Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Georgia Institute of Technology 2009
• 

  Academic Positions Outside Duke

  • Dissertation committee, Tianjin University. 2022 - 2025
• Recognition
• 

  Awards & Honors

  • Shuangchuang Award. Kunshan Jiangsu China. December 2022
• Research
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  Fellowships, Supported Research, & Other Grants

  • 2022 Shuangchuang Grant awarded by Kunshan Jiangsu, China 2022 - 2025
  • General grant award (China) awarded by NSFC (National Natural Science Foundation of China) 2019 - 2023
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Kim H, Zhang X. Design of Repair Templates for CRISPR-Cas9-Triggered Homologous Recombination in Caenorhabditis elegans. Springer Nature. Humana, New York; 2021.
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  • Academic Articles

    • Kim H-M, Hong Y, Chen J. A Decade of CRISPR-Cas Gnome Editing in C. elegans. International Journal of Molecular Sciences. 2022 Dec;23(24):15863.
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    • Ren X, Tian S, Meng Q, Kim H-M. Histone Demethylase AMX-1 Regulates Fertility in a p53/CEP-1 Dependent Manner. Frontiers in Genetics. 2022 Jan;13:929716.
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    • Zhang X, Tian S, Beese-Sims SE, Chen J, Shin N, Colaiácovo MP, Kim H-M. Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. Plos Genetics. 2021 Jul;17(7):e1009715.
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    • Kim H-M, Tian S, Wang S. An affordable plasmid miniprep suitable for proficient microinjection in Caenorhabditis elegans. 3 Biotech. 2020 Aug;10(8):350.
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    • Kim H-M, Colaiácovo MP. CRISPR-Cas9-Guided Genome Engineering in Caenorhabditis elegans. Current Protocols in Molecular Biology. 2019 Dec;129(1):e106.
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    • Ferrandiz N, Barroso C, Telecan O, Shao N, Kim H-M, Testori S, Faull P, Cutillas P, Snijders AP, Colaiácovo MP, Martinez-Perez E. Author Correction: Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. Nature Communications. 2018 Aug;9(1):3558.
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    • Kim H-M, Beese-Sims SE, Colaiácovo MP. Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans. Genetics. 2018 Jun;209(2):409–423.
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    • Ferrandiz N, Barroso C, Telecan O, Shao N, Kim H-M, Testori S, Faull P, Cutillas P, Snijders AP, Colaiácovo MP, Martinez-Perez E. Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. Nature Communications. 2018 Feb;9(1):834.
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    • Gao J, Barroso C, Zhang P, Kim H-M, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong M-Q, Martinez-Perez E, Colaiácovo MP. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes & Development. 2016 Nov;30(21):2404–2416.
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    • Kim H-M, Colaiácovo MP. CRISPR-Cas9-Guided Genome Engineering in C. elegans. Current Protocols in Molecular Biology. 2016 Jul;115:31.7.1-31.7.18.
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    • Norris AD, Kim H-M, Colaiácovo MP, Calarco JA. Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual-Marker Selection Cassettes. Genetics. 2015 Oct;201(2):449–458.
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    • Kim H-M, Colaiácovo MP. New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. Genetics. 2015 Jun;200(2):495–504.
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    • Gao J, Kim H-M, Elia AE, Elledge SJ, Colaiácovo MP. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Plos Genetics. 2015 Mar;11(3):e1005029.
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    • Kim H-M, Colaiácovo MP. DNA Damage Sensitivity Assays in Caenorhabditis elegans. Bio Protocol. 2015 Jan;5(11):e1487.
    • Kim H-M, Colaiácovo MP. ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. Plos Genetics. 2014 Oct;10(10):e1004723.
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    • Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang T-H, Kim H-M, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 Mar;507(7493):448–454.
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    • Sengupta MS, Low WY, Patterson JR, Kim H-M, Traven A, Beilharz TH, Colaiácovo MP, Schisa JA, Boag PR. ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. Journal of Cell Science. 2013 Feb;126(Pt 3):850–859.
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    • Saito TT, Lui DY, Kim H-M, Meyer K, Colaiácovo MP. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. Plos Genetics. 2013 Jan;9(7):e1003586.
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    • Waisertreiger IS-R, Liston VG, Menezes MR, Kim H-M, Lobachev KS, Stepchenkova EI, Tahirov TH, Rogozin IB, Pavlov YI. Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools. Environmental and Molecular Mutagenesis. 2012 Dec;53(9):699–724.
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    • Tang W, Dominska M, Greenwell PW, Harvanek Z, Lobachev KS, Kim H-M, Narayanan V, Mirkin SM, Petes TD. Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae. Plos Genet. 2011 Jan 13;7(1):e1001270.
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    • Kim H-M, Narayanan V, Mieczkowski PA, Petes TD, Krasilnikova MM, Mirkin SM, Lobachev KS. Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair. Embo J. 2008 Nov 5;27(21):2896–2906.
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    • Narayanan V, Mieczkowski PA, Kim H-M, Petes TD, Lobachev KS. The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. Cell. 2006 Jun 30;125(7):1283–1296.
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    • Kim HM, Ohn TB, Min BR, Choi YK. Sequence analysis and insertional inactivation of a gene encoding Moraxella sp. CK-1 cell wall hydrolase. Antonie Van Leeuwenhoek. 2001 Jun;79(2):163–171.
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  • Book Sections

    • Nottke AC, Kim H-M, Colaiácovo MP. Wrestling with Chromosomes: The Roles of SUMO During Meiosis. 2017. p. 185–196.
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  • Scholarly Editions

    • Kim HM, Hong YB, Chen J, Kim H. Genome Editing Components - CRISPR-Cas in C. elegans. Scholarly Community Encyclopedia; 2022.
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  • Preprints

    • Kim H-M, Hong Y, Chen J. A Decade of CRISPR-Cas Genome Editing in C. elegans. Preprints.org. 2022.
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    • Ren X, Tian S, Meng Q, Kim H-M. AMX-1 is necessary for proper fertility and lack of its expression induced sterility in a p53/CEP-1 dependent manner by modulating piwi expression in C. elegans. Research Square. 2022.
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• Teaching & Mentoring
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  Advising & Mentoring

  • Undergraduate students
    Chutian Chen, Semin Kim
    
    Signature work 
    Ethan Lee, Jiani Chen, Yebin Hong
    
    Thesis advisor/co-advisor
    Qinghao Meng (Ph.D)
    Xiaojing Ren (Ms)
    
    Research Fellows
    Xiaoyu Zheng (Ms)
    
    
    
    

  Available to mentor:

  • Masters
• 

  Teaching Activities

  • Biology and Biology Lab (2018-2020), TJU
    Scientific Ethics (2019-2021), TJU
    Microbiology (2017-2021), TJU
    Model organisms (2020- ), TJU
    
    Biochemistry BIOL 305 (2022)
    Cell Signaling BIOL 306 (2022)
    Cancer Genetics BIOL 307 (2022)
    Capstone I 495-045 (2022)
    Capstone II 496-007 (2022) 
    
    Cell Signaling BIOL 306 (2023)
    Research Independent Study 393-008 (2023) 
    Biochemistry BIOL 305 (2023)
    Cancer Genetics BIOL 307 (2023)
    Capstone I 495-005 (2023 Session2)
    
    

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