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Roger Keith Reeves

Professor in Surgery
Surgery, Surgical Sciences

Overview


Dr. Reeves obtained his Ph.D. at the University of Alabama-Birmingham studying dendritic cell biology in lentivirus infections, then completed his postdoctoral training in lentivirus vaccinology, natural killer cells, and innate immunity at the New England Primate Research Center, Massachusetts General Hospital, and Harvard Medical School (HMS). He later became faculty at HMS and Beth Israel Deaconess Medical Center through the rank of Associate Professor. Upon being recruited to Duke University in 2021, Dr. Reeves became a tenured Professor in the Department of Surgery and the Department of Pathology and Director in the Duke Center for Human Systems Immunology. He currently serves as Editor-in-Chief of the journal AIDS Research and Human Retroviruses and is the immediate past chair of the NIH HIV Immunopathogenesis and Vaccine Development study section.  Dr. Reeves also previously sat on NIH F13 fellowship study sections, has served on the HVTN ESI Advisory board for over a decade, and currently is Director of the Duke Center for AIDS Research Developmental Core, collectively mentoring dozens of trainees at all levels. Dr. Reeves’ research has been continuously supported by NIH for well over 15 years, having served as PI on multiple R and P grants  in addition to participating in consortia grants such as the HIV Vaccine Trials Network and BEAT-HIV Delaney Cure Collaboratory. Considered a global expert in natural killer cell biology, his research has provided some of the most detailed characterizations of NK cell responses against viruses, and his team was the first to identify memory and memory-like NK cells in humans and nonhuman primates. With over 100 publications in the field and over 60 as senior author, Dr. Reeves’ group continues to focus on cutting-edge approaches to harness NK cells in the context of vaccines and immunotherapeutics for HIV, CMV, HCV, influenza, SARS-CoV-2, congenital CMV, and cancer.

Current Duke Appointments & Affiliations


Professor in Surgery · 2021 - Present Surgery, Surgical Sciences, Surgery
Director, Center for Human Systems Immunology in Innovation and Comparative Immunobiology · 2021 - Present Surgery, Surgical Sciences, Surgery
Vice Chair of Basic and Translational Research in the Department of Surgery · 2026 - Present Surgery, Clinical Science Departments
Professor of Pathology · 2022 - Present Pathology, Clinical Science Departments
Member of the Duke Human Vaccine Institute · 2023 - Present Duke Human Vaccine Institute, Institutes and Centers
Member of the Duke Cancer Institute · 2025 - Present Duke Cancer Institute, Institutes and Centers

Recent News Items


Published August 10, 2026
Why Is This Fungal STI Going Underdiagnosed?
Published August 9, 2026
International experts discuss emerging infectious disease threats at SRMIST
Published October 30, 2025
Duke Receives $4.5 Million from The Duke Endowment to Fund Initiative Focused on Climate and Health

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Recent Scholarly Works


Iterative multiplex imaging cytometry for cross-species analyses of in situ tissue leukocytes.

Journal article J Immunol Methods · September 2026 Traditional immunohistochemistry techniques are limited in the number of fluorescent detection channels, markers, and staining resolution, which restricts the ability to fully evaluate bulk tissue samples and biopsies. Recent technical advancements, such a ... Full text Link to item Cite

CD49a expression defines a metabolically robust, cytokine-biased liver NK cell subset in rhesus macaques during lentivirus infection.

Journal article Immunol Cell Biol · August 2026 Liver-resident natural killer (LrNK) cells are critical regulators of hepatic immune homeostasis and demonstrate antiviral activity, yet their role in lentivirus infections remains poorly defined. Using a rhesus macaque (RM) model of Simian immunodeficienc ... Full text Link to item Cite
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Recent Grants


Vaccines and Biologics Against Infectious Diseases - T32

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031

Antigen-specific MHC-E-mediated NK-cell targeting of the HIV/SIV reservoir

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031

Neutralizing and FcR-mediating antibody specificities and function in control of HHV-8 infection

ResearchMentor · Awarded by National Institutes of Health · 2026 - 2031

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Education


University of Alabama, Birmingham · 2007 Ph.D.
Mississippi State University · 2002 B.S.