Kyle Todd Mitchell

Journal Article Brain Stimul · December 10, 2025 BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) to treat Parkinson's disease (PD) generates local evoked potentials (DLEPs). DLEPs reflect neural activation by DBS, but the mechanisms underlying the dynamic changes in DLEPs during ... Full text Link to item Cite

Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease: A Nonrandomized Clinical Trial.

Journal Article JAMA Neurol · November 1, 2025 IMPORTANCE: Adaptive deep brain stimulation (aDBS) automatically adjusts stimulation amplitude in response to changes in relevant neural activity in people with Parkinson disease (PD). Whether long-term at-home aDBS is safe and delivers effective therapy i ... Full text Link to item Cite

Local Field Potential Circadian Patterns During Adaptive Deep Brain Stimulation (S32.007).

Journal Article Neurology · April 8, 2025 OBJECTIVE: Characterize circadian patterns of neural activity from basal ganglia nuclei in a naturalistic environment during adaptive deep brain stimulation (aDBS) in people with Parkinson's disease (PD). BACKGROUND: Chronic recordings of local field poten ... Full text Link to item Cite

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Recent Grants

exPDite-2: A Phase 3 Study to Assess the Efficacy and Safety of Midbrain Dopaminergic Neuronal Cell Therapy (Bemdaneprocel) for Participants With Parkinson's Disease

Clinical TrialPrincipal Investigator · Awarded by BlueRock Therapeutics LP · 2025 - 2032

An open-label clinical trial investigating the long-term safety of buntanetap in treating participants with Parkinson's disease

Clinical TrialPrincipal Investigator · Awarded by DCRI-Duke-Site · 2026 - 2029

An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson Disease

ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2027

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Education, Training & Certifications

Medical College of Georgia · 2012 M.D.