Madan Mohan Kwatra | Scholars@Duke

Madan Mohan Kwatra
Associate Professor in Anesthesiology

The focus of this laboratory is on signaling through G protein-coupled receptors and clinical proteomics. These goals are currently being realized through three major projects: (1) Mechanism of signal transduction through substance P receptor in human glioblastomas; (2) Effect of age and diabetes on G protein-coupled receptors in human heart; and (3) Molecular basis of postoperative delirium in the elderly. Our studies use state-of-the-art techniques in protein biochemistry and molecular biology including DNA microarrays. A major goal of project #3 is to identify biomarkers of delirium in plasma using a proteomic approach including analyses by 2D-gel electrophoresis, mass spectrometry,SELDI/TOF (protein-chip), and protein microarrays.

Current Appointments & Affiliations

Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2003
Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2009
Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2010
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1989

Contact Information

146 Sands Bldg, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
kwatr001@mc.duke.edu (919) 681-4782

Background
Education, Training, & Certifications
- Ph.D., University of Montreal (Canada) 1977
Duke Appointment History
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2010 - 2013
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2008 - 2010
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2005 - 2009
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2007 - 2008
- Associate Professor in Nursing, School of Nursing, Duke University 2006 - 2007
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2005 - 2006
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 2005
- Associate Professor in Nursing, School of Nursing, Duke University 2004 - 2005
- Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1999 - 2003
- Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1993 - 1999
- Assistant Research Professor in Medicine, Medicine, Clinical Science Departments 1992 - 1993
- Assistant Medical Research Professor in Pathology, Pathology, Clinical Science Departments 1990
Research
Selected Grants
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Evaluation of VAL-083, either alone or in combination with other agents, for its activity inhibition of glioblastoma subtypes (personalized drug development) awarded by DelMar Pharmaceuticals, Inc. 2017 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Glioblastoma model research awarded by The Miami Foundation 2017 - 2019
- Evaluation of novel anti-cancer agents, either alone or in combination, for activity against glioblastoma subtypes: a personalized medicine approach awarded by Genzada Pharmaceuticals, LLC 2017 - 2019
- Heterogeneity of EGFRvIII-positive glioblastoma and their sensitivity to AZD9291 (Osimertinib) awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2018
- Curtana Pharmacueticals Sponsored Research Agreement awarded by Curtana Pharmaceuticals, Inc. 2016 - 2017
- Evaluation of AZD9291 in Glioblastoma patients with activated EGFR awarded by National Institutes of Health 2015 - 2016
- Targeting GBMs with Activated EGFR with third-generation, brain-penetrating AZD9291 awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2016
- Summer Research fellowship for two undergraduate Pre-Med Students awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014 - 2015
- Truncated NK1R in GBM: Pharmacology and Relationship with Patient Survival awarded by National Institutes of Health 2012 - 2015
- Isolation of stem cells from glioblastoma xenografts with activated EGFR awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014
- Molecular Basis of Postoperative Delirium in the Elderly awarded by National Institutes of Health 2003 - 2010
- Aging And G Protein Coupled Receptors In Human Heart awarded by National Institutes of Health 1998 - 2006
- Beta Adrenoceptors During Cardiopulmonary Bypass awarded by National Institutes of Health 1997 - 2002
- Function Of Human Substance P Receptor awarded by National Institutes of Health 1995 - 2001
- Desensitization Of B-Adrenoceptors During Cardiopulmonary awarded by National Institutes of Health 1997 - 1999
- Function Of Human Substances P Receptor awarded by National Institutes of Health 1995 - 1999
- Function Of Substance P Receptor awarded by National Institutes of Health 1995 - 1999
- Molecular Characterization Of Human Alc-Adrenergic Recept awarded by National Institutes of Health 1996 - 1999
- Transcriptional Regulation Of Human 1a-Adrenoceptors awarded by National Institutes of Health 1996 - 1999
- Excitatory Amino Acids In Ovine Fetal Brain Injury awarded by National Institutes of Health 1996 - 1998
- Aging And G Protein-Coupled Receptor Signaling In Human awarded by National Institutes of Health 1996 - 1997
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kwatra, S. G., E. Boozalis, and M. M. Kwatra. “Effects of neuroimmune axis modulation by aprepitant on antipruritic and global disease severity in patients with cutaneous T-cell lymphoma..” Br J Dermatol 178, no. 5 (May 2018): 1221–22. https://doi.org/10.1111/bjd.16363.
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  - He, Alice, Jihad M. Alhariri, Ronald J. Sweren, Madan M. Kwatra, and Shawn G. Kwatra. “Aprepitant for the Treatment of Chronic Refractory Pruritus..” Biomed Research International 2017 (January 2017). https://doi.org/10.1155/2017/4790810.
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  - Kwatra, Madan M. “A Rational Approach to Target the Epidermal Growth Factor Receptor in Glioblastoma..” Current Cancer Drug Targets 17, no. 3 (January 2017): 290–96. https://doi.org/10.2174/1568009616666161227091522.
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  - Yen, Timothy E., John C. Allen, Sarah K. Rivelli, Stephanie C. Patterson, Meredith R. Metcalf, Benjamin J. Flink, Aibek E. Mirrakhimov, et al. “Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty..” Scientific Reports 6 (February 5, 2016). https://doi.org/10.1038/srep20736.
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  - Brown, Kristine E., Gustavo Chagoya, Shawn G. Kwatra, Timothy Yen, Stephen T. Keir, Mary Cooter, Katherine A. Hoadley, et al. “Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development..” Journal of Neurochemistry 133, no. 5 (June 2015): 730–38. https://doi.org/10.1111/jnc.13032.
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  - Brown, K. E., G. Chagoya, S. G. Kwatra, T. Yen, S. T. Keir, M. Cooter, K. A. Hoadley, et al. “Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: Implications for drug development.” Journal of Neurochemistry 133, no. 5 (2015): 730–38. https://doi.org/10.1111/jnc.13032.
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  - Kwatra, M. M., K. E. Brown, G. Chagoya, S. T. Keir, D. D. Bigner, and J. H. Sampson. “Patient-derived xenografts mirror the proteomic profile of human glioblastoma: implications for personalized drug development..” Neuro Oncol 16 Suppl 3 (July 2014). https://doi.org/10.1093/neuonc/nou208.57.
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  - Mirrakhimov, Aibek E., Carey L. Brewbaker, Andrew D. Krystal, and Madan M. Kwatra. “Obstructive sleep apnea and delirium: exploring possible mechanisms..” Sleep & Breathing = Schlaf & Atmung 18, no. 1 (March 2014): 19–29. https://doi.org/10.1007/s11325-013-0846-z.
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  - Mirrakhimov, A. E., C. L. Brewbaker, A. D. Krystal, and M. M. Kwatra. “Obstructive sleep apnea and delirium: Exploring possible mechanisms.” Sleep and Breathing 18, no. 1 (January 1, 2014): 19–29. https://doi.org/10.1007/s11325-013-0846-z.
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  - Reed, Craig, Shawn G. Kwatra, Kristine Brown, and Madan M. Kwatra. “Revisiting the prehypertension debate: increasing evidence for treatment yet randomized clinical trials are lacking..” Blood Pressure 22, no. 6 (December 2013): 340–43. https://doi.org/10.3109/08037051.2013.787705.
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  - Brown, Kristine E., Aibek E. Mirrakhimov, Kalpana Yeddula, and Madan M. Kwatra. “Propofol and the risk of delirium: exploring the anticholinergic properties of propofol..” Medical Hypotheses 81, no. 4 (October 2013): 536–39. https://doi.org/10.1016/j.mehy.2013.06.027.
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  - Mirrakhimov, Aibek E., Timothy Yen, and Madan M. Kwatra. “Delirium after cardiac surgery: have we overlooked obstructive sleep apnea?.” Medical Hypotheses 81, no. 1 (July 2013): 15–20. https://doi.org/10.1016/j.mehy.2013.03.033.
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  - Brown, K. E., A. E. Mirrakhimov, K. Yeddula, and M. M. Kwatra. “Propofol And The Risk Of Delirium: Exploring The Anticholinergic Properties Of Propofol.” Medical Hypotheses 81, no. 4 (2013): 536–39. https://doi.org/10.1016/j.mehy.2013.06.027.
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  - Mirrakhimov, A. E., T. Yen, and M. M. Kwatra. “Delirium after cardiac surgery: Have we overlooked obstructive sleep apnea?.” Medical Hypotheses 81, no. 1 (2013): 15–20. https://doi.org/10.1016/j.mehy.2013.03.033.
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  - Kwatra, M. M., R. E. Moon, W. D. White, P. T. Trzepacz, and S. K. Rivelli. “In reply..” Anesthesiology 117, no. 6 (December 2012): 1392–93. https://doi.org/10.1097/ALN.0b013e3182735c0f.
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  - Motosko, Catherine, Kristine Brown, and Madan Kwatra. “Insulin-like growth factor 1 and delirium..” International Psychogeriatrics 24, no. 11 (November 2012). https://doi.org/10.1017/s1041610212000464.
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  - Flink, Benjamin J., Sarah K. Rivelli, Elizabeth A. Cox, William D. White, Grace Falcone, Thomas P. Vail, Christopher C. Young, et al. “Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly..” Anesthesiology 116, no. 4 (April 2012): 788–96. https://doi.org/10.1097/ALN.0b013e31824b94fc.
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  - Kwatra, Shawn G., Amanda E. Kiely, and Madan M. Kwatra. “Prehypertension: to treat or not to treat should no longer be the question..” Hypertension (Dallas, Tex. : 1979) 59, no. 4 (April 2012). https://doi.org/10.1161/hypertensionaha.111.190678.
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  - Kwatra, Madan M. “Prevention of intraoperative awareness..” The New England Journal of Medicine 365, no. 21 (November 2011). https://doi.org/10.1056/nejmc1110999.
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  - Kwatra, Madan M., Tara M. Porter, Kristine E. Brown, James E. Herndon, and Darell D. Bigner. “TRUNCATED NEUROKININ 1 RECEPTOR: EXPRESSION IN PRIMARY GLIOBLASTOMAS AND RELATIONSHIP WITH PATIENT SURVIVAL.” Neuro Oncology 13 (November 1, 2011): 82–82.
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  - Kwatra, Shawn G., Laura E. Goldsmith, William D. White, Shu S. Lin, and Madan M. Kwatra. “Low expression of alpha-adrenergic receptors in the aging human heart..” Journal of the American Geriatrics Society 58, no. 1 (January 2010): 210–12. https://doi.org/10.1111/j.1532-5415.2009.02659.x.
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  - Cox, Elizabeth A., Shawn G. Kwatra, Shaanan Shetty, and Madan M. Kwatra. “Flaws in the serum anticholinergic activity assay: implications for the study of delirium..” Journal of the American Geriatrics Society 57, no. 9 (September 2009): 1707–8. https://doi.org/10.1111/j.1532-5415.2009.02411.x.
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  - Akazawa, Toshimasa, Shawn G. Kwatra, Laura E. Goldsmith, Mark D. Richardson, Elizabeth A. Cox, John H. Sampson, and Madan M. Kwatra. “A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas..” Journal of Neurochemistry 109, no. 4 (May 2009): 1079–86. https://doi.org/10.1111/j.1471-4159.2009.06032.x.
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  - Kiely, Amanda Elisabeth, Shawn Gaurav Kwatra, and Madan Mohan Kwatra. “Treating prehypertension: medically sound and economically viable..” Blood Pressure 18, no. 6 (January 2009): 300–303. https://doi.org/10.3109/08037050903444024.
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  - Kwatra, Madan. “Limitations of the anticholinergic risk scale..” Archives of Internal Medicine 168, no. 21 (November 2008). https://doi.org/10.1001/archinte.168.21.2386-a.
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  - Kilts, Jason D., Shu S. Lin, James E. Lowe, and Madan M. Kwatra. “Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors..” Journal of Cardiovascular Pharmacology 50, no. 3 (September 2007): 299–303. https://doi.org/10.1097/fjc.0b013e3180a72632.
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  - Kwatra, M. M. “Delirium in older persons [11].” New England Journal of Medicine 354, no. 23 (June 8, 2006).
  - Kwatra, Madan M. “Delirium in older persons..” The New England Journal of Medicine 354, no. 23 (June 2006): 2509–11. https://doi.org/10.1056/nejmc061003.
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  - Kwatra, Madan M. “Prevention of atrial fibrillation following cardiac surgery..” Jama 295, no. 19 (May 2006): 2247–48. https://doi.org/10.1001/jama.295.19.2247-c.
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  - Yamaguchi, Keisuke, Mark D. Richardson, Darrell D. Bigner, and Madan M. Kwatra. “Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta..” Cancer Chemotherapy and Pharmacology 56, no. 6 (December 2005): 585–93. https://doi.org/10.1007/s00280-005-1030-3.
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  - Kilts, Jason D., Hilary P. Grocott, and Madan M. Kwatra. “G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta..” Journal of Molecular and Cellular Cardiology 38, no. 2 (February 2005): 267–76. https://doi.org/10.1016/j.yjmcc.2004.11.011.
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  - Kilts, J. D., H. P. Grocott, and M. M. Kwatra. “Gαq-coupled receptors in human atrium function through protein kinase C ε and δ.” Journal of Molecular and Cellular Cardiology 38, no. 2 (January 1, 2005): 267–76. https://doi.org/10.1016/j.yjmcc.2004.11.011.
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  - Richardson, Mark D., Jason D. Kilts, and Madan M. Kwatra. “Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects..” Diabetes 53, no. 9 (September 2004): 2392–96. https://doi.org/10.2337/diabetes.53.9.2392.
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  - Kilts, Jason D., Toshimasa Akazawa, Habib E. El-Moalem, Joseph P. Mathew, Mark F. Newman, and Madan M. Kwatra. “Age increases expression and receptor-mediated activation of G alpha i in human atria..” Journal of Cardiovascular Pharmacology 42, no. 5 (November 2003): 662–70. https://doi.org/10.1097/00005344-200311000-00013.
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  - Hagen, Scott A., Amy L. Kondyra, Hilary P. Grocott, Habib El-Moalem, Daniel Bainbridge, Joseph P. Mathew, Mark F. Newman, Joseph G. Reves, Debra A. Schwinn, and Madan M. Kwatra. “Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells..” Anesthesiology 98, no. 2 (February 2003): 343–48. https://doi.org/10.1097/00000542-200302000-00012.
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  - Richardson, Mark D., Anastasia M. Balius, Keisuke Yamaguchi, Emily R. Freilich, Larry S. Barak, and Madan M. Kwatra. “Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize..” Journal of Neurochemistry 84, no. 4 (February 2003): 854–63. https://doi.org/10.1046/j.1471-4159.2003.01577.x.
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  - Kilts, Jason D., Toshimasa Akazawa, Mark D. Richardson, and Madan M. Kwatra. “Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors..” The Journal of Biological Chemistry 277, no. 34 (August 2002): 31257–62. https://doi.org/10.1074/jbc.m203640200.
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  - Warabi, Kengo, Mark D. Richardson, William T. Barry, Keisuke Yamaguchi, Eric D. Roush, Kinya Nishimura, and Madan M. Kwatra. “Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro..” Febs Letters 521, no. 1–3 (June 2002): 140–44. https://doi.org/10.1016/s0014-5793(02)02858-2.
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  - Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “β 2 -Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circulation Research 87, no. 8 (October 13, 2000): 705–9. https://doi.org/10.1161/01.RES.87.8.705.
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  - Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i)..” Circulation Research 87, no. 8 (October 2000): 705–9. https://doi.org/10.1161/01.res.87.8.705.
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  - Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “β₂-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circulation Research 87, no. 8 (2000): 705–9.
  - Roush, E. D., K. Warabi, and M. M. Kwatra. “Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells..” Molecular Pharmacology 55, no. 5 (May 1999): 855–62.
  - Barak, L. S., K. Warabi, X. Feng, M. G. Caron, and M. M. Kwatra. “Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor..” J Biol Chem 274, no. 11 (March 12, 1999): 7565–69. https://doi.org/10.1074/jbc.274.11.7565.
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  - Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. El-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial β-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease.” Circulation 98, no. 19 SUPPL. (November 10, 1998).
  - Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. El-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease.” Circulation 98, no. 19 (November 10, 1998): II275–81.
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  - Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. el-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Duke Heart Center Perioperative Desensitization Group..” Circulation 98, no. 19 Suppl (November 1998): II275–81.
  - Rudner, X. L., D. E. Berkowitz, B. L. Funk, M. M. Kwatra, and D. A. Schwinn. “Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.” Circulation 98, no. 17 (October 27, 1998): 540–540.
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  - Booth, J. V., K. P. Landolfo, L. C. Chesnut, E. Bennett-Guerrero, M. A. Gerhardt, D. M. Atwell, H. E. El-Moalem, et al. “Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group..” Anesthesiology 89, no. 3 (September 1998): 602–11. https://doi.org/10.1097/00000542-199809000-00008.
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  - Booth, J. V., K. P. Landolfo, L. C. Chesnut, E. Bennett-Guerrero, M. A. Gerhardt, D. M. Atwell, H. E. El-Moalem, et al. “Acute depression of myocardial β-adrenergic receptor signaling during cardiopulmonary bypass. Impairment of the adenylyl cyclase moiety.” Anesthesiology 89, no. 3 (September 1, 1998): 602–11. https://doi.org/10.1097/00000542-199809000-00008.
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  - DeLong, E. R., M. M. Kwatra, T. J. Gan, P. S. A. Glass, I. C. Sanderson, W. C. Gilbert, R. L. Coleman, D. A. Lubarsky, and J. G. Reves. “A large population study reveals reduced anesthetic requirements in females.” Anesthesiology 89, no. 3A (September 1, 1998): U191–U191.
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  - Gerhardt, M. A., T. N. Barnett, W. T. Barry, D. A. Schwinn, and M. M. Kwatra. “beta(2)-adrenergic receptors in human atrial membranes activate both G(s) and G(i)..” Anesthesiology 89, no. 3A (September 1, 1998): U233–U233.
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  - Wendelburg, B. E., T. N. Barnett, M. M. Kwatra, and D. A. Schwinn. “Characterization of [H-3]forskolin binding to human atrial membranes.” Anesthesiology 89, no. 3A (September 1, 1998): U464–U464.
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  - Roush, E. D., and M. M. Kwatra. “Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o)..” Febs Letters 428, no. 3 (May 1998): 291–94. https://doi.org/10.1016/s0014-5793(98)00553-5.
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  - Lee, K., C. D. Richardson, M. A. Razik, M. M. Kwatra, and D. A. Schwinn. “Multiple potential regulatory elements in the 5' flanking region of the human alpha 1a-adrenergic receptor..” Dna Sequence : The Journal of Dna Sequencing and Mapping 8, no. 4 (March 1998): 271–76. https://doi.org/10.3109/10425179809008464.
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  - Nishimura, K., K. Warabi, E. D. Roush, J. Frederick, D. A. Schwinn, and M. M. Kwatra. “Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes..” Biochemistry 37, no. 5 (February 1998): 1192–98. https://doi.org/10.1021/bi972302s.
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  - Smiley, R. M., M. M. Kwatra, and D. A. Schwinn. “New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance..” Journal of Cardiothoracic and Vascular Anesthesia 12, no. 1 (February 1998): 80–95. https://doi.org/10.1016/s1053-0770(98)90062-3.
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  - Lee, K., C. D. Richardson, M. A. Razik, M. M. Kwatra, and D. A. Schwinn. “Multiple potential regulatory elements in the 5′ flanking region of the human alalpha;_1a,-adrenergic receptor:short communication.” Mitochondrial Dna 8, no. 4 (1998): 271–76. https://doi.org/10.3109/10425179809008464.
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  - Nishimura, K., J. Frederick, and M. M. Kwatra. “Human substance P receptor expressed in Sf9 cells couples with multiple endogenous G proteins..” Journal of Receptor and Signal Transduction Research 18, no. 1 (January 1998): 51–65. https://doi.org/10.3109/10799899809039164.
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  - Schwinn, D. A., and M. M. Kwatra. “Expression and regulation of alpha 1-adrenergic receptors in human tissues..” Advances in Pharmacology (San Diego, Calif.) 42 (January 1998): 390–94.
  - Kwatra, M. M., K. Nishimura, K. Warabi, E. D. Roush, and D. A. Schwinn. “Membrane-bound human substance p receptor undergoes agonist-dependent phosphorylation by g protein receptor kinase 2 (grk2) to a high stoichiometry and activates grk2 in the absence of gβγ.” Faseb Journal 11, no. 9 (December 1, 1997).
  - Schwinn, D. A., and M. M. Kwatra. “α1,-Adrenoceptor Subtypes in the Human Cardiovascular and Urogenital Systems.” Advances in Pharmacology 42, no. C (December 1, 1997): 390–94. https://doi.org/10.1016/S1054-3589(08)60771-1.
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  - Razik, M. A., K. Lee, R. R. Price, M. R. Williams, R. R. Ongjoco, M. K. Dole, X. L. Rudner, M. M. Kwatra, and D. A. Schwinn. “Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region..” J Biol Chem 272, no. 45 (November 7, 1997): 28237–46. https://doi.org/10.1074/jbc.272.45.28237.
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  - Schwinn, D. A., M. A. Gerhardt, L. C. Chesnut, B. L. Funk, K. P. Landolfo, and M. M. Kwatra. “Acute myocardial beta-adrenergic receptor desensitization during cardiopulmonary bypass for cardiac valve surgery.” Circulation 96, no. 8 (October 21, 1997): 2844–2844.
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  - Schwinn, D. A., and M. M. Kwatra. “α₁,-Adrenoceptor Subtypes in the Human Cardiovascular and Urogenital Systems.” Advances in Pharmacology 42, no. C (1997): 390–94. https://doi.org/10.1016/S1054-3589(08)60771-1.
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  - Chen, B., R. D. Leverette, D. A. Schwinn, and M. M. Kwatra. “Human G(alpha q): cDNA and tissue distribution..” Biochimica Et Biophysica Acta 1281, no. 2 (June 1996): 125–28. https://doi.org/10.1016/0005-2736(96)00039-9.
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  - Kwatra, M. M., J. Schreurs, D. A. Schwinn, M. A. Innis, M. G. Caron, and R. J. Lefkowitz. “Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity..” Protein Expression and Purification 6, no. 6 (December 1995): 717–21. https://doi.org/10.1006/prep.1995.0001.
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  - Nair, L. A., J. Inglese, R. Stoffel, W. J. Koch, R. J. Lefkowitz, M. M. Kwatra, and A. O. Grant. “Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma..” Circulation Research 76, no. 5 (May 1995): 832–38. https://doi.org/10.1161/01.res.76.5.832.
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  - Barak, L. S., M. Tiberi, N. J. Freedman, M. M. Kwatra, R. J. Lefkowitz, and M. G. Caron. “A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration..” The Journal of Biological Chemistry 269, no. 4 (January 1994): 2790–95.
  - Kwatra, M. M., R. J. Lefkowitz, and M. G. Caron. “Partially purified and reconstituted g-protein coupled receptors as substrates of specific receptor kinases.” Methods 6, no. 1 (January 1, 1994): 11–17. https://doi.org/10.1006/meth.1994.1003.
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  - Ramkumar, V., M. Kwatra, J. L. Benovic, and G. L. Stiles. “Erratum: Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase (Biochimica et Biophysica Acta - Molecular Cell Research (1993) 1179 (89-97)).” Biochimica Et Biophysica Acta Molecular Cell Research 1220, no. 2 (January 1, 1994). https://doi.org/10.1016/0167-4889(94)90142-2.
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  - Ramkumar, V., M. Kwatra, J. L. Benovic, G. L. Stiles, and G. L. Stilesa. “Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase..” Biochimica Et Biophysica Acta 1179, no. 1 (October 1993): 89–97. https://doi.org/10.1016/0167-4889(93)90075-z.
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  - Kwatra, M. M., D. A. Schwinn, J. Schreurs, J. L. Blank, C. M. Kim, J. L. Benovic, J. E. Krause, M. G. Caron, and R. J. Lefkowitz. “The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2..” The Journal of Biological Chemistry 268, no. 13 (May 1993): 9161–64.
  - Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family..” The Journal of Biological Chemistry 267, no. 25 (September 1992): 17882–90.
  - Pitcher, J. A., J. Inglese, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. “Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors..” Science (New York, N.Y.) 257, no. 5074 (August 1992): 1264–67. https://doi.org/10.1126/science.1325672.
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  - Kwatra, M. M., D. D. Bigner, and J. A. Cohn. “The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization..” Biochimica Et Biophysica Acta 1134, no. 2 (March 1992): 178–81. https://doi.org/10.1016/0167-4889(92)90042-a.
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  - Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “β-Arrestin2, a novel member of the arrestin/β-arrestin gene family.” Journal of Biological Chemistry 267, no. 25 (January 1, 1992): 17882–90.
  - Humphrey, P. A., A. J. Wong, B. Vogelstein, M. R. Zalutsky, G. N. Fuller, G. E. Archer, H. S. Friedman, M. M. Kwatra, S. H. Bigner, and D. D. Bigner. “Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma..” Proc Natl Acad Sci U S A 87, no. 11 (June 1990): 4207–11. https://doi.org/10.1073/pnas.87.11.4207.
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  - Hosey, M. M., M. M. Kwatra, J. Ptasienski, and R. M. Richardson. “Regulation of receptor function by protein phosphorylation..” Annals of the New York Academy of Sciences 588 (January 1990): 155–63. https://doi.org/10.1111/j.1749-6632.1990.tb13206.x.
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  - Kwatra, M. M., J. L. Benovic, M. G. Caron, R. J. Lefkowitz, and M. M. Hosey. “Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase..” Biochemistry 28, no. 11 (May 1989): 4543–47. https://doi.org/10.1021/bi00437a005.
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  - Kwatra, M. M., J. Ptasienski, and M. M. Hosey. “The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor..” Molecular Pharmacology 35, no. 5 (May 1989): 553–58.
  - KWATRA, M. M., J. PTASIENSKI, and M. M. HOSEY. “AGONIST-INDUCED PHOSPHORYLATION OF THE PIG-ATRIAL MUSCARINIC RECEPTOR AND ITS COMPARISON WITH THE CHICK HEART RECEPTOR.” Faseb Journal 2, no. 4 (March 15, 1988): A624–A624.
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  - Leung, E., M. M. Kwatra, M. M. Hosey, and R. D. Green. “Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling..” The Journal of Pharmacology and Experimental Therapeutics 244, no. 3 (March 1988): 1150–56.
  - Kwatra, M. M., E. Leung, A. C. Maan, K. K. McMahon, J. Ptasienski, R. D. Green, and M. M. Hosey. “Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization..” The Journal of Biological Chemistry 262, no. 34 (December 1987): 16314–21.
  - Kwatra, M. M., E. Leung, M. M. Hosey, and R. D. Green. “N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors..” Journal of Medicinal Chemistry 30, no. 5 (May 1987): 954–56. https://doi.org/10.1021/jm00388a039.
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  - Kwatra, M. M., E. Leung, M. M. Hosey, and R. D. Green. “N⁶-phenyladenosines: Pronounced effect of phenyl substituents on affinity for A₂ adenosine receptors.” Journal of Medicinal Chemistry 30, no. 5 (1987): 954–56.
  - KWATRA, M. M., and M. M. HOSEY. “PHOSPHORYLATION OF THE CARDIAC MUSCARINIC RECEPTOR IN INTACT CHICK HEART AND ITS REGULATION BY A MUSCARINIC AGONIST.” Journal of Biological Chemistry 261, no. 27 (September 25, 1986): 2429–32.
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  - Kwatra, M. M., and M. M. Hosey. “Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist..” The Journal of Biological Chemistry 261, no. 27 (September 1986): 12429–32.
  - KWATRA, M. M., M. M. HOSEY, and R. GREEN. “CHARACTERIZATION OF CARDIAC ADENOSINE RECEPTORS USING N-6-PHENYLADENOSINES AND A NEW RADIOLIGAND, (I-125)-(M-AMINOPHENYL)ADENOSINE.” Federation Proceedings 45, no. 4 (March 5, 1986): 800–800.
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  - Choca, J. I., M. M. Kwatra, M. M. Hosey, and R. D. Green. “Specific photoaffinity labelling of inhibitory adenosine receptors..” Biochemical and Biophysical Research Communications 131, no. 1 (August 1985): 115–21. https://doi.org/10.1016/0006-291x(85)91778-4.
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  - Kwatra, M. M., and T. L. Sourkes. “Substrate-dependent activation energy of the reaction catalyzed by monoamine oxidase..” Archives of Biochemistry and Biophysics 210, no. 2 (September 1981): 531–36. https://doi.org/10.1016/0003-9861(81)90218-6.
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  - Kwatra, M. M., and T. L. Sourkes. “Monoamine oxidase of rat skeletal muscle: substrate specificity and half-life..” Life Sciences 27, no. 24 (December 1980): 2327–31. https://doi.org/10.1016/0024-3205(80)90501-9.
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  - Kwatra, M. M., and T. L. Sourkes. “Monoamine oxidase A and B activities in liver of riboflavin-deficient rats..” Biochemical Pharmacology 29, no. 19 (October 1980): 2693–94. https://doi.org/10.1016/0006-2952(80)90090-8.
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  - Kwatra, M. M., D. Z. Simon, R. L. Salvador, and P. D. Cooper. “Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice..” Journal of Medicinal Chemistry 21, no. 3 (March 1978): 253–57. https://doi.org/10.1021/jm00201a003.
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- Book Sections
  - Goldsmith, L. E., and M. M. Kwatra. “Tachykinin/Substance P/Neurokinin-1 Receptors.” In Encyclopedia of Biological Chemistry: Second Edition, 360–65, 2013. https://doi.org/10.1016/B978-0-12-378630-2.00364-9.
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- Conference Papers
  - Keir, Stephen T., B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Patrick J. Killela, Hai Yan, Madan M. Kwatra, Henry S. Friedman, and Darell D. Bigner. “Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes.” In Cancer Research, Vol. 74, 2014. https://doi.org/10.1158/1538-7445.AM2014-838.
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  - Brown, Kristine E., Stephen T. Keir, John H. Sampson, Darell D. Bigner, and Madan M. Kwatra. “NEUROKININ-1 RECEPTOR: A POTENTIAL TARGET TO INHIBIT PEDIATRIC GLIOBLASTOMAS.” In Neuro Oncology, 14:17–18. OXFORD UNIV PRESS INC, 2012.
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  - Kwatra, Madan M. “DIFFERENTIAL EXPRESSION OF FULL-LENGTH AND TRUNCATED NEUROKININ 1 RECEPTORS IN GLIOBLASTOMA CELLS.” In Neuro Oncology, 12:18–18. OXFORD UNIV PRESS INC, 2010.
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