Lawrence Anthony David | Scholars@Duke

Lawrence Anthony David
Assistant Professor of Molecular Genetics and Microbiology

Current Appointments & Affiliations

Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013
Affiliate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2014
Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018

Contact Information

2171 CIEMAS Building, Box 3382, Durham, NC 27708
Box 3382, 101 Science Drive, Durham, NC 27708
lawrence.david@duke.edu (919) 668-5388
www.ladlab.org

Background
Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2010
Duke Appointment History
- Instructor, Temporary in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013
Recognition
In the News
- OCT 29, 2018
  
  Our Microbes Are Starving, and That’s a Good Thing
- MAY 7, 2018
  
  AI Detects Patterns Of Gut Microbes for Cholera Risk
- MAR 20, 2017
  
  Microbes Evolved to Colonize Different Parts of the Human Body
- SEP 22, 2016 Science News
  
  Ten Scientists to Watch: Lawrence Davids gut check gets personal
- JUN 17, 2016
  
  A Little Dirt Won't Hurt You
- MAR 16, 2016
  
  New Collaborative Seed Grant Program Gives Eight Awards
- APR 15, 2015
  
  Lawrence David Named Searle Scholar
- JUL 25, 2014 National Geographic
  
  Q-and-A: Scientist studied his poop for a year to learn about gut bugs
- MAY 13, 2014 Duke Research Blog
  
  Lawrence David Gets to the Gut of the Matter
- FEB 18, 2014
  
  Five Science Faculty Win Sloan Fellowships
- DEC 12, 2013 Fox News, LiveScience
  
  Changes in diet can alter gut bacteria within 24 hours
- OCT 23, 2013
  
  MIcrobes R Us
Awards & Honors
- Sloan Research Fellowship-Molecular Biology. Alfred P. Sloan Foundation. 2014
- Harvard Society Junior Fellows. Harvard Society of Fellows. 2010
Research
Selected Grants
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Genetic analysis of mucin utilization by Akkermansia muciniphila and its impact on host physiology awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Personalizing prebiotic therapies that target human gut microbiota awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics awarded by National Institutes of Health 2016 - 2021
- Predicting prebiotic effects on human microbiota, behavior, and cognition. awarded by Office of Naval Research 2018 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2021
- Personalized Prebiotics to Optimize Microbiota Metabolism and Improve Transplant Outcomes awarded by Damon Runyon Cancer Research Foundation 2018 - 2019
- AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
- Personalizing prebiotic therapies for astronauts' gut microbiota awarded by Baylor College of Medicine 2017 - 2019
- A high througput platform for screening microbial interactions awarded by Burroughs Wellcome Fund 2016 - 2019
- Using natural bacterial interactions to control host-associated microbial communities awarded by Arnold and Mabel Beckman Foundation 2015 - 2019
- Personalizing prebiotic treatments that manipulate human gut microbiota awarded by University of North Carolina - Chapel Hill 2017 - 2018
- Genetic analysis in an intractable gut microbe awarded by National Institutes of Health 2016 - 2018
- Linking oxygen and bacterial ecology in necrotizing enterocolitis awarded by Hartwell Foundation 2015 - 2018
- Quantifying Nitrogen Limitation in the Gut Microbiota awarded by National Science Foundation 2015 - 2017
- HARDAC+:Reproducible HPC for next-generation genomics awarded by North Carolina Biotechnology Center 2016 - 2017
- Alfred P. Sloan Research Fellowship for Dr. Lawrence David in Computational & Evolutionary Molecular Biology awarded by Alfred P. Sloan Foundation 2014 - 2016
- Automated Library Preparation System for Next-Generation Sequencing awarded by North Carolina Biotechnology Center 2014 - 2015
- Discovering natural bacterial interactions within the human gut microbiota awarded by The Global Probiotic Council 2014 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Washburne, AD, Silverman, JD, Morton, JT, Becker, DJ, Crowley, D, Mukherjee, S, David, LA, and Plowright, RK. "Phylofactorization: a graph partitioning algorithm to identify phylogenetic scales of ecological data." Ecological Monographs (January 1, 2019). Full Text
  - Reese, AT, Pereira, FC, Schintlmeister, A, Berry, D, Wagner, M, Hale, LP, Wu, A, Jiang, S, Durand, HK, Zhou, X, Premont, RT, Diehl, AM, O'Connell, TM, Alberts, SC, Kartzinel, TR, Pringle, RM, Dunn, RR, Wright, JP, and David, LA. "Microbial nitrogen limitation in the mammalian large intestine." Nature Microbiology 3, no. 12 (December 2018): 1441-1450. Full Text
  - Silverman, JD, Durand, HK, Bloom, RJ, Mukherjee, S, and David, LA. "Correction to: Dynamic linear models guide design and analysis of microbiota studies within artificial human guts." Microbiome 6, no. 1 (November 27, 2018): 212-null. Full Text
  - Silverman, JD, Durand, HK, Bloom, RJ, Mukherjee, S, and David, LA. "Dynamic linear models guide design and analysis of microbiota studies within artificial human guts." Microbiome 6, no. 1 (November 12, 2018): 202-null. Full Text
  - Midani, FS, Weil, AA, Chowdhury, F, Begum, YA, Khan, AI, Debela, MD, Durand, HK, Reese, AT, Nimmagadda, SN, Silverman, JD, Ellis, CN, Ryan, ET, Calderwood, SB, Harris, JB, Qadri, F, David, LA, and LaRocque, RC. "Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection." The Journal of Infectious Diseases 218, no. 4 (July 2018): 645-653. Full Text
  - Reese, AT, Cho, EH, Klitzman, B, Nichols, SP, Wisniewski, NA, Villa, MM, Durand, HK, Jiang, S, Midani, FS, Nimmagadda, SN, O'Connell, TM, Wright, JP, Deshusses, MA, and David, LA. "Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut." Elife 7 (June 19, 2018). Full Text Open Access Copy
  - David, LA. "Toward Personalized Control of Human Gut Bacterial Communities." Msystems 3, no. 2 (March 20, 2018). Full Text
  - Reese, AT, Lulow, K, David, LA, and Wright, JP. "Plant community and soil conditions individually affect soil microbial community assembly in experimental mesocosms." Ecology and Evolution 8, no. 2 (January 2018): 1196-1205. Full Text
  - Silverman, JD, Washburne, AD, Mukherjee, S, and David, LA. "A phylogenetic transform enhances analysis of compositional microbiota data." Elife 6 (February 15, 2017). Full Text Open Access Copy
  - Washburne, AD, Silverman, JD, Leff, JW, Bennett, DJ, Darcy, JL, Mukherjee, S, Fierer, N, and David, LA. "Phylogenetic factorization of compositional data yields lineage-level associations in microbiome datasets." PeerJ 5 (January 2017): e2969-. Full Text
  - Boursier, J, Mueller, O, Barret, M, Machado, M, Fizanne, L, Araujo-Perez, F, Guy, CD, Seed, PC, Rawls, JF, David, LA, Hunault, G, Oberti, F, Calès, P, and Diehl, AM. "The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota." Hepatology (Baltimore, Md.) 63, no. 3 (March 2016): 764-775. Full Text
  - David, LA, Materna, AC, Friedman, J, Baptista, MIC, Blackburn, MC, Perrotta, A, Erdman, SE, and Alm, EJ. "Erratum to: Host lifestyle affects human microbiota on daily timescales." Genome Biology 17, no. 1 (January 2016): 117-null. Full Text
  - Wong, S, Stephens, WZ, Burns, AR, Stagaman, K, David, LA, Bohannan, BJM, Guillemin, K, and Rawls, JF. "Ontogenetic Differences in Dietary Fat Influence Microbiota Assembly in the Zebrafish Gut." Mbio 6, no. 5 (September 29, 2015): e00687-e00615. Full Text
  - David, LA, Weil, A, Ryan, ET, Calderwood, SB, Harris, JB, Chowdhury, F, Begum, Y, Qadri, F, LaRocque, RC, and Turnbaugh, PJ. "Gut microbial succession follows acute secretory diarrhea in humans." Mbio 6, no. 3 (May 19, 2015): e00381-e00315. Full Text
  - David, LA, Materna, AC, Friedman, J, Campos-Baptista, MI, Blackburn, MC, Perrotta, A, Erdman, SE, and Alm, EJ. "Host lifestyle affects human microbiota on daily timescales." Genome Biology 15, no. 7 (January 2014): R89-null. Full Text
  - David, LA, Maurice, CF, Carmody, RN, Gootenberg, DB, Button, JE, Wolfe, BE, Ling, AV, Devlin, AS, Varma, Y, Fischbach, MA, Biddinger, SB, Dutton, RJ, and Turnbaugh, PJ. "Diet rapidly and reproducibly alters the human gut microbiome." Nature 505, no. 7484 (January 2014): 559-563. Full Text
  - Szabo, G, Preheim, SP, Kauffman, KM, David, LA, Shapiro, J, Alm, EJ, and Polz, MF. "Reproducibility of Vibrionaceae population structure in coastal bacterioplankton." The Isme Journal 7, no. 3 (March 2013): 509-519. Full Text
  - Smillie, CS, Smith, MB, Friedman, J, Cordero, OX, David, LA, and Alm, EJ. "Ecology drives a global network of gene exchange connecting the human microbiome." Nature 480, no. 7376 (October 30, 2011): 241-244. Full Text
  - David, LA, and Alm, EJ. "Rapid evolutionary innovation during an Archaean genetic expansion." Nature 469, no. 7328 (January 2011): 93-96. Full Text
  - Preheim, SP, Boucher, Y, Wildschutte, H, David, LA, Veneziano, D, Alm, EJ, and Polz, MF. "Metapopulation structure of Vibrionaceae among coastal marine invertebrates." Environmental Microbiology 13, no. 1 (January 2011): 265-275. Full Text
  - Shapiro, BJ, David, LA, Friedman, J, and Alm, EJ. "Looking for Darwin's footprints in the microbial world." Trends in Microbiology 17, no. 5 (May 2009): 196-204. (Review) Full Text
  - Hunt, DE, David, LA, Gevers, D, Preheim, SP, Alm, EJ, and Polz, MF. "Resource partitioning and sympatric differentiation among closely related bacterioplankton." Science (New York, N.Y.) 320, no. 5879 (May 2008): 1081-1085. Full Text
  - Dubin-Thaler, BJ, Hofman, JM, Cai, Y, Xenias, H, Spielman, I, Shneidman, AV, David, LA, Döbereiner, H-G, Wiggins, CH, and Sheetz, MP. "Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading." PloS one 3, no. 11 (January 2008): e3735-. Full Text
  - David, LA, and Wiggins, CH. "Benchmarking of dynamic Bayesian networks inferred from stochastic time-series data." Annals of the New York Academy of Sciences 1115 (December 2007): 90-101. Full Text
  - Glenn, CF, Chow, DK, David, L, Cooke, CA, Gami, MS, Iser, WB, Hanselman, KB, Goldberg, IG, and Wolkow, CA. "Behavioral Deficits During Early Stages of Aging in Caenorhabditis elegans Result From Locomotory Deficits Possibly Linked to Muscle Frailty." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59, no. 12 (December 1, 2004): 1251-1260. Full Text
- Conference Papers
  - Zhang, Y, Zhao, Y, David, L, Henao, R, and Carin, L. "Dynamic poisson factor analysis." January 31, 2017. Full Text
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses