Scholars@Duke
LaShaunta Glover

LaShaunta Glover

Assistant Professor of Population Health Sciences
Population Health Sciences
lashaunta.glover@duke.edu
215 Morris Street, Durham, NC 27708
Duke Box 104023, Durham, NC 27708

Selected Publications

Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles.

Journal Article Journal of the American Society of Nephrology : JASN · April 2025 BackgroundThe APOL1 high-risk haplotype has been associated with chronic kidney disease (CKD) and the deterioration of kidney function, particularly in populations with West African ancestry. However, the mechanisms by which APOL1 risk variants in ... Full text Cite

DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults.

Journal Article Hum Mol Genet · October 7, 2024 Obesity and poverty disproportionally affect African American persons. Epigenetic mechanisms could partially explain the association between socioeconomic disadvantage and body mass index (BMI). We examined the extent to which epigenetic mechanisms mediate ... Full text Link to item Cite

Cardiovascular event reduction among a US population eligible for semaglutide per the SELECT trial.

Journal Article American heart journal · October 2024 BackgroundOur objective was to determine the number of major cardiovascular events (MACE, nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death) and deaths from any cause that could be prevented across varying nationwide uptake ... Full text Cite

Social Networks and Cardiovascular Disease Events in the Jackson Heart Study.

Journal Article Journal of the American Heart Association · November 2023 BackgroundCardiovascular disease (CVD) disproportionately affects Black adults. Greater social networks (SNs), or social connectedness, may lower the risk of CVD events. This study determined the association of SNs and incident CVD and tested medi ... Full text Cite

The Modifying Role of Resilience on Allostatic Load and Cardiovascular Disease Risk in the Jackson Heart Study.

Journal Article J Racial Ethn Health Disparities · October 2023 We examined whether resilience modified associations between allostatic load (AL), a physiological indicator of coping with repeated stressors, and cardiovascular disease (CVD) among 2758 African Americans in the Jackson Heart Study. Baseline AL was quanti ... Full text Link to item Cite

Cumulative socioeconomic status and incident type 2 diabetes among African American adults from the Jackson heart study.

Journal Article SSM Popul Health · June 2023 BACKGROUND: The cumulative socioeconomic status (SES) model posits that childhood and adult experiences accumulate to influence disease risk. While individual SES indicators such as education and income are independently associated with incident type 2 dia ... Full text Link to item Cite

Abstract P248: Plasma Proteins Associated With Depressive Symptoms and Perceived Global Stress Among African American Adults in the Jackson Heart Study

Conference Circulation · February 28, 2023 Introduction: Analyzing plasma proteins is a novel approach to uncover molecular mechanisms by which psychosocial stress may lead to chronic illness, including cardiometabolic disease. Proteomic analy ... Full text Cite

Abstract MP40: John Henryism Moderates the Association Between Income and Heart Failure Among African American Adults From the Jackson Heart Study

Conference Circulation · February 28, 2023 Background: The John Henryism Hypothesis (JHH) posits that repeated high-effort coping in response to systemic social and economic stressors accelerates physiological wear and tear and is, as a result ... Full text Cite

Physicians' Perceptions of Race and Engagement in Race-Based Clinical Practice: a Mixed-Methods Systematic Review and Narrative Synthesis.

Journal Article J Gen Intern Med · November 2022 BACKGROUND: Using race-a socially assigned identity that does not adequately capture human genetic variation-to guide clinical care can result in poor outcomes for racially minoritized patients. This study assessed (1) how physicians conceptualize and use ... Full text Link to item Cite

Goal-striving stress and repeated measures of adiposity in the Jackson heart study.

Journal Article Stress Health · August 2022 Psychosocial stressors are determinants of increases in adiposity. Both psychosocial stressors and adiposity are higher among African Americans (AAs). Therefore, clarifying the stress-obesity link in AAs is important. The stress associated with goal strivi ... Full text Link to item Cite

Associations between perceived discrimination and immune cell composition in the Jackson Heart Study.

Journal Article Brain Behav Immun · July 2022 African American adults suffer disproportionately from several non-communicable and infectious diseases. Among numerous contributing factors, perceived discrimination is considered a stressor for members of historically marginalized groups that contributes ... Full text Link to item Cite

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.

Journal Article HGG Adv · April 14, 2022 Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address th ... Full text Link to item Cite

Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women.

Journal Article J Am Heart Assoc · March 2022 Background Associations between depression, incident heart failure (HF), and mortality are well documented in predominately White samples. Yet, there are sparse data from racial minorities, including those who are women, and depression is underrecognized a ... Full text Open Access Link to item Cite

Goal-Striving Stress and Cardiovascular Risk Factors in the Jackson Heart Study.

Journal Article J Health Care Poor Underserved · 2022 INTRODUCTION: Addressing cardiovascular disease (CVD) risk factors is essential to reducing CVD burden in African Americans (AAs). Goal-striving stress (GSS), the stress associated with fears of failure, is particularly relevant to AAa in a society where t ... Full text Link to item Cite

Optimism and risk of mortality among African-Americans: The Jackson heart study.

Journal Article Prev Med · January 2022 Optimism is associated with reduced mortality risk among Whites, but evidence for this relationship is limited among African-Americans, whose life expectancy is shorter than Whites. This study examined the association between optimism and mortality rate in ... Full text Link to item Cite

A Longitudinal Evaluation of Goal-Striving Stress and Sleep Duration Among African Americans in the Jackson Heart Study.

Journal Article Psychosom Med · October 1, 2021 OBJECTIVE: The purposes of this study were to assess the association between changes in goal-striving stress (GSS) and changes in sleep duration in African Americans (AAs) and to determine if the association varies by sex, age, and/or educational attainmen ... Full text Link to item Cite

Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study.

Journal Article Healthcare (Basel, Switzerland) · May 2021 BackgroundPsychosocial stressors, such as perceived discrimination and depressive symptoms, may shorten telomeres and exacerbate aging-related illnesses.MethodsParticipants from the Jackson Heart Study at visit 1 (2000-2004) with LTL data ... Full text Cite

Optimism and telomere length among African American adults in the Jackson Heart Study.

Journal Article Psychoneuroendocrinology · March 2021 BACKGROUND: Optimism is linked with greater longevity in both White and African American populations. Optimism may enhance longevity by slowing cellular aging, for which leukocyte telomere shortening is a biomarker. However, limited studies have examined t ... Full text Link to item Cite

Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study.

Journal Article J Investig Med · February 2021 African Americans (AAs) are disproportionately affected by kidney disease and also report higher psychosocial stressors than other racial groups. Goal-striving stress (GSS) is an understudied psychosocial stressor related to attempting to accomplish one's ... Full text Link to item Cite

Optimism is associated with chronic kidney disease and rapid kidney function decline among African Americans in the Jackson Heart Study.

Journal Article J Psychosom Res · December 2020 OBJECTIVE: Investigate the association of dispositional optimism with chronic kidney disease (CKD) and rapid kidney function decline (RKFD) and determine if there is modification by age, sex, and educational attainment among African Americans. METHODS: Opt ... Full text Link to item Cite

Goal-Striving Stress and Incident Cardiovascular Disease in Blacks: The Jackson Heart Study.

Journal Article J Am Heart Assoc · May 5, 2020 Background Goal-striving stress (GSS), the stress from striving for goals, is associated with poor health. Less is known about its association with cardiovascular disease (CVD). Methods and Results We used data from the JHS (Jackson Heart Study), a study o ... Full text Open Access Link to item Cite

Cumulative psychosocial factors are associated with cardiovascular disease risk factors and management among African Americans in the Jackson Heart Study.

Journal Article BMC Public Health · April 28, 2020 BACKGROUND: Racial disparities in cardiovascular disease (CVD) have been attributed in part to negative psychosocial factors. Prior studies have demonstrated associations between individual psychosocial factors and CVD risk factors, but little is known abo ... Full text Link to item Cite

Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study.

Journal Article Am J Prev Med · February 2020 INTRODUCTION: Perceiving discriminatory treatment may contribute to systemic inflammation, a risk factor of cardiovascular pathophysiology. This study evaluated the association of self-reported discrimination with changes in high-sensitivity C-reactive pro ... Full text Link to item Cite

The association of goal-striving stress with sleep duration and sleep quality among African Americans in the Jackson Heart Study.

Journal Article Sleep Health · February 2020 BACKGROUND: African Americans (AAs) report a higher frequency of certain stressors over their lifetime which may impact biological processes that can impair sleep. For this reason, goal-striving stress (GSS), the difference between aspiration and achieveme ... Full text Link to item Cite

Life Course Socioeconomic Status and Hypertension in African American Adults: The Jackson Heart Study.

Journal Article Am J Hypertens · January 1, 2020 BACKGROUND: Limited research has examined the association of life-course socioeconomic status (SES) with hypertension prevalence and incidence in a large cohort of African Americans. METHODS: Among 4,761 participants from the Jackson Heart Study (JHS), we ... Full text Link to item Cite

Optimism and cardiovascular health among African Americans in the Jackson Heart Study.

Journal Article Preventive medicine · December 2019 Little research has examined associations of positive psychosocial factors with the American Heart Association Life's Simple 7™ (LS7) among African Americans. This study examined the associations between positive optimistic orientation and LS7 among Africa ... Full text Cite

Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study.

Journal Article Stress Health · April 2019 Leukocyte telomere length (LTL) is a biomarker of cellular aging. African Americans report more stress than other groups; however, the association of psychosocial stressors with biological aging among African Americans remains unclear. The current study ev ... Full text Link to item Cite

Abstract P109: Genetic Correlates of Resilience Among African American Families From the Jackson Heart Study

Conference Circulation · March 5, 2019 Background: Research has reported that measures of resilience, such as optimism, social support, and religious coping are positively associated with longevity, but there are limited studies on the gen ... Full text Cite

Sex differences in the association of psychosocial resources with prevalent type 2 diabetes among African Americans: The Jackson Heart Study.

Journal Article J Diabetes Complications · February 2019 AIM: To examine the association of psychosocial resources with prevalent type 2 diabetes (T2D) in 5104 African American men and women. METHODS: Using data from the Jackson Heart Study (JHS), we evaluated the cross-sectional associations of four psychosocia ... Full text Link to item Cite

Correction to: Goal-Striving Stress is Associated with Chronic Kidney Disease Among Participants in the Jackson Heart Study.

Journal Article J Racial Ethn Health Disparities · February 2019 Please note the following correction in the Methods section of this article: The definition for goal-striving stress in the Jackson Heart Study included achievement defined as "where one was in life 10 years ago," using a 10-point scale. ... Full text Link to item Cite

Goal-Striving Stress Is Associated with Chronic Kidney Disease Among Participants in the Jackson Heart Study.

Journal Article J Racial Ethn Health Disparities · February 2019 OBJECTIVE: Research that assesses the relationship between psychosocial factors and chronic kidney disease (CKD) among African Americans (AAs) is limited. Using the Jackson Heart Study (JHS) cohort data, we investigated the association of goal-striving str ... Full text Link to item Cite

The social patterning of electronic nicotine delivery system use among US adults.

Journal Article Prev Med · November 2018 There is little research examining the social patterning of electronic nicotine delivery system (ENDS) use. This study investigated the association between socioeconomic status (SES) (education, income, and employment status) and current and former ENDS us ... Full text Link to item Cite

Dimensions of and Responses to Perceived Discrimination and Subclinical Disease Among African-Americans in the Jackson Heart Study.

Journal Article J Racial Ethn Health Disparities · October 2018 BACKGROUND: Although discrimination among African Americans (AAs) has been linked to various health outcomes, few studies have examined associations of multiple measures of discrimination with prevalent subclinical disease in a large sample of AAs. OBJECTI ... Full text Link to item Cite

Perceived Discrimination and Reported Trust and Satisfaction with Providers in African Americans: The Jackson Heart Study.

Journal Article Ethn Dis · 2017 OBJECTIVES: 1) To examine the association of multiple dimensions of discrimination with reported trust and satisfaction with providers; 2) to report within-group differences among African Americans (AAs). MAIN MEASURES: Measures of perceived discrimination ... Full text Link to item Cite

Association of kidney stones with atherosclerotic cardiovascular disease among adults in the United States: Considerations by race-ethnicity.

Journal Article Physiol Behav · April 1, 2016 BACKGROUND: There is a paucity of research examining the relationship between kidney stones and risk of cardiovascular disease while considering individuals of different race-ethnicities. PURPOSE: The purpose of this study was to examine the association be ... Full text Link to item Cite

Abstract P229: The Association Of Cumulative Socioeconomic Status And Incident Type 2 Diabetes Among African Americans: The Jackson Heart Study

Conference Background: The burden of type 2 diabetes (T2D) is disproportionately higher among racial and ethnic minorities, particularly African American individuals who have low socioeconomic status (SES). According to the cumulative SES life-course model, stressful ... Link to item Cite