Overview
Molecular Pharmacology Laboratory
The focus of this laboratory is to understand the molecular basis of glioblastoma and inflammatory skin diseases including atopic dermatitis and prurigo nodularis. Within this line of inquiry, the emphasis is on understanding how these diseases alter the function of Gprotein-couped receptors.
The focus of this laboratory is to understand the molecular basis of glioblastoma and inflammatory skin diseases including atopic dermatitis and prurigo nodularis. Within this line of inquiry, the emphasis is on understanding how these diseases alter the function of Gprotein-couped receptors.
Current Duke Appointments & Affiliations
Associate Professor in Anesthesiology
·
2003 - Present
Anesthesiology,
Clinical Science Departments
Associate Professor of Pharmacology & Cancer Biology
·
2010 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Associate Professor in Psychiatry and Behavioral Sciences
·
2021 - Present
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences,
Psychiatry & Behavioral Sciences
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
1989 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
Identification of a distinct circulating CCL chemokine signature in neuropathic pruritus.
Journal article J Am Acad Dermatol · May 20, 2026 Full text Link to item CiteSomatic mutations reveal hyperactive Notch signaling in prurigo nodularis.
Journal article JCI Insight · April 22, 2026 Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by pruritic skin nodules of unknown etiology. Little is known about genetic changes in PN pathogenesis, particularly somatic events, which are often implicated in inflammatory cond ... Full text Link to item CiteNanostring Transcriptomic Analysis Highlights IL-6 Family and TGF-β Pathways in the Pathogenesis of Prurigo Nodularis.
Journal article JID Innov · January 2026 Prurigo nodularis (PN) is a chronic, neuroimmune-driven skin disease characterized by intensely pruritic nodules and marked impairment in QOL. Although PN shares inflammatory features with atopic dermatitis and psoriasis, its underlying pathogenesis remain ... Full text Link to item CiteRecent Grants
Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031GZ17-6.02 as a Novel Therapeutic Agent for Dermatologic
ResearchPrincipal Investigator · Awarded by Genzada Pharmaceuticals, LLC · 2020 - 2028Understanding the Role of Type 2 Inflammation in Prurigo Nodularis
ResearchPrincipal Investigator · Awarded by Sanofi US · 2023 - 2026View All Grants
Education
University of Montreal (Canada) ·
1977
Ph.D.