William Kirby Gottschalk

William Kirby Gottschalk
Assistant Professor of Neurology

Current Appointments & Affiliations

Assistant Professor of Neurology, Neurology, Behavioral Neurology, Neurology 2014

Contact Information

227D Bryan Research Building, Research Drive, Durham, NC 27710
Box 2900 Med Ctr, DUMC Division of Neurology, Durham, NC 27710
kirby.gottschalk@duke.edu (919) 684-6311

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin at Madison 1981
Research
Selected Grants
- Role of the TOMM40 poly-T variant in the pathogenesis of Alzheimer's disease awarded by National Institutes of Health 2013 - 2020
- Sex and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2017 - 2019
- Increasing sensitivity to enviromental stress by humanizing NOS2 in mouse awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Zhao, Xin, Xiaomin Liu, Aiping Zhang, Huashuai Chen, Qing Huo, Weiyang Li, Rui Ye, et al. “The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese..” Aging 10, no. 6 (June 2018): 1206–22. https://doi.org/10.18632/aging.101461.
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  - Chiba-Falek, Ornit, William K. Gottschalk, and Michael W. Lutz. “The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes..” Alzheimers Dement 14, no. 5 (May 2018): 692–98. https://doi.org/10.1016/j.jalz.2018.01.015.
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  - Zeitlow, Kahli, Lefko Charlambous, Isaac Ng, Sonal Gagrani, Mirta Mihovilovic, Shuhong Luo, Daniel L. Rock, Ann Saunders, Allen D. Roses, and W Kirby Gottschalk. “The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease..” Biochimica Et Biophysica Acta. Molecular Basis of Disease 1863, no. 11 (November 2017): 2973–86. https://doi.org/10.1016/j.bbadis.2017.07.031.
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  - Subramanian, Shobana, William K. Gottschalk, So Young Kim, Allen D. Roses, and Ornit Chiba-Falek. “The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster..” Biochimica Et Biophysica Acta. Molecular Basis of Disease 1863, no. 3 (March 2017): 810–16. https://doi.org/10.1016/j.bbadis.2017.01.004.
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  - Roses, Allen, Scott Sundseth, Ann Saunders, William Gottschalk, Dan Burns, and Michael Lutz. “Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease..” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 12, no. 6 (June 2016): 687–94. https://doi.org/10.1016/j.jalz.2016.03.015.
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  - Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Chao Nie, Xiaomin Liu, Lei Feng, et al. “Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages..” Rejuvenation Research 19, no. 3 (June 2016): 195–203. https://doi.org/10.1089/rej.2015.1737.
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  - Zeng, Yi, Chao Nie, Junxia Min, Xiaomin Liu, Mengmeng Li, Huashuai Chen, Hanshi Xu, et al. “Novel loci and pathways significantly associated with longevity..” Scientific Reports 6 (February 25, 2016). https://doi.org/10.1038/srep21243.
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  - Roses, Allen D., P Anthony Akkari, Ornit Chiba-Falek, Michael W. Lutz, William Kirby Gottschalk, Ann Marie Saunders, Bob Saul, Scott Sundseth, and Daniel Burns. “Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing..” Expert Opinion on Drug Metabolism & Toxicology 12, no. 2 (January 2016): 135–47. https://doi.org/10.1517/17425255.2016.1133586.
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  - Crenshaw, Donna G., Karen Asin, William K. Gottschalk, Zhifeng Liang, Nanyin Zhang, and Allen D. Roses. “Effects of low doses of pioglitazone on resting-state functional connectivity in conscious rat brain..” Plos One 10, no. 2 (January 2015). https://doi.org/10.1371/journal.pone.0117973.
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  - Roses, Allen D., Michael W. Lutz, Ann M. Saunders, Dmitry Goldgaber, Robert Saul, Scott S. Sundseth, P Anthony Akkari, et al. “African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles..” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 10, no. 6 (November 2014): 592-601.e2. https://doi.org/10.1016/j.jalz.2014.06.009.
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  - Linnertz, Colton, Lauren Anderson, William Gottschalk, Donna Crenshaw, Michael W. Lutz, Jawara Allen, Sunita Saith, et al. “The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes..” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 10, no. 5 (September 2014): 541–51. https://doi.org/10.1016/j.jalz.2013.08.280.
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  - Roses, Allen D., Michael W. Lutz, Donna G. Crenshaw, Iris Grossman, Ann M. Saunders, and W Kirby Gottschalk. “TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial..” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 9, no. 2 (March 2013): 132–36. https://doi.org/10.1016/j.jalz.2012.10.009.
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  - Crenshaw, D. G., W. K. Gottschalk, M. W. Lutz, I. Grossman, A. M. Saunders, J. R. Burke, K. A. Welsh-Bohmer, S. K. Brannan, D. K. Burns, and A. D. Roses. “Using genetics to enable studies on the prevention of Alzheimer's disease..” Clinical Pharmacology and Therapeutics 93, no. 2 (February 2013): 177–85. https://doi.org/10.1038/clpt.2012.222.
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  - Madauss, Kevin P., William A. Burkhart, Thomas G. Consler, David J. Cowan, William K. Gottschalk, Aaron B. Miller, Steven A. Short, Thuy B. Tran, and Shawn P. Williams. “The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist..” Acta Crystallographica. Section D, Biological Crystallography 65, no. Pt 5 (May 2009): 449–61. https://doi.org/10.1107/S0907444909008014.
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  - Lenhard, James M., and William K. Gottschalk. “Preclinical developments in type 2 diabetes..” Advanced Drug Delivery Reviews 54, no. 9 (November 2002): 1199–1212. https://doi.org/10.1016/s0169-409x(02)00092-3.
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  - Way, J. M., W. W. Harrington, K. K. Brown, W. K. Gottschalk, S. S. Sundseth, T. A. Mansfield, R. K. Ramachandran, T. M. Willson, and S. A. Kliewer. “Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues..” Endocrinology 142, no. 3 (March 2001): 1269–77. https://doi.org/10.1210/endo.142.3.8037.
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  - Ehm, M. G., M. C. Karnoub, H. Sakul, K. Gottschalk, D. C. Holt, J. L. Weber, D. Vaske, et al. “Genomewide search for type 2 diabetes susceptibility genes in four American populations..” American Journal of Human Genetics 66, no. 6 (June 2000): 1871–81. https://doi.org/10.1086/302950.
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  - Yki-Järvinen, H., A. Virkamäki, M. C. Daniels, D. McClain, and W. K. Gottschalk. “Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo..” Metabolism: Clinical and Experimental 47, no. 4 (April 1998): 449–55. https://doi.org/10.1016/s0026-0495(98)90058-0.
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  - Rumberger, J., W. Gottschalk, D. Yarnall, Q. Nguyen, D. Burns, and M. Durcan. “Identification of genetic markers to 20 NIDDM candidate genes by radiation hybrid analysis..” Diabetologia 41, no. 3 (March 1998): 366–67. https://doi.org/10.1007/s001250050918.
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  - Yki-Järvinen, H., C. Vogt, P. Iozzo, R. Pipek, M. C. Daniels, A. Virkamäki, S. Mäkimattila, et al. “UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues..” Diabetologia 40, no. 1 (January 1997): 76–81. https://doi.org/10.1007/s001250050645.
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  - Gottschalk, W. K. “Relationship between insulin-mediated turnover of glucosamine-labeled lipids and activity of the insulin receptor tyrosine kinase..” Archives of Biochemistry and Biophysics 299, no. 1 (November 1992): 137–46. https://doi.org/10.1016/0003-9861(92)90255-u.
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  - Gottschalk, W. K. “The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase..” The Journal of Biological Chemistry 266, no. 14 (May 1991): 8814–19.
  - Gottschalk, W. K., and L. Jarett. “The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays..” Archives of Biochemistry and Biophysics 261, no. 1 (February 1988): 175–85. https://doi.org/10.1016/0003-9861(88)90116-6.
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  - Gottschalk, W. K., S. L. Macaulay, J. O. Macaulay, K. Kelly, J. A. Smith, and L. Jarett. “Characterization of mediators of insulin action..” Annals of the New York Academy of Sciences 488 (January 1986): 385–405. https://doi.org/10.1111/j.1749-6632.1986.tb46573.x.
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  - Gottschalk, W. K., and D. R. Sonneborn. “Evidence that Blastocladiella emersonii zoospore maintenance factor is a sulfhydryl group-containing cyclic ribotide..” The Journal of Biological Chemistry 260, no. 11 (June 1985): 6592–99.
  - Gottschalk, W. K., and D. R. Sonneborn. “Purification of a naturally produced, low molecular weight organic factor that reversibly blocks encystment of Blastocladiella emersonii zoospores..” The Journal of Biological Chemistry 260, no. 11 (June 1985): 6588–91.
  - Gottschalk, W. K., and L. Jarett. “Intracellular mediators of insulin action..” Diabetes/Metabolism Reviews 1, no. 3 (January 1985): 229–59.
  - Gottschalk, W. K., and D. R. Sonneborn. “Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice..” Developmental Biology 93, no. 1 (September 1982): 165–80. https://doi.org/10.1016/0012-1606(82)90250-0.
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  - Gottschalk, W. K., and D. R. Sonneborn. “Blastocladiella emersonii zoospore maintenance factor: A quantitative bioassay used to characterize extracellular appearance and maintenance of factor and interactions between factor, zoospores, and salt.” Experimental Mycology 5, no. 1 (January 1, 1981): 1–14. https://doi.org/10.1016/0147-5975(81)90002-5.
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Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship

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Education, Training, & Certifications

Selected Grants

Selected Publications

Academic Articles

Outreach & Engaged Scholarship