Current Appointments & Affiliations
Associate Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Associate Professor of Pathology
·
2022 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Member in the Duke Clinical Research Institute
·
2021 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage.
Journal Article NPJ Parkinsons Dis · March 1, 2024 Pathogenic mutations in LRRK2 cause Parkinson's disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity. Compounds that target LRRK2 kinase activity are currently being developed and tested in clinical trials. ... Full text Link to item CiteInactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease.
Journal Article Sci Rep · October 18, 2023 Parkinson's disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated fo ... Full text Link to item CiteA blood-based marker of mitochondrial DNA damage in Parkinson's disease.
Journal Article Sci Transl Med · August 30, 2023 Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and neuroprotective or disease-modifying interventions remain elusive. High-throughput markers aimed at stratifying patients on the basis of shared etiology are required to en ... Full text Link to item CiteRecent Grants
The Gut Brain Parkinson's Disease Consortium (GBPDC): Coordinating and Data Management Center (CDMC)
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2029Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2029Automated High-purity Exosome isolation-based AD diagnostics system (AHEADx)
ResearchCo-Principal Investigator · Awarded by National Institute on Aging · 2023 - 2028View All Grants
Education, Training & Certifications
University at Buffalo, Jacobs School of Medicine and Biomedical Sciences ·
2008
Ph.D.