Overview
Dr. Marsolo is a faculty member in the Department of Population Health Sciences (DPHS) and a member of the Duke Clinical Research Institute (DCRI). His current research focuses on infrastructure to support the use of electronic health records (EHRs) and other real-world data sources in observational and comparative effectiveness research and public health surveillance, as well as standards and architectures for multi-center learning health systems. He serves as faculty advisor to the DPHS DataShare Shared Facility and faculty lead for the Pragmatic Health Services Research (PHSR) functional group within the DCRI. Dr. Marsolo received his PhD in Computer Science from The Ohio State University, with a dissertation on data mining, specifically the modeling and classification of biomedical data.
Prior to joining DPHS, Dr. Marsolo was an an Associate Professor in the Division of Biomedical Informatics (BMI) at Cincinnati Children’s Hospital Medical Center (CCHMC). While at CCHMC, Dr. Marsolo served as faculty advisor for BMI Data Services, a shared facility that supported distributed data sharing networks and also developed registry platforms to support learning networks. These included a configurable system for capturing summary or practice-level measures, and a “data-in-once” architecture that allowed information to be collected in the EHR and then be automatically transferred to a registry in order to support chronic care management, quality improvement and research.Area of Expertise: Informatics, Data Quality, Common Data Models, Data Standards and Data Harmonization
Current Appointments & Affiliations
Recent Publications
Traditional and HIV-Specific Risk Factors Associated With Atrial Fibrillation Among Underrepresented Minority Groups With HIV.
Journal Article JACC Adv · December 2025 BACKGROUND: Evaluation of nonvalvular atrial fibrillation/atrial flutter (NVAF) in under-represented racial and ethnic minority groups (UREGs) living with HIV has not been adequately studied. OBJECTIVES: The purpose of this study was to describe the incide ... Full text Link to item CitePatient-directed data capture for clinical research: A pilot study testing two platforms.
Journal Article Contemp Clin Trials · December 2025 BACKGROUND: Patient-directed data capture enables individuals to access and share their electronic health record (EHR) data, potentially supporting patient engagement while also reducing data fragmentation. Although many vendors offer patient-directed data ... Full text Link to item CiteAbstract 4360264: Real World Evaluation of the Eligibility, Uptake, and Cardiometabolic Effects of Tirzepatide: An Analysis from the Platform for Evidence GeneraTion in CArdiometabolic HeaLth (PETAL) Study
Conference Circulation · November 4, 2025 Background: Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon like peptide-1 receptor agonist that has been shown to have cardiometabolic benefits. Howeve ... Full text CiteRecent Grants
Comparative Effectiveness of Emerging Medications in Children with Inflammatory Bowel Disease
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2025 - 2031DCRI D-COHRe Partnership for Innovation, Improved Access, and Operational Capability for Decentralized Clinical Trials of Medical Countermeasures in Public Health Emergencies
ResearchCo Investigator · Awarded by Biomedical Advanced Research and Development Authority · 2024 - 2029Data Services for the Coordinating Center for PCORnet®"
ResearchPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2025 - 2028View All Grants