Current Appointments & Affiliations
Associate Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Associate Professor of Pathology
·
2022 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Member in the Duke Clinical Research Institute
·
2021 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.
Journal Article Acta Neuropathol · October 23, 2025 Parkinson's disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synuclein deposits in post ... Full text Link to item CiteLessons from the Tim Greenamyre model.
Journal Article Neurobiol Dis · September 2025 Full text Link to item CiteLRRK2-mediated mitochondrial dysfunction in Parkinson's disease.
Journal Article Biochem J · May 28, 2025 Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms including tremor, rigidity, and bradykinesia as well as degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). A minority of PD cases are f ... Full text Link to item CiteRecent Grants
PD OLE
Clinical TrialPrincipal Investigator · Awarded by Annovis Bio, Inc. · 2025 - 2030The Gut Brain Parkinson's Disease Consortium (GBPDC): Coordinating and Data Management Center (CDMC)
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2029Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2019 - 2029View All Grants
Education, Training & Certifications
University at Buffalo, Jacobs School of Medicine and Biomedical Sciences ·
2008
Ph.D.