Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Montreal (Canada) 1977
• 

  Previous Appointments & Affiliations

  • Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2009 - 2021
  • Associate Professor in the School of Nursing, School of Nursing, Duke University 2010 - 2013
  • Associate Professor in the School of Nursing, School of Nursing, Duke University 2008 - 2010
  • Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2005 - 2009
  • Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2007 - 2008
  • Associate Professor in Nursing, School of Nursing, Duke University 2006 - 2007
  • Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2005 - 2006
  • Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 2005
  • Associate Professor in Nursing, School of Nursing, Duke University 2004 - 2005
  • Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1999 - 2003
  • Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1993 - 1999
  • Assistant Research Professor in Medicine, Medicine, Clinical Science Departments 1992 - 1993
  • Assistant Medical Research Professor in Pathology, Pathology, Clinical Science Departments 1990
• Research
• 

  Selected Grants

  • Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
  • GZ17-6.02 as a Novel Therapeutic Agent for Dermatologic awarded by Genzada Pharmaceuticals, LLC 2020 - 2024
  • IL-13Ra1 signaling in atopic dermatitis awarded by ASLAN Pharmaceuticals 2022 - 2023
  • Generating Patient-Derived Gliomas within Cerebral Organoids to be Treated with Repurposed Drugs awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2021 - 2022
  • Evaluation of novel anti-cancer agents, either alone or in combination, for activity against glioblastoma subtypes: a personalized medicine approach awarded by Genzada Pharmaceuticals, LLC 2017 - 2021
  • Prurigo Nodularis: Disease Burden and Rationale for Novel Therapeutics awarded by Galderma 2019 - 2021
  • Glioblastoma model research awarded by The Miami Foundation 2017 - 2021
  • Heterogeneity of EGFRvIII-positive glioblastoma and their sensitivity to AZD9291 (Osimertinib) awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2019 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Evaluation of VAL-083, either alone or in combination with other agents, for its activity inhibition of glioblastoma subtypes (personalized drug development) awarded by DelMar Pharmaceuticals, Inc. 2017 - 2020
  • Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
  • Heterogeneity of EGFRvIII-positive glioblastoma and their sensitivity to AZD9291 (Osimertinib) awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2018
  • Curtana Pharmacueticals Sponsored Research Agreement awarded by Curtana Pharmaceuticals, Inc. 2016 - 2017
  • Evaluation of AZD9291 in Glioblastoma patients with activated EGFR awarded by National Institutes of Health 2015 - 2016
  • Targeting GBMs with Activated EGFR with third-generation, brain-penetrating AZD9291 awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2016
  • Summer Research fellowship for two undergraduate Pre-Med Students awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014 - 2015
  • Truncated NK1R in GBM: Pharmacology and Relationship with Patient Survival awarded by National Institutes of Health 2012 - 2015
  • Isolation of stem cells from glioblastoma xenografts with activated EGFR awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014
  • Molecular Basis of Postoperative Delirium in the Elderly awarded by National Institutes of Health 2003 - 2010
  • Aging And G Protein Coupled Receptors In Human Heart awarded by National Institutes of Health 1998 - 2006
  • Same awarded by National Institutes of Health 1997 - 2002
  • Function Of Human Substance P Receptor awarded by National Institutes of Health 1995 - 2001
  • Desensitization Of B-Adrenoceptors During Cardiopulmonary awarded by National Institutes of Health 1997 - 1999
  • Function Of Human Substances P Receptor awarded by National Institutes of Health 1995 - 1999
  • Function Of Substance P Receptor awarded by National Institutes of Health 1995 - 1999
  • Molecular Characterization Of Human Alc-Adrenergic Recept awarded by National Institutes of Health 1996 - 1999
  • Transcriptional Regulation Of Human 1a-Adrenoceptors awarded by National Institutes of Health 1996 - 1999
  • Excitatory Amino Acids In Ovine Fetal Brain Injury awarded by National Institutes of Health 1996 - 1998
  • Aging And G Protein-Coupled Receptor Signaling In Human awarded by National Institutes of Health 1996 - 1997
• 

  External Relationships

  • GBM Pharma, Inc
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Sutaria, Nishadh, Martin Prince Alphonse, Melika Marani, Varsha Parthasarathy, Junwen Deng, Shannon Wongvibulsin, Kyle Williams, et al. “Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans.” J Invest Dermatol 142, no. 5 (May 2022): 1300-1308.e3. https://doi.org/10.1016/j.jid.2021.10.011.
       Full Text  Link to Item
    • Choi, Justin, Zachary A. Bordeaux, Jaimie McKeel, Cory Nanni, Nishadh Sutaria, Gabriella Braun, Cole Davis, et al. “GZ17-6.02 Inhibits the Growth of EGFRvIII+ Glioblastoma.” Int J Mol Sci 23, no. 8 (April 10, 2022). https://doi.org/10.3390/ijms23084174.
       Full Text  Link to Item
    • Belzberg, Micah, Martin Prince Alphonse, Isabelle Brown, Kyle A. Williams, Raveena Khanna, Byron Ho, Shannon Wongvibulsin, et al. “Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization.” J Invest Dermatol 141, no. 9 (September 2021): 2208-2218.e14. https://doi.org/10.1016/j.jid.2021.02.749.
       Full Text  Link to Item
    • Cartron, A. M., T. H. Nguyen, Y. S. Roh, M. M. Kwatra, and S. G. Kwatra. “Janus kinase inhibitors for atopic dermatitis: a promising treatment modality.” Clin Exp Dermatol 46, no. 5 (July 2021): 820–24. https://doi.org/10.1111/ced.14567.
       Full Text  Link to Item
    • Choi, Justin, Cameron E. West, Youkyung S. Roh, Nishadh Sutaria, Shawn G. Kwatra, and Madan M. Kwatra. “Mouse models for actinic keratoses.” J Pharmacol Toxicol Methods 110 (July 2021): 107071. https://doi.org/10.1016/j.vascn.2021.107071.
       Full Text  Link to Item
    • Roh, Youkyung S., Raveena Khanna, Sagar P. Patel, Shilpa Gopinath, Kyle A. Williams, Ravya Khanna, Thomas Pritchard, et al. “Circulating blood eosinophils as a biomarker for variable clinical presentation and therapeutic response in patients with chronic pruritus of unknown origin.” J Allergy Clin Immunol Pract 9, no. 6 (June 2021): 2513-2516.e2. https://doi.org/10.1016/j.jaip.2021.01.034.
       Full Text  Link to Item
    • Roh, Youkyung S., Justin Choi, Nishadh Sutaria, Micah Belzberg, Madan M. Kwatra, and Shawn G. Kwatra. “IL-31 Inhibition as a Therapeutic Approach for the Management of Chronic Pruritic Dermatoses.” Drugs 81, no. 8 (June 2021): 895–905. https://doi.org/10.1007/s40265-021-01521-1.
       Full Text  Link to Item
    • Wongvibulsin, Shannon, Nishadh Sutaria, Suraj Kannan, Martin Prince Alphonse, Micah Belzberg, Kyle A. Williams, Isabelle D. Brown, et al. “Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation.” Sci Rep 11, no. 1 (May 27, 2021): 11175. https://doi.org/10.1038/s41598-021-90105-w.
       Full Text  Link to Item
    • Choi, Justin, Nishadh Sutaria, Youkyung Sophie Roh, Zachary Bordeaux, Martin P. Alphonse, Shawn G. Kwatra, and Madan M. Kwatra. “Translational Relevance of Mouse Models of Atopic Dermatitis.” J Clin Med 10, no. 4 (February 6, 2021). https://doi.org/10.3390/jcm10040613.
       Full Text  Link to Item
    • Patel, Sagar P., Raveena Khanna, Justin Choi, Kyle A. Williams, Youkyung S. Roh, Michael S. Hong, Nishadh H. Sutaria, Thomas Pritchard, Madan M. Kwatra, and Shawn G. Kwatra. “Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels.” J Am Acad Dermatol 84, no. 2 (February 2021): 265–72. https://doi.org/10.1016/j.jaad.2020.08.059.
       Full Text  Link to Item
    • Vasavda, C., B. K. Ho, D. Y. Zhang, K. A. Williams, B. H. Kaffenberger, S. G. Kwatra, and M. M. Kwatra. “First- and third-generation epidermal growth factor receptor inhibitors mediate distinct phosphoprotein signalling networks: implications for adverse dermatological reactions.” Br J Dermatol 183, no. 6 (December 2020): 1105–7. https://doi.org/10.1111/bjd.19263.
       Full Text  Link to Item
    • Huang, A. H., J. K. Canner, K. A. Williams, A. L. Grossberg, M. M. Kwatra, and S. G. Kwatra. “Healthcare resource utilization and payer cost analysis of patients with prurigo nodularis.” Br J Dermatol 183, no. 1 (July 2020): 182–84. https://doi.org/10.1111/bjd.18925.
       Full Text  Link to Item
    • Chagoya, Gustavo, Shawn G. Kwatra, Cory W. Nanni, Callie M. Roberts, Samantha M. Phillips, Sarah Nullmeyergh, Samuel P. Gilmore, et al. “Efficacy of osimertinib against EGFRvIII+ glioblastoma.” Oncotarget 11, no. 22 (June 2, 2020): 2074–82. https://doi.org/10.18632/oncotarget.27599.
       Full Text  Link to Item
    • Hughes, John-Douglas Matthew, Taylor E. Woo, Micah Belzberg, Raveena Khanna, Kyle A. Williams, Madan M. Kwatra, Shahzeb Hassan, and Shawn G. Kwatra. “Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis.” Medicines (Basel) 7, no. 1 (January 8, 2020). https://doi.org/10.3390/medicines7010004.
       Full Text  Link to Item
    • Kwatra, Shawn G., Emily Boozalis, Amy H. Huang, Cory Nanni, Raveena Khanna, Kyle A. Williams, Yevgeniy R. Semenov, et al. “Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists.” Medicines (Basel) 6, no. 4 (December 9, 2019). https://doi.org/10.3390/medicines6040114.
       Full Text  Link to Item
    • Kwon, Christina D., Raveena Khanna, Kyle A. Williams, Madan M. Kwatra, and Shawn G. Kwatra. “Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis.” Medicines (Basel) 6, no. 4 (September 26, 2019). https://doi.org/10.3390/medicines6040097.
       Full Text  Link to Item
    • Kwatra, S. G., E. Boozalis, and M. M. Kwatra. “Effects of neuroimmune axis modulation by aprepitant on antipruritic and global disease severity in patients with cutaneous T-cell lymphoma.” Br J Dermatol 178, no. 5 (May 2018): 1221–22. https://doi.org/10.1111/bjd.16363.
       Full Text  Link to Item
    • He, Alice, Jihad M. Alhariri, Ronald J. Sweren, Madan M. Kwatra, and Shawn G. Kwatra. “Aprepitant for the Treatment of Chronic Refractory Pruritus.” Biomed Res Int 2017 (2017): 4790810. https://doi.org/10.1155/2017/4790810.
       Full Text  Link to Item
    • Kwatra, Madan M. “A Rational Approach to Target the Epidermal Growth Factor Receptor in Glioblastoma.” Curr Cancer Drug Targets 17, no. 3 (2017): 290–96. https://doi.org/10.2174/1568009616666161227091522.
       Full Text  Link to Item
    • Yen, Timothy E., John C. Allen, Sarah K. Rivelli, Stephanie C. Patterson, Meredith R. Metcalf, Benjamin J. Flink, Aibek E. Mirrakhimov, et al. “Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty.” Sci Rep 6 (February 5, 2016): 20736. https://doi.org/10.1038/srep20736.
       Full Text  Link to Item
    • Brown, Kristine E., Gustavo Chagoya, Shawn G. Kwatra, Timothy Yen, Stephen T. Keir, Mary Cooter, Katherine A. Hoadley, et al. “Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development.” J Neurochem 133, no. 5 (June 2015): 730–38. https://doi.org/10.1111/jnc.13032.
       Full Text  Link to Item
    • Kwatra, M. M., K. E. Brown, G. Chagoya, S. T. Keir, D. D. Bigner, and J. H. Sampson. “Patient-derived xenografts mirror the proteomic profile of human glioblastoma: implications for personalized drug development.” Neuro Oncol 16 Suppl 3 (July 2014): iii38. https://doi.org/10.1093/neuonc/nou208.57.
       Full Text  Link to Item
    • Mirrakhimov, Aibek E., Carey L. Brewbaker, Andrew D. Krystal, and Madan M. Kwatra. “Obstructive sleep apnea and delirium: exploring possible mechanisms.” Sleep Breath 18, no. 1 (March 2014): 19–29. https://doi.org/10.1007/s11325-013-0846-z.
       Full Text  Link to Item
    • Reed, Craig, Shawn G. Kwatra, Kristine Brown, and Madan M. Kwatra. “Revisiting the prehypertension debate: increasing evidence for treatment yet randomized clinical trials are lacking.” Blood Press 22, no. 6 (December 2013): 340–43. https://doi.org/10.3109/08037051.2013.787705.
       Full Text  Link to Item
    • Brown, Kristine E., Aibek E. Mirrakhimov, Kalpana Yeddula, and Madan M. Kwatra. “Propofol and the risk of delirium: exploring the anticholinergic properties of propofol.” Med Hypotheses 81, no. 4 (October 2013): 536–39. https://doi.org/10.1016/j.mehy.2013.06.027.
       Full Text  Link to Item
    • Mirrakhimov, Aibek E., Timothy Yen, and Madan M. Kwatra. “Delirium after cardiac surgery: have we overlooked obstructive sleep apnea?” Med Hypotheses 81, no. 1 (July 2013): 15–20. https://doi.org/10.1016/j.mehy.2013.03.033.
       Full Text  Link to Item
    • Kwatra, M. M., R. E. Moon, W. D. White, P. T. Trzepacz, and S. K. Rivelli. “In reply.” Anesthesiology 117, no. 6 (December 2012): 1392–93. https://doi.org/10.1097/ALN.0b013e3182735c0f.
       Full Text  Link to Item
    • Motosko, Catherine, Kristine Brown, and Madan Kwatra. “Insulin-like growth factor 1 and delirium.” Int Psychogeriatr 24, no. 11 (November 2012): 1872. https://doi.org/10.1017/S1041610212000464.
       Full Text  Link to Item
    • Flink, Benjamin J., Sarah K. Rivelli, Elizabeth A. Cox, William D. White, Grace Falcone, Thomas P. Vail, Christopher C. Young, et al. “Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.” Anesthesiology 116, no. 4 (April 2012): 788–96. https://doi.org/10.1097/ALN.0b013e31824b94fc.
       Full Text  Link to Item
    • Kwatra, Shawn G., Amanda E. Kiely, and Madan M. Kwatra. “Prehypertension: to treat or not to treat should no longer be the question.” Hypertension 59, no. 4 (April 2012): e27. https://doi.org/10.1161/HYPERTENSIONAHA.111.190678.
       Full Text  Link to Item
    • Kwatra, Madan M. “Prevention of intraoperative awareness.” N Engl J Med 365, no. 21 (November 24, 2011): 2033. https://doi.org/10.1056/NEJMc1110999.
       Full Text  Link to Item
    • Kwatra, Madan M., Tara M. Porter, Kristine E. Brown, James E. Herndon, and Darell D. Bigner. “TRUNCATED NEUROKININ 1 RECEPTOR: EXPRESSION IN PRIMARY GLIOBLASTOMAS AND RELATIONSHIP WITH PATIENT SURVIVAL.” Neuro Oncology 13 (November 1, 2011): 82–82.
       Link to Item
    • Kwatra, Shawn G., Laura E. Goldsmith, William D. White, Shu S. Lin, and Madan M. Kwatra. “Low expression of alpha-adrenergic receptors in the aging human heart.” J Am Geriatr Soc 58, no. 1 (January 2010): 210–12. https://doi.org/10.1111/j.1532-5415.2009.02659.x.
       Full Text  Link to Item
    • Cox, Elizabeth A., Shawn G. Kwatra, Shaanan Shetty, and Madan M. Kwatra. “Flaws in the serum anticholinergic activity assay: implications for the study of delirium.” J Am Geriatr Soc 57, no. 9 (September 2009): 1707–8. https://doi.org/10.1111/j.1532-5415.2009.02411.x.
       Full Text  Link to Item
    • Akazawa, Toshimasa, Shawn G. Kwatra, Laura E. Goldsmith, Mark D. Richardson, Elizabeth A. Cox, John H. Sampson, and Madan M. Kwatra. “A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas.” J Neurochem 109, no. 4 (May 2009): 1079–86. https://doi.org/10.1111/j.1471-4159.2009.06032.x.
       Full Text  Link to Item
    • Kiely, Amanda Elisabeth, Shawn Gaurav Kwatra, and Madan Mohan Kwatra. “Treating prehypertension: medically sound and economically viable.” Blood Press 18, no. 6 (2009): 300–303. https://doi.org/10.3109/08037050903444024.
       Full Text  Link to Item
    • Kwatra, Madan. “Limitations of the anticholinergic risk scale.” Arch Intern Med 168, no. 21 (November 24, 2008): 2386. https://doi.org/10.1001/archinte.168.21.2386-a.
       Full Text  Link to Item
    • Kilts, Jason D., Shu S. Lin, James E. Lowe, and Madan M. Kwatra. “Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.” J Cardiovasc Pharmacol 50, no. 3 (September 2007): 299–303. https://doi.org/10.1097/FJC.0b013e3180a72632.
       Full Text  Link to Item
    • Kwatra, M. M. “Delirium in older persons [11].” New England Journal of Medicine 354, no. 23 (June 8, 2006): 2510.
    • Kwatra, Madan M. “Delirium in older persons.” N Engl J Med 354, no. 23 (June 8, 2006): 2509–11.
       Link to Item
    • Kwatra, Madan M. “Prevention of atrial fibrillation following cardiac surgery.” Jama 295, no. 19 (May 17, 2006): 2247–48. https://doi.org/10.1001/jama.295.19.2247-c.
       Full Text  Link to Item
    • Yamaguchi, Keisuke, Mark D. Richardson, Darrell D. Bigner, and Madan M. Kwatra. “Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.” Cancer Chemother Pharmacol 56, no. 6 (December 2005): 585–93. https://doi.org/10.1007/s00280-005-1030-3.
       Full Text  Link to Item
    • Kilts, Jason D., Hilary P. Grocott, and Madan M. Kwatra. “G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta.” J Mol Cell Cardiol 38, no. 2 (February 2005): 267–76. https://doi.org/10.1016/j.yjmcc.2004.11.011.
       Full Text  Link to Item
    • Richardson, Mark D., Jason D. Kilts, and Madan M. Kwatra. “Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects.” Diabetes 53, no. 9 (September 2004): 2392–96. https://doi.org/10.2337/diabetes.53.9.2392.
       Full Text  Link to Item
    • Kilts, Jason D., Toshimasa Akazawa, Habib E. El-Moalem, Joseph P. Mathew, Mark F. Newman, and Madan M. Kwatra. “Age increases expression and receptor-mediated activation of G alpha i in human atria.” J Cardiovasc Pharmacol 42, no. 5 (November 2003): 662–70. https://doi.org/10.1097/00005344-200311000-00013.
       Full Text  Link to Item
    • Richardson, Mark D., Anastasia M. Balius, Keisuke Yamaguchi, Emily R. Freilich, Larry S. Barak, and Madan M. Kwatra. “Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.” J Neurochem 84, no. 4 (February 2003): 854–63. https://doi.org/10.1046/j.1471-4159.2003.01577.x.
       Full Text  Link to Item
    • Hagen, Scott A., Amy L. Kondyra, Hilary P. Grocott, Habib El-Moalem, Daniel Bainbridge, Joseph P. Mathew, Mark F. Newman, Joseph G. Reves, Debra A. Schwinn, and Madan M. Kwatra. “Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells.” Anesthesiology 98, no. 2 (February 2003): 343–48. https://doi.org/10.1097/00000542-200302000-00012.
       Full Text  Link to Item
    • Kilts, Jason D., Toshimasa Akazawa, Mark D. Richardson, and Madan M. Kwatra. “Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.” J Biol Chem 277, no. 34 (August 23, 2002): 31257–62. https://doi.org/10.1074/jbc.M203640200.
       Full Text  Link to Item
    • Warabi, Kengo, Mark D. Richardson, William T. Barry, Keisuke Yamaguchi, Eric D. Roush, Kinya Nishimura, and Madan M. Kwatra. “Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro.” Febs Lett 521, no. 1–3 (June 19, 2002): 140–44. https://doi.org/10.1016/s0014-5793(02)02858-2.
       Full Text  Link to Item
    • Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circ Res 87, no. 8 (October 13, 2000): 705–9. https://doi.org/10.1161/01.res.87.8.705.
       Full Text  Link to Item
    • Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “β₂-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circulation Research 87, no. 8 (2000): 705–9.
    • Roush, E. D., K. Warabi, and M. M. Kwatra. “Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.” Mol Pharmacol 55, no. 5 (May 1999): 855–62.
       Link to Item
    • Barak, L. S., K. Warabi, X. Feng, M. G. Caron, and M. M. Kwatra. “Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.” J Biol Chem 274, no. 11 (March 12, 1999): 7565–69. https://doi.org/10.1074/jbc.274.11.7565.
       Full Text  Link to Item
    • Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. El-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial β-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease.” Circulation 98, no. 19 SUPPL. (November 10, 1998).
    • Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. El-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease.” Circulation 98, no. 19 (November 10, 1998): II275–81.
       Link to Item
    • Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. el-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Duke Heart Center Perioperative Desensitization Group.” Circulation 98, no. 19 Suppl (November 10, 1998): II275–81.
       Link to Item
    • Rudner, X. L., D. E. Berkowitz, B. L. Funk, M. M. Kwatra, and D. A. Schwinn. “Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.” Circulation 98, no. 17 (October 27, 1998): 540–540.
       Link to Item
    • Booth, J. V., K. P. Landolfo, L. C. Chesnut, E. Bennett-Guerrero, M. A. Gerhardt, D. M. Atwell, H. E. El-Moalem, et al. “Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group.” Anesthesiology 89, no. 3 (September 1998): 602–11. https://doi.org/10.1097/00000542-199809000-00008.
       Full Text  Link to Item
    • DeLong, E. R., M. M. Kwatra, T. J. Gan, P. S. A. Glass, I. C. Sanderson, W. C. Gilbert, R. L. Coleman, D. A. Lubarsky, and J. G. Reves. “A large population study reveals reduced anesthetic requirements in females.” Anesthesiology 89, no. 3A (September 1, 1998): U191–U191.
       Link to Item
    • Gerhardt, M. A., T. N. Barnett, W. T. Barry, D. A. Schwinn, and M. M. Kwatra. “beta(2)-adrenergic receptors in human atrial membranes activate both G(s) and G(i).” Anesthesiology 89, no. 3A (September 1, 1998): U233–U233.
       Link to Item
    • Wendelburg, B. E., T. N. Barnett, M. M. Kwatra, and D. A. Schwinn. “Characterization of [H-3]forskolin binding to human atrial membranes.” Anesthesiology 89, no. 3A (September 1, 1998): U464–U464.
       Link to Item
    • Roush, E. D., and M. M. Kwatra. “Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o).” Febs Lett 428, no. 3 (May 29, 1998): 291–94. https://doi.org/10.1016/s0014-5793(98)00553-5.
       Full Text  Link to Item
    • Lee, K., C. D. Richardson, M. A. Razik, M. M. Kwatra, and D. A. Schwinn. “Multiple potential regulatory elements in the 5' flanking region of the human alpha 1a-adrenergic receptor.” Dna Seq 8, no. 4 (March 1998): 271–76. https://doi.org/10.3109/10425179809008464.
       Full Text  Link to Item
    • Nishimura, K., K. Warabi, E. D. Roush, J. Frederick, D. A. Schwinn, and M. M. Kwatra. “Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes.” Biochemistry 37, no. 5 (February 3, 1998): 1192–98. https://doi.org/10.1021/bi972302s.
       Full Text  Link to Item
    • Smiley, R. M., M. M. Kwatra, and D. A. Schwinn. “New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance.” J Cardiothorac Vasc Anesth 12, no. 1 (February 1998): 80–95. https://doi.org/10.1016/s1053-0770(98)90062-3.
       Full Text  Link to Item
    • Nishimura, K., J. Frederick, and M. M. Kwatra. “Human substance P receptor expressed in Sf9 cells couples with multiple endogenous G proteins.” J Recept Signal Transduct Res 18, no. 1 (January 1998): 51–65. https://doi.org/10.3109/10799899809039164.
       Full Text  Link to Item
    • Schwinn, D. A., and M. M. Kwatra. “Expression and regulation of alpha 1-adrenergic receptors in human tissues.” Adv Pharmacol 42 (1998): 390–94.
       Link to Item
    • Kwatra, M. M., K. Nishimura, K. Warabi, E. D. Roush, and D. A. Schwinn. “Membrane-bound human substance p receptor undergoes agonist-dependent phosphorylation by g protein receptor kinase 2 (grk2) to a high stoichiometry and activates grk2 in the absence of gβγ.” Faseb Journal 11, no. 9 (December 1, 1997).
    • Schwinn, D. A., and M. M. Kwatra. “α1,-Adrenoceptor Subtypes in the Human Cardiovascular and Urogenital Systems.” Advances in Pharmacology 42, no. C (December 1, 1997): 390–94. https://doi.org/10.1016/S1054-3589(08)60771-1.
       Full Text
    • Razik, M. A., K. Lee, R. R. Price, M. R. Williams, R. R. Ongjoco, M. K. Dole, X. L. Rudner, M. M. Kwatra, and D. A. Schwinn. “Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region.” J Biol Chem 272, no. 45 (November 7, 1997): 28237–46. https://doi.org/10.1074/jbc.272.45.28237.
       Full Text  Link to Item
    • Schwinn, D. A., M. A. Gerhardt, L. C. Chesnut, B. L. Funk, K. P. Landolfo, and M. M. Kwatra. “Acute myocardial beta-adrenergic receptor desensitization during cardiopulmonary bypass for cardiac valve surgery.” Circulation 96, no. 8 (October 21, 1997): 2844–2844.
       Link to Item
    • Chen, B., R. D. Leverette, D. A. Schwinn, and M. M. Kwatra. “Human G(alpha q): cDNA and tissue distribution.” Biochim Biophys Acta 1281, no. 2 (June 11, 1996): 125–28. https://doi.org/10.1016/0005-2736(96)00039-9.
       Full Text  Link to Item
    • Kwatra, M. M., J. Schreurs, D. A. Schwinn, M. A. Innis, M. G. Caron, and R. J. Lefkowitz. “Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity.” Protein Expr Purif 6, no. 6 (December 1995): 717–21. https://doi.org/10.1006/prep.1995.0001.
       Full Text  Link to Item
    • Nair, L. A., J. Inglese, R. Stoffel, W. J. Koch, R. J. Lefkowitz, M. M. Kwatra, and A. O. Grant. “Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma.” Circ Res 76, no. 5 (May 1995): 832–38. https://doi.org/10.1161/01.res.76.5.832.
       Full Text  Link to Item
    • Barak, L. S., M. Tiberi, N. J. Freedman, M. M. Kwatra, R. J. Lefkowitz, and M. G. Caron. “A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.” J Biol Chem 269, no. 4 (January 28, 1994): 2790–95.
       Link to Item
    • Kwatra, M. M., R. J. Lefkowitz, and M. G. Caron. “Partially purified and reconstituted g-protein coupled receptors as substrates of specific receptor kinases.” Methods 6, no. 1 (January 1, 1994): 11–17. https://doi.org/10.1006/meth.1994.1003.
       Full Text
    • Ramkumar, V., M. Kwatra, J. L. Benovic, and G. L. Stiles. “Erratum: Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase (Biochimica et Biophysica Acta - Molecular Cell Research (1993) 1179 (89-97)).” Biochimica Et Biophysica Acta  Molecular Cell Research 1220, no. 2 (January 1, 1994): 229. https://doi.org/10.1016/0167-4889(94)90142-2.
       Full Text
    • Ramkumar, V., M. Kwatra, J. L. Benovic, G. L. Stiles, and G. L. Stilesa. “Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase.” Biochim Biophys Acta 1179, no. 1 (October 7, 1993): 89–97. https://doi.org/10.1016/0167-4889(93)90075-z.
       Full Text  Link to Item
    • Kwatra, M. M., D. A. Schwinn, J. Schreurs, J. L. Blank, C. M. Kim, J. L. Benovic, J. E. Krause, M. G. Caron, and R. J. Lefkowitz. “The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.” J Biol Chem 268, no. 13 (May 5, 1993): 9161–64.
       Link to Item
    • Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.” J Biol Chem 267, no. 25 (September 5, 1992): 17882–90.
       Link to Item
    • Pitcher, J. A., J. Inglese, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. “Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.” Science 257, no. 5074 (August 28, 1992): 1264–67. https://doi.org/10.1126/science.1325672.
       Full Text  Link to Item
    • Kwatra, M. M., D. D. Bigner, and J. A. Cohn. “The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization.” Biochim Biophys Acta 1134, no. 2 (March 16, 1992): 178–81. https://doi.org/10.1016/0167-4889(92)90042-a.
       Full Text  Link to Item
    • Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “β-Arrestin2, a novel member of the arrestin/β-arrestin gene family.” Journal of Biological Chemistry 267, no. 25 (January 1, 1992): 17882–90.
    • Humphrey, P. A., A. J. Wong, B. Vogelstein, M. R. Zalutsky, G. N. Fuller, G. E. Archer, H. S. Friedman, M. M. Kwatra, S. H. Bigner, and D. D. Bigner. “Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.” Proc Natl Acad Sci U S A 87, no. 11 (June 1990): 4207–11. https://doi.org/10.1073/pnas.87.11.4207.
       Full Text  Link to Item
    • Hosey, M. M., M. M. Kwatra, J. Ptasienski, and R. M. Richardson. “Regulation of receptor function by protein phosphorylation.” Ann N Y Acad Sci 588 (1990): 155–63. https://doi.org/10.1111/j.1749-6632.1990.tb13206.x.
       Full Text  Link to Item
    • Kwatra, M. M., J. L. Benovic, M. G. Caron, R. J. Lefkowitz, and M. M. Hosey. “Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase.” Biochemistry 28, no. 11 (May 30, 1989): 4543–47. https://doi.org/10.1021/bi00437a005.
       Full Text  Link to Item
    • Kwatra, M. M., J. Ptasienski, and M. M. Hosey. “The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor.” Mol Pharmacol 35, no. 5 (May 1989): 553–58.
       Link to Item
    • KWATRA, M. M., J. PTASIENSKI, and M. M. HOSEY. “AGONIST-INDUCED PHOSPHORYLATION OF THE PIG-ATRIAL MUSCARINIC RECEPTOR AND ITS COMPARISON WITH THE CHICK HEART RECEPTOR.” Faseb Journal 2, no. 4 (March 15, 1988): A624–A624.
       Link to Item
    • Leung, E., M. M. Kwatra, M. M. Hosey, and R. D. Green. “Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling.” J Pharmacol Exp Ther 244, no. 3 (March 1988): 1150–56.
       Link to Item
    • Kwatra, M. M., E. Leung, A. C. Maan, K. K. McMahon, J. Ptasienski, R. D. Green, and M. M. Hosey. “Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.” J Biol Chem 262, no. 34 (December 5, 1987): 16314–21.
       Link to Item
    • Kwatra, M. M., E. Leung, M. M. Hosey, and R. D. Green. “N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.” J Med Chem 30, no. 5 (May 1987): 954–56. https://doi.org/10.1021/jm00388a039.
       Full Text  Link to Item
    • Kwatra, M. M., E. Leung, M. M. Hosey, and R. D. Green. “N⁶-phenyladenosines: Pronounced effect of phenyl substituents on affinity for A₂ adenosine receptors.” Journal of Medicinal Chemistry 30, no. 5 (1987): 954–56.
    • KWATRA, M. M., and M. M. HOSEY. “PHOSPHORYLATION OF THE CARDIAC MUSCARINIC RECEPTOR IN INTACT CHICK HEART AND ITS REGULATION BY A MUSCARINIC AGONIST.” Journal of Biological Chemistry 261, no. 27 (September 25, 1986): 2429–32.
       Link to Item
    • Kwatra, M. M., and M. M. Hosey. “Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist.” J Biol Chem 261, no. 27 (September 25, 1986): 12429–32.
       Link to Item
    • KWATRA, M. M., M. M. HOSEY, and R. GREEN. “CHARACTERIZATION OF CARDIAC ADENOSINE RECEPTORS USING N-6-PHENYLADENOSINES AND A NEW RADIOLIGAND, (I-125)-(M-AMINOPHENYL)ADENOSINE.” Federation Proceedings 45, no. 4 (March 5, 1986): 800–800.
       Link to Item
    • Choca, J. I., M. M. Kwatra, M. M. Hosey, and R. D. Green. “Specific photoaffinity labelling of inhibitory adenosine receptors.” Biochem Biophys Res Commun 131, no. 1 (August 30, 1985): 115–21. https://doi.org/10.1016/0006-291x(85)91778-4.
       Full Text  Link to Item
    • Kwatra, M. M., and T. L. Sourkes. “Substrate-dependent activation energy of the reaction catalyzed by monoamine oxidase.” Arch Biochem Biophys 210, no. 2 (September 1981): 531–36. https://doi.org/10.1016/0003-9861(81)90218-6.
       Full Text  Link to Item
    • Kwatra, M. M., and T. L. Sourkes. “Monoamine oxidase of rat skeletal muscle: substrate specificity and half-life.” Life Sci 27, no. 24 (December 15, 1980): 2327–31. https://doi.org/10.1016/0024-3205(80)90501-9.
       Full Text  Link to Item
    • Kwatra, M. M., and T. L. Sourkes. “Monoamine oxidase A and B activities in liver of riboflavin-deficient rats.” Biochem Pharmacol 29, no. 19 (October 1, 1980): 2693–94. https://doi.org/10.1016/0006-2952(80)90090-8.
       Full Text  Link to Item
    • Kwatra, M. M., D. Z. Simon, R. L. Salvador, and P. D. Cooper. “Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice.” J Med Chem 21, no. 3 (March 1978): 253–57. https://doi.org/10.1021/jm00201a003.
       Full Text  Link to Item

  • Book Sections

    • McKeel, J. A., and M. M. Kwatra. “Receptors.” In Encyclopedia of Biological Chemistry: Third Edition, 6:307–13, 2021. https://doi.org/10.1016/B978-0-12-819460-7.00313-3.
       Full Text
    • Goldsmith, L. E., and M. M. Kwatra. “Tachykinin/Substance P/Neurokinin-1 Receptors.” In Encyclopedia of Biological Chemistry: Second Edition, 360–65, 2013. https://doi.org/10.1016/B978-0-12-378630-2.00364-9.
       Full Text

  • Conference Papers

    • Kwatra, S. G., K. A. Whang, E. Boozalis, C. Roberts, and M. M. Kwatra. “730 Truncated neurokinin 1 receptor (NK1R) is the predominant form of NK1R in human keratinocytes.” In Journal of Investigative Dermatology, 138:S124–S124. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.739.
       Full Text
    • Vasavda, C., M. M. Kwatra, and S. G. Kwatra. “1079 Phospho-proteomic profiling reveals distinct signaling pathways by first and third generation EGFR inhibitors in human keratinocytes: Implications for adverse dermatologic reactions.” In Journal of Investigative Dermatology, 138:S183–S183. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.1092.
       Full Text
    • Kwatra, Madan, Cory Nanni, Callie Roberts, Shawn Kwatra, Glenn J. Lesser, and Mark R. Gilbert. “HETEROGENEITY OF EGFRvIII-POSITIVE GLIOBLASTOMA STEM CELLS: IMPLICATIONS FOR PERSONALIZED DRUG DEVELOPMENT.” In Neuro Oncology, 19:55–55. OXFORD UNIV PRESS INC, 2017.
       Link to Item
    • Keir, Stephen T., B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Madan M. Kwatra, Henry S. Friedman, and Dare D. Bigner. “Identification and treatment data of xenografts representing TCGA-defined glioblastoma subtypes.” In Cancer Research, Vol. 75, 2015. https://doi.org/10.1158/1538-7445.AM2015-2435A.
       Full Text  Link to Item
    • Keir, Stephen T., B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Patrick J. Killela, Hai Yan, Madan M. Kwatra, Henry S. Friedman, and Darell D. Bigner. “Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes.” In Cancer Research, Vol. 74, 2014. https://doi.org/10.1158/1538-7445.AM2014-838.
       Full Text  Link to Item
    • Keir, Stephen, Charles Pegram, Eric Lipp, Ahmed Rasheed, Vidyalakshmi Chandramohan, Chien-Tsun Kuan, Madan Kwatra, Hai Yan, and Darell Bigner. “ESTABLISHMENT OF SEVEN NEW PERMANENT PEDIATRIC BRAIN TUMOR LINES.” In Neuro Oncology, 15:10–10. OXFORD UNIV PRESS INC, 2013.
       Link to Item
    • Brown, Kristine E., Stephen T. Keir, John H. Sampson, Darell D. Bigner, and Madan M. Kwatra. “NEUROKININ-1 RECEPTOR: A POTENTIAL TARGET TO INHIBIT PEDIATRIC GLIOBLASTOMAS.” In Neuro Oncology, 14:17–18. OXFORD UNIV PRESS INC, 2012.
       Link to Item
    • Kwatra, Madan M. “DIFFERENTIAL EXPRESSION OF FULL-LENGTH AND TRUNCATED NEUROKININ 1 RECEPTORS IN GLIOBLASTOMA CELLS.” In Neuro Oncology, 12:18–18. OXFORD UNIV PRESS INC, 2010.
       Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • PHARM 394: Research Independent Study 2022
  • PHARM 494: Research Independent Study 2022
  • CMB 797: Modern Techniques in Molecular Biology 2021
  • PHARM 393: Research Independent Study 2021
  • PHARM 394: Research Independent Study 2021
  • PHARM 493: Research Independent Study 2021
  • PHARM 494: Research Independent Study 2021
  • CMB 797: Modern Techniques in Molecular Biology 2020
  • PHARM 393: Research Independent Study 2020
  • PHARM 394: Research Independent Study 2020
  • PHARM 493: Research Independent Study 2020
  • PHARM 494: Research Independent Study 2020

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.