Current Appointments & Affiliations
Adjunct Assistant Professor in the Department of Medicine
·
2015 - Present
Medicine, Cardiology,
Medicine
Recent Publications
S-nitrosylation is required for β2AR desensitization and experimental asthma.
Journal Article Mol Cell · August 18, 2022 The β2-adrenergic receptor (β2AR), a prototypic G-protein-coupled receptor (GPCR), is a powerful driver of bronchorelaxation, but the effectiveness of β-agonist drugs in asthma is limited by desensitization and tachyphylaxis. We find that during activation ... Full text Link to item CiteStructural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
Journal Article Nat Commun · April 22, 2021 Arrestins recognize different receptor phosphorylation patterns and convert this information to selective arrestin functions to expand the functional diversity of the G protein-coupled receptor (GPCR) superfamilies. However, the principles governing arrest ... Full text Link to item CiteDeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
Journal Article Nat Commun · September 25, 2020 Characterization of the dynamic conformational changes in membrane protein signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains challenging. Here we report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMSiPhe) ... Full text Link to item CiteRecent Grants
Mitochondrial Protein Acetylation and Energy Metabolism in Muscle
FellowshipConsultant · Awarded by National Institutes of Health · 2015 - 2018Regulation of Cardiac Adrenergic Function by S-nitrosylation
ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2009View All Grants
Education, Training & Certifications
Oklahoma State University, Stillwater ·
2003
Ph.D.
Beijing Medical University (China) ·
1993
M.D.