D. Frinkley, and M. L. Palmeri. “Shear wave velocity estimation using acoustic radiation force impulsive excitation in liver In Vivo.” Proceedings Ieee Ultrasonics Symposium 1 (December 1, 2006): 1156–60. https://doi.org/10.1109/ULTSYM.2006.298.
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  - Palmeri, Mark L., Stephen A. McAleavey, Kelly L. Fong, Gregg E. Trahey, and Kathryn R. Nightingale. “Dynamic mechanical response of elastic spherical inclusions to impulsive acoustic radiation force excitation.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 53, no. 11 (November 2006): 2065–79. https://doi.org/10.1109/tuffc.2006.146.
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  - Palmeri, Mark L., Stephen A. McAleavey, Gregg E. Trahey, and Kathryn R. Nightingale. “Ultrasonic tracking of acoustic radiation force-induced displacements in homogeneous media.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 53, no. 7 (July 2006): 1300–1313. https://doi.org/10.1109/tuffc.2006.1665078.
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  - Soo, Mary Scott, Sujata V. Ghate, Jay A. Baker, Eric L. Rosen, Ruth Walsh, Brenda N. Warwick, A. R. Ramachandran, and Kathryn R. Nightingale. “Streaming detection for evaluation of indeterminate sonographic breast masses: a pilot study.” Ajr Am J Roentgenol 186, no. 5 (May 2006): 1335–41. https://doi.org/10.2214/AJR.05.0005.
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  - Palmeri, Mark L., Kristin D. Frinkley, Katherine G. Oldenburg, and Kathryn R. Nightingale. “Characterizing acoustic attenuation of homogeneous media using focused impulsive acoustic radiation force.” Ultrasonic Imaging 28, no. 2 (April 2006): 114–28. https://doi.org/10.1177/016173460602800204.
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  - Paschal, Cynthia B., Kathy R. Nightingale, and Kristina M. Ropella. “Undergraduate biomedical imaging education.” Annals of Biomedical Engineering 34, no. 2 (February 2006): 232–38. https://doi.org/10.1007/s10439-005-9031-2.
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  - Nightingale, Kathryn, Mark Palmeri, and Gregg Trahey. “Analysis of contrast in images generated with transient acoustic radiation force.” Ultrasound in Medicine & Biology 32, no. 1 (January 2006): 61–72. https://doi.org/10.1016/j.ultrasmedbio.2005.08.008.
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  - Zhai, L., M. Palmeri, R. Nightingale, M. Gottfried, K. Ludwig, and K. Nightingale. “A combined indenter/ARFI imaging system.” Proceedings Ieee Ultrasonics Symposium 1 (December 1, 2005): 609–12. https://doi.org/10.1109/ULTSYM.2005.1602926.
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  - Palmeri, Mark L., Amy C. Sharma, Richard R. Bouchard, Roger W. Nightingale, and Kathryn R. Nightingale. “A finite-element method model of soft tissue response to impulsive acoustic radiation force.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 52, no. 10 (October 2005): 1699–1712. https://doi.org/10.1109/tuffc.2005.1561624.
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  - Fahey, Brian J., Kathryn R. Nightingale, Rendon C. Nelson, Mark L. Palmeri, and Gregg E. Trahey. “Acoustic radiation force impulse imaging of the abdomen: demonstration of feasibility and utility.” Ultrasound Med Biol 31, no. 9 (September 2005): 1185–98. https://doi.org/10.1016/j.ultrasmedbio.2005.05.004.
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  - Fahey, Brian J., Kathryn R. Nightingale, Stephen A. McAleavey, Mark L. Palmeri, Patrick D. Wolf, and Gregg E. Trahey. “Acoustic radiation force impulse imaging of myocardial radiofrequency ablation: initial in vivo results.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 52, no. 4 (April 2005): 631–41. https://doi.org/10.1109/tuffc.2005.1428046.
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  - Palmeri, Mark L., Kristin D. Frinkley, Liang Zhai, Marcia Gottfried, Rex C. Bentley, Kirk Ludwig, and Kathryn R. Nightingale. “Acoustic radiation force impulse (ARFI) imaging of the gastrointestinal tract.” Ultrason Imaging 27, no. 2 (April 2005): 75–88. https://doi.org/10.1177/016173460502700202.
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  - Trahey, Gregg E., Mark L. Palmeri, Rex C. Bentley, and Kathryn R. Nightingale. “Acoustic radiation force impulse imaging of the mechanical properties of arteries: in vivo and ex vivo results.” Ultrasound Med Biol 30, no. 9 (September 2004): 1163–71. https://doi.org/10.1016/j.ultrasmedbio.2004.07.022.
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  - Palmeri, M. L., and K. R. Nightingale. “On the thermal effects associated with radiation force imaging of soft tissue.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 51, no. 5 (May 1, 2004): 551–65. https://doi.org/10.1109/TUFFC.2004.1320828.
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  - Palmeri, Mark L., and Kathryn R. Nightingale. “On the thermal effects associated with radiation force imaging of soft tissue.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 51, no. 5 (May 2004): 551–65.
  - Palmeri, Mark L., Kristin D. Frinkley, and Kathryn R. Nightingale. “Experimental studies of the thermal effects associated with radiation force imaging of soft tissue.” Ultrasonic Imaging 26, no. 2 (April 2004): 100–114. https://doi.org/10.1177/016173460402600203.
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  - Fahey, Brian J., Kathryn R. Nightingale, Deborah L. Stutz, and Gregg E. Trahey. “Acoustic radiation force impulse imaging of thermally- and chemically-induced lesions in soft tissues: preliminary ex vivo results.” Ultrasound in Medicine & Biology 30, no. 3 (March 2004): 321–28. https://doi.org/10.1016/j.ultrasmedbio.2003.11.012.
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  - Nightingale, K., M. S. Soo, M. Palmeri, A. Congdon, K. Frinkley, and G. Trahey. “Imaging tissue mechanical properties using impulsive acoustic radiation force.” 2004 2nd Ieee International Symposium on Biomedical Imaging: Macro to Nano 1 (January 1, 2004): 41–44. https://doi.org/10.1109/isbi.2004.1398469.
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  - Nightingale, K., M. Palmeri, R. Bouchard, and G. Trahey. “Acoustic radiation force impulse imaging: A parametric analysis of factors affecting image quality.” Proceedings of the Ieee Ultrasonics Symposium 1 (December 1, 2003): 548–53.
  - Nightingale, Kathryn, Stephen McAleavey, and Gregg Trahey. “Shear-wave generation using acoustic radiation force: in vivo and ex vivo results.” Ultrasound in Medicine & Biology 29, no. 12 (December 2003): 1715–23. https://doi.org/10.1016/j.ultrasmedbio.2003.08.008.
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  - Pinton, G. F., M. L. Palmeri, S. A. McAleavey, K. R. Nightingale, and G. E. Trahey. “ARFI imaging of the cardiovascular system.” Proceedings of the Ieee Ultrasonics Symposium 1 (December 1, 2003): 228–31.
  - Gallippi, Caterina M., Kathryn R. Nightingale, and Gregg E. Trahey. “BSS-based filtering of physiological and ARFI-induced tissue and blood motion.” Ultrasound in Medicine & Biology 29, no. 11 (November 2003): 1583–92. https://doi.org/10.1016/j.ultrasmedbio.2003.07.002.
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  - McAleavey, Stephen A., Kathryn R. Nightingale, and Gregg E. Trahey. “Estimates of echo correlation and measurement bias in acoustic radiation force impulse imaging.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 50, no. 6 (June 2003): 631–41. https://doi.org/10.1109/tuffc.2003.1209550.
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  - Nightingale, Kathryn, Rex Bentley, and Gregg Trahey. “Observations of tissue response to acoustic radiation force: opportunities for imaging.” Ultrason Imaging 24, no. 3 (July 2002): 129–38. https://doi.org/10.1177/016173460202400301.
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  - Nightingale, Kathryn, Mary Scott Soo, Roger Nightingale, and Gregg Trahey. “Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility.” Ultrasound Med Biol 28, no. 2 (February 2002): 227–35. https://doi.org/10.1016/s0301-5629(01)00499-9.
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  - Nightingale, K., M. S. Soo, R. Nightingale, R. Bentley, D. Stutz, M. Palmeri, J. Dahl, and G. Trahey. “Acoustic radiation force impulse imaging: Remote palpation of the mechanical properties of tissue.” Proceedings of the Ieee Ultrasonics Symposium 2 (2002): 1821–30.
  - Nightingale, K., R. Nightingale, D. Stutz, and G. Trahey. “Acoustic radiation force impulse imaging of in vivo vastus medialis muscle under varying isometric load.” Ultrasonic Imaging 24, no. 2 (2002): 100–108.
  - Nightingale, K., R. Nightingale, and G. Trahey. “Evaluation of the mechanical properties of active skeletal muscle using acoustic radiation force impulse imaging.” Proceedings of the Ieee Ultrasonics Symposium 2 (December 1, 2001): 1627–31.
  - Nightingale, K. R., M. L. Palmeri, R. W. Nightingale, and G. E. Trahey. “On the feasibility of remote palpation using acoustic radiation force.” J Acoust Soc Am 110, no. 1 (July 2001): 625–34. https://doi.org/10.1121/1.1378344.
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  - Nightingale, K. R., M. S. Soo, R. W. Nightingale, and G. E. Trahey. “Investigation of real-time remote palpation imaging.” Proceedings of Spie the International Society for Optical Engineering 4325 (January 1, 2001): 113–19. https://doi.org/10.1117/12.428187.
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  - Nightingale, K., M. S. Soo, R. Nightingale, R. Bentley, and G. Trahey. “In vivo demonstration of acoustic radiation force impulse (ARFI) imaging in the thyroid, abdomen, and breast.” Proceedings of the Ieee Ultrasonics Symposium 2 (2001): 1633–38.
  - Nightingale, K. R., R. W. Nightingale, M. L. Palmeri, and G. E. Trahey. “A finite element model of remote palpation of breast lesions using radiation force: factors affecting tissue displacement.” Ultrasonic Imaging 22, no. 1 (January 2000): 35–54. https://doi.org/10.1177/016173460002200103.
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  - Nightingale, K. R., and G. E. Trahey. “A finite element model for simulating acoustic streaming in cystic breast lesions with experimental validation.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 47, no. 1 (January 2000): 201–14. https://doi.org/10.1109/58.818763.
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  - Nightingale, K. R., P. J. Kornguth, and G. E. Trahey. “The use of acoustic streaming in breast lesion diagnosis: a clinical study.” Ultrasound in Medicine & Biology 25, no. 1 (January 1999): 75–87. https://doi.org/10.1016/s0301-5629(98)00152-5.
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  - Friemel, B. H., L. N. Bohs, K. R. Nightingale, and G. E. Trahey. “Speckle decorrelation due to two-dimensional flow gradients.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 45, no. 2 (January 1998): 317–27. https://doi.org/10.1109/58.660142.
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  - Dayton, P. A., K. E. Morgan, A. L. Klibanov, G. Brandenburger, K. R. Nightingale, and K. W. Ferrara. “A preliminary evaluation of the effects of primary and secondary radiation forces on acoustic contrast agents.” Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 44, no. 6 (December 1, 1997): 1264–77. https://doi.org/10.1109/58.656630.
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  - Bohs, L. N., B. J. Geiman, K. R. Nightingale, C. D. Choi, B. H. Friemel, and G. E. Trahey. “Ensemble tracking: a new method for 2D vector velocity measurement.” Proceedings of the Ieee Ultrasonics Symposium 2 (December 1, 1995): 1485–88.
  - Bohs, L. N., B. H. Friemel, J. Kisslo, D. T. Harfe, K. R. Nightingale, and G. E. Trahey. “Three-dimensional flow images by reconstruction from two-dimensional vector velocity maps.” J Am Soc Echocardiogr 8, no. 6 (November 1995): 915–23. https://doi.org/10.1016/s0894-7317(05)80016-1.
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  - Nightingale, K. R., P. J. Kornguth, W. F. Walker, B. A. McDermott, and G. E. Trahey. “A novel ultrasonic technique for differentiating cysts from solid lesions: preliminary results in the breast.” Ultrasound in Medicine & Biology 21, no. 6 (January 1995): 745–51. https://doi.org/10.1016/0301-5629(95)00020-r.
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  - Nightingale, K. R., P. J. Kornguth, W. F. Walker, S. C. Glasgow, E. A. Jett, and G. E. Trahey. “Generation and detection of acoustic streaming to differentiate between solid and cystic breast lesions.” Proceedings of the Ieee Ultrasonics Symposium 3 (January 1, 1994): 1653–56. https://doi.org/10.1109/ultsym.1994.401907.
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  - Alsberg, E., G. E. Trahey, L. N. Bohs, B. H. Friemel, K. R. Nightingale, and W. F. Walker. “Three-dimensional flow visualization via reconstruction from successive two-dimensional vector velocity maps.” Proceedings of 16th Annual International Conference of the Ieee Engineering in Medicine and Biology Society, n.d. https://doi.org/10.1109/iembs.1994.411884.
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- Book Sections
  - Rosenzweig, S., Z. Miller, T. Polascik, and K. Nightingale. “Prostate elastography.” In Prostate Ultrasound: Current Practice and Future Directions, 163–72, 2015. https://doi.org/10.1007/978-1-4939-1948-2_12.
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  - Rosenzweig, S., L. Zhai, and K. R. Nightingale. “Prostate elastrography.” In Imaging and Focal Therapy of Early Prostate Cancer, 165–72, 2013. https://doi.org/10.1007/978-1-62703-182-0_13.
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- Conference Papers
  - Caenen, A., A. E. Knight, N. C. Rouze, N. B. Bottenus, P. Segers, and K. R. Nightingale. “Measuring elastic nonlinearity in a soft solid using a tilted acoustic radiation force for shear wave excitation.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:221–23, 2019. https://doi.org/10.1109/ULTSYM.2019.8926155.
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  - Chan, D. Y., D. C. Morris, M. L. Palmeri, and K. R. Nightingale. “A Fully Convolutional Neural Network for Rapid Displacement Estimation in ARFI Imaging.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:111–14, 2019. https://doi.org/10.1109/ULTSYM.2019.8925911.
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  - Chan, D. Y., N. C. Rouze, M. L. Palmeri, and K. R. Nightingale. “Bayesian Shear Wave Speed Reconstruction with an On-Axis ARFI Prior.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:213–16, 2019. https://doi.org/10.1109/ULTSYM.2019.8925845.
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  - Jin, F. Q., M. Postiglione, A. E. Knight, A. R. Cardones, K. R. Nightingale, and M. L. Palmeri. “Comparison of Deep Learning and Classical Image Processing for Skin Segmentation.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:1152–55, 2019. https://doi.org/10.1109/ULTSYM.2019.8926233.
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  - Knight, A. E., A. B. Pely, F. Q. Jin, A. R. Cardones, M. L. Palmeri, and K. R. Nightingale. “Analysis of Factors Affecting Shear Wave Speed in in vivo Skin.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:970–73, 2019. https://doi.org/10.1109/ULTSYM.2019.8925965.
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  - Morris, D. C., D. Y. Chan, H. Chen, M. L. Palmeri, T. J. Polascik, W. C. Foo, J. Huang, J. Mamou, and K. R. Nightingale. “Multiparametric Ultrasound for the Targeting of Prostate Cancer using ARFI, SWEI, B-mode, and QUS.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:880–83, 2019. https://doi.org/10.1109/ULTSYM.2019.8926035.
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  - Rouze, N. C., A. Caenen, and K. R. Nightingale. “Wave Speeds and Green's Tensors for Shear Wave Propagation in Incompressible, Hyperelastic Materials with Uniaxial Stretch.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:427–30, 2019. https://doi.org/10.1109/ULTSYM.2019.8925659.
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  - Trutna, C. A., N. C. Rouze, M. L. Palmeri, and K. R. Nightingale. “Robust Model-Based Viscoelastic Characterization of QIBA Phantoms through Fractional Derivative Group Shear Wave Speeds.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:1391–94, 2019. https://doi.org/10.1109/ULTSYM.2019.8925625.
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  - Trutna, C. A., S. L. Lipman, M. L. Palmeri, and K. R. Nightingale. “Large Field-Of-View Shear Wave Elasticity Imaging with Combined On- and Off-Axis Stiffness Estimation for High Frame Rate Hepatic HCC Screening.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:1368–71, 2019. https://doi.org/10.1109/ULTSYM.2019.8925904.
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  - Zhang, B., and K. R. Nightingale. “Experimental Comparison of Diagnostic Imaging Pressure Fields through the Abdominal Wall with Water.” In Ieee International Ultrasonics Symposium, Ius, 2019-October:2230–32, 2019. https://doi.org/10.1109/ULTSYM.2019.8925681.
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  - Zhang, B., W. Long, G. F. Pinton, and K. R. Nightingale. “On the Use of Spatial Coherence for in Situ Peak Rarefaction Pressure Estimation.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2018-October, 2018. https://doi.org/10.1109/ULTSYM.2018.8579928.
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  - Chan, D. Y., S. L. Lipman, M. L. Palmeri, D. C. Morris, T. J. Polascik, N. C. Rouze, and K. R. Nightingale. “Prostate Shear Wave Elastography: Multiresolution Reconstruction Dependence on Push Beam Spacing.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2018-January, 2018. https://doi.org/10.1109/ULTSYM.2018.8580076.
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  - Cody Morris, D., D. Y. Chan, M. L. Palmeri, T. J. Glass, M. M. McCormick, K. Jack Tay, T. J. Polascik, R. T. Gupta, and K. R. Nightingale. “Correlation Between 3D ARFI and Quantitative Imaging Metrics from SWEI and Multi-Parametric MRI in Vivo in Normal and Cancerous Prostate Tissue.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2018-January, 2018. https://doi.org/10.1109/ULTSYM.2018.8579729.
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  - Hollender, P., A. Knight, A. Caenen, N. Shashikumar, I. Lee, M. Palmeri, K. Nightingale, and G. Trahey. “Anisotropic Constructive Shearwave Interference Measurement of Transversely Anisotropic Materials.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2018-January, 2018. https://doi.org/10.1109/ULTSYM.2018.8579927.
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  - Lipman, S. L., M. L. Palmeri, and K. R. Nightingale. “Large Field-of-View Shear Wave Imaging for Hepatocellular Carcinoma Screening.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2018-January, 2018. https://doi.org/10.1109/ULTSYM.2018.8579901.
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  - Deng, Y., M. Palmeri, N. Rouze, C. Haystead, and K. Nightingale. “Investigating the impact of elevated acoustic output in B-mode harmonic imaging and harmonic motion tracking.” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8092172.
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  - Knight, A., P. Hollender, K. Nightingale, and M. Palmeri. “Constructive shearwave imaging: Feasibility and improvements in SNR.” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8092847.
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  - Knight, A., P. Hollender, N. Shashikumar, K. Nightingale, and M. Palmeri. “Constructive shearwave interference (CSI): Concept and feasibility.” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8092564.
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  - Morris, D. C., N. C. Rouze, M. L. Palmeri, and K. R. Nightingale. “Group shear wave based viscoelastic parameter estimation in SWEI: Analysis of sources of bias.” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8092888.
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  - Morris, D. C., N. Rouze, M. Palmeri, and K. Nightingale. “Group-shearwave based viscoelastic parameter estimation: Analysis of sources of bias.” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8092059.
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  - Rouze, N. C., C. A. Trutna, Y. Deng, M. L. Palmeri, and K. R. Nightingale. “Comparison of SWEI methods for measuring the frequency dependent phase velocity and attenuation in viscoelastic materials.” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8092915.
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  - Rouze, N. C., C. A. Trutna, Y. Deng, M. L. Palmeri, and K. R. Nightingale. “Comparison of methods for measuring the frequency dependent phase velocity and attenuation in viscoelastic materials.” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8092234.
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  - Zhang, B., G. Pinton, B. Tripathi, Y. Deng, and K. Nightingale. “Nonlinear ultrasound propagation in homogeneous and heterogeneous media: Factors affecting the in situ Mechanical Index (MI).” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8091884.
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  - Zhang, B., G. Pinton, Y. Deng, B. Tripathi, and K. Nightingale. “Nonlinear Ultrasound Propagation in Homogeneous and Heterogeneous Media: Factors Affecting the in situ Mechanical Index (MI).” In Ieee International Ultrasonics Symposium, Ius, 2017. https://doi.org/10.1109/ULTSYM.2017.8091514.
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  - Lipman, S. L., N. C. Rouze, M. L. Palmeri, and K. R. Nightingale. “On the feasibility of estimating ultrasonic shear wave attenuation using amplitude-based methods.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2016-November, 2016. https://doi.org/10.1109/ULTSYM.2016.7728789.
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  - Palmeri, M., T. Glass, R. Gupta, M. McCormick, A. Brown, T. Polascik, S. Rosenzweig, A. Buck, and K. Nightingale. “Comparison between 3D ARFI imaging and mpMRI in detecting clinically-significant prostate cancer lesions.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2016-November, 2016. https://doi.org/10.1109/ULTSYM.2016.7728618.
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  - Pely, A., K. R. Nightingale, and M. L. Palmeri. “Dispersion analysis in skin using FEM: Characterizing the effects of the lower boundary material on the propagation of shear waves.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2016-November, 2016. https://doi.org/10.1109/ULTSYM.2016.7728410.
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  - Rouze, N. C., Y. Deng, M. L. Palmeri, and K. R. Nightingale. “Robust characterization of viscoelastic materials from measurements of group shear wave speeds.” In Ieee International Ultrasonics Symposium, Ius, Vol. 2016-November, 2016. https://doi.org/10.1109/ULTSYM.2016.7728832.
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  - Deng, Y., M. L. Palmeri, N. C. Rouze, C. M. Haysteady, and K. R. Nightingale. “Quantifying the benefit of elevated acoustic output in harmonic imaging.” In 2015 Ieee International Ultrasonics Symposium, Ius 2015, 2015. https://doi.org/10.1109/ULTSYM.2015.0299.
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  - Deng, Y., N. C. Rouze, M. L. Palmeri, and K. R. Nightingale. “System dependent sources of error in time-of-flight shear wave speed measurements.” In 2015 Ieee International Ultrasonics Symposium, Ius 2015, 2015. https://doi.org/10.1109/ULTSYM.2015.0267.
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  - Lee, S. Y., A. R. Cardones, K. Nightingale, and M. Palmeri. “Characterizing sclerotic skin stiffness with Acoustic Radiation Force Impulse (ARFI) and Shear Wave Elasticity Imaging (SWEI).” In 2015 Ieee International Ultrasonics Symposium, Ius 2015, 2015. https://doi.org/10.1109/ULTSYM.2015.0098.
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  - Palmeri, M., K. Nightingale, S. Fielding, N. Rouze, Y. Deng, T. Lynch, S. Chen, et al. “RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media.” In 2015 Ieee International Ultrasonics Symposium, Ius 2015, 2015. https://doi.org/10.1109/ULTSYM.2015.0283.
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  - Rouze, N. C., M. L. Palmeri, and K. R. Nightingale. “Measurement of the frequency dependent phase velocity and attenuation from the Fourier description of shear wave propagation: Addressing geometric spreading arising from spatially asymmetric Gaussian excitations.” In 2015 Ieee International Ultrasonics Symposium, Ius 2015, 2015. https://doi.org/10.1109/ULTSYM.2015.0199.
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  - Deng, Y., M. L. Palmeri, N. C. Rouze, S. J. Rosenzweig, M. F. Abdelmalek, and K. R. Nightingale. “Analyzing the impact of increasing Mechanical Index (MI) and energy deposition on shear wave speed (SWS) reconstruction in human liver.” In Ieee International Ultrasonics Symposium, Ius, 719–22, 2014. https://doi.org/10.1109/ULTSYM.2014.0177.
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  - Hollender, P., S. Rosenzweig, K. Nightingale, and G. Trahey. “Micro-elasticity (μ-E): CNR and resolution of acoustic radiation force impulse imaging and single- and multiple track location shear wave elasticity imaging for visualizing small targets.” In Ieee International Ultrasonics Symposium, Ius, 703–6, 2014. https://doi.org/10.1109/ULTSYM.2014.0173.
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  - Lipman, S. L., N. C. Rouze, M. L. Palmeri, and K. R. Nightingale. “Improving the accuracy of shear wave speed reconstructions using 4D directional filters in the presence of reflection artifacts.” In Ieee International Ultrasonics Symposium, Ius, 2312–15, 2014. https://doi.org/10.1109/ULTSYM.2014.0576.
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  - Miller, Z. A., M. L. Palmeri, S. J. Rosenzweig, T. J. Glass, K. R. Nightingale, T. J. Polascik, A. Buck, and J. Madden. “3D in vivo ARFI imaging: Prostate cancer sensitivity.” In Ieee International Ultrasonics Symposium, Ius, 209–12, 2014. https://doi.org/10.1109/ULTSYM.2014.0053.
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  - Palmeri, M. L., Y. Deng, N. C. Rouze, and K. R. Nightingale. “Dependence of shear wave spectral content on acoustic radiation force excitation duration and spatial beamwidth.” In Ieee International Ultrasonics Symposium, Ius, 1105–8, 2014. https://doi.org/10.1109/ULTSYM.2014.0271.
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  - Rouze, N. C., M. L. Palmeri, and K. R. Nightingale. “Estimation of model parameters characterizing dispersion in ARFI induced shear waves in in vivo human liver.” In Ieee International Ultrasonics Symposium, Ius, 983–86, 2014. https://doi.org/10.1109/ULTSYM.2014.0241.
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  - Hall, T. J., A. Milkowski, B. Garra, P. Carson, M. Palmeri, K. Nightingale, T. Lynch, et al. “RSNA/QIBA: Shear wave speed as a biomarker for liver fibrosis staging.” In Ieee International Ultrasonics Symposium, Ius, 397–400, 2013. https://doi.org/10.1109/ULTSYM.2013.0103.
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  - Nightingale, K. R., N. C. Rouze, M. H. Wang, S. J. Rosenzweig, and M. L. Palmeri. “3D elasticity imaging with acoustic radiation force.” In Ieee International Ultrasonics Symposium, Ius, 531–36, 2013. https://doi.org/10.1109/ULTSYM.2013.0138.
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  - Rosenzweig, S., N. Rouze, B. Byram, M. Palmeri, T. Polascik, and K. Nightingale. “Bayesian shear wave speed estimation for in vivo 3D imaging of the prostate.” In Ieee International Ultrasonics Symposium, Ius, 1260–63, 2013. https://doi.org/10.1109/ULTSYM.2013.0322.
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  - Rosenzweig, S., M. Palmeri, N. Rouze, S. Lipman, E. Kulbacki, J. Madden, T. Polascik, and K. Nightingale. “Comparison of concurrently acquired in vivo 3D ARFI and SWEI images of the prostate.” In Ieee International Ultrasonics Symposium, Ius, 97–100, 2012. https://doi.org/10.1109/ULTSYM.2012.0024.
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  - Rotemberg, V., B. Byram, M. Wang, M. L. Palmeri, and K. R. Nightingale. “Characterizing expansion and stiffening of the canine liver with increasing hepatic pressure.” In Ieee International Ultrasonics Symposium, Ius, 101–4, 2012. https://doi.org/10.1109/ULTSYM.2012.0025.
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  - Wang, M. H., B. C. Byram, M. L. Palmeri, N. C. Rouze, and K. R. Nightingale. “3D shear wave imaging of anisotropic mechanical properties of muscle using a 2D matrix array transducer.” In Ieee International Ultrasonics Symposium, Ius, 5–8, 2012. https://doi.org/10.1109/ULTSYM.2012.0002.
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  - Nightingale, K., M. Wang, S. Rosenzweig, V. Rotemberg, N. Rouze, and M. Palmeri. “TH‐C‐217BCD‐06: Acoustic Radiation Force Based Imaging: An Overview.” In Medical Physics, 39:4004, 2012. https://doi.org/10.1118/1.4736335.
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  - Hsu, C. M. L., T. J. Polascik, M. S. Davenport, C. Kauffman, R. T. Gupta, E. Kulbacki, J. Madden, S. L. Lipman, M. L. Palmeri, and K. R. Nightingale. “Methodology to register prostate B-mode and ARFI images to MR and histology.” In Ieee International Ultrasonics Symposium, Ius, 1866–69, 2011. https://doi.org/10.1109/ULTSYM.2011.0466.
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  - Nightingale, K. R., N. C. Rouze, M. H. Wang, L. Zhai, and M. L. Palmeri. “Comparison of qualitative and quantitative acoustic radiation force based elasticity imaging methods.” In Proceedings International Symposium on Biomedical Imaging, 1606–9, 2011. https://doi.org/10.1109/ISBI.2011.5872710.
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  - Nightingale, K., M. Palmeri, N. Rouze, S. Rosenzweig, M. Wang, and G. Trahey. “TU‐G‐220‐01: Quantitative Elasticity Imaging with Acoustic Radiation Force Induced Shear Waves.” In Medical Physics, 38:3788–89, 2011. https://doi.org/10.1118/1.3613261.
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  - Palmeri, M. L., N. C. Rouze, M. H. Wang, X. Ding, and K. R. Nightingale. “Quantifying the impact of shear wavelength and kernel size on shear wave speed estimation.” In Proceedings Ieee Ultrasonics Symposium, 13–16, 2010. https://doi.org/10.1109/ULTSYM.2010.5935798.
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  - Wang, M. H., M. L. Palmeri, N. C. Rouze, D. Xu, and K. R. Nightingale. “Improving precision of tissue shear modulus quantification within theregion of acoustic radiation force excitation with compounded displacementestimates.” In Proceedings Ieee Ultrasonics Symposium, 1600–1603, 2010. https://doi.org/10.1109/ULTSYM.2010.5935944.
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  - Wang, Michael, Mark Palmeri, Ned Rouze, Veronica Rotemberg, Barry Moser, Cynthia D. Guy, Anna Mae Diehl, Manal F. Abdelmalek, and Kathryn Nightingale. “NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS WITH QUANTITATIVE ACOUSTIC RADIATION FORCE METHODS.” In Hepatology, 50:743A-744A. JOHN WILEY & SONS INC, 2009.
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  - Bing, K. F., V. M. Rotemberg, M. L. Palmeri, and K. R. Nightingale. “Concurrent ARFI imaging and HIFU ablation using a diagnostic transducer array and ultrasound system with custom beam sequences.” In Proceedings Ieee Ultrasonics Symposium, 65–68, 2009. https://doi.org/10.1109/ULTSYM.2009.5441759.
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  - Wang, M. H., M. L. Palmeri, V. M. Rotemberg, N. C. Rouze, and K. R. Nightingale. “Robust hepatic shear modulus reconstruction using acoustic radiation force and RANSAC.” In Proceedings Ieee Ultrasonics Symposium, 169–72, 2009. https://doi.org/10.1109/ULTSYM.2009.5441567.
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  - Zhai, L., J. Madden, V. Mouraviev, T. Polascik, and K. Nightingale. “Correlation between SWEI and ARFI image findings in ex vivo human prostates.” In Proceedings Ieee Ultrasonics Symposium, 523–26, 2009. https://doi.org/10.1109/ULTSYM.2009.5441796.
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  - Palmeri, M. L., D. Xu, L. Zhai, and K. R. Nightingale. “Acoustic radiation force based quantification of tissue shear modulus within the region of excitation.” In Proceedings Ieee Ultrasonics Symposium, 2009–12, 2008. https://doi.org/10.1109/ULTSYM.2008.0495.
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  - Wang, M., M. Palmeri, N. Rouze, K. Nightingale, and M. Hobson. “Investigating the effects of viscosity on focused, impulsive, acoustic radiation force induced shear wave morphology.” In Proceedings Ieee Ultrasonics Symposium, 647–50, 2008. https://doi.org/10.1109/ULTSYM.2008.0155.
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  - Zhai, L., J. Dahl, J. Madden, V. Mouraviev, T. Polascik, M. Palmeri, and K. Nightingale. “Three-dimensional acoustic radiation force impulse (ARFI) imaging of human prostates in vivo.” In Proceedings Ieee Ultrasonics Symposium, 540–43, 2008. https://doi.org/10.ll09/ULTSYM.2008.0131.
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  - Zhai, L., S. Hsu, R. Bouchard, and K. Nightingale. “A combined ARFI sequence for 2D displacement imaging and shear wave velocity mapping.” In Proceedings Ieee Ultrasonics Symposium, 2013–16, 2008. https://doi.org/10.1109/ULTSYM.2008.0496.
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  - Zhai, Liang, Jeremy Dahl, John Madden, Vladimir Mouraviev, Thomas Polascik, Mark Palmeri, and Kathryn Nightingale. “Three-dimensional acoustic radiation force impulse (ARFI) imaging of human prostates in vivo.” In 2008 Ieee Ultrasonics Symposium. IEEE, 2008. https://doi.org/10.1109/ultsym.2008.0131.
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  - Frinkley, K., S. Rosenzweig, and K. Nightingale. “Therapeutic potential metric for diagnostic transducers.” In Proceedings Ieee Ultrasonics Symposium, 116–19, 2007. https://doi.org/10.1109/ULTSYM.2007.42.
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  - Huettel, L. G., J. Forbes, L. Franzoni, R. Malkin, J. Nadeau, K. Nightingale, and G. A. Ybarra. “Transcending the traditional: Using tablet PCs to enhance engineering and computer science instruction.” In Proceedings Frontiers in Education Conference, Fie, 2007. https://doi.org/10.1109/FIE.2007.4417869.
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  - Zhai, L., J. Madden, V. Mouraviev, T. Polascik, and K. Nightingale. “Visualizing the anatomic structures of human prostates using Acoustic Radiation Force Impulse (ARFI) imaging.” In Proceedings Ieee Ultrasonics Symposium, 432–35, 2007. https://doi.org/10.1109/ULTSYM.2007.117.
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  - Trahey, G. E., M. Palmeri, K. Nightingale, and J. Dahl. “Radiation force imaging: Challenges and opportunities.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 6513, 2007. https://doi.org/10.1117/12.719470.
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  - Huettel, Lisa G., Jeff Forbes, Linda Franzoni, Robert Malkin, Joseph Nadeau, Kathy Nightingale, and Gary A. Ybarra. “Transcending the traditional: Using Tablet PCs to enhance engineering and computer science instruction.” In 2007 37th Annual Frontiers in Education Conference, Global Engineering : Knowledge Without Borders Opportunities Without Passports, Vols 1 4, 1724–29. IEEE, 2007.
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  - Palmeri, M., K. Frinkley, K. Oldenburg, and K. Nightingale. “Characterizing acoustic attenuation using focused impulsive acoustic radiation force.” In Proceedings Ieee Ultrasonics Symposium, 1:1680–85, 2006. https://doi.org/10.1109/ULTSYM.2006.422.
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  - Frinkley, K., M. Palmeri, and K. Nightingale. “Controlled spatio-temporal heating patterns using a commercial, diagnostic ultrasound system.” In Proceedings Ieee Ultrasonics Symposium, 2:1130–34, 2005. https://doi.org/10.1109/ULTSYM.2005.1603049.
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  - Pinton, G. F., S. A. McAleavey, J. J. Dahl, K. R. Nightingale, and G. E. Trahey. “Real-time Acoustic Radiation Force Impulse imaging.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, 5750:226–35, 2005. https://doi.org/10.1117/12.595846.
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  - Sharma, A., G. Trahey, K. Frinkley, M. S. Soo, M. Palmeri, and K. Nightingale. “Image processing and data acquisition optimization for Acoustic Radiation Force Impulse imaging of in vivo breast masses.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, 5750:205–15, 2005. https://doi.org/10.1117/12.593473.
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  - Nightingale, K., M. Palmeri, K. Frinkley, A. Sharma, L. Zhai, and G. Trahey. “Ultrasonic imaging of the mechanical properties of tissues using localized, transient acoustic radiation FORCE.” In Icassp, Ieee International Conference on Acoustics, Speech and Signal Processing Proceedings, V:981–84, 2005. https://doi.org/10.1109/ICASSP.2005.1416470.
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  - Soo, M. S., J. A. Baker, S. V. Ghate, R. Walsh, B. Warwick, and K. Nightingale. “Streaming detection for evaluation of indeterminate sono-graphic breast masses - A pilot study.” In American Journal of Roentgenology, 184:27–27. AMER ROENTGEN RAY SOC, 2005.
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  - Sharma, A. C., M. S. Soo, G. E. Trahey, and K. R. Nightingale. “Acoustic radiation force impulse imaging of in vivo breast masses.” In Proceedings Ieee Ultrasonics Symposium, 1:728–31, 2004.
  - Palmeri, M., K. Frinkley, L. Zhai, R. Bentley, K. Ludwig, M. Gottfried, and K. Nightingale. “Acoustic Radiation Force Impulse (ARFI) imaging of the gastrointestinal tract.” In Proceedings Ieee Ultrasonics Symposium, 1:744–47, 2004.
  - Fahey, B. J., K. R. Nightingale, P. D. Wolf, and G. E. Trahey. “ARFI imaging of thermal lesions in ex vivo and in vivo soft tissues.” In Proceedings of the Ieee Ultrasonics Symposium, 1:562–67, 2003.
  - Gallippi, C. M., K. R. Nightingale, and G. E. Trahey. “Blind source separation-based adaptive filtering of physiological and ARFI-induced tissue, blood, and cyst fluid motion, in-vivo.” In Proceedings of the Ieee Ultrasonics Symposium, 1:841–46, 2003.
  - Hsu, S. J., M. L. Palermi, K. R. Nightingale, S. A. McAleavey, J. D. Dahl, and G. E. Trahey. “Shear wave anisotropy imaging.” In Proceedings of the Ieee Ultrasonics Symposium, 2:1090–93, 2003.
  - Hsu, S. J., M. L. Palermi, K. R. Nightingale, S. A. McAleavey, J. D. Dahl, and G. E. Trahey. “Shear wave anisotropy imaging.” In Proceedings of the Ieee Ultrasonics Symposium, 1:921–24, 2003.
  - Palmeri, M. L., and K. R. Nightingale. “Thermal effects associated with acoustic radiation force impulse imaging.” In Proceedings of the Ieee Ultrasonics Symposium, 1:232–37, 2003.
  - McAleavey, S. A., K. R. Nightingale, D. L. Stutz, S. J. Hsu, and G. E. Trahey. “Image reconstruction with acoustic radiation force induced shear waves.” In Proceedings of Spie the International Society for Optical Engineering, 5035:223–34, 2003. https://doi.org/10.1117/12.480275.
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  - Trahey, G. E., J. J. Dahl, S. A. McAleavey, C. M. Gallippi, and K. R. Nightingale. “Arterial stiffness measurements with acoustic radiation force impulse imaging.” In Proceedings of Spie the International Society for Optical Engineering, 5035:235–41, 2003. https://doi.org/10.1117/12.479966.
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  - Nightingale, K., D. Stutz, R. Bentley, and G. Trahey. “Acoustic radiation force impulse imaging: EX vivo and in vivo demonstration of transient shear wave propagation.” In Proceedings International Symposium on Biomedical Imaging, 2002-January:525–28, 2002. https://doi.org/10.1109/ISBI.2002.1029310.
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  - Nightingale, K., M. Palmeri, R. Nightingale, and G. Trahey. “Acoustic remote palpation: Initial in vivo results.” In Proceedings of the Ieee Ultrasonics Symposium, 2:1553–58, 2000.
  - Nightingale, K., R. Nightingale, M. Palmeri, and G. Trahey. “Finite element analysis of radiation force induced tissue motion with experimental validation.” In Proceedings of the Ieee Ultrasonics Symposium, 2:1319–23, 1999.
  - Nightingale, K., P. Kornguth, S. Breit, S. Liu, and G. Trahey. “Utilization of acoustic streaming to classify breast lesions in vivo.” In Proceedings of the Ieee Ultrasonics Symposium, 2:1419–22, 1997.
  - Nightingale, K. R., P. J. Kornguth, and G. E. Trahey. “Streaming detection: improvements in sensitivity.” In Proceedings of the Ieee Ultrasonics Symposium, 2:1261–64, 1996.
  - Alsberg, E., G. E. Trahey, L. N. Bohs, B. H. Friemel, K. R. Nightingale, and W. F. Walker. “Three-dimensional flow visualization via reconstruction from successive two-dimensional vector velocity maps.” In Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 16:598–99, 1994.
  - Friemel, B. H., K. R. Nightingale, L. N. Bohs, and G. E. Trahey. “Wall filtering challenges in two-dimensional vector velocity estimation.” In Proceedings of the Ieee Ultrasonics Symposium, 2:1031–34, 1993.
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