Jason David Kilts | Scholars@Duke

Jason David Kilts
Assistant Professor in Psychiatry and Behavioral Sciences

Current Appointments & Affiliations

Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2010

Contact Information

508 Fulton Street, Building 15, Room 404B, Durham, NC 27705
Box 3094 Med Ctr, Durham, NC 27710
kilts001@mc.duke.edu (919) 286-0411

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina at Chapel Hill 1998
Research
Selected Grants
- IPA - Jason Kilts awarded by Durham Veterans Affairs Medical Center 2013 - 2015
- IPA - Jason Kilts awarded by Veterans Administration Medical Center 2011 - 2013
- IPA Extension - Jason Kilts awarded by Veterans Administration Medical Center 2009 - 2011
- IPA - Jason Kilts awarded by Veterans Administration Medical Center 2007 - 2009
- Aging And G Protein Coupled Receptors In Human Heart awarded by National Institutes of Health 1998 - 2006
Publications & Artistic Works
Selected Publications
- Book Sections
  - Marx, CE, Naylor, JC, Kilts, JD, Dunn, CE, Tupler, LA, Szabo, ST, Capehart, BP, Morey, RA, Shampine, LJ, and Acheson, SK. "Neurosteroids and traumatic brain injury translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veterans." In Translational Research in Traumatic Brain Injury, 145-161. April 21, 2016.
- Conference Papers
  - Nayllor, JC, Payne, VM, Calhoun, PS, Morey, RA, Beckham, JC, Tupler, LA, Duncan, GE, Shampine, LJ, Kilts, JD, and Marx, CE. "L-serine predicts self-reported pain in female OEF/OIF veterans." April 1, 2008. Link to Item
- Journal Articles
  - Swanson, J, Easter, M, Brancu, M, VA Mid-Atlantic MIRECC Workgroup, , and Fairbank, JA. "Informing Federal Policy on Firearm Restrictions for Veterans with Fiduciaries: Risk Indicators in the Post-Deployment Mental Health Study." Administration and Policy in Mental Health (May 24, 2018). Full Text
  - Martindale, SL, Epstein, EL, Taber, KH, Rowland, JA, Brancu, M, Beckham, JC, Calhoun, PS, Dedert, E, Elbogen, EB, Fairbank, JA, Green, KT, Hurley, RA, Kilts, JD, Kimbrel, N, Kirby, A, Marx, CE, McCarthy, G, McDonald, SD, Miller-Mumford, M, Moore, SD, Morey, RA, Naylor, JC, Pickett, TC, Runnals, JJ, Swinkels, C, Szabo, ST, Tupler, LA, Van Voorhees, EE, Wagner, HR, Weiner, RD, and Yoash-Gantz, RE. "Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans." Archives of Physical Medicine and Rehabilitation (May 2018). Full Text
  - Sun, D, Davis, SL, Haswell, CC, Swanson, CA, Mid-Atlantic MIRECC Workgroup, , LaBar, KS, Fairbank, JA, and Morey, RA. "Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder." Frontiers in Psychiatry 9 (January 2018): 90-null. Full Text
  - Martindale, SL, Farrell-Carnahan, LV, Ulmer, CS, Kimbrel, NA, McDonald, SD, Rowland, JA, and VA Mid-Atlantic MIRECC Registry Workgroup, . "Sleep quality in returning veterans: The influence of mild traumatic brain injury." Rehabilitation Psychology 62, no. 4 (November 2017): 563-570. Full Text
  - Naylor, JC, Ryan Wagner, H, Brancu, M, Shepherd-Banigan, M, Elbogen, E, Kelley, M, Fecteau, T, Goldstein, K, Kimbrel, NA, Marx, CE, VA Mid-Atlantic MIRECC Work Group, , VA Mid-Atlantic MIRECC Women Veterans Work Group, , and Strauss, JL. "Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning." Pain medicine (Malden, Mass.) 18, no. 9 (September 2017): 1658-1667. Full Text
  - Elbogen, EB, Wagner, HR, Kimbrel, NA, Brancu, M, Naylor, J, Graziano, R, Crawford, E, and VA Mid-Atlantic MIRECC Workgroup, . "Risk Factors for Concurrent Suicidal Ideation and Violent Impulses in Military Veterans." Psychological assessment (June 19, 2017). Full Text
  - Servatius, RJ, Marx, CE, Sinha, S, Avcu, P, Kilts, JD, Naylor, JC, and Pang, KCH. "Brain and Serum Androsterone Is Elevated in Response to Stress in Rats with Mild Traumatic Brain Injury." FRONTIERS IN NEUROSCIENCE 10 (August 26, 2016). Full Text Link to Item
  - Schry, AR, Beckham, JC, The Va Mid-Atlantic Mirecc Workgroup, , and Calhoun, PS. "Sexual revictimization among Iraq and Afghanistan war era veterans." Psychiatry Research 240 (June 2016): 406-411. Full Text
  - Naylor, JC, Kilts, JD, Strauss, JL, Szabo, ST, Dunn, CE, Wagner, HR, Hamer, RM, Shampine, LJ, Zanga, JR, Marx, CE, Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and and Clinical Center Workgroup, . "An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans." Journal of Rehabilitation Research and Development 53, no. 4 (January 2016): 499-510. Full Text
  - Naylor, JC, Kilts, JD, Szabo, ST, Dunn, CE, Keefe, FJ, Tupler, LA, Shampine, LJ, Morey, RA, Strauss, JL, Hamer, RM, Wagner, HR, MIRECC Workgroup, , and Marx, CE. "Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics." Pain Medicine (Malden, Mass.) 17, no. 1 (January 2016): 25-32. Full Text Open Access Copy
  - Servatius, RJ, Marx, CE, Sinha, S, Avcu, P, Kilts, JD, Naylor, JC, and Pang, KCH. "Brain and Serum Androsterone Is Elevated in Response to Stress in Rats with Mild Traumatic Brain Injury." Frontiers in neuroscience 10 (January 2016): 379-. Full Text
  - Schry, AR, Hibberd, R, Wagner, HR, Turchik, JA, Kimbrel, NA, Wong, M, Elbogen, EE, Strauss, JL, Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center Workgroup, , and Brancu, M. "Functional correlates of military sexual assault in male veterans." Psychol Serv 12, no. 4 (November 2015): 384-393. Full Text Link to Item
  - Kimbrel, NA, Garrett, ME, Dennis, MF, Liu, Y, Patanam, I, Workgroup, VM-AM, Ashley-Koch, AE, Hauser, MA, and Beckham, JC. "Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder." Psychiatry research 229, no. 1-2 (September 2015): 326-331. Full Text
  - Kelley, ML, Brancu, M, Robbins, AT, D'Lima, GM, Strauss, JL, Curry, JF, Fairbank, JA, Runnals, J, VA Mid-Atlantic MIRECC Women Veterans Workgroup, and VA Mid-Atlantic MIRECC Workgroup, . "Drug use and childhood-, military- and post-military trauma exposure among women and men veterans." Drug and alcohol dependence 152 (July 2015): 201-208. Full Text
  - Naylor, JC, Kilts, JD, Bradford, DW, Strauss, JL, Capehart, BP, Szabo, ST, Smith, KD, Dunn, CE, Conner, KM, Davidson, JRT, Wagner, HR, Hamer, RM, and Marx, CE. "A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment." International clinical psychopharmacology 30, no. 3 (May 2015): 167-174. Full Text
  - Naylor, JC, Kilts, JD, Bradford, DW, Strauss, JL, Capehart, BP, Szabo, ST, Smith, KD, Dunn, CE, Conner, KM, Davidson, JRT, Wagner, HR, Hamer, RM, and Marx, CE. "A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment." International Clinical Psychopharmacology 30, no. 3 (April 14, 2015): 167-174. Full Text
  - Youssef, NA, Bradford, DW, Kilts, JD, Szabo, ST, Naylor, JC, Allen, TB, Strauss, JL, Hamer, RM, Brancu, M, Shampine, LJ, and Marx, CE. "Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder." Crisis 36, no. 1 (January 2015): 46-54. Full Text
  - Marx, CE, Lee, J, Subramaniam, M, Rapisarda, A, Bautista, DCT, Chan, E, Kilts, JD, Buchanan, RW, Wai, EP, Verma, S, Sim, K, Hariram, J, Jacob, R, Keefe, RSE, and Chong, SA. "Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia." Psychopharmacology 231, no. 17 (September 2014): 3647-3662. Full Text
  - Marx, CE, Lee, J, Subramaniam, M, Rapisarda, A, Bautista, DCT, Chan, E, Kilts, JD, Buchanan, RW, Wai, EP, Verma, S, Sim, K, Hariram, J, Jacob, R, Keefe, RSE, and Chong, SA. "Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia." Psychopharmacology 231, no. 17 (September 1, 2014): 3647-3662. Full Text
  - Szabo, ST, Kilts, JD, Naylor, JC, Youssef, NA, Strauss, JL, Morey, RA, Brancu, M, Hamer, RM, Bradford, DW, VA Mid-Atlantic MIRECC Work Group, , and Marx, CE. "Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling." Military Medicine 179, no. 5 (May 2014): 486-491. Full Text
  - Naylor, JC, Dolber, TR, Strauss, JL, Kilts, JD, Strauman, TJ, Bradford, DW, Szabo, ST, Youssef, NA, Connor, KM, Davidson, JRT, and Marx, CE. "A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans." Psychiatry Res 206, no. 2-3 (April 30, 2013): 318-320. Full Text Open Access Copy Link to Item
  - Naylor, JC, Dolber, TR, Strauss, JL, Kilts, JD, Strauman, TJ, Bradford, DW, Szabo, ST, Youssef, NA, Connor, KM, Davidson, JRT, and Marx, CE. "A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans." Psychiatry research 206, no. 2-3 (January 1, 2013): 318-320.
  - Naylor, JC, Dolber, TR, Strauss, JL, Kilts, JD, Strauman, TJ, Bradford, DW, Szabo, ST, Youssef, NA, Connor, KM, Davidson, JRT, and Marx, CE. "A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans." Psychiatry research 206, no. 2-3 (2013): 318-320. Full Text
  - Youssef, NA, Marx, CE, Bradford, DW, Zinn, S, Hertzberg, MA, Kilts, JD, Naylor, JC, Butterfield, MI, and Strauss, JL. "An open-label pilot study of aripiprazole for male and female veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants." Int Clin Psychopharmacol 27, no. 4 (July 2012): 191-196. Full Text Link to Item
  - Marx, CE, Bradford, DW, Hamer, RM, Naylor, JC, Allen, TB, Lieberman, JA, Strauss, JL, and Kilts, JD. "Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence." Neuroscience 191 (September 15, 2011): 78-90. (Review) Full Text Link to Item
  - Kilts, JD, Tupler, LA, Keefe, FJ, Payne, VM, Hamer, RM, Naylor, JC, Calnaido, RP, Morey, RA, Strauss, JL, Parke, G, Massing, MW, Youssef, NA, Shampine, LJ, tVeterans Affairs Mid-Atlantic Mental Illness, Research, Education and Clinical Center Workgroup, , and Marx, CE. "Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001." Pain Medicine (Malden, Mass.) 11, no. 10 (October 2010): 1469-1476. Full Text
  - Naylor, JC, Kilts, JD, Hulette, CM, Steffens, DC, Blazer, DG, Ervin, JF, Strauss, JL, Allen, TB, Massing, MW, Payne, VM, Youssef, NA, Shampine, LJ, and Marx, CE. "Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects." Biochimica Et Biophysica Acta 1801, no. 8 (August 2010): 951-959. Full Text
  - Marx, CE, Keefe, RSE, Buchanan, RW, Hamer, RM, Kilts, JD, Bradford, DW, Strauss, JL, Naylor, JC, Payne, VM, Lieberman, JA, Savitz, AJ, Leimone, LA, Dunn, L, Porcu, P, Morrow, AL, and Shampine, LJ. "Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 34, no. 8 (July 2009): 1885-1903. Full Text
  - Marx, CE, Keefe, RS, Payne, VM, Kilts, JD, Strauss, JL, Naylor, JC, Hamer, RM, Buchanan, RW, Lieberman, JA, Shampine, LJ, and Massing, MW. "NEUROSTEROIDS AS NOVEL THERAPEUTIC AGENTS IN SCHIZOPHRENIA AND PTSD." SCHIZOPHRENIA BULLETIN 35 (March 2009): 368-368. Link to Item
  - Payne, VM, Kilts, JD, Naylor, JC, Strauss, JL, Calhoun, PS, Madison, RD, and Marx, CE. "Allopregnanolone and pregnenolone alterations following pharmacological agents in rodents and clinic populations." (December 1, 2008): 369-383. (Chapter) Full Text
  - Naylor, JC, Hulette, CM, Steffens, DC, Shampine, LJ, Ervin, JF, Payne, VM, Massing, MW, Kilts, JD, Strauss, JL, Calhoun, PS, Calnaido, RP, Blazer, DG, Lieberman, JA, Madison, RD, and Marx, CE. "Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage." The Journal of Clinical Endocrinology and Metabolism 93, no. 8 (August 2008): 3173-3178. Full Text
  - Marx, CE, Yuan, P, Kilts, JD, Madison, RD, Shampine, LJ, and Manji, HK. "Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice." Int J Neuropsychopharmacol 11, no. 4 (June 2008): 547-552. Full Text Link to Item
  - Kilts, JD, Lin, SS, Lowe, JE, and Kwatra, MM. "Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors." Journal of Cardiovascular Pharmacology 50, no. 3 (September 2007): 299-303. Full Text
  - Kilts, JD, Grocott, HP, and Kwatra, MM. "G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta." J Mol Cell Cardiol 38, no. 2 (February 2005): 267-276. Full Text Link to Item
  - Kilts, JD, Grocott, HP, and Kwatra, MM. "Gαq-coupled receptors in human atrium function through protein kinase C ε and δ." Journal of Molecular and Cellular Cardiology 38, no. 2 (January 1, 2005): 267-276. Full Text
  - Richardson, MD, Kilts, JD, and Kwatra, MM. "Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects." Diabetes 53, no. 9 (September 2004): 2392-2396. Full Text
  - Kilts, JD, Akazawa, T, El-Moalem, HE, Mathew, JP, Newman, MF, and Kwatra, MM. "Age increases expression and receptor-mediated activation of G alpha i in human atria." Journal of Cardiovascular Pharmacology 42, no. 5 (November 2003): 662-670. Full Text
  - Kilts, JD, Akazawa, T, Richardson, MD, and Kwatra, MM. "Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors." The Journal of Biological Chemistry 277, no. 34 (August 2002): 31257-31262. Full Text
  - Mottola, DM, Kilts, JD, Lewis, MM, Connory, HS, Walker, QD, Jones, SR, Booth, RG, Hyslop, DK, Piercey, M, Wightman, RM, Lawler, CP, Nichols, DE, and Mailman, RB. "Erratum: Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2receptors linked to adenylate cyclase (Journal of Pharcology and Experimental Therapeutics (2002) 301 (1166-1179))." Journal of Pharmacology and Experimental Therapeutics 302, no. 1 (July 4, 2002): 406-null.
  - Mottola, DM, Kilts, JD, Lewis, MM, Connory, HS, Walker, QD, Jones, SR, Booth, RG, Hyslop, DK, Piercey, M, Wightman, RM, Lawler, CP, Nichols, DE, and Mailman, RB. "Functional selectivity of dopamine receptor agonists. I. selective activation of postsynaptic dopamine D-2 receptors linked to adenylate cyclase (vol 301, pg 1166, 2002)." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 302, no. 1 (July 2002): 406-406. Link to Item
  - Kilts, JD, Connery, HS, Arrington, EG, Lewis, MM, Lawler, CP, Oxford, GS, O'Malley, KL, Todd, RD, Blake, BL, Nichols, DE, and Mailman, RB. "Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs." The Journal of Pharmacology and Experimental Therapeutics 301, no. 3 (June 2002): 1179-1189. Full Text
  - Mottola, DM, Kilts, JD, Lewis, MM, Connery, HS, Walker, QD, Jones, SR, Booth, RG, Hyslop, DK, Piercey, M, Wightman, RM, Lawler, CP, Nichols, DE, and Mailman, RB. "Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase." The Journal of Pharmacology and Experimental Therapeutics 301, no. 3 (June 2002): 1166-1178. Full Text
  - Kilts, JD, Gerhardt, MA, Richardson, MD, Sreeram, G, Mackensen, GB, Grocott, HP, White, WD, Davis, RD, Newman, MF, Reves, JG, Schwinn, DA, and Kwatra, MM. "Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i)." Circ Res 87, no. 8 (October 13, 2000): 705-709. Link to Item
  - Kilts, JD, Gerhardt, MA, Richardson, MD, Sreeram, G, Mackensen, GB, Grocott, HP, White, WD, Davis, RD, Newman, MF, Reves, JG, Schwinn, DA, and Kwatra, MM. "β2-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i)." Circulation Research 87, no. 8 (October 13, 2000): 705-709.
  - Kilts, JD, Gerhardt, MA, Richardson, MD, Sreeram, G, Mackensen, GB, Grocott, HP, White, WD, Davis, RD, Newman, MF, Reves, JG, Schwinn, DA, and Kwatra, MM. "β₂-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i)." Circulation Research 87, no. 8 (2000): 705-709.
  - Doll, MK, Nichols, DE, Kilts, JD, Prioleau, C, Lawler, CP, Lewis, MM, and Mailman, RB. "Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane." Journal of Medicinal Chemistry 42, no. 5 (March 1999): 935-940. Full Text

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Education, Training, & Certifications

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles