Keith Allen Marsolo | Scholars@Duke

Keith Allen Marsolo
Instructor in the Department of Population Health Sciences

Area of Expertise: Informatics

Current Appointments & Affiliations

Instructor in the Department of Population Health Sciences, Population Health Sciences, Basic Science Departments 2018
Member of the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2018

Contact Information

keith.marsolo@duke.edu

Background
Education, Training, & Certifications
- Ph.D., Ohio State University 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Aronson, S, Babb, L, Ames, D, Gibbs, RA, Venner, E, Connelly, JJ, Marsolo, K, Weng, C, Williams, MS, Hartzler, AL, Liang, WH, Ralston, JD, Devine, EB, Murphy, S, Chute, CG, Caraballo, PJ, Kullo, IJ, Freimuth, RR, Rasmussen, LV, Wehbe, FH, Peterson, JF, Robinson, JR, Wiley, K, Overby Taylor, C, and eMERGE Network EHRI Working Group, . "Empowering genomic medicine by establishing critical sequencing result data flows: the eMERGE example." Journal of the American Medical Informatics Association : Jamia 25, no. 10 (October 2018): 1375-1381. Full Text
  - Raman, SR, Curtis, LH, Temple, R, Andersson, T, Ezekowitz, J, Ford, I, James, S, Marsolo, K, Mirhaji, P, Rocca, M, Rothman, RL, Sethuraman, B, Stockbridge, N, Terry, S, Wasserman, SM, Peterson, ED, and Hernandez, AF. "Leveraging electronic health records for clinical research." American Heart Journal 202 (August 2018): 13-19. Full Text
  - Walsh, KE, Marsolo, KA, Davis, C, Todd, T, Martineau, B, Arbaugh, C, Verly, F, Samson, C, and Margolis, P. "Accuracy of the medication list in the electronic health record—implications for care, research, and improvement." Journal of the American Medical Informatics Association 25, no. 7 (July 1, 2018): 909-912. Full Text
  - Qualls, LG, Phillips, TA, Hammill, BG, Topping, J, Louzao, DM, Brown, JS, Curtis, LH, and Marsolo, K. "Evaluating Foundational Data Quality in the National Patient-Centered Clinical Research Network (PCORnet®)." Egems (Washington, Dc) 6, no. 1 (April 13, 2018): 3-null. Full Text
  - Hall, ES, Greenberg, JM, Muglia, LJ, Divekar, P, Zahner, J, Gholap, J, Leonard, M, and Marsolo, K. "Implementation of a Regional Perinatal Data Repository from Clinical and Billing Records." Maternal and Child Health Journal 22, no. 4 (April 2018): 485-493. Full Text
  - Lingren, T, Sadhasivam, S, Zhang, X, and Marsolo, K. "Electronic medical records as a replacement for prospective research data collection in postoperative pain and opioid response studies." International Journal of Medical Informatics 111 (March 2018): 45-50. Full Text
  - Khare, R, Utidjian, L, Ruth, BJ, Kahn, MG, Burrows, E, Marsolo, K, Patibandla, N, Razzaghi, H, Colvin, R, Ranade, D, Kitzmiller, M, Eckrich, D, and Bailey, LC. "A longitudinal analysis of data quality in a large pediatric data research network." Journal of the American Medical Informatics Association : Jamia 24, no. 6 (November 2017): 1072-1079. Full Text
  - Weber, GM, Adams, WG, Bernstam, EV, Bickel, JP, Fox, KP, Marsolo, K, Raghavan, VA, Turchin, A, Zhou, X, Murphy, SN, and Mandl, KD. "Biases introduced by filtering electronic health records for patients with "complete data"." Journal of the American Medical Informatics Association : Jamia 24, no. 6 (November 2017): 1134-1141. Full Text
  - Hall, ES, Marsolo, K, and Greenberg, JM. "Evaluation of identifier field agreement in linked neonatal records." Journal of Perinatology : Official Journal of the California Perinatal Association 37, no. 8 (August 2017): 969-974. Full Text
  - Marsolo, K, Shuman, W, Nix, J, Morrison, CF, Mullins, LL, and Pai, AL. "Reducing Parental Uncertainty Around Childhood Cancer: Implementation Decisions and Design Trade-Offs in Developing an Electronic Health Record-Linked Mobile App." Jmir Research Protocols 6, no. 6 (June 26, 2017): e122-null. Full Text
  - Verma, SS, Cooke Bailey, JN, Lucas, A, Bradford, Y, Linneman, JG, Hauser, MA, Pasquale, LR, Peissig, PL, Brilliant, MH, McCarty, CA, Haines, JL, Wiggs, JL, Vrabec, TR, Tromp, G, Ritchie, MD, eMERGE Network, , and NEIGHBOR Consortium, . "Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium." Plos Genetics 12, no. 9 (September 13, 2016): e1006186-null. Full Text
  - Connolly, N, Anixt, J, Manning, P, Ping-I Lin, D, Marsolo, KA, and Bowers, K. "Maternal metabolic risk factors for autism spectrum disorder-An analysis of electronic medical records and linked birth data." Autism Research : Official Journal of the International Society for Autism Research 9, no. 8 (August 2016): 829-837. Full Text
  - Lingren, T, Thaker, V, Brady, C, Namjou, B, Kennebeck, S, Bickel, J, Patibandla, N, Ni, Y, Van Driest, SL, Chen, L, Roach, A, Cobb, B, Kirby, J, Denny, J, Bailey-Davis, L, Williams, MS, Marsolo, K, Solti, I, Holm, IA, Harley, J, Kohane, IS, Savova, G, and Crimmins, N. "Developing an Algorithm to Detect Early Childhood Obesity in Two Tertiary Pediatric Medical Centers." Applied Clinical Informatics 7, no. 3 (July 20, 2016): 693-706. Full Text
  - Martin, LJ, Franciosi, JP, Collins, MH, Abonia, JP, Lee, JJ, Hommel, KA, Varni, JW, Grotjan, JT, Eby, M, He, H, Marsolo, K, Putnam, PE, Garza, JM, Kaul, A, Wen, T, and Rothenberg, ME. "Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease." The Journal of Allergy and Clinical Immunology 135, no. 6 (June 2015): 1519-28.e8. Full Text
  - Herr, TM, Bielinski, SJ, Bottinger, E, Brautbar, A, Brilliant, M, Chute, CG, Cobb, BL, Denny, JC, Hakonarson, H, Hartzler, AL, Hripcsak, G, Kannry, J, Kohane, IS, Kullo, IJ, Lin, S, Manzi, S, Marsolo, K, Overby, CL, Pathak, J, Peissig, P, Pulley, J, Ralston, J, Rasmussen, L, Roden, DM, Tromp, G, Uphoff, T, Weng, C, Wolf, W, Williams, MS, and Starren, J. "Practical considerations in genomic decision support: The eMERGE experience." Journal of Pathology Informatics 6 (January 2015): 50-null. Full Text
  - Marsolo, K, Margolis, PA, Forrest, CB, Colletti, RB, and Hutton, JJ. "A Digital Architecture for a Network-Based Learning Health System: Integrating Chronic Care Management, Quality Improvement, and Research." Egems (Washington, Dc) 3, no. 1 (January 2015): 1168-null. Full Text
  - Namjou, B, Marsolo, K, Lingren, T, Ritchie, MD, Verma, SS, Cobb, BL, Perry, C, Kitchner, TE, Brilliant, MH, Peissig, PL, Borthwick, KM, Williams, MS, Grafton, J, Jarvik, GP, Holm, IA, and Harley, JB. "A GWAS Study on Liver Function Test Using eMERGE Network Participants." Plos One 10, no. 9 (January 2015): e0138677-null. Full Text
  - Shonce, ER, Marsolo, K, Margolis, P, and Opipari-Arrigan, L. "The Levine Experience in Piloting Electronic Patient Engagement Tools in a Pediatric Specialty Clinic Setting." The Journal for Nurse Practitioners 10, no. 10 (November 2014): 851-855. Full Text
  - Ward, MJ, Marsolo, KA, and Froehle, CM. "Applications of business analytics in healthcare." Business Horizons 57, no. 5 (September 2014): 571-582. Full Text
  - Deleger, L, Lingren, T, Ni, Y, Kaiser, M, Stoutenborough, L, Marsolo, K, Kouril, M, Molnar, K, and Solti, I. "Preparing an annotated gold standard corpus to share with extramural investigators for de-identification research." Journal of Biomedical Informatics 50 (August 2014): 173-183. Full Text
  - Forrest, CB, Crandall, WV, Bailey, LC, Zhang, P, Joffe, MM, Colletti, RB, Adler, J, Baron, HI, Berman, J, del Rosario, F, Grossman, AB, Hoffenberg, EJ, Israel, EJ, Kim, SC, Lightdale, JR, Margolis, PA, Marsolo, K, Mehta, DI, Milov, DE, Patel, AS, Tung, J, and Kappelman, MD. "Effectiveness of anti-TNFα for Crohn disease: research in a pediatric learning health system." Pediatrics 134, no. 1 (July 2014): 37-44. Full Text
  - Forrest, CB, Margolis, PA, Bailey, LC, Marsolo, K, Del Beccaro, MA, Finkelstein, JA, Milov, DE, Vieland, VJ, Wolf, BA, Yu, FB, and Kahn, MG. "PEDSnet: a National Pediatric Learning Health System." Journal of the American Medical Informatics Association : Jamia 21, no. 4 (July 2014): 602-606. Full Text
  - Mandl, KD, Kohane, IS, McFadden, D, Weber, GM, Natter, M, Mandel, J, Schneeweiss, S, Weiler, S, Klann, JG, Bickel, J, Adams, WG, Ge, Y, Zhou, X, Perkins, J, Marsolo, K, Bernstam, E, Showalter, J, Quarshie, A, Ofili, E, Hripcsak, G, and Murphy, SN. "Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture." Journal of the American Medical Informatics Association : Jamia 21, no. 4 (July 2014): 615-620. Full Text
  - Henderson, CJ, Ngeow, J, Collins, MH, Martin, LJ, Putnam, PE, Abonia, JP, Marsolo, K, Eng, C, and Rothenberg, ME. "Increased prevalence of eosinophilic gastrointestinal disorders in pediatric PTEN hamartoma tumor syndromes." Journal of Pediatric Gastroenterology and Nutrition 58, no. 5 (May 2014): 553-560. Full Text
  - Namjou, B, Marsolo, K, Caroll, RJ, Denny, JC, Ritchie, MD, Verma, SS, Lingren, T, Porollo, A, Cobb, BL, Perry, C, Kottyan, LC, Rothenberg, ME, Thompson, SD, Holm, IA, Kohane, IS, and Harley, JB. "Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis." Frontiers in Genetics 5 (January 2014): 401-null. Full Text
  - Marsolo, K, and Spooner, SA. "Clinical genomics in the world of the electronic health record." Genetics in Medicine : Official Journal of the American College of Medical Genetics 15, no. 10 (October 2013): 786-791. (Review) Full Text
  - Abonia, JP, Wen, T, Stucke, EM, Grotjan, T, Griffith, MS, Kemme, KA, Collins, MH, Putnam, PE, Franciosi, JP, von Tiehl, KF, Tinkle, BT, Marsolo, KA, Martin, LJ, Ware, SM, and Rothenberg, ME. "High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders." The Journal of Allergy and Clinical Immunology 132, no. 2 (August 2013): 378-386. Full Text
  - Franciosi, JP, Hommel, KA, Bendo, CB, King, EC, Collins, MH, Eby, MD, Marsolo, K, Abonia, JP, von Tiehl, KF, Putnam, PE, Greenler, AJ, Greenberg, AB, Bryson, RA, Davis, CM, Olive, AP, Gupta, SK, Erwin, EA, Klinnert, MD, Spergel, JM, Denham, JM, Furuta, GT, Rothenberg, ME, and Varni, JW. "PedsQL eosinophilic esophagitis module: feasibility, reliability, and validity." Journal of Pediatric Gastroenterology and Nutrition 57, no. 1 (July 2013): 57-66. Full Text
  - Bonafide, CP, Brady, PW, Keren, R, Conway, PH, Marsolo, K, and Daymont, C. "Development of heart and respiratory rate percentile curves for hospitalized children." Pediatrics 131, no. 4 (April 2013): e1150-e1157. Full Text
  - Marsolo, K. "In Search of a Data-in-Once, Electronic Health Record-Linked, Multicenter Registry-How Far We Have Come and How Far We Still Have to Go." Egems 1, no. 1 (January 17, 2013): 1003-null. Full Text
  - Deleger, L, Molnar, K, Savova, G, Xia, F, Lingren, T, Li, Q, Marsolo, K, Jegga, A, Kaiser, M, Stoutenborough, L, and Solti, I. "Large-scale evaluation of automated clinical note de-identification and its impact on information extraction." Journal of the American Medical Informatics Association : Jamia 20, no. 1 (January 2013): 84-94. Full Text
  - Mandl, KD, Edge, S, Malone, C, Marsolo, K, and Natter, MD. "Next-generation registries: fusion of data for care, and research." Amia Joint Summits on Translational Science Proceedings. Amia Joint Summits on Translational Science 2013 (January 2013): 164-167.
  - Marsolo, K. "Informatics and operations--let's get integrated." Journal of the American Medical Informatics Association : Jamia 20, no. 1 (January 2013): 122-124. Full Text
  - Namjou, B, Keddache, M, Marsolo, K, Wagner, M, Lingren, T, Cobb, B, Perry, C, Kennebeck, S, Holm, IA, Li, R, Crimmins, NA, Martin, L, Solti, I, Kohane, IS, and Harley, JB. "EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children." Frontiers in Genetics 4 (January 2013): 268-null. Full Text
  - Natter, MD, Quan, J, Ortiz, DM, Bousvaros, A, Ilowite, NT, Inman, CJ, Marsolo, K, McMurry, AJ, Sandborg, CI, Schanberg, LE, Wallace, CA, Warren, RW, Weber, GM, and Mandl, KD. "An i2b2-based, generalizable, open source, self-scaling chronic disease registry." Journal of the American Medical Informatics Association : Jamia 20, no. 1 (January 2013): 172-179. Full Text
  - Marsolo, K, Corsmo, J, Barnes, MG, Pollick, C, Chalfin, J, Nix, J, Smith, C, and Ganta, R. "Challenges in creating an opt-in biobank with a registrar-based consent process and a commercial EHR." Journal of the American Medical Informatics Association : Jamia 19, no. 6 (November 2012): 1115-1118. Full Text
  - Marsolo, K. "Approaches to facilitate institutional review board approval of multicenter research studies." Medical Care 50 Suppl (July 2012): S77-S81. Full Text
  - Pai, ALH, Rausch, J, Tackett, A, Marsolo, K, Drotar, D, and Goebel, J. "System for integrated adherence monitoring: real-time non-adherence risk assessment in pediatric kidney transplantation." Pediatric Transplantation 16, no. 4 (June 2012): 329-334. Full Text
  - Deleger, L, Li, Q, Lingren, T, Kaiser, M, Molnar, K, Stoutenborough, L, Kouril, M, Marsolo, K, and Solti, I. "Building gold standard corpora for medical natural language processing tasks." Amia ... Annual Symposium Proceedings. Amia Symposium 2012 (January 2012): 144-153.
  - Widdice, LE, Bernstein, DI, Leonard, AC, Marsolo, KA, and Kahn, JA. "Adherence to the HPV vaccine dosing intervals and factors associated with completion of 3 doses." Pediatrics 127, no. 1 (January 2011): 77-84. Full Text
  - Giannini, CM, Kim, HK, Mortensen, J, Mortensen, J, Marsolo, K, and Huppert, J. "Culture of non-genital sites increases the detection of gonorrhea in women." Journal of Pediatric and Adolescent Gynecology 23, no. 4 (August 2010): 246-252. Full Text
  - Marsolo, K, and Parthasarathy, S. "On the use of structure and sequence-based features for protein classification and retrieval." Knowledge and Information Systems 14, no. 1 (January 2008): 59-80. Full Text
  - Wen, H, Marsolo, KA, Bennett, EE, Kutten, KS, Lewis, RP, Lipps, DB, Epstein, ND, Plehn, JF, and Croisille, P. "Adaptive postprocessing techniques for myocardial tissue tracking with displacement-encoded MR imaging." Radiology 246, no. 1 (January 2008): 229-240. Full Text
  - Marsolo, K, Twa, M, Bullimore, MA, and Parthasarathy, S. "Spatial Modeling and Classification of Corneal Shape." Ieee Transactions on Information Technology in Biomedicine 11, no. 2 (March 2007): 203-212. Full Text
  - Marsolo, K, Twa, M, Bullimore, MA, and Parthasarathy, S. "Spatial modeling and classification of corneal shape." Ieee Transactions on Information Technology in Biomedicine : a Publication of the Ieee Engineering in Medicine and Biology Society 11, no. 2 (March 2007): 203-212. Full Text
- Conference Papers
  - Maro, JC, Reich, CG, Marsolo, K, Uyama, Y, Filion, KB, and Sturkenboom, MCJM. "Long live the "medical data janitors": International data quality assurance practices in distributed data networks." : WILEY, August 1, 2018. Link to Item
  - Khare, R, Utidjian, L, Schulte, G, Marsolo, K, and Bailey, C. "Identifying and Understanding Data Quality Issues in a Pediatric Distributed Research Network." : AMIA, 2015.
  - Nichols, WC, Pauciulo, MW, Lutz, K, Winslow, C, Walsworth, A, Gygi, A, Marsolo, K, Harley, JB, and Martin, LJ. "National Biologic Sample And Data Repository For Pah Update." International Conference of the American-Thoracic-Society (ATS). Denver, CO. May 15, 2015 - May 20, 2015.: AMER THORACIC SOC, January 1, 2015. Link to Item
  - Klein, DJ, Khoury, JC, Marsolo, K, Sorter, M, Hornung, L, and Dolan, LM. "Metformin (Met) Prevents Weight Gain in Youth on Second Generation Antipsychotics (SGA)." : AMER DIABETES ASSOC, July 1, 2013. Link to Item
  - Pauciulo, M, Reponen, A, Brearton, M, Lutz, K, Harley, J, Barnes, M, Martin, L, Marsolo, K, and Nichols, WC. "National Biological Sample And Data Repository For Who Group 1 Pulmonary Arterial Hypertension." : AMER THORACIC SOC, January 1, 2013. Link to Item
  - Marsolo, K, Parthasarathy, S, Twa, M, and Bullimore, M. "Ensernble-learning by model-based spatial averaging." AMS/IMS/SIAM Joint Summer Research Conference on Machine and Statistical Learning - Prediction and Discovery. Snowbird, UT. June 25, 2006 - June 29, 2006.: AMER MATHEMATICAL SOC, January 1, 2007. Link to Item
  - Marsolo, K, Parthasarathy, S, and Ramamohanarao, K. "Structure-based querying of proteins using wavelets." December 1, 2006. Full Text
  - Marsolo, K, and Parthasarathy, S. "On the use of structure and sequence-based features for protein classification and retrieval." December 1, 2006. Full Text
  - Marsolo, K, and Parthasarathy, S. "Protein classification using summaries of profile-based frequency matrices." January 1, 2006.
  - Marsolo, K, Parthasarathy, S, Twa, M, and Bullimore, M. "A model-based approach to visualizing classification decisions for patient diagnosis." December 1, 2005.
  - Marsolo, K, Parthasarathy, S, Twa, M, and Bullimore, MA. "Classification of biomedical data through model-based spatial averaging." December 1, 2005. Full Text
  - Marsolo, K, Parthasarathy, S, and Ding, C. "A multi-level approach to SCOP fold recognition." December 1, 2005. Full Text
  - Marsolo, K, and Parthasarathy, S. "Alternate representation of distance matrices for characterization of protein structure." December 1, 2005. Full Text

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Education, Training, & Certifications

Selected Publications

Academic Articles

Conference Papers