Kyle McPherson

I work with Dr. Catherine Bowes Rickman in the Department of Ophthalmology, where we are developing therapies to prevent blindness in age-related macular degeneration.

Current Duke Appointments & Affiliations

Student School of Medicine

Recent Scholarly Works

The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in <i>Drosophila</i> larvae.

Journal article Proceedings of the National Academy of Sciences of the United States of America · October 2025 Nutrient intake drives secretion of insulin and insulin-like peptides that stimulate anabolic metabolism and tissue growth. Eight Drosophila insulin-like peptides (Dilps) are encoded in the Drosophila genome; whether these Dilps respond unifo ... Full text Cite

Truncated complement factor H Y402 gene therapy rescues C3 glomerulonephritis.

Journal article Mol Ther · August 6, 2025 There are no effective therapies for patients with dry age-related macular degeneration (AMD) or C3 glomerulonephritis (C3G). Unfortunately, past efforts to treat C3G using exogenous human complement factor H (CFH) found limited success due to immune rejec ... Full text Link to item Cite

Synchronizing Drosophila larvae with the salivary gland reporter Sgs3-GFP for discovery of phenotypes in the late third instar stage.

Journal article Developmental Biology · August 2024 Full text Cite

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Recent Grants

Gene therapy targeting CFH and lipoprotein dynamics in AMD

ResearchGraduate Student · Awarded by National Institutes of Health · 2025 - 2028

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