Current Appointments & Affiliations
Instructor in the Department of Medicine
·
2024 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2024 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development
Journal Article Cell Host and Microbe · February 12, 2025 Identifying HIV-1 envelope (Env) traits associated with neutralization cross-reactivity is crucial for vaccine design. Variable loops 1 and 2 (V1V2), positioned at the Env trimer apex, are key regions linked to neutralization. We describe non-canonical cys ... Full text CiteSafety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial.
Journal Article Nat Med · December 2024 Human immunodeficiency virus type 1 (HIV-1)-specific broadly neutralizing monoclonal antibodies (bNAbs) have to date shown transient viral suppression when administered as monotherapy or as a cocktail of two antibodies1-4. A combination of three bNAbs prov ... Full text Link to item CiteNeonatal immunity associated with heterologous HIV-1 neutralizing antibody induction in SHIV-infected Rhesus Macaques.
Journal Article Nat Commun · November 27, 2024 The details of the pediatric immune system that supports induction of antibodies capable of neutralizing geographically-diverse or heterologous HIV-1 is currently unclear. Here we explore the pediatric immune environment in neonatal macaque undergoing Simi ... Full text Link to item CiteRecent Grants
SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens
ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies
ResearchCo Investigator · Awarded by University of Minnesota · 2022 - 2026SHIV/HIV Env-antibody coevolution as a molecular guide to V3 glycan targeted vaccine design
ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2024 - 2026View All Grants
Education, Training & Certifications
Rutgers University New Brunswick ·
2013
Ph.D.