Overview
Molecular Pharmacology Laboratory
The focus of this laboratory is to understand the molecular basis of glioblastoma and inflammatory skin diseases including atopic dermatitis and prurigo nodularis. Within this line of inquiry, the emphasis is on understanding how these diseases alter the function of Gprotein-couped receptors.
The focus of this laboratory is to understand the molecular basis of glioblastoma and inflammatory skin diseases including atopic dermatitis and prurigo nodularis. Within this line of inquiry, the emphasis is on understanding how these diseases alter the function of Gprotein-couped receptors.
Current Appointments & Affiliations
Associate Professor in Anesthesiology
·
2003 - Present
Anesthesiology,
Clinical Science Departments
Associate Professor of Pharmacology & Cancer Biology
·
2010 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Associate Professor in Psychiatry and Behavioral Sciences
·
2021 - Present
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences,
Psychiatry & Behavioral Sciences
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
1989 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping.
Journal Article Sci Rep · January 14, 2025 Erythroderma is a severe and heterogeneous inflammatory skin condition with little guidance on the approach to management in cases of unknown etiology. To guide therapeutic selection, we sought to create an immunophenotyping platform able to identify aberr ... Full text Link to item CiteSpatial Mass Cytometry-Based Single-Cell Imaging Reveals a Disrupted Epithelial-Immune Axis in Prurigo Nodularis.
Journal Article J Invest Dermatol · November 2024 Prurigo nodularis (PN) is a chronic, inflammatory skin condition that disproportionately affects African Americans and features intensely pruritic, hyperkeratotic nodules on the extremities and trunk. PN is understudied compared with other inflammatory ski ... Full text Link to item CiteExcoriation Disorder Is Characterized by Systemic Glutamatergic Dysfunction.
Journal Article J Invest Dermatol · September 2024 Full text Link to item CiteRecent Grants
Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026Understanding the Role of Type 2 Inflammation in Prurigo Nodularis
ResearchPrincipal Investigator · Awarded by Sanofi US · 2023 - 2025Anti-fibrotic mechanisms of IL-31 blockade in prurigo nodularis
ResearchPrincipal Investigator · Awarded by Galderma · 2023 - 2025View All Grants
Education, Training & Certifications
University of Montreal (Canada) ·
1977
Ph.D.