Lauren Haynes

Journal Article PLoS Pathog · October 2024 Viral infection leads to heterogeneous cellular outcomes ranging from refractory to abortive and fully productive states. Single cell transcriptomics enables a high resolution view of these distinct post-infection states. Here, we have interrogated the hos ... Full text Open Access Link to item Cite

Investigating the phylogenetic history of toxin tolerance in mushroom-feeding Drosophila.

Journal Article Ecology and evolution · December 2023 Understanding how and when key novel adaptations evolved is a central goal of evolutionary biology. Within the immigrans-tripunctata radiation of Drosophila, many mushroom-feeding species are tolerant of host toxins, such as cyclopeptides, th ... Full text Cite

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells.

Journal Article Nat Immunol · August 2022 The recombination-activating genes (RAG) 1 and 2 are indispensable for diversifying the primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the bone marrow; however, the impact of RAG1/RAG2 on peripheral tolerance is ... Full text Link to item Cite