Madan Mohan Kwatra | Scholars@Duke

Madan Mohan Kwatra
Associate Professor in Anesthesiology

The focus of this laboratory is on signaling through G protein-coupled receptors and clinical proteomics. These goals are currently being realized through three major projects: (1) Mechanism of signal transduction through substance P receptor in human glioblastomas; (2) Effect of age and diabetes on G protein-coupled receptors in human heart; and (3) Molecular basis of postoperative delirium in the elderly. Our studies use state-of-the-art techniques in protein biochemistry and molecular biology including DNA microarrays. A major goal of project #3 is to identify biomarkers of delirium in plasma using a proteomic approach including analyses by 2D-gel electrophoresis, mass spectrometry,SELDI/TOF (protein-chip), and protein microarrays.

Current Appointments & Affiliations

Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2003
Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2005
Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2005
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1989

Contact Information

146 Sands Bldg, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
kwatr001@mc.duke.edu (919) 681-4782

Background
Education, Training, & Certifications
- Ph.D., University of Montreal (Canada) 1977
Duke Appointment History
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2010 - 2013
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2004 - 2010
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 2005
- Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1999 - 2003
- Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1993 - 1999
- Assistant Research Professor in Medicine, Medicine, Clinical Science Departments 1992 - 1993
- Assistant Medical Research Professor in Pathology, Pathology, Clinical Science Departments 1990
Research
Selected Grants
- Evaluation of VAL-083, either alone or in combination with other agents, for its activity inhibition of glioblastoma subtypes (personalized drug development) awarded by DelMar Pharmaceuticals, Inc. 2017 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Evaluation of novel anti-cancer agents, either alone or in combination, for activity against glioblastoma subtypes: a personalized medicine approach awarded by Genzada Pharmaceuticals, LLC 2017 - 2019
- Curtana Pharmacueticals Sponsored Research Agreement awarded by Curtana Pharmaceuticals, Inc. 2016 - 2017
- Evaluation of AZD9291 in Glioblastoma patients with activated EGFR awarded by National Institutes of Health 2015 - 2016
- Targeting GBMs with Activated EGFR with third-generation, brain-penetrating AZD9291 awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2016
- Summer Research fellowship for two undergraduate Pre-Med Students awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014 - 2015
- Truncated NK1R in GBM: Pharmacology and Relationship with Patient Survival awarded by National Institutes of Health 2012 - 2015
- Isolation of stem cells from glioblastoma xenografts with activated EGFR awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014
- Molecular Basis of Postoperative Delirium in the Elderly awarded by National Institutes of Health 2003 - 2010
- Aging And G Protein Coupled Receptors In Human Heart awarded by National Institutes of Health 1998 - 2006
- Beta Adrenoceptors During Cardiopulmonary Bypass awarded by National Institutes of Health 1997 - 2002
- Function Of Human Substance P Receptor awarded by National Institutes of Health 1995 - 2001
- Desensitization Of B-Adrenoceptors During Cardiopulmonary awarded by National Institutes of Health 1997 - 1999
- Function Of Human Substances P Receptor awarded by National Institutes of Health 1995 - 1999
- Function Of Substance P Receptor awarded by National Institutes of Health 1995 - 1999
- Molecular Characterization Of Human Alc-Adrenergic Recept awarded by National Institutes of Health 1996 - 1999
- Transcriptional Regulation Of Human 1a-Adrenoceptors awarded by National Institutes of Health 1996 - 1999
- Excitatory Amino Acids In Ovine Fetal Brain Injury awarded by National Institutes of Health 1996 - 1998
- Aging And G Protein-Coupled Receptor Signaling In Human awarded by National Institutes of Health 1996 - 1997
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Keir, ST, Rasheed, BA, Hoadley, KA, Roskoski, MA, Gasinski, D, Killela, PJ, Yan, H, Kwatra, MM, Friedman, HS, and Bigner, DD. "Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes." October 1, 2014. Full Text
  - Brown, KE, Keir, ST, Sampson, JH, Bigner, DD, and Kwatra, MM. "NEUROKININ-1 RECEPTOR: A POTENTIAL TARGET TO INHIBIT PEDIATRIC GLIOBLASTOMAS." October 2012. Link to Item
  - Kwatra, MM. "DIFFERENTIAL EXPRESSION OF FULL-LENGTH AND TRUNCATED NEUROKININ 1 RECEPTORS IN GLIOBLASTOMA CELLS." November 2010. Link to Item
- Journal Articles
  - Kwatra, MM. "A Rational Approach to Target the Epidermal Growth Factor Receptor in Glioblastoma." Current cancer drug targets 17, no. 3 (January 2017): 290-296. Full Text
  - Yen, TE, Allen, JC, Rivelli, SK, Patterson, SC, Metcalf, MR, Flink, BJ, Mirrakhimov, AE, Lagoo, SA, Vail, TP, Young, CC, Moon, RE, Trzepacz, PT, and Kwatra, MM. "Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty." Scientific reports 6 (February 5, 2016): 20736-. Full Text
  - Brown, KE, Chagoya, G, Kwatra, SG, Yen, T, Keir, ST, Cooter, M, Hoadley, KA, Rasheed, A, Lipp, ES, Mclendon, R, Ali-Osman, F, Bigner, DD, Sampson, JH, and Kwatra, MM. "Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development." Journal of neurochemistry 133, no. 5 (June 2015): 730-738. Full Text
  - Brown, KE, Chagoya, G, Kwatra, SG, Yen, T, Keir, ST, Cooter, M, Hoadley, KA, Rasheed, A, Lipp, ES, McLendon, R, Ali-Osman, F, Bigner, DD, Sampson, JH, and Kwatra, MM. "Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: Implications for drug development." Journal of Neurochemistry 133, no. 5 (2015): 730-738. Full Text
  - Kwatra, MM, Brown, KE, Chagoya, G, Keir, ST, Bigner, DD, and Sampson, JH. "Patient-derived xenografts mirror the proteomic profile of human glioblastoma: implications for personalized drug development." Neuro Oncol 16 Suppl 3 (July 2014): iii38-. Full Text Link to Item
  - Mirrakhimov, AE, Brewbaker, CL, Krystal, AD, and Kwatra, MM. "Obstructive sleep apnea and delirium: exploring possible mechanisms." Sleep Breath 18, no. 1 (March 2014): 19-29. (Review) Full Text Link to Item
  - Mirrakhimov, AE, Brewbaker, CL, Krystal, AD, and Kwatra, MM. "Obstructive sleep apnea and delirium: Exploring possible mechanisms." Sleep and Breathing 18, no. 1 (January 1, 2014): 19-29. (Review) Full Text
  - Reed, C, Kwatra, SG, Brown, K, and Kwatra, MM. "Revisiting the prehypertension debate: increasing evidence for treatment yet randomized clinical trials are lacking." Blood Press 22, no. 6 (December 2013): 340-343. Full Text Link to Item
  - Brown, KE, Mirrakhimov, AE, Yeddula, K, and Kwatra, MM. "Propofol and the risk of delirium: exploring the anticholinergic properties of propofol." Med Hypotheses 81, no. 4 (October 2013): 536-539. Full Text Link to Item
  - Mirrakhimov, AE, Yen, T, and Kwatra, MM. "Delirium after cardiac surgery: have we overlooked obstructive sleep apnea?." Med Hypotheses 81, no. 1 (July 2013): 15-20. Full Text Link to Item
  - Brown, KE, Mirrakhimov, AE, Yeddula, K, and Kwatra, MM. "Propofol And The Risk Of Delirium: Exploring The Anticholinergic Properties Of Propofol." Medical Hypotheses 81, no. 4 (2013): 536-539. Full Text
  - Mirrakhimov, AE, Yen, T, and Kwatra, MM. "Delirium after cardiac surgery: Have we overlooked obstructive sleep apnea?." Medical Hypotheses 81, no. 1 (2013): 15-20. Full Text
  - Kwatra, MM, Moon, RE, White, WD, Trzepacz, PT, and Rivelli, SK. "In reply." Anesthesiology 117, no. 6 (December 2012): 1392-1393. Full Text Link to Item
  - Flink, BJ, Rivelli, SK, Cox, EA, White, WD, Falcone, G, Vail, TP, Young, CC, Bolognesi, MP, Krystal, AD, Trzepacz, PT, Moon, RE, and Kwatra, MM. "Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly." Anesthesiology 116, no. 4 (April 2012): 788-796. Full Text Link to Item
  - Kwatra, SG, Kiely, AE, and Kwatra, MM. "Prehypertension: to treat or not to treat should no longer be the question." Hypertension 59, no. 4 (April 2012): e27-. (Letter) Full Text Link to Item
  - Motosko, C, Brown, K, and Kwatra, M. "Insulin-like growth factor 1 and delirium." International Psychogeriatrics 24, no. 11 (2012): 1872--. Full Text
  - Kwatra, MM. "Prevention of intraoperative awareness." N Engl J Med 365, no. 21 (November 24, 2011): 2033-. (Letter) Full Text Link to Item
  - Kwatra, MM, Porter, TM, Brown, KE, Herndon, JE, and Bigner, DD. "TRUNCATED NEUROKININ 1 RECEPTOR: EXPRESSION IN PRIMARY GLIOBLASTOMAS AND RELATIONSHIP WITH PATIENT SURVIVAL." NEURO-ONCOLOGY 13 (November 2011): 82-82. Link to Item
  - Kwatra, SG, Goldsmith, LE, White, WD, Lin, SS, and Kwatra, MM. "Low expression of alpha-adrenergic receptors in the aging human heart." J Am Geriatr Soc 58, no. 1 (January 2010): 210-212. (Letter) Full Text Link to Item
  - Cox, EA, Kwatra, SG, Shetty, S, and Kwatra, MM. "Flaws in the serum anticholinergic activity assay: implications for the study of delirium." J Am Geriatr Soc 57, no. 9 (September 2009): 1707-1708. (Letter) Full Text Link to Item
  - Akazawa, T, Kwatra, SG, Goldsmith, LE, Richardson, MD, Cox, EA, Sampson, JH, and Kwatra, MM. "A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas." J Neurochem 109, no. 4 (May 2009): 1079-1086. Full Text Link to Item
  - Kiely, AE, Kwatra, SG, and Kwatra, MM. "Treating prehypertension: medically sound and economically viable." Blood Press 18, no. 6 (2009): 300-303. Full Text Link to Item
  - Kwatra, M. "Limitations of the anticholinergic risk scale." Archives of Internal Medicine 168, no. 21 (2008): 2386--. Full Text
  - Kilts, JD, Lin, SS, Lowe, JE, and Kwatra, MM. "Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors." J Cardiovasc Pharmacol 50, no. 3 (September 2007): 299-303. Full Text Link to Item
  - Kwatra, MM. "Delirium in older persons." N Engl J Med 354, no. 23 (June 8, 2006): 2509-2511. (Letter) Link to Item
  - Kwatra, MM. "Prevention of atrial fibrillation following cardiac surgery." JAMA 295, no. 19 (May 17, 2006): 2247-2248. (Letter) Full Text Link to Item
  - Kwatra, MM. "Delirium in older persons [11]." New England Journal of Medicine 354, no. 23 (2006): 2510--.
  - Yamaguchi, K, Richardson, MD, Bigner, DD, and Kwatra, MM. "Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta." Cancer Chemother Pharmacol 56, no. 6 (December 2005): 585-593. Full Text Link to Item
  - Kilts, JD, Grocott, HP, and Kwatra, MM. "G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta." J Mol Cell Cardiol 38, no. 2 (February 2005): 267-276. Full Text Link to Item
  - Kilts, JD, Grocott, HP, and Kwatra, MM. "Gαq-coupled receptors in human atrium function through protein kinase C ε and δ." Journal of Molecular and Cellular Cardiology 38, no. 2 (February 1, 2005): 267-276. Full Text
  - Richardson, MD, Kilts, JD, and Kwatra, MM. "Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects." Diabetes 53, no. 9 (September 2004): 2392-2396. Link to Item
  - Kilts, JD, Akazawa, T, El-Moalem, HE, Mathew, JP, Newman, MF, and Kwatra, MM. "Age increases expression and receptor-mediated activation of G alpha i in human atria." J Cardiovasc Pharmacol 42, no. 5 (November 2003): 662-670. Link to Item
  - Hagen, SA, Kondyra, AL, Grocott, HP, El-Moalem, H, Bainbridge, D, Mathew, JP, Newman, MF, Reves, JG, Schwinn, DA, and Kwatra, MM. "Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells." Anesthesiology 98, no. 2 (February 2003): 343-348. Link to Item
  - Richardson, MD, Balius, AM, Yamaguchi, K, Freilich, ER, Barak, LS, and Kwatra, MM. "Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize." J Neurochem 84, no. 4 (February 2003): 854-863. Link to Item
  - Kilts, JD, Akazawa, T, Richardson, MD, and Kwatra, MM. "Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors." J Biol Chem 277, no. 34 (August 23, 2002): 31257-31262. Full Text Link to Item
  - Warabi, K, Richardson, MD, Barry, WT, Yamaguchi, K, Roush, ED, Nishimura, K, and Kwatra, MM. "Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro." FEBS Lett 521, no. 1-3 (June 19, 2002): 140-144. Link to Item
  - Kilts, JD, Gerhardt, MA, Richardson, MD, Sreeram, G, Mackensen, GB, Grocott, HP, White, WD, Davis, RD, Newman, MF, Reves, JG, Schwinn, DA, and Kwatra, MM. "Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i)." Circ Res 87, no. 8 (October 13, 2000): 705-709. Link to Item
  - Kilts, JD, Gerhardt, MA, Richardson, MD, Sreeram, G, Mackensen, GB, Grocott, HP, White, WD, Davis, RD, Newman, MF, Reves, JG, Schwinn, DA, and Kwatra, MM. "β2-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i)." Circulation Research 87, no. 8 (October 13, 2000): 705-709.
  - Kilts, JD, Gerhardt, MA, Richardson, MD, Sreeram, G, Mackensen, GB, Grocott, HP, White, WD, Davis, RD, Newman, MF, Reves, JG, Schwinn, DA, and Kwatra, MM. "β₂-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i)." Circulation Research 87, no. 8 (2000): 705-709.
  - Roush, ED, Warabi, K, and Kwatra, MM. "Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells." Mol Pharmacol 55, no. 5 (May 1999): 855-862. Link to Item
  - Barak, LS, Warabi, K, Feng, X, Caron, MG, and Kwatra, MM. "Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor." J Biol Chem 274, no. 11 (March 12, 1999): 7565-7569. Link to Item
  - Gerhardt, MA, Booth, JV, Chesnut, LC, Funk, BL, El-Moalem, HE, Kwatra, MM, Schwinn, DA, and Gr, DHCPD. "Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease." CIRCULATION 98, no. 19 (November 10, 1998): II275-II281. Link to Item
  - Gerhardt, MA, Booth, JV, Chesnut, LC, Funk, BL, el-Moalem, HE, Kwatra, MM, and Schwinn, DA. "Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Duke Heart Center Perioperative Desensitization Group." Circulation 98, no. 19 Suppl (November 10, 1998): II275-II281. Link to Item
  - Rudner, XL, Berkowitz, DE, Funk, BL, Kwatra, MM, and Schwinn, DA. "Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age." CIRCULATION 98, no. 17 (October 27, 1998): 540-540. Link to Item
  - Booth, JV, Landolfo, KP, Chesnut, LC, Bennett-Guerrero, E, Gerhardt, MA, Atwell, DM, El-Moalem, HE, Smith, MS, Funk, BL, Kuhn, CM, Kwatra, MM, and Schwinn, DA. "Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group." Anesthesiology 89, no. 3 (September 1998): 602-611. Link to Item
  - DeLong, ER, Kwatra, MM, Gan, TJ, Glass, PSA, Sanderson, IC, Gilbert, WC, Coleman, RL, Lubarsky, DA, and Reves, JG. "A large population study reveals reduced anesthetic requirements in females." ANESTHESIOLOGY 89, no. 3A (September 1998): U191-U191. Link to Item
  - Gerhardt, MA, Barnett, TN, Barry, WT, Schwinn, DA, and Kwatra, MM. "beta(2)-adrenergic receptors in human atrial membranes activate both G(s) and G(i)." ANESTHESIOLOGY 89, no. 3A (September 1998): U233-U233. Link to Item
  - Wendelburg, BE, Barnett, TN, Kwatra, MM, and Schwinn, DA. "Characterization of [H-3]forskolin binding to human atrial membranes." ANESTHESIOLOGY 89, no. 3A (September 1998): U464-U464. Link to Item
  - Roush, ED, and Kwatra, MM. "Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o)." FEBS Lett 428, no. 3 (May 29, 1998): 291-294. Link to Item
  - Lee, K, Richardson, CD, Razik, MA, Kwatra, MM, and Schwinn, DA. "Multiple potential regulatory elements in the 5' flanking region of the human alpha 1a-adrenergic receptor." DNA Seq 8, no. 4 (March 1998): 271-276. Link to Item
  - Nishimura, K, Warabi, K, Roush, ED, Frederick, J, Schwinn, DA, and Kwatra, MM. "Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes." Biochemistry 37, no. 5 (February 3, 1998): 1192-1198. Full Text Link to Item
  - Smiley, RM, Kwatra, MM, and Schwinn, DA. "New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance." J Cardiothorac Vasc Anesth 12, no. 1 (February 1998): 80-95. (Review) Link to Item
  - Booth, JV, Landolfo, KP, Chesnut, LC, Bennett-Guerrero, E, Gerhardt, MA, Atwell, DM, El-Moalem, HE, Smith, MS, Funk, BL, Kuhn, CM, Kwatra, MM, and Schwinn, DA. "Acute depression of myocardial β-adrenergic receptor signaling during cardiopulmonary bypass. Impairment of the adenylyl cyclase moiety." Anesthesiology 89, no. 3 (1998): 602-611. Full Text
  - Gerhardt, MA, Booth, JV, Chesnut, LC, Funk, BL, El-Moalem, HE, Kwatra, MM, and Schwinn, DA. "Acute myocardial β-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease." Circulation 98, no. 19 SUPPL. (1998): II275-II281.
  - Lee, K, Richardson, CD, Razik, MA, Kwatra, MM, and Schwinn, DA. "Multiple potential regulatory elements in the 5′ flanking region of the human alalpha;_1a,-adrenergic receptor:short communication." Mitochondrial DNA 8, no. 4 (1998): 271-276. Full Text
  - Nishimura, K, Frederick, J, and Kwatra, MM. "Human substance P receptor expressed in Sf9 cells couples with multiple endogenous G proteins." J Recept Signal Transduct Res 18, no. 1 (January 1998): 51-65. Full Text Link to Item
  - Schwinn, DA, and Kwatra, MM. "Expression and regulation of alpha 1-adrenergic receptors in human tissues." Adv Pharmacol 42 (1998): 390-394. Link to Item
  - Schwinn, DA, and Kwatra, MM. "α1,-Adrenoceptor Subtypes in the Human Cardiovascular and Urogenital Systems." Advances in Pharmacology 42, no. C (December 1, 1997): 390-394. Full Text
  - Razik, MA, Lee, K, Price, RR, Williams, MR, Ongjoco, RR, Dole, MK, Rudner, XL, Kwatra, MM, and Schwinn, DA. "Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region." J Biol Chem 272, no. 45 (November 7, 1997): 28237-28246. Link to Item
  - Schwinn, DA, Gerhardt, MA, Chesnut, LC, Funk, BL, Landolfo, KP, and Kwatra, MM. "Acute myocardial beta-adrenergic receptor desensitization during cardiopulmonary bypass for cardiac valve surgery." CIRCULATION 96, no. 8 (October 21, 1997): 2844-2844. Link to Item
  - Kwatra, MM, Nishimura, K, Warabi, K, Roush, ED, and Schwinn, DA. "Membrane-bound human substance p receptor undergoes agonist-dependent phosphorylation by g protein receptor kinase 2 (grk2) to a high stoichiometry and activates grk2 in the absence of g_βγ." FASEB Journal 11, no. 9 (1997): A1056-.
  - Schwinn, DA, and Kwatra, MM. "α₁,-Adrenoceptor Subtypes in the Human Cardiovascular and Urogenital Systems." Advances in Pharmacology 42, no. C (1997): 390-394. Full Text
  - Chen, B, Leverette, RD, Schwinn, DA, and Kwatra, MM. "Human G(alpha q): cDNA and tissue distribution." Biochim Biophys Acta 1281, no. 2 (June 11, 1996): 125-128. Link to Item
  - Kwatra, MM, Schreurs, J, Schwinn, DA, Innis, MA, Caron, MG, and Lefkowitz, RJ. "Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity." Protein Expr Purif 6, no. 6 (December 1995): 717-721. Full Text Link to Item
  - Nair, LA, Inglese, J, Stoffel, R, Koch, WJ, Lefkowitz, RJ, Kwatra, MM, and Grant, AO. "Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma." Circ Res 76, no. 5 (May 1995): 832-838. Link to Item
  - Barak, LS, Tiberi, M, Freedman, NJ, Kwatra, MM, Lefkowitz, RJ, and Caron, MG. "A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration." J Biol Chem 269, no. 4 (January 28, 1994): 2790-2795. Link to Item
  - Kwatra, MM, Lefkowitz, RJ, and Caron, MG. "Partially Purified and Reconstituted G-Protein Coupled Receptors as Substrates of Specific Receptor Kinases." Methods 6, no. 1 (1994): 11-17. Full Text
  - Ramkumar, V, Kwatra, M, Benovic, JL, and Stiles, GL. "Erratum: Functional consequences of A₁ adenosine-receptor phosphorylation by the β-adrenergic receptor kinase (Biochimica et Biophysica Acta - Molecular Cell Research (1993) 1179 (89-97))." Biochimica et Biophysica Acta - Molecular Cell Research 1220, no. 2 (1994): 229--. Full Text
  - Ramkumar, V, Kwatra, M, Benovic, JL, Stiles, GL, and Stilesa, GL. "Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase." Biochim Biophys Acta 1179, no. 1 (October 7, 1993): 89-97. Link to Item
  - Kwatra, MM, Schwinn, DA, Schreurs, J, Blank, JL, Kim, CM, Benovic, JL, Krause, JE, Caron, MG, and Lefkowitz, RJ. "The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2." J Biol Chem 268, no. 13 (May 5, 1993): 9161-9164. Link to Item
  - Attramadal, H, Arriza, JL, Aoki, C, Dawson, TM, Codina, J, Kwatra, MM, Snyder, SH, Caron, MG, and Lefkowitz, RJ. "Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family." J Biol Chem 267, no. 25 (September 5, 1992): 17882-17890. Link to Item
  - Pitcher, JA, Inglese, J, Higgins, JB, Arriza, JL, Casey, PJ, Kim, C, Benovic, JL, Kwatra, MM, Caron, MG, and Lefkowitz, RJ. "Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors." Science 257, no. 5074 (August 28, 1992): 1264-1267. Link to Item
  - Kwatra, MM, Bigner, DD, and Cohn, JA. "The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization." Biochim Biophys Acta 1134, no. 2 (March 16, 1992): 178-181. Link to Item
  - Attramadal, H, Arriza, JL, Aoki, C, Dawson, TM, Codina, J, Kwatra, MM, Snyder, SH, Caron, MG, and Lefkowitz, RJ. "β-arrestin2, a novel member of the arrestin/β-arrestin gene family." Journal of Biological Chemistry 267, no. 25 (1992): 17882-17890.
  - Humphrey, PA, Wong, AJ, Vogelstein, B, Zalutsky, MR, Fuller, GN, Archer, GE, Friedman, HS, Kwatra, MM, Bigner, SH, and Bigner, DD. "Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma." Proc Natl Acad Sci U S A 87, no. 11 (June 1990): 4207-4211. Link to Item
  - Hosey, MM, Kwatra, MM, Ptasienski, J, and Richardson, RM. "Regulation of receptor function by protein phosphorylation." Ann N Y Acad Sci 588 (1990): 155-163. (Review) Link to Item
  - Kwatra, MM, Benovic, JL, Caron, MG, Lefkowitz, RJ, and Hosey, MM. "Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase." Biochemistry 28, no. 11 (May 30, 1989): 4543-4547. Link to Item
  - Kwatra, MM, Ptasienski, J, and Hosey, MM. "The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor." Mol Pharmacol 35, no. 5 (May 1989): 553-558. Link to Item
  - KWATRA, MM, PTASIENSKI, J, and HOSEY, MM. "AGONIST-INDUCED PHOSPHORYLATION OF THE PIG-ATRIAL MUSCARINIC RECEPTOR AND ITS COMPARISON WITH THE CHICK HEART RECEPTOR." FASEB JOURNAL 2, no. 4 (March 15, 1988): A624-A624. Link to Item
  - Leung, E, Kwatra, MM, Hosey, MM, and Green, RD. "Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling." J Pharmacol Exp Ther 244, no. 3 (March 1988): 1150-1156. Link to Item
  - Kwatra, MM, Leung, E, Maan, AC, McMahon, KK, Ptasienski, J, Green, RD, and Hosey, MM. "Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization." J Biol Chem 262, no. 34 (December 5, 1987): 16314-16321. Link to Item
  - Kwatra, MM, Leung, E, Hosey, MM, and Green, RD. "N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors." J Med Chem 30, no. 5 (May 1987): 954-956. Link to Item
  - Kwatra, MM, Leung, E, Hosey, MM, and Green, RD. "N⁶-phenyladenosines: Pronounced effect of phenyl substituents on affinity for A₂ adenosine receptors." Journal of Medicinal Chemistry 30, no. 5 (1987): 954-956.
  - KWATRA, MM, and HOSEY, MM. "PHOSPHORYLATION OF THE CARDIAC MUSCARINIC RECEPTOR IN INTACT CHICK HEART AND ITS REGULATION BY A MUSCARINIC AGONIST." JOURNAL OF BIOLOGICAL CHEMISTRY 261, no. 27 (September 25, 1986): 2429-2432. Link to Item
  - Kwatra, MM, and Hosey, MM. "Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist." J Biol Chem 261, no. 27 (September 25, 1986): 12429-12432. Link to Item
  - KWATRA, MM, HOSEY, MM, and GREEN, R. "CHARACTERIZATION OF CARDIAC ADENOSINE RECEPTORS USING N-6-PHENYLADENOSINES AND A NEW RADIOLIGAND, (I-125)-(M-AMINOPHENYL)ADENOSINE." FEDERATION PROCEEDINGS 45, no. 4 (March 5, 1986): 800-800. Link to Item
  - Choca, JI, Kwatra, MM, Hosey, MM, and Green, RD. "Specific photoaffinity labelling of inhibitory adenosine receptors." Biochem Biophys Res Commun 131, no. 1 (August 30, 1985): 115-121. Link to Item
  - Kwatra, MM, and Sourkes, TL. "Substrate-dependent activation energy of the reaction catalyzed by monoamine oxidase." Arch Biochem Biophys 210, no. 2 (September 1981): 531-536. Link to Item
  - Kwatra, MM, and Sourkes, TL. "Monoamine oxidase of rat skeletal muscle: substrate specificity and half-life." Life Sci 27, no. 24 (December 15, 1980): 2327-2331. Link to Item
  - Kwatra, MM, and Sourkes, TL. "Monoamine oxidase A and B activities in liver of riboflavin-deficient rats." Biochem Pharmacol 29, no. 19 (October 1, 1980): 2693-2694. Link to Item
  - Kwatra, MM, Simon, DZ, Salvador, RL, and Cooper, PD. "Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice." J Med Chem 21, no. 3 (March 1978): 253-257. Link to Item
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