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Kshitij G. Wagh

Instructor in the Department of Medicine
Duke Human Vaccine Institute

Current Appointments & Affiliations


Instructor in the Department of Medicine · 2024 - Present Duke Human Vaccine Institute, Institutes and Centers
Member of the Duke Human Vaccine Institute · 2024 - Present Duke Human Vaccine Institute, Institutes and Centers

Recent Publications


A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.

Journal Article Structure · July 3, 2025 Anti-HIV envelope broadly neutralizing antibodies (bnAbs) are alternatives to conventional antiretrovirals with the potential to prevent and treat infection, reduce latent reservoirs, and/or mediate a functional cure. Clinical trials with "first-generation ... Full text Link to item Cite

Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.

Journal Article Cell Rep · June 24, 2025 Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 CD4-binding site (CD4bs) occur infrequently in macaques and humans and have not been reproducibly elicited in any outbred animal model. To address this challenge, we first isolated RHA10, an infec ... Full text Link to item Cite
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Recent Grants


Optimizing glycan shield coverage, germline B cell receptor targeting and epitope diversity of V2-apex targeted HIV-1 Env immunogens

ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2024 - 2029

Novel vaccine design approached to prevent HIV

ResearchPrincipal Investigator · Awarded by California Institute of Technology · 2025 - 2028

SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens

ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

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Education, Training & Certifications


Rutgers University New Brunswick · 2013 Ph.D.