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Bradley Jason Kolls

Associate Professor of Neurology
Neurology, Neurocritical Care
Duke Box 2900, DUMC, Durham, NC 27710
Department of Neurology, Bryan Research Building, Durham, NC 27710

Selected Publications


Regionalization of stroke systems of care in the stroke belt states: The IMPROVE stroke care quality improvement program.

Journal Article Am Heart J · March 2024 BACKGROUND: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate acu ... Full text Link to item Cite

Optimization of a translational murine model of closed-head traumatic brain injury.

Journal Article Neurol Res · January 10, 2024 Traumatic brain injury (TBI) from closed-head trauma is a leading cause of disability, with limited effective interventions. Many TBI models impact brain parenchyma directly, and are limited by the fact that these forces do not recapitulate clinically rele ... Full text Link to item Cite

Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.

Journal Article Commun Biol · March 9, 2023 The underlying etiologies of seizures are highly heterogeneous and remain incompletely understood. While studying the unfolded protein response (UPR) pathways in the brain, we unexpectedly discovered that transgenic mice (XBP1s-TG) expressing spliced X-box ... Full text Link to item Cite

Using the ICH score during acute telestroke consults to triage transfer to tertiary centers.

Journal Article J Stroke Cerebrovasc Dis · March 2023 OBJECTIVE: Constrained resources at tertiary centers indicate a need for re-exploration of the practice of routinely transferring all community hospital patients with complex conditions such as hemorrhagic stroke (ICH). We addressed the clinical question o ... Full text Link to item Cite

Evaluation of a tailored epilepsy training program for healthcare providers in Uganda.

Journal Article Epilepsy Behav · January 2023 OBJECTIVE: This study evaluated an epilepsy training program for healthcare workers that was designed to improve their knowledge of epilepsy, its treatment, and its psychosocial effects. METHODS: This single group, before and after survey was conducted in ... Full text Link to item Cite

Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury.

Journal Article Exp Brain Res · September 2022 The treatment of traumatic brain injury (TBI) in military populations is hindered by underreporting and underdiagnosis. Clinical symptoms and outcomes may be mitigated with an effective pre-injury prophylaxis. This study evaluates whether CN-105, a 5-amino ... Full text Link to item Cite

Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke: A Post Hoc Analysis From the AUGUSTUS Trial.

Journal Article JAMA Cardiol · July 1, 2022 IMPORTANCE: Data are limited regarding the risk of cerebrovascular ischemic events and major bleeding in patients with atrial fibrillation (AF) and recent acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI). OBJECTIVE: Determine t ... Full text Link to item Cite

Machine Learning for Predicting Discharge Disposition After Traumatic Brain Injury.

Journal Article Neurosurgery · June 1, 2022 BACKGROUND: Current traumatic brain injury (TBI) prognostic calculators are commonly used to predict the mortality and Glasgow Outcome Scale, but these outcomes are most relevant for severe TBI. Because mild and moderate TBI rarely reaches severe outcomes, ... Full text Link to item Cite

Machine Learning for Predicting In-Hospital Mortality After Traumatic Brain Injury in Both High-Income and Low- and Middle-Income Countries.

Journal Article Neurosurgery · May 1, 2022 BACKGROUND: Machine learning (ML) holds promise as a tool to guide clinical decision making by predicting in-hospital mortality for patients with traumatic brain injury (TBI). Previous models such as the international mission for prognosis and clinical tri ... Full text Link to item Cite

Toward Generalizable Trajectory Planning for Human Intracerebral Trials and Therapy.

Journal Article Stereotact Funct Neurosurg · 2022 INTRODUCTION: Stereotactic neurosurgical techniques are increasingly used to deliver biologics, such as cells and viruses, although standardized procedures are necessary to ensure consistency and reproducibility. OBJECTIVE: We provide an instructional guid ... Full text Link to item Cite

Association of time-temperature curves with outcomes in temperature management for cardiac arrest.

Journal Article BMJ Neurol Open · 2022 BACKGROUND/PURPOSE: Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target duration, the con ... Full text Open Access Link to item Cite

Socioeconomic Influence on Emergency Medical Services Utilization for Acute Stroke: Think Nationally, Act Locally.

Journal Article Neurohospitalist · October 2021 BACKGROUND AND PURPOSE: Rates of emergency medical services (EMS) utilization for acute stroke remain low nationwide, despite the time-sensitive nature of the disease. Prior research suggests several demographic and social factors are associated with EMS u ... Full text Link to item Cite

Surgical intervention and patient factors associated with poor outcomes in patients with traumatic brain injury at a tertiary care hospital in Uganda.

Journal Article J Neurosurg · March 26, 2021 OBJECTIVE: The purpose of this study was to investigate whether neurosurgical intervention for traumatic brain injury (TBI) is associated with reduced risks of death and clinical deterioration in a low-income country with a relatively high neurosurgical ca ... Full text Link to item Cite

Sociocultural determinants and patterns of healthcare utilization for epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is a global public health concern, with the majority of cases occurring in lower- and middle-income countries where the treatment gap remains formidable. In this study, we simultaneously explore how beliefs about epilepsy causation, per ... Full text Link to item Cite

Hospital-based epilepsy care in Uganda: A prospective study of three major public referral hospitals.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: This study sets out to describe the current demographics of people with epilepsy (PWE) attending hospital-based care in Uganda and the epilepsy treatment practices within three of the largest Ugandan public referral hospitals. METHODS: In a six- ... Full text Link to item Cite

Leveraging the lessons learned from studies on the cultural context of epilepsy care in Uganda: Opportunities and future directions.

Journal Article Epilepsy Behav · January 2021 In this summary paper, we review the body of research contained in this special issue, The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda, and corollary recommendations for a way forward. We review key findings and conclusions for ... Full text Link to item Cite

Barriers to biomedical care for people with epilepsy in Uganda: A cross-sectional study.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy, a neurological disorder with effective biomedical treatment, remains largely untreated in Uganda. Potential reasons for this treatment gap (TG) include limited access to trained providers and clinics, social stigmata of seizures, cultu ... Full text Link to item Cite

A practical method for determining automated EEG interpretation software performance on continuous Video-EEG monitoring data

Journal Article Informatics in Medicine Unlocked · January 1, 2021 Despite evidence to suggest that as many as 30% of hospitalized patients with altered mental status may be having subclinical seizures for which treatment may improve patient outcomes, the adoption of continuous video electroencephalography (EEG) monitorin ... Full text Cite

ApoE mimetic improves pathology and memory in a model of Alzheimer's disease.

Journal Article Brain Res · April 15, 2020 Alzheimer's disease (AD) is the most common form of dementia and is characterized pathologically by Aβ plaques. Current treatments are purely symptomatic despite decades of intensive research interest. Notably, patients with the APOE4 allele are at increas ... Full text Link to item Cite

Regionalization of stroke systems of care in the stroke belt states: The IMPROVE stroke care quality improvement program.

Journal Article Am Heart J · March 2024 BACKGROUND: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate acu ... Full text Link to item Cite

Optimization of a translational murine model of closed-head traumatic brain injury.

Journal Article Neurol Res · January 10, 2024 Traumatic brain injury (TBI) from closed-head trauma is a leading cause of disability, with limited effective interventions. Many TBI models impact brain parenchyma directly, and are limited by the fact that these forces do not recapitulate clinically rele ... Full text Link to item Cite

Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.

Journal Article Commun Biol · March 9, 2023 The underlying etiologies of seizures are highly heterogeneous and remain incompletely understood. While studying the unfolded protein response (UPR) pathways in the brain, we unexpectedly discovered that transgenic mice (XBP1s-TG) expressing spliced X-box ... Full text Link to item Cite

Using the ICH score during acute telestroke consults to triage transfer to tertiary centers.

Journal Article J Stroke Cerebrovasc Dis · March 2023 OBJECTIVE: Constrained resources at tertiary centers indicate a need for re-exploration of the practice of routinely transferring all community hospital patients with complex conditions such as hemorrhagic stroke (ICH). We addressed the clinical question o ... Full text Link to item Cite

Evaluation of a tailored epilepsy training program for healthcare providers in Uganda.

Journal Article Epilepsy Behav · January 2023 OBJECTIVE: This study evaluated an epilepsy training program for healthcare workers that was designed to improve their knowledge of epilepsy, its treatment, and its psychosocial effects. METHODS: This single group, before and after survey was conducted in ... Full text Link to item Cite

Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury.

Journal Article Exp Brain Res · September 2022 The treatment of traumatic brain injury (TBI) in military populations is hindered by underreporting and underdiagnosis. Clinical symptoms and outcomes may be mitigated with an effective pre-injury prophylaxis. This study evaluates whether CN-105, a 5-amino ... Full text Link to item Cite

Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke: A Post Hoc Analysis From the AUGUSTUS Trial.

Journal Article JAMA Cardiol · July 1, 2022 IMPORTANCE: Data are limited regarding the risk of cerebrovascular ischemic events and major bleeding in patients with atrial fibrillation (AF) and recent acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI). OBJECTIVE: Determine t ... Full text Link to item Cite

Machine Learning for Predicting Discharge Disposition After Traumatic Brain Injury.

Journal Article Neurosurgery · June 1, 2022 BACKGROUND: Current traumatic brain injury (TBI) prognostic calculators are commonly used to predict the mortality and Glasgow Outcome Scale, but these outcomes are most relevant for severe TBI. Because mild and moderate TBI rarely reaches severe outcomes, ... Full text Link to item Cite

Machine Learning for Predicting In-Hospital Mortality After Traumatic Brain Injury in Both High-Income and Low- and Middle-Income Countries.

Journal Article Neurosurgery · May 1, 2022 BACKGROUND: Machine learning (ML) holds promise as a tool to guide clinical decision making by predicting in-hospital mortality for patients with traumatic brain injury (TBI). Previous models such as the international mission for prognosis and clinical tri ... Full text Link to item Cite

Toward Generalizable Trajectory Planning for Human Intracerebral Trials and Therapy.

Journal Article Stereotact Funct Neurosurg · 2022 INTRODUCTION: Stereotactic neurosurgical techniques are increasingly used to deliver biologics, such as cells and viruses, although standardized procedures are necessary to ensure consistency and reproducibility. OBJECTIVE: We provide an instructional guid ... Full text Link to item Cite

Association of time-temperature curves with outcomes in temperature management for cardiac arrest.

Journal Article BMJ Neurol Open · 2022 BACKGROUND/PURPOSE: Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target duration, the con ... Full text Open Access Link to item Cite

Socioeconomic Influence on Emergency Medical Services Utilization for Acute Stroke: Think Nationally, Act Locally.

Journal Article Neurohospitalist · October 2021 BACKGROUND AND PURPOSE: Rates of emergency medical services (EMS) utilization for acute stroke remain low nationwide, despite the time-sensitive nature of the disease. Prior research suggests several demographic and social factors are associated with EMS u ... Full text Link to item Cite

Surgical intervention and patient factors associated with poor outcomes in patients with traumatic brain injury at a tertiary care hospital in Uganda.

Journal Article J Neurosurg · March 26, 2021 OBJECTIVE: The purpose of this study was to investigate whether neurosurgical intervention for traumatic brain injury (TBI) is associated with reduced risks of death and clinical deterioration in a low-income country with a relatively high neurosurgical ca ... Full text Link to item Cite

Sociocultural determinants and patterns of healthcare utilization for epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is a global public health concern, with the majority of cases occurring in lower- and middle-income countries where the treatment gap remains formidable. In this study, we simultaneously explore how beliefs about epilepsy causation, per ... Full text Link to item Cite

Hospital-based epilepsy care in Uganda: A prospective study of three major public referral hospitals.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: This study sets out to describe the current demographics of people with epilepsy (PWE) attending hospital-based care in Uganda and the epilepsy treatment practices within three of the largest Ugandan public referral hospitals. METHODS: In a six- ... Full text Link to item Cite

Leveraging the lessons learned from studies on the cultural context of epilepsy care in Uganda: Opportunities and future directions.

Journal Article Epilepsy Behav · January 2021 In this summary paper, we review the body of research contained in this special issue, The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda, and corollary recommendations for a way forward. We review key findings and conclusions for ... Full text Link to item Cite

Barriers to biomedical care for people with epilepsy in Uganda: A cross-sectional study.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy, a neurological disorder with effective biomedical treatment, remains largely untreated in Uganda. Potential reasons for this treatment gap (TG) include limited access to trained providers and clinics, social stigmata of seizures, cultu ... Full text Link to item Cite

A practical method for determining automated EEG interpretation software performance on continuous Video-EEG monitoring data

Journal Article Informatics in Medicine Unlocked · January 1, 2021 Despite evidence to suggest that as many as 30% of hospitalized patients with altered mental status may be having subclinical seizures for which treatment may improve patient outcomes, the adoption of continuous video electroencephalography (EEG) monitorin ... Full text Cite

ApoE mimetic improves pathology and memory in a model of Alzheimer's disease.

Journal Article Brain Res · April 15, 2020 Alzheimer's disease (AD) is the most common form of dementia and is characterized pathologically by Aβ plaques. Current treatments are purely symptomatic despite decades of intensive research interest. Notably, patients with the APOE4 allele are at increas ... Full text Link to item Cite

Implementation of Best Practices-Developing and Optimizing Regional Systems of Stroke Care: Design and Methodology.

Journal Article Am Heart J · April 2020 The AHA Guidelines recommend developing multi-tiered systems for the care of patients with acute stroke.1 An ideal stroke system of care should ensure that all patients receive the most efficient and timely care, regardless of how they first enter or acces ... Full text Link to item Cite

Autoimmune Encephalitis: NMDA Receptor Encephalitis as an Example of Translational Neuroscience.

Journal Article Neurotherapeutics · April 2020 Autoimmune encephalitis (AE) is a group of disorders causing synaptic receptor dysfunction with a broad range of neurological symptoms that has been historically difficult to differentiate clinically. Today, AE represents an excellent example of the rapid ... Full text Link to item Cite

Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome.

Journal Article J Am Coll Cardiol · January 21, 2020 BACKGROUND: Lipoprotein(a) concentration is associated with cardiovascular events. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C). OBJECTIVES: A pre-specified ana ... Full text Link to item Cite

Comparison of health record vitals and continuously acquired vitals data identifies key differences in clinical impression

Journal Article Informatics in Medicine Unlocked · January 1, 2020 This study aimed to investigate how intermittent ICU data documented by nursing in the electronic medical record (EMR) corresponds to that obtained from continuous data acquisition (CDA) and the differences in perception by medical providers. Both descript ... Full text Cite

COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications.

Journal Article SN Compr Clin Med · 2020 The concurrence of COVID-19 with Guillain-Barre syndrome (GBS) can increase the likelihood of neuromuscular respiratory failure, autonomic dysfunction, and other life-threatening symptoms. Currently, very little is known about the underlying mechanisms, cl ... Full text Open Access Link to item Cite

Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes.

Journal Article Circulation · November 5, 2019 BACKGROUND: The 2018 US cholesterol management guidelines recommend additional lipid-lowering therapies for secondary prevention in patients with low-density lipoprotein cholesterol ≥70 mg/dL or non-high-density lipoprotein cholesterol ≥100 mg/dL despite m ... Full text Link to item Cite

Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial.

Journal Article Circ Cardiovasc Qual Outcomes · November 2019 BACKGROUND: In ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), alirocumab was compared with placebo, added to high-intensity or maximum tolerated statin treatment after acute coron ... Full text Link to item Cite

Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial.

Journal Article J Am Coll Cardiol · September 3, 2019 BACKGROUND: Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACEs) and death. The impact of lipid lowering by proprotein convertase subtilisin-kexin type 9 inh ... Full text Link to item Cite

Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery.

Journal Article J Am Coll Cardiol · September 3, 2019 BACKGROUND: Patients with acute coronary syndrome (ACS) and history of coronary artery bypass grafting (CABG) are at high risk for recurrent cardiovascular events and death. OBJECTIVES: This study sought to determine the clinical benefit of adding alirocum ... Full text Link to item Cite

Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial.

Journal Article Eur Heart J · September 1, 2019 AIMS: The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related ... Full text Link to item Cite

Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.

Journal Article Lancet Diabetes Endocrinol · August 2019 BACKGROUND: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4-1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary ... Full text Link to item Cite

Effect of Alirocumab on Mortality After Acute Coronary Syndromes.

Journal Article Circulation · July 9, 2019 BACKGROUND: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrom ... Full text Link to item Cite

Stroke in Patients With Peripheral Artery Disease.

Journal Article Stroke · June 2019 Background and Purpose- Predictors of stroke and transient ischemic attack (TIA) in patients with peripheral artery disease (PAD) are poorly understood. The primary aims of this analysis were to (1) determine the incidence of ischemic/hemorrhagic stroke an ... Full text Open Access Link to item Cite

Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial.

Journal Article J Am Coll Cardiol · February 5, 2019 BACKGROUND: The ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial compared alirocumab with placebo, added to high-intensity or maximum-tolerated statin treatment, after acute co ... Full text Link to item Cite

Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial.

Journal Article J Am Heart Assoc · December 18, 2018 Background Vorapaxar, a protease-activated receptor-1 antagonist, is approved for secondary prevention of cardiovascular events but is associated with increased intracranial hemorrhage. Methods and Results TRACER (Thrombin Receptor Antagonist for Clinical ... Full text Link to item Cite

Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH.

Journal Article Stroke Vasc Neurol · December 2018 OBJECTIVE: Subarachnoid haemorrhage (SAH) accounts for 3% of all strokes, and is associated with significant morbidity and mortality. There is growing evidence implicating apolipoprotein E (apoE) in mediating adaptive anti-inflammatory and neuroprotective ... Full text Link to item Cite

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.

Journal Article N Engl J Med · November 29, 2018 BACKGROUND: Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9), wou ... Full text Link to item Cite

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.

Journal Article Lancet · October 27, 2018 BACKGROUND: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine t ... Full text Link to item Cite

Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures.

Journal Article Ann Neurol · June 2018 OBJECTIVE: The optimal treatment of nonconvulsive seizures in critically ill patients is uncertain. We evaluated the comparative effectiveness of the antiseizure drugs lacosamide (LCM) and fosphenytoin (fPHT) in this population. METHODS: The TRENdS (Treatm ... Full text Link to item Cite

Implementation of Continuous Video-Electroencephalography at a Community Hospital Enhances Care and Reduces Costs.

Journal Article Neurocrit Care · April 2018 BACKGROUND: Despite data indicating the importance of continuous video-electroencephalography (cvEEG) monitoring, adoption has been slow outside major academic centers. Barriers to adoption include the need for technologists, equipment, and cvEEG readers. ... Full text Link to item Cite

Posttraumatic Seizures

Chapter · January 1, 2018 Posttraumatic seizures are relatively common following moderate to severe brain injury, although the mechanisms by which this occurs remain incompletely defined. A number of conventional antiepileptic drugs have proven effective in suppressing early seizur ... Full text Cite

Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort.

Journal Article Clin Cardiol · October 2017 BACKGROUND: In 2011, the US Food and Drug Administration requested that GlaxoSmithKline perform retrospective adjudication of cardiovascular (CV) events reported in the bupropion drug-development trials for smoking cessation. HYPOTHESIS: Retrospective adju ... Full text Link to item Cite

Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy.

Journal Article Blood · June 1, 2017 We investigated the frequency and characteristics of intracranial hemorrhage (ICH), the factors associated with the risk of ICH, and outcomes post-ICH overall and by randomized treatment. We identified patients with ICH from the overall trial population en ... Full text Link to item Cite

Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model.

Journal Article Sci Rep · April 21, 2017 At present, there are no proven pharmacological treatments demonstrated to improve long term functional outcomes following traumatic brain injury(TBI). In the setting of non-penetrating TBI, sterile brain inflammatory responses are associated with the deve ... Full text Link to item Cite

Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke.

Journal Article Ann Clin Transl Neurol · April 2017 OBJECTIVE: At present, the absence of a pharmacological neuroprotectant represents an important unmet clinical need in the treatment of ischemic and traumatic brain injury. Recent evidence suggests that administration of apolipoprotein E mimetic therapies ... Full text Link to item Cite

Posttraumatic Seizures

Chapter · January 1, 2017 Posttraumatic seizures are relatively common following moderate to severe brain injury, although the mechanisms by which this occurs remain incompletely defined. A number of conventional antiepileptic drugs have proven effective in suppressing early seizur ... Full text Cite

Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study.

Journal Article J Am Heart Assoc · September 13, 2016 BACKGROUND: The PCSK9 antibody alirocumab (75 mg every 2 weeks; Q2W) as monotherapy reduced low-density lipoprotein-cholesterol (LDL-C) levels by 47%. Because the option of a monthly dosing regimen is convenient, ODYSSEY CHOICE II evaluated alirocumab 150  ... Full text Link to item Cite

Inter-rater agreement on identification of electrographic seizures and periodic discharges in ICU EEG recordings.

Journal Article Clin Neurophysiol · September 2015 OBJECTIVE: This study investigated inter-rater agreement (IRA) among EEG experts for the identification of electrographic seizures and periodic discharges (PDs) in continuous ICU EEG recordings. METHODS: Eight board-certified EEG experts independently iden ... Full text Link to item Cite

Diagnostic Accuracy of Electrographic Seizure Detection by Neurophysiologists and Non-Neurophysiologists in the Adult ICU Using a Panel of Quantitative EEG Trends.

Journal Article J Clin Neurophysiol · August 2015 PURPOSE: To evaluate the sensitivity and specificity of a panel of quantitative EEG (qEEG) trends for seizure detection in adult intensive care unit (ICU) patients when reviewed by neurophysiologists and non-neurophysiologists. METHODS: One hour qEEG panel ... Full text Open Access Link to item Cite

Reducing the Cost of Continuous EEG Monitoring

Journal Article Journal of Clinical Neurophysiology · October 2014 Full text Cite

Integration of EEG lead placement templates into traditional technologist-based staffing models reduces costs in continuous video-EEG monitoring service.

Journal Article J Clin Neurophysiol · June 2014 PURPOSE: The purpose of this study was to determine the relative cost reductions within different staffing models for continuous video-electroencephalography (cvEEG) service by introducing a template system for 10/20 lead application. METHODS: We compared ... Full text Link to item Cite

Implanted electrodes for multi-month EEG.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2014 An implanted electroencephalogram (EEG) recorder would help diagnose infrequent seizure-like events. A proof-of-concept study quantified the electrical characteristics of the electrodes planned for the proposed recorder. The electrodes were implanted in an ... Full text Link to item Cite

N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration.

Journal Article J Neurosci Res · October 2013 During development, neuronal activity is used as a cue to guide synaptic rearrangements to refine connections. Many studies, especially in the visual system, have shown that the N-methyl-D-aspartate receptor (NMDAr) plays a key role in mediating activity-d ... Full text Link to item Cite

Seizure predisposition after perinatal hypoxia: effects of subsequent age and of an epilepsy predisposing gene mutation.

Journal Article Epilepsia · October 2013 PURPOSE: There is a gap in our knowledge of the factors that modulate the predisposition to seizures following perinatal hypoxia. Herein, we investigate in a mouse model the effects of two distinct factors: developmental stage after the occurrence of the p ... Full text Link to item Cite

Lacosamide improves outcome in a murine model of traumatic brain injury.

Journal Article Neurocrit Care · August 2013 BACKGROUND: Use of antiepileptic drugs (AED's) is common in the neurocritical care setting. However, there remains a great deal of controversy regarding the optimal agent. Studies associating the prophylactic use of AED's with poor outcomes are heavily bia ... Full text Link to item Cite

Targeting telestroke: benchmarking time performance in telestroke consultations.

Journal Article J Stroke Cerebrovasc Dis · May 2013 OBJECTIVE: To describe the length of time physicians spend completing telestroke consultations and examine factors associated with that period. METHODS: This is a retrospective review of data from telestroke software. Clinical data obtained between July 20 ... Full text Link to item Cite

Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors.

Journal Article Neurocrit Care · February 2012 BACKGROUND: There were nearly 700,000 patients in the United States in 2010 living with brain tumor diagnoses. The incidence of seizures in this population is as high as 70% and is historically difficult to control. Approximately 30-40% of brain tumors pat ... Full text Open Access Link to item Cite

Electroencephalography leads placed by nontechnologists using a template system produce signals equal in quality to technologist-applied, collodion disk leads.

Journal Article J Clin Neurophysiol · February 2012 The purpose of this study was to compare the quality of the electroencephalographic (EEG) data obtained with a BraiNet template in a practical use setting, to that obtained with standard 10/20 spaced, technologist-applied, collodion-based disk leads. Pairs ... Full text Link to item Cite

Endovascular treatment of venous sinus thrombosis: a case report and review of the literature.

Journal Article J Neurointerv Surg · March 2011 Dural venous sinus thrombosis (DVST) is a pathological phenomenon resulting from vascular occlusion of the cerebral venous sinuses. The mainstay of therapy for DVST is anticoagulation but more aggressive interventional therapies must be considered when med ... Full text Link to item Cite

Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes.

Journal Article Neurocrit Care · December 2010 BACKGROUND: Studies devoted to intensive glucose control suggested that the intensive insulin therapy (IIT) approach could effectively reduce complications associated with critical illness. A program of IIT with the goal of achieving a blood glucose of 80- ... Full text Link to item Cite

Neuroprotection in subarachnoid hemorrhage.

Journal Article Stroke · October 2010 Despite advances in aneurysm ablation and the initial management of patients presenting with aneurysmal subarachnoid hemorrhage, delayed cerebral ischemia remains a significant source of morbidity. Traditionally, delayed cerebral ischemia was thought to be ... Full text Link to item Cite

Assessment of hairline EEG as a screening tool for nonconvulsive status epilepticus.

Journal Article Epilepsia · May 2007 PURPOSE: Because of the high incidence of nonconvulsive status epilepticus (NCSE), the attraction of a "quick and easy" screening electroencephalogram (EEG) is obvious. Previous studies have shown utility of hairline EEG in diagnosing epilepsy. However, th ... Full text Link to item Cite

Apomorphine: a rapid rescue agent for the management of motor fluctuations in advanced Parkinson disease.

Journal Article Clin Neuropharmacol · 2006 Parkinson disease is one of the most common neurodegenerative diseases in the United States, and the number of late stage patients is rising. In advance-stage disease, fluctuations in motor function, variability in response to dopaminergic therapy, and dys ... Full text Link to item Cite

Factor XIII deficiency mistaken for battered child syndrome: case of "correct" test ordering negated by a commonly accepted qualitative test with limited negative predictive value.

Journal Article Am J Hematol · December 2002 We report herein a case of Factor XIII deficiency that remained undiagnosed until 2 years of age. Part of the delay in diagnosis was a consequence of testing that was performed on a blood sample obtained after plasma transfusion therapy for a life-threaten ... Full text Link to item Cite

Spontaneous retinal activity is tonic and does not drive tectal activity during activity-dependent refinement in regeneration.

Journal Article J Neurosci · April 1, 2002 During development, waves of activity periodically spread across retina to produce correlated activity that is thought to drive activity-dependent ordering in optic fibers. We asked whether similar waves of activity are produced in the retina of adult gold ... Full text Link to item Cite

Increased spontaneous unit activity and appearance of spontaneous negative potentials in the goldfish tectum during refinement of the optic projection.

Journal Article J Neurosci · January 1, 2000 Spontaneous (not retinally driven) postsynaptic activity was examined during activity-dependent refinement of optic fibers in the goldfish tectum. Unit recordings in vivo and in vitro demonstrated that spontaneous tectal activity increased to 150% of norma ... Full text Link to item Cite