Roger Keith Reeves | Scholars@Duke

Roger Keith Reeves
Professor in Surgery

Formerly of Harvard Medical School and Beth Israel Deaconess Medical Center, Dr. R. Keith Reeves is currently tenured Professor of Surgery at Duke University, as well as Director of the Division of Innate and Comparative Immunology and Head of Innovation Partnerships in the Center for Human Systems Immunology. He is also currently the Director of the Duke CFAR Developmental Core and Editor-in-Chief of AIDS Research and Human Retroviruses. Over his academic career he has published extensively in the field of NK cell biology, providing some of the most comprehensive analyses of NK cells and innate lymphoid cells, including the first characterization of memory NK cells in any primate species. Dr. Reeves’ research has been supported by NIH for over a decade by individual and consortia grants, and in addition to independent work, he collaborates as part of the HIV Vaccine Trials Network (HVTN) and the BEAT-HIV Martin Delaney HIV Cure Collaboratory. Dr. Reeves has also served on multiple standing NIH study sections (HIV Immunopathogenesis and Vaccine Development), as well as on standing and ad hoc grant review committees for amfAR, the United States-Israel Binational Science Foundation, the UK Medical Research Council and California Institute of Regenerative Medicine, among others. Considered a global expert in NK cell biology, Dr. Reeves’ group continues to focus on cutting edge approaches to harness NK cells in the context of vaccines and antiviral therapeutics for HIV, CMV, HCV, influenza and SARSCoV2.

Current Appointments & Affiliations

Professor in Surgery, Surgery, Surgical Sciences, Surgery 2021
Professor of Pathology, Pathology, Clinical Science Departments 2022

Contact Information

keith.reeves@duke.edu

Background
Education, Training, & Certifications
- Ph.D., University of Alabama Birmingham 2007
- B.S., Mississippi State University 2002
Leadership & Clinical Positions at Duke
- Director, Division of Innate and Comparative Immunology 2021 - present
  Director, Duke Center for AIDS Research Developmental Core 2021 - present
Academic Positions Outside Duke
- Adjunct Faculty, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center. 2021 - 2030
- Associate Professor of Medicine, Harvard Medical School. 2017 - 2021
Recognition
In the News
- FEB 11, 2022
  
  Duke Surgery Ranks #1 in NIH Funding
- SEP 23, 2021
  
  R. Keith Reeves, PhD, Joins Duke Surgery's Center of Human Systems Immunology
- FEB 23, 2021 The New York Times
  
  Future Vaccines Depend on Test Subjects in Short Supply: Monkeys
- AUG 31, 2020 The Atlantic
  
  America Is Running Low on a Crucial Resource for COVID-19 Vaccines
- APR 9, 2020 Endpoints News
  
  Natural killers are coming for Covid-19 and the therapy, experts say, could make things worse
- OCT 16, 2015 amfAR, The Foundation for AIDS Research
  
  Natural Killers Adapt :: The Foundation for AIDS Research
- JUL 15, 2015 amfAR, The Foundation for AIDS Research
  
  Are Early Immune Defenses Helping HIV Flourish?
Research
Selected Grants
- Heterosubtypic immunity to influenza virus mediated by MHC-E-restricted memory NK cells awarded by National Institutes of Health 2021 - 2026
- Fine Mechanisms of Adaptive NK Cell Formation Against HIV and SIV awarded by National Institutes of Health 2021 - 2026
- NK cell mobilization as a pathogenic etiology of SARSCoV2 gastrointestinal disease awarded by National Institutes of Health 2021 - 2024
- Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid Follicles awarded by National Institutes of Health 2021 - 2023
- Next Generation Broadly Neutralizing Antibodies to Clear HIV-1 Reservoir awarded by University of Maryland, Baltimore 2021 - 2022
- Antigen-Specific NK Cell Memory Against SIV and HIV Vaccines awarded by National Institutes of Health 2021 - 2022
- Microbial and innate immune mechanisms of oral inflammation during SIV infection awarded by National Institutes of Health 2021 - 2022
- BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy awarded by Wistar Institute of Anatomy and Biology 2021 - 2022
- Natural killer cell receptor-expressing B cells as regulators of mucosal immunity in SIV infection awarded by National Institutes of Health 2021
External Relationships
- Mary Ann Liebert Publishing
- Qihan Bio
- Takeda Pharmaceutical Co. Ltd.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Sugawara, Sho, R Keith Reeves, and Stephanie Jost. “Learning to Be Elite: Lessons From HIV-1 Controllers and Animal Models on Trained Innate Immunity and Virus Suppression.” Front Immunol 13 (2022): 858383. https://doi.org/10.3389/fimmu.2022.858383.
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  - Jones, Rhianna, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Brady Hueber, Griffin Woolley, Spandan V. Shah, Scott Smith, Valerie Varner, and R Keith Reeves. “Systemic and mucosal mobilization of granulocyte subsets during lentiviral infection.” Immunology 164, no. 2 (October 2021): 348–57. https://doi.org/10.1111/imm.13376.
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  - Jones, Rhianna, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, et al. “Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.” Sci Rep 11, no. 1 (July 15, 2021): 14507. https://doi.org/10.1038/s41598-021-93918-x.
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  - Tan, C Sabrina, and R Keith Reeves. “HIV on the brain: is neurosignalling damage irreversible even on antiretroviral therapy?” Aids 35, no. 9 (July 15, 2021): 1503–4. https://doi.org/10.1097/QAD.0000000000002957.
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  - Jones, Rhianna, Cordelia Manickam, Daniel Ram, Kyle Kroll, Brady Hueber, Griffin Woolley, Spandan Shah, Scott Smith, Valerie Varner, and Keith Reeves. “Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection,” March 20, 2021. https://doi.org/10.1101/2021.03.19.436235.
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  - Huot, Nicolas, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, et al. “SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.” Nat Commun 12, no. 1 (February 24, 2021): 1282. https://doi.org/10.1038/s41467-021-21402-1.
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  - Sugawara, Sho, Cordelia Manickam, and R Keith Reeves. “TRIGGERED: could refocused cell signaling be key to natural killer cell-based HIV immunotherapeutics?” Aids 35, no. 2 (February 2, 2021): 165–76. https://doi.org/10.1097/QAD.0000000000002743.
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  - Jones, Rhianna, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan Shah, et al. “Probiotic Supplementation Reduces Inflammatory Profiles But Does Not Prevent Oral Immune Perturbations During SIV Infection,” December 18, 2020. https://doi.org/10.1101/2020.12.17.423321.
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  - Manickam, Cordelia, Sho Sugawara, and R Keith Reeves. “Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020.” Plos Pathog 16, no. 8 (August 2020): e1008820. https://doi.org/10.1371/journal.ppat.1008820.
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  - Ram, Daniel R., Christian F. Arias, Kyle Kroll, Brady Hueber, Cordelia Manickam, Rhianna A. Jones, Scott T. Smith, Spandan V. Shah, Valerie H. Varner, and R Keith Reeves. “Characterization of Rhesus Macaque Liver-Resident CD49a+ NK Cells During Retrovirus Infections.” Front Immunol 11 (2020): 1676. https://doi.org/10.3389/fimmu.2020.01676.
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  - Manickam, Cordelia, and R Keith Reeves. “Silent damage? Occult HCV replication and histological disease may occur following apparent HCV clearance.” Ebiomedicine 47 (September 2019): 12–13. https://doi.org/10.1016/j.ebiom.2019.08.029.
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  - Ghofrani, Joshua, Olivier Lucar, Haley Dugan, R Keith Reeves, and Stephanie Jost. “Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.” Eur J Immunol 49, no. 8 (August 2019): 1153–66. https://doi.org/10.1002/eji.201847931.
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  - Ram, Daniel R., Cordelia Manickam, Olivier Lucar, Spandan V. Shah, and R Keith Reeves. “Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?” J Leukoc Biol 105, no. 6 (June 2019): 1253–59. https://doi.org/10.1002/JLB.MR0718-303R.
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  - Manickam, Cordelia, Haiying Li, Spandan V. Shah, Kyle Kroll, and R Keith Reeves. “Non-linear multidimensional flow cytometry analyses delineate NK cell phenotypes in normal and HIV-infected chimpanzees.” Int Immunol 31, no. 3 (March 5, 2019): 175–80. https://doi.org/10.1093/intimm/dxy076.
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  - Manickam, Cordelia, Spandan V. Shah, Junsuke Nohara, Guido Ferrari, and R Keith Reeves. “Monkeying Around: Using Non-human Primate Models to Study NK Cell Biology in HIV Infections.” Front Immunol 10 (2019): 1124. https://doi.org/10.3389/fimmu.2019.01124.
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  - Shah, Spandan V., Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, and R Keith Reeves. “CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.” Cell Rep 25, no. 10 (December 4, 2018): 2766-2774.e3. https://doi.org/10.1016/j.celrep.2018.11.020.
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  - Ram, Daniel R., Kyle Kroll, and R Keith Reeves. “Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes.” J Med Primatol 47, no. 5 (October 2018): 302–4. https://doi.org/10.1111/jmp.12371.
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  - Manickam, Cordelia, Chiadika Nwanze, Daniel R. Ram, Spandan V. Shah, Scott Smith, Rhianna Jones, Brady Hueber, et al. “Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract.” Aids 32, no. 12 (July 31, 2018): 1571–78. https://doi.org/10.1097/QAD.0000000000001855.
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  - Chettimada, Sukrutha, David R. Lorenz, Vikas Misra, Simon T. Dillon, R Keith Reeves, Cordelia Manickam, Susan Morgello, Gregory D. Kirk, Shruti H. Mehta, and Dana Gabuzda. “Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy.” Sci Rep 8, no. 1 (May 8, 2018): 7227. https://doi.org/10.1038/s41598-018-25515-4.
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  - Ram, Daniel R., Cordelia Manickam, Brady Hueber, Hannah L. Itell, Sallie R. Permar, Valerie Varner, and R Keith Reeves. “Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques.” Plos Pathog 14, no. 5 (May 2018): e1007104. https://doi.org/10.1371/journal.ppat.1007104.
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  - Manickam, Cordelia, Spandan V. Shah, Olivier Lucar, Daniel R. Ram, and R Keith Reeves. “Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections.” Front Immunol 9 (2018): 2862. https://doi.org/10.3389/fimmu.2018.02862.
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  - Manickam, Cordelia, Amanda J. Martinot, Rhianna A. Jones, Valerie Varner, and R Keith Reeves. “Hepatic immunopathology during occult hepacivirus re-infection.” Virology 512 (December 2017): 48–55. https://doi.org/10.1016/j.virol.2017.08.037.
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  - Manickam, Cordelia, Lynn Wachtman, Amanda J. Martinot, Luis D. Giavedoni, and R Keith Reeves. “Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus).” Plos One 12, no. 1 (2017): e0170240. https://doi.org/10.1371/journal.pone.0170240.
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  - Shah, Spandan V., Cordelia Manickam, Daniel R. Ram, and R Keith Reeves. “Innate Lymphoid Cells in HIV/SIV Infections.” Front Immunol 8 (2017): 1818. https://doi.org/10.3389/fimmu.2017.01818.
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  - Manickam, Cordelia, Premeela Rajakumar, Lynn Wachtman, Joshua A. Kramer, Amanda J. Martinot, Valerie Varner, Luis D. Giavedoni, and R Keith Reeves. “Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection.” J Virol 90, no. 20 (October 15, 2016): 9153–62. https://doi.org/10.1128/JVI.01051-16.
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  - Reeves, R Keith, Haiying Li, Stephanie Jost, Eryn Blass, Hualin Li, Jamie L. Schafer, Valerie Varner, et al. “Antigen-specific NK cell memory in rhesus macaques.” Nat Immunol 16, no. 9 (September 2015): 927–32. https://doi.org/10.1038/ni.3227.
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- Preprints
  - Huot, Nicolas, Cyril Planchais, Vanessa Contreras, Beatrice Jacquelin, Caroline Petitdemange, Marie Lazzerini, Pierre Rosenbaum, et al. “Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection.,” April 25, 2022. https://doi.org/10.21203/rs.3.rs-1561222/v1.
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  - Kroll, Kyle, Spandan Shah, Olivier Lucar, Thomas Premeaux, Cecilia Shikuma, Michael Corley, Matthew Mosher, Scott Bowler, Lishomwa Ndhlovu, and Keith Reeves. “Disruption of natural killer cell homing as a biomarker in persons aging with or without HIV.” BioRxiv, January 6, 2022. https://doi.org/10.1101/2022.01.05.475089.
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Education, Training, & Certifications

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles

Preprints