Madan Mohan Kwatra | Scholars@Duke

Madan Mohan Kwatra
Associate Professor in Anesthesiology

The focus of this laboratory is on signaling through G protein-coupled receptors and clinical proteomics. These goals are currently being realized through three major projects: (1) Mechanism of signal transduction through substance P receptor in human glioblastomas; (2) Effect of age and diabetes on G protein-coupled receptors in human heart; and (3) Molecular basis of postoperative delirium in the elderly. Our studies use state-of-the-art techniques in protein biochemistry and molecular biology including DNA microarrays. A major goal of project #3 is to identify biomarkers of delirium in plasma using a proteomic approach including analyses by 2D-gel electrophoresis, mass spectrometry,SELDI/TOF (protein-chip), and protein microarrays.

Current Appointments & Affiliations

Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2003
Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2010
Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2021
Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1989

Contact Information

146 Sands Bldg, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
kwatr001@mc.duke.edu (919) 681-4782

Background
Education, Training, & Certifications
- Ph.D., University of Montreal (Canada) 1977
Previous Appointments & Affiliations
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2009 - 2021
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2010 - 2013
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2008 - 2010
- Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2005 - 2009
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2007 - 2008
- Associate Professor in Nursing, School of Nursing, Duke University 2006 - 2007
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2005 - 2006
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 2005
- Associate Professor in Nursing, School of Nursing, Duke University 2004 - 2005
- Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1999 - 2003
- Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1993 - 1999
- Assistant Research Professor in Medicine, Medicine, Clinical Science Departments 1992 - 1993
- Assistant Medical Research Professor in Pathology, Pathology, Clinical Science Departments 1990
Research
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Anti-fibrotic mechanisms of IL-31 blockade in prurigo nodularis awarded by Galderma 2023 - 2024
- GZ17-6.02 as a Novel Therapeutic Agent for Dermatologic awarded by Genzada Pharmaceuticals, LLC 2020 - 2024
- Prurigo Nodularis: Disease Burden and Rationale for Novel Therapeutics awarded by Galderma 2022 - 2023
- IL-13Ra1 signaling in atopic dermatitis awarded by ASLAN Pharmaceuticals 2022 - 2023
- Generating Patient-Derived Gliomas within Cerebral Organoids to be Treated with Repurposed Drugs awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2021 - 2022
- Evaluation of novel anti-cancer agents, either alone or in combination, for activity against glioblastoma subtypes: a personalized medicine approach awarded by Genzada Pharmaceuticals, LLC 2017 - 2021
- Glioblastoma model research awarded by The Miami Foundation 2017 - 2021
- Heterogeneity of EGFRvIII-positive glioblastoma and their sensitivity to AZD9291 (Osimertinib) awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2019 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Evaluation of VAL-083, either alone or in combination with other agents, for its activity inhibition of glioblastoma subtypes (personalized drug development) awarded by DelMar Pharmaceuticals, Inc. 2017 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Heterogeneity of EGFRvIII-positive glioblastoma and their sensitivity to AZD9291 (Osimertinib) awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2018
- Curtana Pharmacueticals Sponsored Research Agreement awarded by Curtana Pharmaceuticals, Inc. 2016 - 2017
- Evaluation of AZD9291 in Glioblastoma patients with activated EGFR awarded by National Institutes of Health 2015 - 2016
- Targeting GBMs with Activated EGFR with third-generation, brain-penetrating AZD9291 awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2016
- Summer Research fellowship for two undergraduate Pre-Med Students awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014 - 2015
- Truncated NK1R in GBM: Pharmacology and Relationship with Patient Survival awarded by National Institutes of Health 2012 - 2015
- Isolation of stem cells from glioblastoma xenografts with activated EGFR awarded by Musella Foundation For Brain Tumor Research & Information, Inc 2014
- Molecular Basis of Postoperative Delirium in the Elderly awarded by National Institutes of Health 2003 - 2010
- Aging And G Protein Coupled Receptors In Human Heart awarded by National Institutes of Health 1998 - 2006
- Same awarded by National Institutes of Health 1997 - 2002
- Function Of Human Substance P Receptor awarded by National Institutes of Health 1995 - 2001
- Desensitization Of B-Adrenoceptors During Cardiopulmonary awarded by National Institutes of Health 1997 - 1999
- Function Of Human Substances P Receptor awarded by National Institutes of Health 1995 - 1999
- Function Of Substance P Receptor awarded by National Institutes of Health 1995 - 1999
- Molecular Characterization Of Human Alc-Adrenergic Recept awarded by National Institutes of Health 1996 - 1999
- Transcriptional Regulation Of Human 1a-Adrenoceptors awarded by National Institutes of Health 1996 - 1999
- Excitatory Amino Acids In Ovine Fetal Brain Injury awarded by National Institutes of Health 1996 - 1998
- Aging And G Protein-Coupled Receptor Signaling In Human awarded by National Institutes of Health 1996 - 1997
External Relationships
- GBM Pharma, Inc
- Glioblastoma Foundation
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Le, Thomas K., Isabelle Brown, Rebecca Goldberg, Matthew T. Taylor, Junwen Deng, Varsha Parthasarathy, Zachary A. Bordeaux, et al. “Cutaneous Toxicities Associated with Immune Checkpoint Inhibitors: An Observational, Pharmacovigilance Study.” J Invest Dermatol 142, no. 11 (November 2022): 2896-2908.e4. https://doi.org/10.1016/j.jid.2022.04.020.
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  - Sutaria, Nishadh, Martin Prince Alphonse, Melika Marani, Varsha Parthasarathy, Junwen Deng, Shannon Wongvibulsin, Kyle Williams, et al. “Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans.” The Journal of Investigative Dermatology 142, no. 5 (May 2022): 1300-1308.e3. https://doi.org/10.1016/j.jid.2021.10.011.
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  - Choi, Justin, Zachary A. Bordeaux, Jaimie McKeel, Cory Nanni, Nishadh Sutaria, Gabriella Braun, Cole Davis, et al. “GZ17-6.02 Inhibits the Growth of EGFRvIII+ Glioblastoma.” Int J Mol Sci 23, no. 8 (April 10, 2022). https://doi.org/10.3390/ijms23084174.
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  - Deng, Junwen, Varsha Parthasarathy, Melika Marani, Zachary Bordeaux, Kevin Lee, Chi Trinh, Hannah L. Cornman, et al. “Extracellular matrix and dermal nerve growth factor dysregulation in prurigo nodularis compared to atopic dermatitis.” Front Med (Lausanne) 9 (2022): 1022889. https://doi.org/10.3389/fmed.2022.1022889.
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  - Belzberg, Micah, Martin Prince Alphonse, Isabelle Brown, Kyle A. Williams, Raveena Khanna, Byron Ho, Shannon Wongvibulsin, et al. “Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization.” J Invest Dermatol 141, no. 9 (September 2021): 2208-2218.e14. https://doi.org/10.1016/j.jid.2021.02.749.
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  - Cartron, A. M., T. H. Nguyen, Y. S. Roh, M. M. Kwatra, and S. G. Kwatra. “Janus kinase inhibitors for atopic dermatitis: a promising treatment modality.” Clin Exp Dermatol 46, no. 5 (July 2021): 820–24. https://doi.org/10.1111/ced.14567.
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  - Roh, Youkyung S., Raveena Khanna, Sagar P. Patel, Shilpa Gopinath, Kyle A. Williams, Ravya Khanna, Thomas Pritchard, et al. “Circulating blood eosinophils as a biomarker for variable clinical presentation and therapeutic response in patients with chronic pruritus of unknown origin.” J Allergy Clin Immunol Pract 9, no. 6 (June 2021): 2513-2516.e2. https://doi.org/10.1016/j.jaip.2021.01.034.
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  - Roh, Youkyung S., Justin Choi, Nishadh Sutaria, Micah Belzberg, Madan M. Kwatra, and Shawn G. Kwatra. “IL-31 Inhibition as a Therapeutic Approach for the Management of Chronic Pruritic Dermatoses.” Drugs 81, no. 8 (June 2021): 895–905. https://doi.org/10.1007/s40265-021-01521-1.
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  - Wongvibulsin, Shannon, Nishadh Sutaria, Suraj Kannan, Martin Prince Alphonse, Micah Belzberg, Kyle A. Williams, Isabelle D. Brown, et al. “Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation.” Sci Rep 11, no. 1 (May 27, 2021): 11175. https://doi.org/10.1038/s41598-021-90105-w.
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  - Choi, Justin, Nishadh Sutaria, Youkyung Sophie Roh, Zachary Bordeaux, Martin P. Alphonse, Shawn G. Kwatra, and Madan M. Kwatra. “Translational Relevance of Mouse Models of Atopic Dermatitis.” J Clin Med 10, no. 4 (February 6, 2021). https://doi.org/10.3390/jcm10040613.
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  - Patel, Sagar P., Raveena Khanna, Justin Choi, Kyle A. Williams, Youkyung S. Roh, Michael S. Hong, Nishadh H. Sutaria, Thomas Pritchard, Madan M. Kwatra, and Shawn G. Kwatra. “Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels.” J Am Acad Dermatol 84, no. 2 (February 2021): 265–72. https://doi.org/10.1016/j.jaad.2020.08.059.
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  - Choi, Justin, Cameron E. West, Youkyung S. Roh, Nishadh Sutaria, Shawn G. Kwatra, and Madan M. Kwatra. “Mouse models for actinic keratoses.” J Pharmacol Toxicol Methods 110 (2021): 107071. https://doi.org/10.1016/j.vascn.2021.107071.
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  - Vasavda, C., B. K. Ho, D. Y. Zhang, K. A. Williams, B. H. Kaffenberger, S. G. Kwatra, and M. M. Kwatra. “First- and third-generation epidermal growth factor receptor inhibitors mediate distinct phosphoprotein signalling networks: implications for adverse dermatological reactions.” Br J Dermatol 183, no. 6 (December 2020): 1105–7. https://doi.org/10.1111/bjd.19263.
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  - Huang, A. H., J. K. Canner, K. A. Williams, A. L. Grossberg, M. M. Kwatra, and S. G. Kwatra. “Healthcare resource utilization and payer cost analysis of patients with prurigo nodularis.” Br J Dermatol 183, no. 1 (July 2020): 182–84. https://doi.org/10.1111/bjd.18925.
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  - Chagoya, Gustavo, Shawn G. Kwatra, Cory W. Nanni, Callie M. Roberts, Samantha M. Phillips, Sarah Nullmeyergh, Samuel P. Gilmore, et al. “Efficacy of osimertinib against EGFRvIII+ glioblastoma.” Oncotarget 11, no. 22 (June 2, 2020): 2074–82. https://doi.org/10.18632/oncotarget.27599.
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  - Hughes, John-Douglas Matthew, Taylor E. Woo, Micah Belzberg, Raveena Khanna, Kyle A. Williams, Madan M. Kwatra, Shahzeb Hassan, and Shawn G. Kwatra. “Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis.” Medicines (Basel) 7, no. 1 (January 8, 2020). https://doi.org/10.3390/medicines7010004.
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  - Kwatra, Shawn G., Emily Boozalis, Amy H. Huang, Cory Nanni, Raveena Khanna, Kyle A. Williams, Yevgeniy R. Semenov, et al. “Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists.” Medicines (Basel) 6, no. 4 (December 9, 2019). https://doi.org/10.3390/medicines6040114.
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  - Kwon, Christina D., Raveena Khanna, Kyle A. Williams, Madan M. Kwatra, and Shawn G. Kwatra. “Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis.” Medicines (Basel) 6, no. 4 (September 26, 2019). https://doi.org/10.3390/medicines6040097.
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  - Kwatra, S. G., E. Boozalis, and M. M. Kwatra. “Effects of neuroimmune axis modulation by aprepitant on antipruritic and global disease severity in patients with cutaneous T-cell lymphoma.” Br J Dermatol 178, no. 5 (May 2018): 1221–22. https://doi.org/10.1111/bjd.16363.
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  - He, Alice, Jihad M. Alhariri, Ronald J. Sweren, Madan M. Kwatra, and Shawn G. Kwatra. “Aprepitant for the Treatment of Chronic Refractory Pruritus.” Biomed Res Int 2017 (2017): 4790810. https://doi.org/10.1155/2017/4790810.
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  - Kwatra, Madan M. “A Rational Approach to Target the Epidermal Growth Factor Receptor in Glioblastoma.” Curr Cancer Drug Targets 17, no. 3 (2017): 290–96. https://doi.org/10.2174/1568009616666161227091522.
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  - Yen, Timothy E., John C. Allen, Sarah K. Rivelli, Stephanie C. Patterson, Meredith R. Metcalf, Benjamin J. Flink, Aibek E. Mirrakhimov, et al. “Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty.” Sci Rep 6 (February 5, 2016): 20736. https://doi.org/10.1038/srep20736.
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  - Brown, Kristine E., Gustavo Chagoya, Shawn G. Kwatra, Timothy Yen, Stephen T. Keir, Mary Cooter, Katherine A. Hoadley, et al. “Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development.” J Neurochem 133, no. 5 (June 2015): 730–38. https://doi.org/10.1111/jnc.13032.
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  - Patterson, S. C., S. G. Kwatra, M. Berger, and M. M. Kwatra. “Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link.” Current Anesthesiology Reports 5, no. 1 (March 1, 2015): 41–47. https://doi.org/10.1007/s40140-014-0092-3.
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  - Kwatra, M. M., K. E. Brown, G. Chagoya, S. T. Keir, D. D. Bigner, and J. H. Sampson. “Patient-derived xenografts mirror the proteomic profile of human glioblastoma: implications for personalized drug development.” Neuro Oncol 16 Suppl 3 (July 2014): iii38. https://doi.org/10.1093/neuonc/nou208.57.
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  - Mirrakhimov, Aibek E., Carey L. Brewbaker, Andrew D. Krystal, and Madan M. Kwatra. “Obstructive sleep apnea and delirium: exploring possible mechanisms.” Sleep Breath 18, no. 1 (March 2014): 19–29. https://doi.org/10.1007/s11325-013-0846-z.
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  - Reed, Craig, Shawn G. Kwatra, Kristine Brown, and Madan M. Kwatra. “Revisiting the prehypertension debate: increasing evidence for treatment yet randomized clinical trials are lacking.” Blood Press 22, no. 6 (December 2013): 340–43. https://doi.org/10.3109/08037051.2013.787705.
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  - Brown, Kristine E., Aibek E. Mirrakhimov, Kalpana Yeddula, and Madan M. Kwatra. “Propofol and the risk of delirium: exploring the anticholinergic properties of propofol.” Med Hypotheses 81, no. 4 (October 2013): 536–39. https://doi.org/10.1016/j.mehy.2013.06.027.
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  - Mirrakhimov, Aibek E., Timothy Yen, and Madan M. Kwatra. “Delirium after cardiac surgery: have we overlooked obstructive sleep apnea?” Med Hypotheses 81, no. 1 (July 2013): 15–20. https://doi.org/10.1016/j.mehy.2013.03.033.
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  - Kwatra, M. M., R. E. Moon, W. D. White, P. T. Trzepacz, and S. K. Rivelli. “In reply.” Anesthesiology 117, no. 6 (December 2012): 1392–93. https://doi.org/10.1097/ALN.0b013e3182735c0f.
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  - Motosko, Catherine, Kristine Brown, and Madan Kwatra. “Insulin-like growth factor 1 and delirium.” Int Psychogeriatr 24, no. 11 (November 2012): 1872. https://doi.org/10.1017/S1041610212000464.
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  - Flink, Benjamin J., Sarah K. Rivelli, Elizabeth A. Cox, William D. White, Grace Falcone, Thomas P. Vail, Christopher C. Young, et al. “Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.” Anesthesiology 116, no. 4 (April 2012): 788–96. https://doi.org/10.1097/ALN.0b013e31824b94fc.
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  - Kwatra, Shawn G., Amanda E. Kiely, and Madan M. Kwatra. “Prehypertension: to treat or not to treat should no longer be the question.” Hypertension 59, no. 4 (April 2012): e27. https://doi.org/10.1161/HYPERTENSIONAHA.111.190678.
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  - Kwatra, Madan M. “Prevention of intraoperative awareness.” N Engl J Med 365, no. 21 (November 24, 2011): 2033. https://doi.org/10.1056/NEJMc1110999.
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  - Kwatra, Madan M., Tara M. Porter, Kristine E. Brown, James E. Herndon, and Darell D. Bigner. “TRUNCATED NEUROKININ 1 RECEPTOR: EXPRESSION IN PRIMARY GLIOBLASTOMAS AND RELATIONSHIP WITH PATIENT SURVIVAL.” Neuro Oncology 13 (November 1, 2011): 82–82.
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  - Kwatra, Shawn G., Laura E. Goldsmith, William D. White, Shu S. Lin, and Madan M. Kwatra. “Low expression of alpha-adrenergic receptors in the aging human heart.” J Am Geriatr Soc 58, no. 1 (January 2010): 210–12. https://doi.org/10.1111/j.1532-5415.2009.02659.x.
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  - Cox, Elizabeth A., Shawn G. Kwatra, Shaanan Shetty, and Madan M. Kwatra. “Flaws in the serum anticholinergic activity assay: implications for the study of delirium.” J Am Geriatr Soc 57, no. 9 (September 2009): 1707–8. https://doi.org/10.1111/j.1532-5415.2009.02411.x.
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  - Akazawa, Toshimasa, Shawn G. Kwatra, Laura E. Goldsmith, Mark D. Richardson, Elizabeth A. Cox, John H. Sampson, and Madan M. Kwatra. “A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas.” J Neurochem 109, no. 4 (May 2009): 1079–86. https://doi.org/10.1111/j.1471-4159.2009.06032.x.
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  - Kiely, Amanda Elisabeth, Shawn Gaurav Kwatra, and Madan Mohan Kwatra. “Treating prehypertension: medically sound and economically viable.” Blood Press 18, no. 6 (2009): 300–303. https://doi.org/10.3109/08037050903444024.
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  - Kwatra, Madan. “Limitations of the anticholinergic risk scale.” Arch Intern Med 168, no. 21 (November 24, 2008): 2386. https://doi.org/10.1001/archinte.168.21.2386-a.
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  - Kilts, Jason D., Shu S. Lin, James E. Lowe, and Madan M. Kwatra. “Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.” J Cardiovasc Pharmacol 50, no. 3 (September 2007): 299–303. https://doi.org/10.1097/FJC.0b013e3180a72632.
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  - Kwatra, M. M. “Delirium in older persons [11].” New England Journal of Medicine 354, no. 23 (June 8, 2006): 2510.
  - Kwatra, Madan M. “Delirium in older persons.” N Engl J Med 354, no. 23 (June 8, 2006): 2509–11.
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  - Kwatra, Madan M. “Prevention of atrial fibrillation following cardiac surgery.” Jama 295, no. 19 (May 17, 2006): 2247–48. https://doi.org/10.1001/jama.295.19.2247-c.
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  - Yamaguchi, Keisuke, Mark D. Richardson, Darrell D. Bigner, and Madan M. Kwatra. “Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.” Cancer Chemother Pharmacol 56, no. 6 (December 2005): 585–93. https://doi.org/10.1007/s00280-005-1030-3.
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  - Kilts, Jason D., Hilary P. Grocott, and Madan M. Kwatra. “G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta.” J Mol Cell Cardiol 38, no. 2 (February 2005): 267–76. https://doi.org/10.1016/j.yjmcc.2004.11.011.
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  - Richardson, Mark D., Jason D. Kilts, and Madan M. Kwatra. “Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects.” Diabetes 53, no. 9 (September 2004): 2392–96. https://doi.org/10.2337/diabetes.53.9.2392.
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  - Kilts, Jason D., Toshimasa Akazawa, Habib E. El-Moalem, Joseph P. Mathew, Mark F. Newman, and Madan M. Kwatra. “Age increases expression and receptor-mediated activation of G alpha i in human atria.” J Cardiovasc Pharmacol 42, no. 5 (November 2003): 662–70. https://doi.org/10.1097/00005344-200311000-00013.
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  - Richardson, Mark D., Anastasia M. Balius, Keisuke Yamaguchi, Emily R. Freilich, Larry S. Barak, and Madan M. Kwatra. “Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.” J Neurochem 84, no. 4 (February 2003): 854–63. https://doi.org/10.1046/j.1471-4159.2003.01577.x.
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  - Hagen, Scott A., Amy L. Kondyra, Hilary P. Grocott, Habib El-Moalem, Daniel Bainbridge, Joseph P. Mathew, Mark F. Newman, Joseph G. Reves, Debra A. Schwinn, and Madan M. Kwatra. “Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells.” Anesthesiology 98, no. 2 (February 2003): 343–48. https://doi.org/10.1097/00000542-200302000-00012.
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  - Kilts, Jason D., Toshimasa Akazawa, Mark D. Richardson, and Madan M. Kwatra. “Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.” J Biol Chem 277, no. 34 (August 23, 2002): 31257–62. https://doi.org/10.1074/jbc.M203640200.
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  - Warabi, Kengo, Mark D. Richardson, William T. Barry, Keisuke Yamaguchi, Eric D. Roush, Kinya Nishimura, and Madan M. Kwatra. “Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro.” Febs Lett 521, no. 1–3 (June 19, 2002): 140–44. https://doi.org/10.1016/s0014-5793(02)02858-2.
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  - Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circ Res 87, no. 8 (October 13, 2000): 705–9. https://doi.org/10.1161/01.res.87.8.705.
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  - Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “β₂-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circulation Research 87, no. 8 (2000): 705–9.
  - Roush, E. D., K. Warabi, and M. M. Kwatra. “Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.” Mol Pharmacol 55, no. 5 (May 1999): 855–62.
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  - Barak, L. S., K. Warabi, X. Feng, M. G. Caron, and M. M. Kwatra. “Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.” J Biol Chem 274, no. 11 (March 12, 1999): 7565–69. https://doi.org/10.1074/jbc.274.11.7565.
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  - Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. El-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial β-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease.” Circulation 98, no. 19 SUPPL. (November 10, 1998).
  - Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. El-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease.” Circulation 98, no. 19 (November 10, 1998): II275–81.
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  - Gerhardt, M. A., J. V. Booth, L. C. Chesnut, B. L. Funk, H. E. el-Moalem, M. M. Kwatra, and D. A. Schwinn. “Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Duke Heart Center Perioperative Desensitization Group.” Circulation 98, no. 19 Suppl (November 10, 1998): II275–81.
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  - Rudner, X. L., D. E. Berkowitz, B. L. Funk, M. M. Kwatra, and D. A. Schwinn. “Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.” Circulation 98, no. 17 (October 27, 1998): 540–540.
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  - Booth, J. V., K. P. Landolfo, L. C. Chesnut, E. Bennett-Guerrero, M. A. Gerhardt, D. M. Atwell, H. E. El-Moalem, et al. “Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group.” Anesthesiology 89, no. 3 (September 1998): 602–11. https://doi.org/10.1097/00000542-199809000-00008.
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  - DeLong, E. R., M. M. Kwatra, T. J. Gan, P. S. A. Glass, I. C. Sanderson, W. C. Gilbert, R. L. Coleman, D. A. Lubarsky, and J. G. Reves. “A large population study reveals reduced anesthetic requirements in females.” Anesthesiology 89, no. 3A (September 1, 1998): U191–U191.
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  - Gerhardt, M. A., T. N. Barnett, W. T. Barry, D. A. Schwinn, and M. M. Kwatra. “beta(2)-adrenergic receptors in human atrial membranes activate both G(s) and G(i).” Anesthesiology 89, no. 3A (September 1, 1998): U233–U233.
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  - Wendelburg, B. E., T. N. Barnett, M. M. Kwatra, and D. A. Schwinn. “Characterization of [H-3]forskolin binding to human atrial membranes.” Anesthesiology 89, no. 3A (September 1, 1998): U464–U464.
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  - Roush, E. D., and M. M. Kwatra. “Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o).” Febs Lett 428, no. 3 (May 29, 1998): 291–94. https://doi.org/10.1016/s0014-5793(98)00553-5.
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  - Lee, K., C. D. Richardson, M. A. Razik, M. M. Kwatra, and D. A. Schwinn. “Multiple potential regulatory elements in the 5' flanking region of the human alpha 1a-adrenergic receptor.” Dna Seq 8, no. 4 (March 1998): 271–76. https://doi.org/10.3109/10425179809008464.
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  - Nishimura, K., K. Warabi, E. D. Roush, J. Frederick, D. A. Schwinn, and M. M. Kwatra. “Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes.” Biochemistry 37, no. 5 (February 3, 1998): 1192–98. https://doi.org/10.1021/bi972302s.
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  - Smiley, R. M., M. M. Kwatra, and D. A. Schwinn. “New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance.” J Cardiothorac Vasc Anesth 12, no. 1 (February 1998): 80–95. https://doi.org/10.1016/s1053-0770(98)90062-3.
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  - Nishimura, K., J. Frederick, and M. M. Kwatra. “Human substance P receptor expressed in Sf9 cells couples with multiple endogenous G proteins.” J Recept Signal Transduct Res 18, no. 1 (January 1998): 51–65. https://doi.org/10.3109/10799899809039164.
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  - Schwinn, D. A., and M. M. Kwatra. “Expression and regulation of alpha 1-adrenergic receptors in human tissues.” Adv Pharmacol 42 (1998): 390–94.
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  - Kwatra, M. M., K. Nishimura, K. Warabi, E. D. Roush, and D. A. Schwinn. “Membrane-bound human substance p receptor undergoes agonist-dependent phosphorylation by g protein receptor kinase 2 (grk2) to a high stoichiometry and activates grk2 in the absence of gβγ.” Faseb Journal 11, no. 9 (December 1, 1997).
  - Schwinn, D. A., and M. M. Kwatra. “α1,-Adrenoceptor Subtypes in the Human Cardiovascular and Urogenital Systems.” Advances in Pharmacology 42, no. C (December 1, 1997): 390–94. https://doi.org/10.1016/S1054-3589(08)60771-1.
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  - Razik, M. A., K. Lee, R. R. Price, M. R. Williams, R. R. Ongjoco, M. K. Dole, X. L. Rudner, M. M. Kwatra, and D. A. Schwinn. “Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region.” J Biol Chem 272, no. 45 (November 7, 1997): 28237–46. https://doi.org/10.1074/jbc.272.45.28237.
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  - Schwinn, D. A., M. A. Gerhardt, L. C. Chesnut, B. L. Funk, K. P. Landolfo, and M. M. Kwatra. “Acute myocardial beta-adrenergic receptor desensitization during cardiopulmonary bypass for cardiac valve surgery.” Circulation 96, no. 8 (October 21, 1997): 2844–2844.
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  - Chen, B., R. D. Leverette, D. A. Schwinn, and M. M. Kwatra. “Human G(alpha q): cDNA and tissue distribution.” Biochim Biophys Acta 1281, no. 2 (June 11, 1996): 125–28. https://doi.org/10.1016/0005-2736(96)00039-9.
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  - Kwatra, M. M., J. Schreurs, D. A. Schwinn, M. A. Innis, M. G. Caron, and R. J. Lefkowitz. “Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity.” Protein Expr Purif 6, no. 6 (December 1995): 717–21. https://doi.org/10.1006/prep.1995.0001.
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  - Nair, L. A., J. Inglese, R. Stoffel, W. J. Koch, R. J. Lefkowitz, M. M. Kwatra, and A. O. Grant. “Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma.” Circ Res 76, no. 5 (May 1995): 832–38. https://doi.org/10.1161/01.res.76.5.832.
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  - Barak, L. S., M. Tiberi, N. J. Freedman, M. M. Kwatra, R. J. Lefkowitz, and M. G. Caron. “A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.” J Biol Chem 269, no. 4 (January 28, 1994): 2790–95.
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  - Kwatra, M. M., R. J. Lefkowitz, and M. G. Caron. “Partially purified and reconstituted g-protein coupled receptors as substrates of specific receptor kinases.” Methods 6, no. 1 (January 1, 1994): 11–17. https://doi.org/10.1006/meth.1994.1003.
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  - Ramkumar, V., M. Kwatra, J. L. Benovic, and G. L. Stiles. “Erratum: Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase (Biochimica et Biophysica Acta - Molecular Cell Research (1993) 1179 (89-97)).” Biochimica Et Biophysica Acta Molecular Cell Research 1220, no. 2 (January 1, 1994): 229. https://doi.org/10.1016/0167-4889(94)90142-2.
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  - Ramkumar, V., M. Kwatra, J. L. Benovic, G. L. Stiles, and G. L. Stilesa. “Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase.” Biochim Biophys Acta 1179, no. 1 (October 7, 1993): 89–97. https://doi.org/10.1016/0167-4889(93)90075-z.
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  - Kwatra, M. M., D. A. Schwinn, J. Schreurs, J. L. Blank, C. M. Kim, J. L. Benovic, J. E. Krause, M. G. Caron, and R. J. Lefkowitz. “The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.” J Biol Chem 268, no. 13 (May 5, 1993): 9161–64.
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  - Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.” J Biol Chem 267, no. 25 (September 5, 1992): 17882–90.
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  - Pitcher, J. A., J. Inglese, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. “Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.” Science 257, no. 5074 (August 28, 1992): 1264–67. https://doi.org/10.1126/science.1325672.
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  - Kwatra, M. M., D. D. Bigner, and J. A. Cohn. “The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization.” Biochim Biophys Acta 1134, no. 2 (March 16, 1992): 178–81. https://doi.org/10.1016/0167-4889(92)90042-a.
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  - Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “β-Arrestin2, a novel member of the arrestin/β-arrestin gene family.” Journal of Biological Chemistry 267, no. 25 (January 1, 1992): 17882–90.
  - Humphrey, P. A., A. J. Wong, B. Vogelstein, M. R. Zalutsky, G. N. Fuller, G. E. Archer, H. S. Friedman, M. M. Kwatra, S. H. Bigner, and D. D. Bigner. “Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.” Proc Natl Acad Sci U S A 87, no. 11 (June 1990): 4207–11. https://doi.org/10.1073/pnas.87.11.4207.
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  - Hosey, M. M., M. M. Kwatra, J. Ptasienski, and R. M. Richardson. “Regulation of receptor function by protein phosphorylation.” Ann N Y Acad Sci 588 (1990): 155–63. https://doi.org/10.1111/j.1749-6632.1990.tb13206.x.
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  - Kwatra, M. M., J. L. Benovic, M. G. Caron, R. J. Lefkowitz, and M. M. Hosey. “Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase.” Biochemistry 28, no. 11 (May 30, 1989): 4543–47. https://doi.org/10.1021/bi00437a005.
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  - Kwatra, M. M., J. Ptasienski, and M. M. Hosey. “The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor.” Mol Pharmacol 35, no. 5 (May 1989): 553–58.
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  - KWATRA, M. M., J. PTASIENSKI, and M. M. HOSEY. “AGONIST-INDUCED PHOSPHORYLATION OF THE PIG-ATRIAL MUSCARINIC RECEPTOR AND ITS COMPARISON WITH THE CHICK HEART RECEPTOR.” Faseb Journal 2, no. 4 (March 15, 1988): A624–A624.
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  - Leung, E., M. M. Kwatra, M. M. Hosey, and R. D. Green. “Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling.” J Pharmacol Exp Ther 244, no. 3 (March 1988): 1150–56.
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  - Kwatra, M. M., E. Leung, A. C. Maan, K. K. McMahon, J. Ptasienski, R. D. Green, and M. M. Hosey. “Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.” J Biol Chem 262, no. 34 (December 5, 1987): 16314–21.
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  - Kwatra, M. M., E. Leung, M. M. Hosey, and R. D. Green. “N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.” J Med Chem 30, no. 5 (May 1987): 954–56. https://doi.org/10.1021/jm00388a039.
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  - Kwatra, M. M., E. Leung, M. M. Hosey, and R. D. Green. “N⁶-phenyladenosines: Pronounced effect of phenyl substituents on affinity for A₂ adenosine receptors.” Journal of Medicinal Chemistry 30, no. 5 (1987): 954–56.
  - KWATRA, M. M., and M. M. HOSEY. “PHOSPHORYLATION OF THE CARDIAC MUSCARINIC RECEPTOR IN INTACT CHICK HEART AND ITS REGULATION BY A MUSCARINIC AGONIST.” Journal of Biological Chemistry 261, no. 27 (September 25, 1986): 2429–32.
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  - Kwatra, M. M., and M. M. Hosey. “Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist.” J Biol Chem 261, no. 27 (September 25, 1986): 12429–32.
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  - KWATRA, M. M., M. M. HOSEY, and R. GREEN. “CHARACTERIZATION OF CARDIAC ADENOSINE RECEPTORS USING N-6-PHENYLADENOSINES AND A NEW RADIOLIGAND, (I-125)-(M-AMINOPHENYL)ADENOSINE.” Federation Proceedings 45, no. 4 (March 5, 1986): 800–800.
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  - Choca, J. I., M. M. Kwatra, M. M. Hosey, and R. D. Green. “Specific photoaffinity labelling of inhibitory adenosine receptors.” Biochem Biophys Res Commun 131, no. 1 (August 30, 1985): 115–21. https://doi.org/10.1016/0006-291x(85)91778-4.
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  - Kwatra, M. M., and T. L. Sourkes. “Substrate-dependent activation energy of the reaction catalyzed by monoamine oxidase.” Arch Biochem Biophys 210, no. 2 (September 1981): 531–36. https://doi.org/10.1016/0003-9861(81)90218-6.
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  - Kwatra, M. M., and T. L. Sourkes. “Monoamine oxidase of rat skeletal muscle: substrate specificity and half-life.” Life Sci 27, no. 24 (December 15, 1980): 2327–31. https://doi.org/10.1016/0024-3205(80)90501-9.
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  - Kwatra, M. M., and T. L. Sourkes. “Monoamine oxidase A and B activities in liver of riboflavin-deficient rats.” Biochem Pharmacol 29, no. 19 (October 1, 1980): 2693–94. https://doi.org/10.1016/0006-2952(80)90090-8.
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  - Kwatra, M. M., D. Z. Simon, R. L. Salvador, and P. D. Cooper. “Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice.” J Med Chem 21, no. 3 (March 1978): 253–57. https://doi.org/10.1021/jm00201a003.
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- Book Sections
  - McKeel, J. A., and M. M. Kwatra. “Receptors.” In Encyclopedia of Biological Chemistry: Third Edition, 6:307–13, 2021. https://doi.org/10.1016/B978-0-12-819460-7.00313-3.
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  - Goldsmith, L. E., and M. M. Kwatra. “Tachykinin/Substance P/Neurokinin-1 Receptors.” In Encyclopedia of Biological Chemistry: Second Edition, 360–65, 2013. https://doi.org/10.1016/B978-0-12-378630-2.00364-9.
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- Conference Papers
  - Kwatra, S. G., K. A. Whang, E. Boozalis, C. Roberts, and M. M. Kwatra. “730 Truncated neurokinin 1 receptor (NK1R) is the predominant form of NK1R in human keratinocytes.” In Journal of Investigative Dermatology, 138:S124–S124. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.739.
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  - Vasavda, C., M. M. Kwatra, and S. G. Kwatra. “1079 Phospho-proteomic profiling reveals distinct signaling pathways by first and third generation EGFR inhibitors in human keratinocytes: Implications for adverse dermatologic reactions.” In Journal of Investigative Dermatology, 138:S183–S183. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.1092.
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  - Kwatra, Madan, Cory Nanni, Callie Roberts, Shawn Kwatra, Glenn J. Lesser, and Mark R. Gilbert. “HETEROGENEITY OF EGFRvIII-POSITIVE GLIOBLASTOMA STEM CELLS: IMPLICATIONS FOR PERSONALIZED DRUG DEVELOPMENT.” In Neuro Oncology, 19:55–55. OXFORD UNIV PRESS INC, 2017.
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  - Keir, Stephen T., B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Madan M. Kwatra, Henry S. Friedman, and Dare D. Bigner. “Identification and treatment data of xenografts representing TCGA-defined glioblastoma subtypes.” In Cancer Research, Vol. 75, 2015. https://doi.org/10.1158/1538-7445.AM2015-2435A.
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  - Keir, Stephen T., B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Patrick J. Killela, Hai Yan, Madan M. Kwatra, Henry S. Friedman, and Darell D. Bigner. “Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes.” In Cancer Research, Vol. 74, 2014. https://doi.org/10.1158/1538-7445.AM2014-838.
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  - Keir, Stephen, Charles Pegram, Eric Lipp, Ahmed Rasheed, Vidyalakshmi Chandramohan, Chien-Tsun Kuan, Madan Kwatra, Hai Yan, and Darell Bigner. “ESTABLISHMENT OF SEVEN NEW PERMANENT PEDIATRIC BRAIN TUMOR LINES.” In Neuro Oncology, 15:10–10. OXFORD UNIV PRESS INC, 2013.
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  - Brown, Kristine E., Stephen T. Keir, John H. Sampson, Darell D. Bigner, and Madan M. Kwatra. “NEUROKININ-1 RECEPTOR: A POTENTIAL TARGET TO INHIBIT PEDIATRIC GLIOBLASTOMAS.” In Neuro Oncology, 14:17–18. OXFORD UNIV PRESS INC, 2012.
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  - Kwatra, Madan M. “DIFFERENTIAL EXPRESSION OF FULL-LENGTH AND TRUNCATED NEUROKININ 1 RECEPTORS IN GLIOBLASTOMA CELLS.” In Neuro Oncology, 12:18–18. OXFORD UNIV PRESS INC, 2010.
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