William Kirby Gottschalk

William Kirby Gottschalk
Assistant Professor in Neurology

Current Appointments & Affiliations

Assistant Professor in Neurology, Neurology, Behavioral Neurology, Neurology 2021
Assistant Professor in Pathology, Pathology, Clinical Science Departments 2020

Contact Information

227D Bryan Research Building, Research Drive, Durham, NC 27710
Box 2900 Med Ctr, DUMC Division of Neurology, Durham, NC 27710
kirby.gottschalk@duke.edu (919) 684-6311

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin - Madison 1981
Previous Appointments & Affiliations
- Assistant Professor of Neurology, Neurology, Behavioral Neurology, Neurology 2014 - 2020
Research
Selected Grants
- Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)" awarded by National Institutes of Health 2020 - 2024
- Gender and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2019 - 2024
- Hematopoietic Stem Cell Transplantation Combined with CSF1 Inhibition to Attenuate the Pathogenesis of Alzheimer's Disease awarded by National Institutes of Health 2021 - 2022
- Role of the TOMM40 poly-T variant in the pathogenesis of Alzheimer's disease awarded by National Institutes of Health 2013 - 2020
- Gender and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2017 - 2019
- Increasing sensitivity to enviromental stress by humanizing NOS2 in mouse awarded by National Institutes of Health 2009 - 2012
External Relationships
- Zinfandel Pharmaceuticals, Inc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Li, Tianqi, Colleen Pappas, Scott T. Le, Qian Wang, Brandon S. Klinedinst, Brittany A. Larsen, Amy Pollpeter, et al. “APOE, TOMM40, and sex interactions on neural network connectivity.” Neurobiol Aging 109 (January 2022): 158–65. https://doi.org/10.1016/j.neurobiolaging.2021.09.020.
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  - Li, Tianqi, Colleen Pappas, Scott T. Le, Qian Wang, Brandon S. Klinedinst, Brittany A. Larsen, Amy Pollpeter, et al. “APOE, TOMM40, and Sex Interactions on Neural Network Connectivity.” Alzheimers Dement 17 Suppl 12 (December 2021): e058171. https://doi.org/10.1002/alz.058171.
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  - Adams, Kendra J., Joan G. Wilson, David S. Millington, M Arthur Moseley, Carol A. Colton, J Will Thompson, and W Kirby Gottschalk. “Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models.” J Am Soc Mass Spectrom 32, no. 6 (June 2, 2021): 1448–58. https://doi.org/10.1021/jasms.1c00055.
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  - Bryan, Jordan, Arpita Mandan, Gauri Kamat, W Kirby Gottschalk, Alexandra Badea, Kendra J. Adams, J Will Thompson, et al. “Likelihood ratio statistics for gene set enrichment in Alzheimer's disease pathways.” Alzheimers Dement 17, no. 4 (April 2021): 561–73. https://doi.org/10.1002/alz.12223.
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  - Saunders, Ann M., Daniel K. Burns, and William Kirby Gottschalk. “Reassessment of Pioglitazone for Alzheimer's Disease.” Front Neurosci 15 (2021): 666958. https://doi.org/10.3389/fnins.2021.666958.
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  - Zeng, Yi, Chao Nie, Junxia Min, Huashuai Chen, Xiaomin Liu, Rui Ye, Zhihua Chen, et al. “Sex Differences in Genetic Associations With Longevity.” Jama Netw Open 1, no. 4 (August 2018): e181670. https://doi.org/10.1001/jamanetworkopen.2018.1670.
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  - Zhao, Xin, Xiaomin Liu, Aiping Zhang, Huashuai Chen, Qing Huo, Weiyang Li, Rui Ye, et al. “The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.” Aging (Albany Ny) 10, no. 6 (June 5, 2018): 1206–22. https://doi.org/10.18632/aging.101461.
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  - Chiba-Falek, Ornit, William K. Gottschalk, and Michael W. Lutz. “The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.” Alzheimers Dement 14, no. 5 (May 2018): 692–98. https://doi.org/10.1016/j.jalz.2018.01.015.
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  - Zeitlow, Kahli, Lefko Charlambous, Isaac Ng, Sonal Gagrani, Mirta Mihovilovic, Shuhong Luo, Daniel L. Rock, Ann Saunders, Allen D. Roses, and W Kirby Gottschalk. “The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease.” Biochim Biophys Acta Mol Basis Dis 1863, no. 11 (November 2017): 2973–86. https://doi.org/10.1016/j.bbadis.2017.07.031.
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  - Subramanian, Shobana, William K. Gottschalk, So Young Kim, Allen D. Roses, and Ornit Chiba-Falek. “The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster.” Biochim Biophys Acta Mol Basis Dis 1863, no. 3 (March 2017): 810–16. https://doi.org/10.1016/j.bbadis.2017.01.004.
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  - Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Chao Nie, Xiaomin Liu, Lei Feng, et al. “Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.” Rejuvenation Res 19, no. 3 (June 2016): 195–203. https://doi.org/10.1089/rej.2015.1737.
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  - Roses, Allen, Scott Sundseth, Ann Saunders, William Gottschalk, Dan Burns, and Michael Lutz. “Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.” Alzheimers Dement 12, no. 6 (June 2016): 687–94. https://doi.org/10.1016/j.jalz.2016.03.015.
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  - Zeng, Yi, Chao Nie, Junxia Min, Xiaomin Liu, Mengmeng Li, Huashuai Chen, Hanshi Xu, et al. “Novel loci and pathways significantly associated with longevity.” Sci Rep 6 (February 25, 2016): 21243. https://doi.org/10.1038/srep21243.
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  - Roses, Allen D., P Anthony Akkari, Ornit Chiba-Falek, Michael W. Lutz, William Kirby Gottschalk, Ann Marie Saunders, Bob Saul, Scott Sundseth, and Daniel Burns. “Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing.” Expert Opin Drug Metab Toxicol 12, no. 2 (2016): 135–47. https://doi.org/10.1517/17425255.2016.1133586.
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  - Crenshaw, Donna G., Karen Asin, William K. Gottschalk, Zhifeng Liang, Nanyin Zhang, and Allen D. Roses. “Effects of low doses of pioglitazone on resting-state functional connectivity in conscious rat brain.” Plos One 10, no. 2 (2015): e0117973. https://doi.org/10.1371/journal.pone.0117973.
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  - Roses, Allen D., Michael W. Lutz, Ann M. Saunders, Dmitry Goldgaber, Robert Saul, Scott S. Sundseth, P Anthony Akkari, et al. “African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.” Alzheimers Dement 10, no. 6 (November 2014): 592-601.e2. https://doi.org/10.1016/j.jalz.2014.06.009.
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  - Linnertz, Colton, Lauren Anderson, William Gottschalk, Donna Crenshaw, Michael W. Lutz, Jawara Allen, Sunita Saith, et al. “The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.” Alzheimers Dement 10, no. 5 (September 2014): 541–51. https://doi.org/10.1016/j.jalz.2013.08.280.
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  - Roses, Allen D., Michael W. Lutz, Donna G. Crenshaw, Iris Grossman, Ann M. Saunders, and W Kirby Gottschalk. “TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.” Alzheimers Dement 9, no. 2 (March 2013): 132–36. https://doi.org/10.1016/j.jalz.2012.10.009.
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  - Crenshaw, D. G., W. K. Gottschalk, M. W. Lutz, I. Grossman, A. M. Saunders, J. R. Burke, K. A. Welsh-Bohmer, S. K. Brannan, D. K. Burns, and A. D. Roses. “Using genetics to enable studies on the prevention of Alzheimer's disease.” Clin Pharmacol Ther 93, no. 2 (February 2013): 177–85. https://doi.org/10.1038/clpt.2012.222.
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  - Madauss, Kevin P., William A. Burkhart, Thomas G. Consler, David J. Cowan, William K. Gottschalk, Aaron B. Miller, Steven A. Short, Thuy B. Tran, and Shawn P. Williams. “The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.” Acta Crystallogr D Biol Crystallogr 65, no. Pt 5 (May 2009): 449–61. https://doi.org/10.1107/S0907444909008014.
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  - Lenhard, James M., and William K. Gottschalk. “Preclinical developments in type 2 diabetes.” Adv Drug Deliv Rev 54, no. 9 (November 5, 2002): 1199–1212. https://doi.org/10.1016/s0169-409x(02)00092-3.
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  - Way, J. M., W. W. Harrington, K. K. Brown, W. K. Gottschalk, S. S. Sundseth, T. A. Mansfield, R. K. Ramachandran, T. M. Willson, and S. A. Kliewer. “Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.” Endocrinology 142, no. 3 (March 2001): 1269–77. https://doi.org/10.1210/endo.142.3.8037.
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  - Ehm, M. G., M. C. Karnoub, H. Sakul, K. Gottschalk, D. C. Holt, J. L. Weber, D. Vaske, et al. “Genomewide search for type 2 diabetes susceptibility genes in four American populations.” Am J Hum Genet 66, no. 6 (June 2000): 1871–81. https://doi.org/10.1086/302950.
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  - Yki-Järvinen, H., A. Virkamäki, M. C. Daniels, D. McClain, and W. K. Gottschalk. “Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.” Metabolism 47, no. 4 (April 1998): 449–55. https://doi.org/10.1016/s0026-0495(98)90058-0.
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  - Rumberger, J., W. Gottschalk, D. Yarnall, Q. Nguyen, D. Burns, and M. Durcan. “Identification of genetic markers to 20 NIDDM candidate genes by radiation hybrid analysis.” Diabetologia 41, no. 3 (March 1998): 366–67. https://doi.org/10.1007/s001250050918.
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  - Yki-Järvinen, H., C. Vogt, P. Iozzo, R. Pipek, M. C. Daniels, A. Virkamäki, S. Mäkimattila, et al. “UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.” Diabetologia 40, no. 1 (January 1997): 76–81. https://doi.org/10.1007/s001250050645.
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  - Gottschalk, W. K. “Relationship between insulin-mediated turnover of glucosamine-labeled lipids and activity of the insulin receptor tyrosine kinase.” Arch Biochem Biophys 299, no. 1 (November 15, 1992): 137–46. https://doi.org/10.1016/0003-9861(92)90255-u.
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  - Gottschalk, W. K. “The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase.” J Biol Chem 266, no. 14 (May 15, 1991): 8814–19.
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  - Gottschalk, W. K., and L. Jarett. “The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays.” Arch Biochem Biophys 261, no. 1 (February 15, 1988): 175–85. https://doi.org/10.1016/0003-9861(88)90116-6.
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  - Gottschalk, W. K., S. L. Macaulay, J. O. Macaulay, K. Kelly, J. A. Smith, and L. Jarett. “Characterization of mediators of insulin action.” Ann N Y Acad Sci 488 (1986): 385–405. https://doi.org/10.1111/j.1749-6632.1986.tb46573.x.
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  - Gottschalk, W. K., and D. R. Sonneborn. “Evidence that Blastocladiella emersonii zoospore maintenance factor is a sulfhydryl group-containing cyclic ribotide.” J Biol Chem 260, no. 11 (June 10, 1985): 6592–99.
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  - Gottschalk, W. K., and D. R. Sonneborn. “Purification of a naturally produced, low molecular weight organic factor that reversibly blocks encystment of Blastocladiella emersonii zoospores.” J Biol Chem 260, no. 11 (June 10, 1985): 6588–91.
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  - Gottschalk, W. K., and L. Jarett. “Intracellular mediators of insulin action.” Diabetes Metab Rev 1, no. 3 (1985): 229–59. https://doi.org/10.1002/dmr.5610010302.
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  - Gottschalk, W. K., and D. R. Sonneborn. “Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice.” Dev Biol 93, no. 1 (September 1982): 165–80. https://doi.org/10.1016/0012-1606(82)90250-0.
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  - Gottschalk, W. K., and D. R. Sonneborn. “Blastocladiella emersonii zoospore maintenance factor: A quantitative bioassay used to characterize extracellular appearance and maintenance of factor and interactions between factor, zoospores, and salt.” Experimental Mycology 5, no. 1 (January 1, 1981): 1–14. https://doi.org/10.1016/0147-5975(81)90002-5.
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Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship

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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

External Relationships

Selected Publications

Academic Articles

Outreach & Engaged Scholarship