Roger Keith Reeves
Professor in Surgery
Formerly of Harvard Medical School and Beth Israel Deaconess Medical Center, Dr. R. Keith Reeves is currently tenured Professor of Surgery at Duke University, as well as Director of the Division of Innate and Comparative Immunology and Head of Innovation Partnerships in the Center for Human Systems Immunology. He is also currently the Director of the Duke CFAR Developmental Core and Editor-in-Chief of AIDS Research and Human Retroviruses. Over his academic career he has published extensively in the field of NK cell biology, providing some of the most comprehensive analyses of NK cells and innate lymphoid cells, including the first characterization of memory NK cells in any primate species. Dr. Reeves’ research has been supported by NIH for over a decade by individual and consortia grants, and in addition to independent work, he collaborates as part of the HIV Vaccine Trials Network (HVTN) and the BEAT-HIV Martin Delaney HIV Cure Collaboratory. Dr. Reeves has also served on multiple standing NIH study sections (HIV Immunopathogenesis and Vaccine Development), as well as on standing and ad hoc grant review committees for amfAR, the United States-Israel Binational Science Foundation, the UK Medical Research Council and California Institute of Regenerative Medicine, among others. Considered a global expert in NK cell biology, Dr. Reeves’ group continues to focus on cutting edge approaches to harness NK cells in the context of vaccines and antiviral therapeutics for HIV, CMV, HCV, influenza and SARSCoV2.
Current Appointments & Affiliations
- Professor in Surgery, Surgery, Surgical Sciences, Surgery 2021
- Professor of Pathology, Pathology, Clinical Science Departments 2022
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., University of Alabama Birmingham 2007
- B.S., Mississippi State University 2002
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Leadership & Clinical Positions at Duke
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Director, Division of Innate and Comparative Immunology 2021 - present
Director, Duke Center for AIDS Research Developmental Core 2021 - present
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Director, Division of Innate and Comparative Immunology 2021 - present
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Academic Positions Outside Duke
- Adjunct Faculty, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center. 2021 - 2030
- Associate Professor of Medicine, Harvard Medical School. 2017 - 2021
- Recognition
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In the News
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FEB 11, 2022 -
SEP 23, 2021 -
FEB 23, 2021 The New York Times -
AUG 31, 2020 The Atlantic -
APR 9, 2020 Endpoints News -
OCT 16, 2015 amfAR, The Foundation for AIDS Research -
JUL 15, 2015 amfAR, The Foundation for AIDS Research
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- Research
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Selected Grants
- SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens awarded by National Institutes of Health 2022 - 2027
- Heterosubtypic immunity to influenza virus mediated by MHC-E-restricted memory NK cells awarded by National Institutes of Health 2021 - 2026
- Fine Mechanisms of Adaptive NK Cell Formation Against HIV and SIV awarded by National Institutes of Health 2021 - 2026
- Role of eosinophils in SIV infection awarded by National Institutes of Health 2022 - 2024
- NK cell mobilization as a pathogenic etiology of SARSCoV2 gastrointestinal disease awarded by National Institutes of Health 2021 - 2024
- Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid Follicles awarded by National Institutes of Health 2021 - 2023
- BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy awarded by Wistar Institute of Anatomy and Biology 2021 - 2023
- Role of maternal-fetal interface NK cells in pregnancy maintenance and congenital CMV transmission awarded by Weill Cornell Medicine 2022 - 2023
- Natural killer cell receptor-expressing B cells as regulators of mucosal immunity in SIV infection awarded by National Institutes of Health 2021 - 2022
- Next Generation Broadly Neutralizing Antibodies to Clear HIV-1 Reservoir awarded by University of Maryland, Baltimore 2021 - 2022
- Antigen-Specific NK Cell Memory Against SIV and HIV Vaccines awarded by National Institutes of Health 2021 - 2022
- Microbial and innate immune mechanisms of oral inflammation during SIV infection awarded by National Institutes of Health 2021 - 2022
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External Relationships
- Mary Ann Liebert Publishing
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kroll, Kyle, and R Keith Reeves. “Protocol for identification and computational analysis of human natural killer cells using flow cytometry and R (Accepted).” Star Protocols 4, no. 1 (March 2023): 102044–102044. https://doi.org/10.1016/j.xpro.2023.102044.Full Text
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Cooper, Amanda, Adam Sidaway, Abishek Chandrashekar, Elizabeth Latta, Krishnendu Chakraborty, Jingyou Yu, Katherine McMahan, et al. “A genetically engineered, stem-cell-derived cellular vaccine.” Cell Rep Med 3, no. 12 (December 20, 2022): 100843. https://doi.org/10.1016/j.xcrm.2022.100843.Full Text Open Access Copy Link to Item
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Woolley, Griffin, Matthew Mosher, Kyle Kroll, Rhianna Jones, Brady Hueber, Sho Sugawara, Cordelia Manickam, et al. “Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events.” J Virol, December 13, 2022, e0151922. https://doi.org/10.1128/jvi.01519-22.Full Text Link to Item
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Kroll, Kyle W., Spandan V. Shah, Olivier A. Lucar, Thomas A. Premeaux, Cecilia M. Shikuma, Michael J. Corley, Matthew Mosher, et al. “Mucosal-homing natural killer cells are associated with aging in persons living with HIV.” Cell Rep Med 3, no. 10 (October 18, 2022): 100773. https://doi.org/10.1016/j.xcrm.2022.100773.Full Text Link to Item
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Le, Toby, Roger Keith Reeves, and Lyle Robert McKinnon. “The functional diversity of tissue-resident natural killer cells against infection.” Immunology 167, no. 1 (September 2022): 28–39. https://doi.org/10.1111/imm.13523.Full Text Link to Item
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Sugawara, Sho, R Keith Reeves, and Stephanie Jost. “Learning to Be Elite: Lessons From HIV-1 Controllers and Animal Models on Trained Innate Immunity and Virus Suppression.” Front Immunol 13 (2022): 858383. https://doi.org/10.3389/fimmu.2022.858383.Full Text Link to Item
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Gopalakrishnan, Raja Mohan, Malika Aid, Noe B. Mercado, Caitlin Davis, Shaily Malik, Emma Geiger, Valerie Varner, et al. “Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection.” Jci Insight 6, no. 20 (October 22, 2021). https://doi.org/10.1172/jci.insight.152013.Full Text Link to Item
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Jones, Rhianna, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Brady Hueber, Griffin Woolley, Spandan V. Shah, Scott Smith, Valerie Varner, and R Keith Reeves. “Systemic and mucosal mobilization of granulocyte subsets during lentiviral infection.” Immunology 164, no. 2 (October 2021): 348–57. https://doi.org/10.1111/imm.13376.Full Text Link to Item
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Jones, Rhianna, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, et al. “Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.” Sci Rep 11, no. 1 (July 15, 2021): 14507. https://doi.org/10.1038/s41598-021-93918-x.Full Text Link to Item
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Tan, C Sabrina, and R Keith Reeves. “HIV on the brain: is neurosignalling damage irreversible even on antiretroviral therapy?” Aids 35, no. 9 (July 15, 2021): 1503–4. https://doi.org/10.1097/QAD.0000000000002957.Full Text Link to Item
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Huot, Nicolas, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, et al. “SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.” Nat Commun 12, no. 1 (February 24, 2021): 1282. https://doi.org/10.1038/s41467-021-21402-1.Full Text Open Access Copy Link to Item
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Sugawara, Sho, Cordelia Manickam, and R Keith Reeves. “TRIGGERED: could refocused cell signaling be key to natural killer cell-based HIV immunotherapeutics?” Aids 35, no. 2 (February 2, 2021): 165–76. https://doi.org/10.1097/QAD.0000000000002743.Full Text Link to Item
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Mercado, Noe B., Roland Zahn, Frank Wegmann, Carolin Loos, Abishek Chandrashekar, Jingyou Yu, Jinyan Liu, et al. “Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.” Nature 590, no. 7844 (February 2021): E25. https://doi.org/10.1038/s41586-020-03100-y.Full Text Link to Item
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Jones, Rhianna, Cordelia Manickam, Daniel Ram, Kyle Kroll, Brady Hueber, Griffin Woolley, Spandan Shah, Scott Smith, Valerie Varner, and Keith Reeves. “Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection,” 2021. https://doi.org/10.1101/2021.03.19.436235.Full Text
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Ram, Daniel R., Kyle Kroll, and R Keith Reeves. “Skipped Over: Tuning Natural Killer Cells Toward HIV Through Alternative Splicing.” Aids Res Hum Retroviruses 36, no. 12 (December 2020): 969–72. https://doi.org/10.1089/AID.2020.0116.Full Text Link to Item
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Manickam, Cordelia, Sho Sugawara, and R Keith Reeves. “Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020.” Plos Pathog 16, no. 8 (August 2020): e1008820. https://doi.org/10.1371/journal.ppat.1008820.Full Text Link to Item
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Hueber, Brady, Alan D. Curtis, Kyle Kroll, Valerie Varner, Rhianna Jones, Sachi Pathak, Michelle Lifton, Koen K. A. Van Rompay, Kristina De Paris, and R Keith Reeves. “Functional Perturbation of Mucosal Group 3 Innate Lymphoid and Natural Killer Cells in Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus-Infected Infant Rhesus Macaques.” J Virol 94, no. 5 (February 14, 2020). https://doi.org/10.1128/JVI.01644-19.Full Text Link to Item
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Jones, Rhianna, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan Shah, et al. “Probiotic Supplementation Reduces Inflammatory Profiles But Does Not Prevent Oral Immune Perturbations During SIV Infection,” 2020. https://doi.org/10.1101/2020.12.17.423321.Full Text
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Ram, Daniel R., Christian F. Arias, Kyle Kroll, Brady Hueber, Cordelia Manickam, Rhianna A. Jones, Scott T. Smith, Spandan V. Shah, Valerie H. Varner, and R Keith Reeves. “Characterization of Rhesus Macaque Liver-Resident CD49a+ NK Cells During Retrovirus Infections.” Front Immunol 11 (2020): 1676. https://doi.org/10.3389/fimmu.2020.01676.Full Text Link to Item
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Manickam, Cordelia, and R Keith Reeves. “Silent damage? Occult HCV replication and histological disease may occur following apparent HCV clearance.” Ebiomedicine 47 (September 2019): 12–13. https://doi.org/10.1016/j.ebiom.2019.08.029.Full Text Link to Item
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Ram, Daniel R., Olivier Lucar, Brady Hueber, and R Keith Reeves. “Simian Immunodeficiency Virus Infection Modulates CD94+ (KLRD1+) NK Cells in Rhesus Macaques.” J Virol 93, no. 16 (August 15, 2019). https://doi.org/10.1128/JVI.00731-19.Full Text Link to Item
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Ghofrani, Joshua, Olivier Lucar, Haley Dugan, R Keith Reeves, and Stephanie Jost. “Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.” Eur J Immunol 49, no. 8 (August 2019): 1153–66. https://doi.org/10.1002/eji.201847931.Full Text Link to Item
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Ram, Daniel R., Cordelia Manickam, Olivier Lucar, Spandan V. Shah, and R Keith Reeves. “Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?” J Leukoc Biol 105, no. 6 (June 2019): 1253–59. https://doi.org/10.1002/JLB.MR0718-303R.Full Text Link to Item
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Manickam, Cordelia, Haiying Li, Spandan V. Shah, Kyle Kroll, and R Keith Reeves. “Non-linear multidimensional flow cytometry analyses delineate NK cell phenotypes in normal and HIV-infected chimpanzees.” Int Immunol 31, no. 3 (March 5, 2019): 175–80. https://doi.org/10.1093/intimm/dxy076.Full Text Link to Item
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Lewis, George K., Margaret E. Ackerman, Gabriella Scarlatti, Christiane Moog, Marjorie Robert-Guroff, Stephen J. Kent, Julie Overbaugh, R Keith Reeves, Guido Ferrari, and Bargavi Thyagarajan. “Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1.” Front Immunol 10 (2019): 1025. https://doi.org/10.3389/fimmu.2019.01025.Full Text Link to Item
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Manickam, Cordelia, Spandan V. Shah, Junsuke Nohara, Guido Ferrari, and R Keith Reeves. “Monkeying Around: Using Non-human Primate Models to Study NK Cell Biology in HIV Infections.” Front Immunol 10 (2019): 1124. https://doi.org/10.3389/fimmu.2019.01124.Full Text Link to Item
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Shah, Spandan V., Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, and R Keith Reeves. “CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.” Cell Rep 25, no. 10 (December 4, 2018): 2766-2774.e3. https://doi.org/10.1016/j.celrep.2018.11.020.Full Text Link to Item
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Ram, Daniel R., Kyle Kroll, and R Keith Reeves. “Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes.” J Med Primatol 47, no. 5 (October 2018): 302–4. https://doi.org/10.1111/jmp.12371.Full Text Link to Item
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Manickam, Cordelia, Chiadika Nwanze, Daniel R. Ram, Spandan V. Shah, Scott Smith, Rhianna Jones, Brady Hueber, et al. “Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract.” Aids 32, no. 12 (July 31, 2018): 1571–78. https://doi.org/10.1097/QAD.0000000000001855.Full Text Link to Item
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Chettimada, Sukrutha, David R. Lorenz, Vikas Misra, Simon T. Dillon, R Keith Reeves, Cordelia Manickam, Susan Morgello, Gregory D. Kirk, Shruti H. Mehta, and Dana Gabuzda. “Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy.” Sci Rep 8, no. 1 (May 8, 2018): 7227. https://doi.org/10.1038/s41598-018-25515-4.Full Text Link to Item
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Ram, Daniel R., Cordelia Manickam, Brady Hueber, Hannah L. Itell, Sallie R. Permar, Valerie Varner, and R Keith Reeves. “Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques.” Plos Pathog 14, no. 5 (May 2018): e1007104. https://doi.org/10.1371/journal.ppat.1007104.Full Text Link to Item
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Manickam, Cordelia, Spandan V. Shah, Olivier Lucar, Daniel R. Ram, and R Keith Reeves. “Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections.” Front Immunol 9 (2018): 2862. https://doi.org/10.3389/fimmu.2018.02862.Full Text Link to Item
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Manickam, Cordelia, Amanda J. Martinot, Rhianna A. Jones, Valerie Varner, and R Keith Reeves. “Hepatic immunopathology during occult hepacivirus re-infection.” Virology 512 (December 2017): 48–55. https://doi.org/10.1016/j.virol.2017.08.037.Full Text Link to Item
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Manickam, Cordelia, Lynn Wachtman, Amanda J. Martinot, Luis D. Giavedoni, and R Keith Reeves. “Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus).” Plos One 12, no. 1 (2017): e0170240. https://doi.org/10.1371/journal.pone.0170240.Full Text Link to Item
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Shah, Spandan V., Cordelia Manickam, Daniel R. Ram, and R Keith Reeves. “Innate Lymphoid Cells in HIV/SIV Infections.” Front Immunol 8 (2017): 1818. https://doi.org/10.3389/fimmu.2017.01818.Full Text Link to Item
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Manickam, Cordelia, Premeela Rajakumar, Lynn Wachtman, Joshua A. Kramer, Amanda J. Martinot, Valerie Varner, Luis D. Giavedoni, and R Keith Reeves. “Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection.” J Virol 90, no. 20 (October 15, 2016): 9153–62. https://doi.org/10.1128/JVI.01051-16.Full Text Link to Item
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Reeves, R Keith, Haiying Li, Stephanie Jost, Eryn Blass, Hualin Li, Jamie L. Schafer, Valerie Varner, et al. “Antigen-specific NK cell memory in rhesus macaques.” Nat Immunol 16, no. 9 (September 2015): 927–32. https://doi.org/10.1038/ni.3227.Full Text Link to Item
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Schafer, Jamie L., Haiying Li, Tristan I. Evans, Jacob D. Estes, and R Keith Reeves. “Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-Infected Lymph Nodes Associated with In Situ Differentiation and Functional Anergy.” J Virol 89, no. 13 (July 2015): 6887–94. https://doi.org/10.1128/JVI.00660-15.Full Text Link to Item
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Conference Papers
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Manickam, Cordelia, Kyle Kroll, Rhianna Jones, and Roger Reeves. “Single cell based high-throughput Ig and TCR repertoire sequencing analysis in rhesus macaques.” In Journal of Medical Primatology, 51:292–93, 2022.Link to Item
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Manickam, Cordelia, Kyle Kroll, Rhianna Jones, and Roger Reeves. “Multiplex imaging and analysis of novel natural killer-like B cells in non-human primates.” In Journal of Medical Primatology, 51:292–292, 2022.Link to Item
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Spreng, Rachel, Marina Tuyishime, Brady Hueber, Junsuke Nohara, Derrick Goodman, Cliburn Chan, R Whitney Edwards, et al. “Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among Rhesus macaques.” In Journal of Medical Primatology, 51:312–312, 2022.Link to Item
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Preprints
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Huot, Nicolas, Cyril Planchais, Vanessa Contreras, Beatrice Jacquelin, Caroline Petitdemange, Marie Lazzerini, Pierre Rosenbaum, et al. “Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection.,” April 25, 2022. https://doi.org/10.21203/rs.3.rs-1561222/v1.Full Text Link to Item
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Kroll, Kyle, Spandan Shah, Olivier Lucar, Thomas Premeaux, Cecilia Shikuma, Michael Corley, Matthew Mosher, Scott Bowler, Lishomwa Ndhlovu, and Keith Reeves. “Disruption of natural killer cell homing as a biomarker in persons aging with or without HIV.” BioRxiv, 2022. https://doi.org/10.1101/2022.01.05.475089.Full Text
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