Lawrence Anthony David
Assistant Professor of Molecular Genetics and Microbiology
Current Appointments & Affiliations
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018
- Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2019
Contact Information
- 2171 CIEMAS Building, Box 3382, Durham, NC 27708
- Box 3382, 101 Science Drive, Durham, NC 27708
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lawrence.david@duke.edu
(919) 668-5388
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www.ladlab.org
- Background
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Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2010
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Duke Appointment History
- Affiliate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2014 - 2019
- Instructor, Temporary in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013
- Recognition
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In the News
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OCT 29, 2018 -
MAY 7, 2018 -
MAR 20, 2017 -
SEP 22, 2016 Science News -
JUN 17, 2016 -
MAR 16, 2016 -
APR 15, 2015 -
JUL 25, 2014 National Geographic -
MAY 13, 2014 Duke Research Blog -
FEB 18, 2014 -
DEC 12, 2013 Fox News, LiveScience -
OCT 23, 2013
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Awards & Honors
- Research
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Selected Grants
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Genetic analysis of mucin utilization by Akkermansia muciniphila and its impact on host physiology awarded by National Institutes of Health 2018 - 2023
- Genetic analysis of mucin utilization by Akkermansia muciniphila and its impact on host physiology awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Personalizing prebiotic therapies that target human gut microbiota awarded by National Institutes of Health 2017 - 2022
- Personalizing prebiotic therapies that target human gut microbiota awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics awarded by National Institutes of Health 2016 - 2021
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics awarded by National Institutes of Health 2016 - 2021
- Predicting prebiotic effects on human microbiota, behavior, and cognition. awarded by Office of Naval Research 2018 - 2021
- Accurate and automated tracking of patient urine and stool 2019 - 2021
- Personalized Prebiotics to Optimize Microbiota Metabolism and Improve Transplant Outcomes 2018 - 2020
- Using natural bacterial interactions to control host-associated microbial communities awarded by Arnold and Mabel Beckman Foundation 2015 - 2020
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
- Personalizing prebiotic therapies for astronauts' gut microbiota awarded by Baylor College of Medicine 2017 - 2019
- A high througput platform for screening microbial interactions awarded by Burroughs Wellcome Fund 2016 - 2019
- Personalizing prebiotic treatments that manipulate human gut microbiota awarded by University of North Carolina - Chapel Hill 2017 - 2018
- Genetic analysis in an intractable gut microbe awarded by National Institutes of Health 2016 - 2018
- Linking oxygen and bacterial ecology in necrotizing enterocolitis 2015 - 2018
- Quantifying Nitrogen Limitation in the Gut Microbiota awarded by National Science Foundation 2015 - 2017
- HARDAC+:Reproducible HPC for next-generation genomics 2016 - 2017
- Alfred P. Sloan Research Fellowship for Dr. Lawrence David in Computational & Evolutionary Molecular Biology awarded by Alfred P. Sloan Foundation 2014 - 2016
- Automated Library Preparation System for Next-Generation Sequencing 2014 - 2015
- Discovering natural bacterial interactions within the human gut microbiota 2014 - 2015
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Industry Relationships
- Kaleido Biosciences
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Reese, Aspen T., Tyler R. Kartzinel, Brianna L. Petrone, Peter J. Turnbaugh, Robert M. Pringle, and Lawrence A. David. “Using DNA Metabarcoding To Evaluate the Plant Component of Human Diets: a Proof of Concept..” Msystems 4, no. 5 (October 8, 2019). https://doi.org/10.1128/mSystems.00458-19.Full Text Link to Item
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Washburne, A. D., J. D. Silverman, J. T. Morton, D. J. Becker, D. Crowley, S. Mukherjee, L. A. David, and R. K. Plowright. “Phylofactorization: a graph partitioning algorithm to identify phylogenetic scales of ecological data.” Ecological Monographs 89, no. 2 (May 1, 2019). https://doi.org/10.1002/ecm.1353.Full Text
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Reese, Aspen T., Fátima C. Pereira, Arno Schintlmeister, David Berry, Michael Wagner, Laura P. Hale, Anchi Wu, et al. “Microbial nitrogen limitation in the mammalian large intestine..” Nat Microbiol 3, no. 12 (December 2018): 1441–50. https://doi.org/10.1038/s41564-018-0267-7.Full Text Link to Item
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Silverman, Justin D., Heather K. Durand, Rachael J. Bloom, Sayan Mukherjee, and Lawrence A. David. “Correction to: Dynamic linear models guide design and analysis of microbiota studies within artificial human guts..” Microbiome 6, no. 1 (November 27, 2018). https://doi.org/10.1186/s40168-018-0601-6.Full Text Link to Item
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Silverman, Justin D., Heather K. Durand, Rachael J. Bloom, Sayan Mukherjee, and Lawrence A. David. “Dynamic linear models guide design and analysis of microbiota studies within artificial human guts..” Microbiome 6, no. 1 (November 12, 2018). https://doi.org/10.1186/s40168-018-0584-3.Full Text Link to Item
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Midani, Firas S., Ana A. Weil, Fahima Chowdhury, Yasmin A. Begum, Ashraful I. Khan, Meti D. Debela, Heather K. Durand, et al. “Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection..” J Infect Dis 218, no. 4 (July 13, 2018): 645–53. https://doi.org/10.1093/infdis/jiy192.Full Text Link to Item
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Reese, Aspen T., Eugenia H. Cho, Bruce Klitzman, Scott P. Nichols, Natalie A. Wisniewski, Max M. Villa, Heather K. Durand, et al. “Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut..” Elife 7 (June 19, 2018). https://doi.org/10.7554/eLife.35987.Full Text Open Access Copy Link to Item
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David, Lawrence A. “Toward Personalized Control of Human Gut Bacterial Communities..” Msystems 3, no. 2 (March 2018). https://doi.org/10.1128/mSystems.00165-17.Full Text Link to Item
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Reese, Aspen T., Kyrstin Lulow, Lawrence A. David, and Justin P. Wright. “Plant community and soil conditions individually affect soil microbial community assembly in experimental mesocosms..” Ecol Evol 8, no. 2 (January 2018): 1196–1205. https://doi.org/10.1002/ece3.3734.Full Text Link to Item
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Silverman, Justin D., Alex D. Washburne, Sayan Mukherjee, and Lawrence A. David. “A phylogenetic transform enhances analysis of compositional microbiota data..” Elife 6 (February 15, 2017). https://doi.org/10.7554/eLife.21887.Full Text Open Access Copy Link to Item
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Washburne, Alex D., Justin D. Silverman, Jonathan W. Leff, Dominic J. Bennett, John L. Darcy, Sayan Mukherjee, Noah Fierer, and Lawrence A. David. “Phylogenetic factorization of compositional data yields lineage-level associations in microbiome datasets..” Peerj 5 (2017). https://doi.org/10.7717/peerj.2969.Full Text Link to Item
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David, Lawrence A., Arne C. Materna, Jonathan Friedman, Maria I. C. Baptista, Matthew C. Blackburn, Allison Perrotta, Susan E. Erdman, and Eric J. Alm. “Erratum to: Host lifestyle affects human microbiota on daily timescales..” Genome Biol 17, no. 1 (May 31, 2016). https://doi.org/10.1186/s13059-016-0988-y.Full Text Link to Item
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Boursier, Jérôme, Olaf Mueller, Matthieu Barret, Mariana Machado, Lionel Fizanne, Felix Araujo-Perez, Cynthia D. Guy, et al. “The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota..” Hepatology 63, no. 3 (March 2016): 764–75. https://doi.org/10.1002/hep.28356.Full Text Link to Item
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Wong, Sandi, W Zac Stephens, Adam R. Burns, Keaton Stagaman, Lawrence A. David, Brendan J. M. Bohannan, Karen Guillemin, and John F. Rawls. “Ontogenetic Differences in Dietary Fat Influence Microbiota Assembly in the Zebrafish Gut..” Mbio 6, no. 5 (September 29, 2015): e00687–e00615. https://doi.org/10.1128/mBio.00687-15.Full Text Link to Item
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David, Lawrence A., Ana Weil, Edward T. Ryan, Stephen B. Calderwood, Jason B. Harris, Fahima Chowdhury, Yasmin Begum, Firdausi Qadri, Regina C. LaRocque, and Peter J. Turnbaugh. “Gut microbial succession follows acute secretory diarrhea in humans..” Mbio 6, no. 3 (May 19, 2015): e00381–e00315. https://doi.org/10.1128/mBio.00381-15.Full Text Link to Item
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David, Lawrence A., Corinne F. Maurice, Rachel N. Carmody, David B. Gootenberg, Julie E. Button, Benjamin E. Wolfe, Alisha V. Ling, et al. “Diet rapidly and reproducibly alters the human gut microbiome..” Nature 505, no. 7484 (January 23, 2014): 559–63. https://doi.org/10.1038/nature12820.Full Text Link to Item
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David, Lawrence A., Arne C. Materna, Jonathan Friedman, Maria I. Campos-Baptista, Matthew C. Blackburn, Allison Perrotta, Susan E. Erdman, and Eric J. Alm. “Host lifestyle affects human microbiota on daily timescales..” Genome Biol 15, no. 7 (2014). https://doi.org/10.1186/gb-2014-15-7-r89.Full Text Link to Item
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Szabo, Gitta, Sarah P. Preheim, Kathryn M. Kauffman, Lawrence A. David, Jesse Shapiro, Eric J. Alm, and Martin F. Polz. “Reproducibility of Vibrionaceae population structure in coastal bacterioplankton..” Isme J 7, no. 3 (March 2013): 509–19. https://doi.org/10.1038/ismej.2012.134.Full Text Link to Item
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Smillie, Chris S., Mark B. Smith, Jonathan Friedman, Otto X. Cordero, Lawrence A. David, and Eric J. Alm. “Ecology drives a global network of gene exchange connecting the human microbiome..” Nature 480, no. 7376 (October 30, 2011): 241–44. https://doi.org/10.1038/nature10571.Full Text Link to Item
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David, Lawrence A., and Eric J. Alm. “Rapid evolutionary innovation during an Archaean genetic expansion..” Nature 469, no. 7328 (January 6, 2011): 93–96. https://doi.org/10.1038/nature09649.Full Text Link to Item
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Preheim, Sarah P., Yan Boucher, Hans Wildschutte, Lawrence A. David, Daniele Veneziano, Eric J. Alm, and Martin F. Polz. “Metapopulation structure of Vibrionaceae among coastal marine invertebrates..” Environ Microbiol 13, no. 1 (January 2011): 265–75. https://doi.org/10.1111/j.1462-2920.2010.02328.x.Full Text Link to Item
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Shapiro, B Jesse, Lawrence A. David, Jonathan Friedman, and Eric J. Alm. “Looking for Darwin's footprints in the microbial world..” Trends Microbiol 17, no. 5 (May 2009): 196–204. https://doi.org/10.1016/j.tim.2009.02.002.Full Text Link to Item
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Hunt, Dana E., Lawrence A. David, Dirk Gevers, Sarah P. Preheim, Eric J. Alm, and Martin F. Polz. “Resource partitioning and sympatric differentiation among closely related bacterioplankton..” Science 320, no. 5879 (May 23, 2008): 1081–85. https://doi.org/10.1126/science.1157890.Full Text Link to Item
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Dubin-Thaler, Benjamin J., Jake M. Hofman, Yunfei Cai, Harry Xenias, Ingrid Spielman, Anna V. Shneidman, Lawrence A. David, Hans-Günther Döbereiner, Chris H. Wiggins, and Michael P. Sheetz. “Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading..” Plos One 3, no. 11 (2008). https://doi.org/10.1371/journal.pone.0003735.Full Text Link to Item
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David, Lawrence A., and Chris H. Wiggins. “Benchmarking of dynamic Bayesian networks inferred from stochastic time-series data..” Ann N Y Acad Sci 1115 (December 2007): 90–101. https://doi.org/10.1196/annals.1407.009.Full Text Link to Item
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Glenn, C. F., D. K. Chow, L. David, C. A. Cooke, M. S. Gami, W. B. Iser, K. B. Hanselman, I. G. Goldberg, and C. A. Wolkow. “Behavioral Deficits During Early Stages of Aging in Caenorhabditis elegans Result From Locomotory Deficits Possibly Linked to Muscle Frailty.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59, no. 12 (December 1, 2004): 1251–60. https://doi.org/10.1093/gerona/59.12.1251.Full Text
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Conference Papers
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Zhang, Y., Y. Zhao, L. David, R. Henao, and L. Carin. “Dynamic poisson factor analysis.” In Proceedings Ieee International Conference on Data Mining, Icdm, 1359–64, 2017. https://doi.org/10.1109/ICDM.2016.111.Full Text
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- Teaching & Mentoring
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Recent Courses
- BIOLOGY 728F: University Program in Genetics and Genomics Biological Solutions Module VI 2019
- CMB 778F: University Program in Genetics and Genomics Biological Solutions Module VI 2019
- EGR 393: Research Projects in Engineering 2019
- MGM 293: Research Independent Study I 2019
- MGM 593: Research Independent Study 2019
- MGM 778F: University Program in Genetics and Genomics Biological Solutions Module VI 2019
- UPGEN 778F: University Program in Genetics and Genomics Biological Solutions Module VI 2019
- BIOLOGY 728B: University Program in Genetics and Genomics Biological Solutions Module Il 2018
- CMB 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2018
- MGM 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2018
- UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2018
- BME 494: Projects in Biomedical Engineering (GE) 2017
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