Kevin William Southerland

Journal Article Ann Vasc Surg · December 2025 BACKGROUND: The Hemodialysis Reliable Outflow (HeRO) graft combines an arteriovenous graft with a central venous stent, allowing for hemodialysis access in patients with end-stage renal disease limited by central venous stenosis. The impact of anticoagulat ... Full text Link to item Cite

Incidence and risk factors for Hemodialysis Reliable Outflow bypass graft infection.

Journal Article J Vasc Surg · December 2025 BACKGROUND: Hemodialysis Reliable Outflow (HeRO) graft implantation is performed as a last resort option for hemodialysis access in patients limited by central venous stenosis or occlusion. In this single-center series, we examined the incidence, risk fact ... Full text Link to item Cite

Leveraging the Transfer Center to Improve Access to Vascular Surgical Care at a Tertiary Academic Medical Center.

Journal Article Ann Vasc Surg · October 15, 2025 BACKGROUND: Vascular surgeons are essential to maintaining a safe operating room environment for all surgical specialties, in addition to managing primary vascular diseases. The value of the vascular surgery service line within a health-care system has bee ... Full text Link to item Cite

Perioperative and long-term outcomes after Hemodialysis Reliable Outflow (HeRO) graft surgery.

Journal Article J Vasc Surg · October 2025 OBJECTIVE: The Hemodialysis Reliable Outflow (HeRO) graft offers hemodialysis access options for patients who have developed central venous stenosis or occlusion. In this single-center study, we report our perioperative and long-term outcomes after HeRO gr ... Full text Link to item Cite

Implementation of an acute care vascular surgery "Surgeon of the Week" model improves efficiency of inpatient care delivery.

Journal Article J Vasc Surg · October 2025 OBJECTIVE: Acute care vascular surgery (ACVS) comprises a significant proportion of modern vascular surgery practice. Given the burden of ACVS at our institution, we have transitioned from a traditional "on call" model to a "Surgeon of the Week" (SOW) mode ... Full text Link to item Cite

A rare case of hemorrhage from spontaneous disconnection of super-HeRO adapter and early-cannulation graft: A case report.

Journal Article J Vasc Access · March 23, 2025 To overcome the limitations of central venous occlusion or stenosis (CVO) in complex chronic hemodialysis patients, the Hemodialysis Reliable Outflow (HeRO) vascular access graft was created as an alternative means of vascular access that bypasses the CVO ... Full text Link to item Cite

Effectiveness of Negative Pressure Wound Therapy on Groin Surgical Site Infection After Lower Extremity Bypass for Chronic Limb-Threatening Ischemia.

Journal Article Ann Vasc Surg · February 2025 BACKGROUND: Surgical site infections (SSIs) are a common cause of patient morbidity, hospital readmission, and reoperation after lower extremity bypass (LEBs) surgery for chronic limb-threatening ischemia (CLTI). Recent studies on the use of incisional neg ... Full text Link to item Cite

Characterizing Early-Onset Surgical Site Infection After Lower Extremity Bypass Surgery.

Journal Article Ann Vasc Surg · February 2025 BACKGROUND: Surgical site infections (SSI) are the most common complication following lower extremity bypass (LEB) surgery. SSIs contribute to significant patient morbidity and healthcare expenditure, and accurate detection of SSIs remains an important ste ... Full text Link to item Cite

Bioengineered Human Arteries for the Repair of Vascular Injuries.

Journal Article JAMA Surg · February 1, 2025 IMPORTANCE: Vascular injuries require urgent repair to minimize loss of limb and life. Standard revascularization relies on autologous vein or synthetic grafts, but alternative options are needed when adequate vein is not feasible and when clinical conditi ... Full text Link to item Cite

Postoperative Bleeding Complications are Common among Patients Undergoing Transcarotid Artery Revascularization.

Journal Article Ann Vasc Surg · January 2025 BACKGROUND: Current practice guidelines recommend dual antiplatelet therapy for at least 30 days postoperatively after transcarotid artery revascularization (TCAR) to promote stent patency. However, many patients are already taking other antithrombotic med ... Full text Link to item Cite

Understanding the Scope of Acute Care Vascular Surgery at a Tertiary Academic Medical System.

Journal Article Ann Vasc Surg · January 2025 BACKGROUND: The restructuring of nonelective general surgery and nationwide implementation of the acute care surgery paradigm has improved patient outcomes and healthcare resource utilization. Although vascular surgery maintains one of the highest acuity r ... Full text Link to item Cite

The current status of aortic training among vascular surgery trainees in the United States

Journal Article Jvs Vascular Insights · January 1, 2025 Background: The recent advent of endovascular aneurysm repair has shifted the landscape of abdominal aortic aneurysm treatment from an open to a primarily endovascular approach. Previous studies have reported a decline in open abdominal aortic aneurysm rep ... Full text Cite

Vascular adhesion molecule 1+ fibro-adipogenic progenitors mark fatty infiltration in chronic limb-threatening ischemia.

Journal Article JVS Vasc Sci · 2025 BACKGROUND: Skeletal muscle health and function are critical determinants of clinical outcomes in peripheral arterial disease. Chronic limb-threatening ischemia (CLTI), the most severe clinical manifestation of peripheral arterial disease, is associated wi ... Full text Link to item Cite

Impact of Wound Closure Technique on Surgical Site Infection After Lower Extremity Bypass Surgery.

Journal Article Ann Vasc Surg · December 2024 BACKGROUND: Surgical site infections (SSIs) are among the most common complications after lower extremity bypass (LEB). Both patient and hospital-related factors have been associated with SSI after LEB; however, the impact of surgical closure technique on ... Full text Link to item Cite

Prophylactic Sartorius Flap Reconstruction Is Associated With Reduced Vascular Graft Infection.

Journal Article J Surg Res · December 2024 INTRODUCTION: Complications in the femoral area following vascular surgery are frequent and linked to considerable morbidity, including the risk of underlying graft infection. Sartorius muscle flaps are an important adjunct for the treatment of wound compl ... Full text Link to item Cite

Role of long noncoding RNAs in diabetes-associated peripheral arterial disease.

Journal Article Cardiovasc Diabetol · July 24, 2024 Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial disease (PAD). Various types of cells, including but not limited to endothelial cells (ECs), vascular smooth muscle cells ( ... Full text Link to item Cite

Surgical outcomes of patients with inferior vena cava leiomyosarcoma.

Journal Article J Vasc Surg Venous Lymphat Disord · July 2024 INTRODUCTION: Primary vascular leiomyosarcomas are incredibly rare and have a poor prognosis. The purpose of this study was to analyze the surgical outcomes of patients with primary inferior vena cava (IVC) leiomyosarcoma. METHODS: We performed a retrospec ... Full text Link to item Cite

Leveraging Computational Fluid Dynamics for Next-Generation Preoperative Planning in Vascular Surgery.

Conference Annu Int Conf IEEE Eng Med Biol Soc · July 2024 Chronic limb-threatening ischemia (CLTI) is one of the leading causes of permanent disability and death in the United States and around the world. Surgical revascularization is the mainstay of treatment for CLTI, but patients still suffer high rates of lim ... Full text Link to item Cite

Feasibility and Intermediate Results of Transcarotid Revascularization with a Prosthetic Conduit.

Conference Ann Vasc Surg · June 2024 BACKGROUND: Transcarotid artery revascularization (TCAR) is a hybrid technique with excellent initial outcomes. The technical success and safety of TCAR is heavily dependent on an anatomically suitable common carotid artery (CCA). Many patients do not meet ... Full text Link to item Cite

Risk factors and consequences of wound complications following sartorius flap reconstruction.

Journal Article J Vasc Surg · February 2024 OBJECTIVE: Groin wound complications are common following vascular surgery and can lead to significant patient morbidity. Sartorius muscle flap coverage may help to prevent vascular graft infection in the setting of wound dehiscence or infection. However, ... Full text Link to item Cite

Current Status and Principles for the Treatment and Prevention of Diabetic Foot Ulcers in the Cardiovascular Patient Population: A Scientific Statement From the American Heart Association.

Journal Article Circulation · January 23, 2024 Despite the known higher risk of cardiovascular disease in individuals with type 2 diabetes, the pathophysiology and optimal management of diabetic foot ulcers (DFUs), a leading complication associated with diabetes, is complex and continues to evolve. Com ... Full text Link to item Cite

Failure-to-Salvage After Femoropopliteal Bypass Surgery is Associated With Nonmodifiable Risk Factors.

Journal Article J Surg Res · January 2024 INTRODUCTION: Bypass graft failure and major amputation are among the worst complications after femoropopliteal bypass surgery. In this large multicenter analysis, we examined our incidence and risk factors for failure-to-salvage (FTS) following either byp ... Full text Link to item Cite

Prosthetic Conduit Use Does Not Adversely Impact Outcomes after Open Repair of Popliteal Artery Aneurysms.

Journal Article Ann Vasc Surg · January 2024 BACKGROUND: Single segment, greater saphenous vein (GSV) conduit is considered the optimal bypass conduit among patients undergoing bypass surgery for peripheral artery disease (PAD). While this data has been extrapolated to patients undergoing bypass for ... Full text Link to item Cite

First experience of evaluation of the impact of high-matrix size reconstruction in image quality in arterial CT runoff studies of the lower extremities.

Journal Article Eur Radiol · December 2023 OBJECTIVES: To determine whether image reconstruction with a higher matrix size improves image quality for lower extremity CTA studies. METHODS: Raw data from 50 consecutive lower extremity CTA studies acquired on two MDCT scanners (SOMATOM Flash, Force) i ... Full text Link to item Cite

A national analysis of vascular surgery resident operative experience in peripheral artery disease.

Journal Article J Vasc Surg · December 2023 BACKGROUND: Endovascular and hybrid interventions have played an increasingly prominent role in the treatment of peripheral arterial disease (PAD) in the past decade. This shift has prompted concerns about the adequacy of open surgical training for current ... Full text Link to item Cite

Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells.

Journal Article Genome Med · November 10, 2023 BACKGROUND: Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral arterial disease (PAD), is associated with a 1-year limb amputation rate of approximately 15-20% and substantial mortality. A key feature of CLTI is the compromised ... Full text Link to item Cite

Preoperative Anemia is Associated with Poorer Postoperative Outcomes in Patients Undergoing Infrainguinal Bypass Surgery.

Journal Article Ann Vasc Surg · November 2023 BACKGROUND: Preoperative anemia is an important, modifiable risk factor among surgical patients. However, data are scarce on the impact of preoperative anemia on postoperative outcomes after infrainguinal bypass. METHODS: In this multi-institutional analys ... Full text Link to item Cite

Sex-based differences in outcomes after lower extremity bypass for chronic limb-threatening ischemia.

Journal Article Atherosclerosis · November 2023 BACKGROUND AND AIMS: Lower extremity bypass surgery is an effective treatment option for patients with chronic limb-threatening ischemia (CLTI). Recent studies have suggested that sex-based differences may impact patient outcomes following lower extremity ... Full text Link to item Cite

The Opportunity for Impactful Integration of Vascular and Podiatric Care.

Journal Article J Clin Med · September 27, 2023 BACKGROUND: The importance of collaboration between vascular and podiatric surgeons has been well-established. High-level partnerships are integral to the development of multidisciplinary programs and wound care centers, ultimately resulting in improved pa ... Full text Link to item Cite

Hemodialysis Reliable Outflow (HeRO) graft creation in upper extremities abandoned due to stent obstruction via recanalization and HeRO outflow component insertion across stent interstices.

Journal Article J Vasc Access · September 2023 BACKGROUND: The purpose of this study was to assess the feasibility and outcomes of recanalization and subsequent HeRO graft outflow component insertion across stent interstices in patients with an otherwise abandoned upper extremity. METHODS: Over a 10-ye ... Full text Link to item Cite

A minimally invasive approach for management of pancreaticoduodenal artery and gastroduodenal artery aneurysm with celiac artery occlusion.

Journal Article J Vasc Surg Cases Innov Tech · September 2023 Management of pancreaticoduodenal artery aneurysms (PDAAs) and gastroduodenal artery aneurysms (GDAAs) with concomitant celiac occlusion represents a challenging clinical scenario. Here, we describe a 62-year-old female with PDAA and GDAA complicated by ce ... Full text Link to item Cite

Study protocol of a randomized controlled trial of fistula vs. graft arteriovenous vascular access in older adults with end-stage kidney disease on hemodialysis: the AV access trial.

Journal Article BMC Nephrol · February 24, 2023 BACKGROUND: Treatment of end-stage kidney disease (ESKD) with hemodialysis requires surgical creation of an arteriovenous (AV) vascular access-fistula (AVF) or graft (AVG)-to avoid (or limit) the use of a central venous catheter (CVC). AVFs have long been ... Full text Link to item Cite

Muscle progenitor cells are required for skeletal muscle regeneration and prevention of adipogenesis after limb ischemia.

Journal Article Front Cardiovasc Med · 2023 Skeletal muscle injury in peripheral artery disease (PAD) has been attributed to vascular insufficiency, however evidence has demonstrated that muscle cell responses play a role in determining outcomes in limb ischemia. Here, we demonstrate that genetic ab ... Full text Link to item Cite

Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease.

Journal Article Methodist Debakey Cardiovasc J · 2023 Peripheral arterial disease (PAD) represents a global health concern with a rising prevalence attributed to factors such as obesity, diabetes, aging, and smoking. Among patients with PAD, chronic limb-threatening ischemia (CLTI) is the most severe manifest ... Full text Link to item Cite

Underutilization of Guideline-based Abdominal Aortic Aneurysm Screening in an Academic Health System.

Conference Ann Vasc Surg · July 2022 OBJECTIVES: The US Preventive Services Task Force (USPSTF) recommends a 1 time screening for AAA with ultrasonography in men aged 65-75 who have ever smoked. Our objectives were to identify the AAA screening rates in a large academic health system and asse ... Full text Link to item Cite

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization.

Journal Article Mol Cell · March 17, 2022 The long-range interactions of cis-regulatory elements (cREs) play a central role in gene regulation. cREs can be characterized as accessible chromatin sequences. However, it remains technically challenging to comprehensively identify their spatial interac ... Full text Link to item Cite

Retrograde Transamputation Revascularization: A Case Report.

Journal Article Ann Vasc Surg · July 2021 Below-knee amputation remains the most common level of amputation in patients with lower extremity gangrene and critical limb ischemia. Failure to heal, requiring additional operative debridement or conversion to an above-knee amputation remains a signific ... Full text Link to item Cite

Cerebral monitoring during transcarotid artery revascularization with flow reversal via transcranial doppler ultrasound examination.

Journal Article J Vasc Surg · January 2021 OBJECTIVE: Transcarotid artery revascularization (TCAR) is a hybrid technique for carotid artery revascularization that relies on proximal carotid occlusion with flow reversal for distal embolic protection. The hemodynamic response of the intracranial circ ... Full text Link to item Cite

Safety and Feasibility of Simultaneous Transcarotid Revascularization With Flow Reversal and Coronary Artery Bypass Grafting for Concomitant Carotid Artery Stenosis and Coronary Artery Disease.

Journal Article Vasc Endovascular Surg · July 2020 OBJECTIVE: The management of patients with combined severe carotid artery and coronary artery disease (CAD) is controversial. Transcarotid stenting with flow reversal (TCAR) is a novel hybrid technique for carotid revascularization. We sought to investigat ... Full text Link to item Cite

A Hybrid Approach to Radiation-Induced Axillary Artery Hemorrhage.

Journal Article Vasc Endovascular Surg · February 2020 Axillary artery blowout is a rare life- and limb-threatening condition. The traditional surgical approach of ligation and extra-anatomic bypass is associated with a high morbidity and mortality. We present a case report of a 65-year-old male with axillary ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Simultaneous transcarotid artery revascularization with flow reversal and coronary artery bypass grafting: A novel hybrid technique.

Conference J Vasc Surg Cases Innov Tech · December 2019 Optimal management of concomitant coronary artery disease and carotid artery stenosis remains unknown. Current treatment strategies for patients with significant dual disease burden include simultaneous carotid endarterectomy and coronary artery bypass gra ... Full text Link to item Cite

An analysis of the vascular injuries and attempted resuscitation surrounding the assassination of Martin Luther King Jr.

Journal Article J Vasc Surg · November 2019 Martin Luther King Jr was the most prominent civil rights leader in the United States in the 1960s. He was shot by an assassin in Memphis, Tennessee, on April 4, 1968. After the shooting he was taken to a local hospital where he had an unsuccessful resusci ... Full text Link to item Cite

The evolution of care improves outcome in blunt thoracic aortic injury: A Western Trauma Association multicenter study.

Journal Article J Trauma Acute Care Surg · December 2017 BACKGROUND: The management of blunt thoracic aortic injury (BTAI) has evolved radically in the last decade with changes in the processes of care and the introduction of thoracic endovascular aortic repair (TEVAR). These changes have wrought improved outcom ... Full text Link to item Cite

BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.

Journal Article Circulation · July 18, 2017 BACKGROUND: Critical limb ischemia is a manifestation of peripheral artery disease that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown. We previously discovered 2 overlapping quantitativ ... Full text Link to item Cite

The impact of femoral arterial thrombosis in paediatric cardiac catheterisation: a national study.

Journal Article Cardiol Young · July 2017 BACKGROUND: Previous studies have identified risk factors for femoral arterial thrombosis after paediatric cardiac catheterisation, but none of them have evaluated the clinical and economic significance of this complication at the population level. Therefo ... Full text Link to item Cite

Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.

Journal Article J Vasc Surg · October 2016 OBJECTIVE: The primary preclinical model of peripheral artery disease, which involves acute limb ischemia (ALI), can result in appreciable muscle injury that is attributed to the acuity of the ischemic injury. A less acute model of murine limb ischemia usi ... Full text Link to item Cite

Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.

Journal Article J Card Fail · February 2016 BACKGROUND: Although primary graft dysfunction (PGD) is a leading cause of mortality and morbidity early post-heart transplant, relatively little is known regarding mechanisms involved in PGD development. METHODS AND RESULTS: We examined the relationship b ... Full text Link to item Cite

Historical perspectives of The American Association for Thoracic Surgery: Dr David B. Skinner (1935-2003)--a surgeon and something more.

Other J Thorac Cardiovasc Surg · January 2016 Full text Link to item Cite

Assessing Consequences of Intraaortic Balloon Counterpulsation Versus Left Ventricular Assist Devices at the Time of Heart Transplantation.

Journal Article ASAIO J · 2016 The proportion of heart transplant recipients bridged with durable, intracorporeal left ventricular assist devices (dLVADs) has dramatically increased; however, concern exists regarding obligate repeat sternotomy, increased bleeding risk because of anticoa ... Full text Link to item Cite

Central venous pressure after coronary artery bypass surgery: does it predict postoperative mortality or renal failure?

Conference J Crit Care · December 2014 OBJECTIVE: Although hemodynamic monitoring is often performed after coronary artery bypass grafting (CABG), the role of monitoring postoperative central venous pressure (CVP) measurement as a predictor of clinical outcomes is unknown. As such, this study t ... Full text Link to item Cite

An isolated working heart system for large animal models.

Journal Article J Vis Exp · June 11, 2014 Since its introduction in the late 19(th) century, the Langendorff isolated heart perfusion apparatus, and the subsequent development of the working heart model, have been invaluable tools for studying cardiovascular function and disease(1-15). Although th ... Full text Open Access Link to item Cite

Heart Transplantation After Left Ventricular Assist Device

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · January 1, 2014 Full text Cite

Impact of donor cardiac arrest on heart transplantation.

Journal Article Surgery · August 2013 BACKGROUND: Cardiac transplantation is an effective therapy for patients with end-stage heart failure, but it is still hindered by the lack of donor organs. A history of donor cardiac arrest raises trepidation regarding the possibility of poor post-transpl ... Full text Link to item Cite

Gene therapy for the prevention of vein graft disease.

Journal Article Transl Res · April 2013 Ischemic cardiovascular disease remains the leading cause of death worldwide. Despite advances in the medical management of atherosclerosis over the past several decades, many patients require arterial revascularization to reduce mortality and alleviate is ... Full text Link to item Cite

Current readings: Surgical management of heart failure.

Journal Article Semin Thorac Cardiovasc Surg · 2013 There are a myriad of surgical therapies for patients with end-stage congestive heart failure. Coronary revascularization and mitral valve repair have clear clinical benefits in appropriately selected patients. Further investigation is required before the ... Full text Link to item Cite

Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device.

Journal Article J Thorac Cardiovasc Surg · April 2009 OBJECTIVE: It is generally accepted that patients who require biventricular assist device support have poorer outcomes than those requiring isolated left ventricular assist device support. However, it is unknown how the timing of biventricular assist devic ... Full text Link to item Cite

Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support.

Journal Article J Heart Lung Transplant · December 2008 BACKGROUND: Right ventricular (RV) failure after left ventricular assist device (LVAD) placement is a serious complication and is difficult to predict. In the era of destination therapy and the total artificial heart, predicting post-LVAD RV failure requir ... Full text Link to item Cite