Kara Wegermann
Medical Instructor in the Department of Medicine
My research focuses on genetic predictors of progression in non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). I have investigated predictors of clinical progression in non-alcoholic fatty liver disease using the Duke NAFLD clinical database and biorepository. I find the genetic and modifiable risk factors for liver disease fascinating, particularly because of the potential for clinical intervention before cirrhosis or HCC are established.
Current Appointments & Affiliations
- Medical Instructor in the Department of Medicine, Medicine, Gastroenterology, Medicine 2022
Contact Information
- Background
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Education, Training, & Certifications
- Gastroenterology Fellowship, Gastroenterology, Duke University School of Medicine 2017 - 2021
- Chief Resident, Internal Medicine, Internal Medicine, Durham Veterans Administration Medical Center 2018 - 2019
- Gastroenterology Fellowship, Medicine, Duke University School of Medicine 2017 - 2018
- Internal Medicine Residency, Internal Medicine, Duke University School of Medicine 2014 - 2017
- Internal Medicine Residency, Medicine, Duke University School of Medicine 2014 - 2017
- M.D., Harvard Medical School 2014
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Previous Appointments & Affiliations
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2018 - 2019
- Research
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Selected Grants
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External Relationships
- Mallinckrodt Pharmaceuticals
- Publications & Artistic Works
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Selected Publications
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Books
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Freedman, Jennifer A., Muthana Al Abo, Tyler A. Allen, Sean A. Piwarski, Kara Wegermann, and Steven R. Patierno. Biological Aspects of Cancer Health Disparities. Vol. 72, 2021. https://doi.org/10.1146/annurev-med-070119-120305.Full Text Link to Item
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Academic Articles
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Wegermann, Kara, Jacqueline B. Henson, and Lindsay Y. King. “CON: Intrahepatic cholangiocarcinoma should be a contraindication to liver transplantation.” Clin Liver Dis (Hoboken) 21, no. 2 (February 2023): 52–55. https://doi.org/10.1097/CLD.0000000000000010.Full Text Link to Item
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Aby, Elizabeth S., Ghady Moafa, Nyan Latt, Mohammad T. Sultan, Paula A. Cacioppo, Sonal Kumar, Raymond T. Chung, et al. “Long-term clinical outcomes of patients with COVID-19 and chronic liver disease: US multicenter COLD study.” Hepatol Commun 7, no. 1 (January 1, 2023): e8874. https://doi.org/10.1097/01.HC9.0000897224.68874.de.Full Text Link to Item
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Henson, Jacqueline B., Kara Wegermann, Yuval A. Patel, Julius M. Wilder, and Andrew J. Muir. “Access to technology to support telehealth in areas without specialty care for liver disease.” Hepatology 77, no. 1 (January 1, 2023): 176–85. https://doi.org/10.1002/hep.32597.Full Text Link to Item
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Wegermann, Kara, Julius M. Wilder, Alice Parish, Donna Niedzwiecki, Ziad F. Gellad, Andrew J. Muir, and Yuval A. Patel. “Racial and Socioeconomic Disparities in Utilization of Telehealth in Patients with Liver Disease During COVID-19.” Dig Dis Sci 67, no. 1 (January 2022): 93–99. https://doi.org/10.1007/s10620-021-06842-5.Full Text Link to Item
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Fudim, Marat, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, et al. “Nonalcoholic Fatty Liver Disease and Risk of Heart Failure Among Medicare Beneficiaries.” J Am Heart Assoc 10, no. 22 (November 16, 2021): e021654. https://doi.org/10.1161/JAHA.121.021654.Full Text Link to Item
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Salah, Husam M., Ambarish Pandey, Anzhela Soloveva, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan, Kara Wegermann, et al. “Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction.” Jacc Basic Transl Sci 6, no. 11 (November 2021): 918–32. https://doi.org/10.1016/j.jacbts.2021.07.010.Full Text Link to Item
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Samoylova, Mariya L., Kara Wegermann, Brian I. Shaw, Samuel J. Kesseli, Sandra Au, Christine Park, Samantha E. Halpern, et al. “The Impact of the 2017 Kidney Allocation Policy Change on Simultaneous Liver-Kidney Utilization and Outcomes.” Liver Transpl 27, no. 8 (August 2021): 1106–15. https://doi.org/10.1002/lt.26053.Full Text Link to Item
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Wegermann, Kara, Yuval Patel, and Julius Wilder. “Health Equity and Telemedicine in Gastroenterology and Hepatology.” Clin Gastroenterol Hepatol 19, no. 8 (August 2021): 1516–19. https://doi.org/10.1016/j.cgh.2021.04.024.Full Text Link to Item
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Kim, Donghee, Nia Adeniji, Nyann Latt, Sonal Kumar, Patricia P. Bloom, Elizabeth S. Aby, Ponni Perumalswami, et al. “Predictors of Outcomes of COVID-19 in Patients With Chronic Liver Disease: US Multi-center Study.” Clin Gastroenterol Hepatol 19, no. 7 (July 2021): 1469-1479.e19. https://doi.org/10.1016/j.cgh.2020.09.027.Full Text Link to Item
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Wegermann, Kara. “Scoping Out a Better Parental Leave Policy for Gastroenterology Fellows.” Clin Gastroenterol Hepatol 19, no. 7 (July 2021): 1307–9. https://doi.org/10.1016/j.cgh.2021.01.040.Full Text Link to Item
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Peters, Anthony E., Ambarish Pandey, Colby Ayers, Kara Wegermann, Robert W. McGarrah, Justin L. Grodin, Manal F. Abdelmalek, et al. “Association of liver fibrosis risk scores with clinical outcomes in patients with heart failure with preserved ejection fraction: findings from TOPCAT.” Esc Heart Fail 8, no. 2 (April 2021): 842–48. https://doi.org/10.1002/ehf2.13250.Full Text Link to Item
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Wegermann, Kara, Ayako Suzuki, Alisha M. Mavis, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “REPLY.” Hepatology 73, no. 4 (April 2021): 1625. https://doi.org/10.1002/hep.31593.Full Text Link to Item
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Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Cynthia D. Guy, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “Serum Bile Acid, Vitamin E, and Serotonin Metabolites Are Associated With Future Liver-Related Events in Nonalcoholic Fatty Liver Disease.” Hepatol Commun 5, no. 4 (April 2021): 608–17. https://doi.org/10.1002/hep4.1665.Full Text Link to Item
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Wegermann, Kara, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein-Chung Chow, et al. “Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD.” Hepatol Commun 5, no. 4 (April 2021): 598–607. https://doi.org/10.1002/hep4.1668.Full Text Link to Item
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Adeniji, Nia, Rotonya M. Carr, Elizabeth S. Aby, Andreea M. Catana, Kara Wegermann, and Renumathy Dhanasekaran. “Socioeconomic Factors Contribute to the Higher Risk of COVID-19 in Racial and Ethnic Minorities With Chronic Liver Diseases.” Gastroenterology 160, no. 4 (March 2021): 1406-1409.e3. https://doi.org/10.1053/j.gastro.2020.11.035.Full Text Link to Item
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Wegermann, Kara, Ayako Suzuki, Alisha M. Mavis, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “Tackling Nonalcoholic Fatty Liver Disease: Three Targeted Populations.” Hepatology 73, no. 3 (March 2021): 1199–1206. https://doi.org/10.1002/hep.31533.Full Text Link to Item
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Wegermann, Kara, Jeongeun Hyun, and Anna Mae Diehl. “Molecular Mechanisms Linking Nonalcoholic Steatohepatitis to Cancer.” Clin Liver Dis (Hoboken) 17, no. 1 (January 2021): 6–10. https://doi.org/10.1002/cld.1006.Full Text Link to Item
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Darlington, Kimberly, Kara Wegermann, and Darin Dufault. “Successful banding of nodular gastric antral vascular ectasia in patients with refractory anemia.” Gastrointest Endosc 92, no. 2 (August 2020): 422–23. https://doi.org/10.1016/j.gie.2020.04.003.Full Text Link to Item
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Sullivan, Brian, Cecelia Zhang, Kara Wegermann, Tzu-Hao Lee, and David A. Leiman. “Standardizing inpatient colonoscopy preparations improves quality and provider satisfaction.” Int J Health Care Qual Assur ahead-of-print, no. ahead-of-print (March 9, 2020). https://doi.org/10.1108/IJHCQA-11-2019-0186.Full Text Open Access Copy Link to Item
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Wegermann, Kara, and Jatin Roper. “An Insoluble Mystery: Fiber and Diverticulitis.” Gastroenterology 158, no. 4 (March 2020): 1167–68. https://doi.org/10.1053/j.gastro.2020.01.020.Full Text Link to Item
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Patel, Yuval A., Kara Wegermann, Carl L. Berg, and Lindsay Y. King. “Patient 1 with decompensated nonalcoholic steatohepatitis cirrhosis with inability to lose weight should undergo transplantation.” Clin Liver Dis (Hoboken) 11, no. 6 (June 2018): 149–51. https://doi.org/10.1002/cld.703.Full Text Link to Item
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Wegermann, Kara, Anna Mae Diehl, and Cynthia A. Moylan. “Disease pathways and molecular mechanisms of nonalcoholic steatohepatitis.” Clin Liver Dis (Hoboken) 11, no. 4 (April 2018): 87–91. https://doi.org/10.1002/cld.709.Full Text Link to Item
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Wegermann, Kara, Ricardo Henao, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, and Cynthia A. Moylan. “Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study.” Plos One 13, no. 9 (2018): e0204308. https://doi.org/10.1371/journal.pone.0204308.Full Text Link to Item
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Seraj, Siamak M., Emily J. Campbell, Sarah K. Argyropoulos, Kara Wegermann, Raymond T. Chung, and James M. Richter. “Hospital readmissions in decompensated cirrhotics: Factors pointing toward a prevention strategy.” World J Gastroenterol 23, no. 37 (October 7, 2017): 6868–76. https://doi.org/10.3748/wjg.v23.i37.6868.Full Text Link to Item
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Wegermann, K., and C. A. Moylan. “Epigenetics of Childhood Obesity.” Current Pediatrics Reports 5, no. 3 (September 1, 2017): 111–17. https://doi.org/10.1007/s40124-017-0133-8.Full Text
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Abril, Maria K., Adam S. Barnett, Kara Wegermann, Eric Fountain, Andrew Strand, Benjamin M. Heyman, Britton A. Blough, et al. “Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing.” Open Forum Infect Dis 3, no. 3 (September 2016): ofw144. https://doi.org/10.1093/ofid/ofw144.Full Text Open Access Copy Link to Item
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Mueller, Jessica L., Lindsay Y. King, Kara B. Johnson, Tian Gao, Lauren D. Nephew, Darshan Kothari, Mary Ann Simpson, et al. “Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study.” Clin Transplant 30, no. 4 (April 2016): 452–60. https://doi.org/10.1111/ctr.12710.Full Text Link to Item
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King, Lindsay Y., Claudia Canasto-Chibuque, Kara B. Johnson, Shun Yip, Xintong Chen, Kensuke Kojima, Manjeet Deshmukh, et al. “A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration.” Gut 64, no. 8 (August 2015): 1296–1302. https://doi.org/10.1136/gutjnl-2014-307862.Full Text
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Johnson, Kara B., Jessica L. Mueller, Tracey G. Simon, Hui Zheng, Lindsay Y. King, Robert S. Makar, Debra A. Gervais, and Raymond T. Chung. “Reduced Albumin Dosing During Large-Volume Paracentesis Is Not Associated with Adverse Clinical Outcomes.” Digestive Diseases and Sciences 60, no. 7 (July 2015): 2190–95. https://doi.org/10.1007/s10620-015-3578-z.Full Text
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King, Lindsay Y., Kara B. Johnson, Hui Zheng, Lan Wei, Thomas Gudewicz, Yujin Hoshida, Kathleen E. Corey, et al. “Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis.” Edited by Erica Villa. Plos One 9, no. 12 (December 12, 2014): e114747–e114747. https://doi.org/10.1371/journal.pone.0114747.Full Text
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Wu, Ying, Kara B. Johnson, Giorgio Roccaro, Joanna Lopez, Hui Zheng, Anthony Muiru, Nneka Ufere, Ruma Rajbhandari, Omar Kattan, and Raymond T. Chung. “Poor Adherence to AASLD Guidelines for Chronic Hepatitis B Management and Treatment in a Large Academic Medical Center.” American Journal of Gastroenterology 109, no. 6 (June 2014): 867–75. https://doi.org/10.1038/ajg.2014.72.Full Text
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Johnson, Kara B., Emily J. Campbell, Heng Chi, Hui Zheng, Lindsay Y. King, Ying Wu, Andrew DeLemos, et al. “Advanced Disease, Diuretic Use, and Marital Status Predict Hospital Admissions in an Ambulatory Cirrhosis Cohort.” Digestive Diseases and Sciences 59, no. 1 (January 2014): 174–82. https://doi.org/10.1007/s10620-013-2832-5.Full Text
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Conference Papers
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Kappus, Matthew R., Kara Wegermann, Erol Bozdogan, Yuval A. Patel, Gemini Janas, Erin Shropshire, Alice Parish, Donna Niedzwiecki, Andrew J. Muir, and Mustafa Bashir. “Use of Skeletal Muscle Index as a Predictor of Wait-List Mortality in Patients With End-Stage Liver Disease.” In Liver Transpl, 26:1090–99, 2020. https://doi.org/10.1002/lt.25802.Full Text Link to Item
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