Kayla Wilhoit

Journal Article bioRxiv · September 18, 2025 Cryptococcus neoformans is a fungal pathogen of humans that causes life-threatening meningoencephalitis. During infection, enlarged, polyploid titan cells are produced that promote survival, evade immune cells, and generate diverse progeny. These titan cel ... Full text Link to item Cite

Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts.

Journal Article Cell Rep · August 26, 2025 Opportunistic microbial pathogens that infect humans must adapt to radically different fitness landscapes as they transition from the external environment to the host niche. The nature, frequency, and magnitude of genomic changes that accompany adaptation ... Full text Link to item Cite

Convergent Evolution and Predictability of Gene Copy Numbers Associated with Diets in Mammals.

Journal Article Genome biology and evolution · February 2025 Convergent evolution, the evolution of the same or similar phenotypes in phylogenetically independent lineages, is a widespread phenomenon in nature. If the genetic basis for convergent evolution is predictable to some extent, it may be possible to infer o ... Full text Cite

Drift drives the evolution of chromosome number II: The impact of range size on genome evolution in Carnivora

Journal Article Journal of Heredity · August 20, 2024 AbstractChromosome number is a fundamental genomic trait that is often the first recorded characteristic of a genome. Across large clades, a common pattern emerges: many or even most lineages exhibit relativ ... Full text Cite

Worse than nothing at all: the inequality of fusions joining autosomes to the PAR and non-PAR portions of sex chromosomes

Journal Article PeerJ · July 23, 2024 Chromosomal fusions play an integral role in genome remodeling and karyotype evolution. Fusions that join a sex chromosome to an autosome are particularly abundant across the tree of life. However, previous models on the establishment of such fusio ... Full text Cite

Automatic Classification of Magnetic Resonance Histology of Peripheral Arterial Chronic Total Occlusions Using a Variational Autoencoder: A Feasibility Study

Journal Article Diagnostics · May 31, 2023 The novel approach of our study consists in adapting and in evaluating a custom-made variational autoencoder (VAE) using two-dimensional (2D) convolutional neural networks (CNNs) on magnetic resonance imaging (MRI) images for differentiate soft vs. ... Full text Cite