Lawrence Anthony David | Scholars@Duke

Lawrence Anthony David
Assistant Professor of Molecular Genetics and Microbiology

Current Appointments & Affiliations

Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013
Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018

Contact Information

2171 CIEMAS Building, Box 3382, Durham, NC 27708
Box 3382, 101 Science Drive, Durham, NC 27708
lawrence.david@duke.edu (919) 668-5388
www.ladlab.org

Background
Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 2010
Duke Appointment History
- Affiliate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2014 - 2019
- Instructor, Temporary in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2013
Recognition
In the News
- OCT 29, 2018
  
  Our Microbes Are Starving, and That’s a Good Thing
- MAY 7, 2018
  
  AI Detects Patterns Of Gut Microbes for Cholera Risk
- MAR 20, 2017
  
  Microbes Evolved to Colonize Different Parts of the Human Body
- SEP 22, 2016 Science News
  
  Ten Scientists to Watch: Lawrence Davids gut check gets personal
- JUN 17, 2016
  
  A Little Dirt Won't Hurt You
- MAR 16, 2016
  
  New Collaborative Seed Grant Program Gives Eight Awards
- APR 15, 2015
  
  Lawrence David Named Searle Scholar
- JUL 25, 2014 National Geographic
  
  Q-and-A: Scientist studied his poop for a year to learn about gut bugs
- MAY 13, 2014 Duke Research Blog
  
  Lawrence David Gets to the Gut of the Matter
- FEB 18, 2014
  
  Five Science Faculty Win Sloan Fellowships
- DEC 12, 2013 Fox News, LiveScience
  
  Changes in diet can alter gut bacteria within 24 hours
- OCT 23, 2013
  
  MIcrobes R Us
Awards & Honors
- Sloan Research Fellowship-Molecular Biology. Alfred P. Sloan Foundation. 2014
- Harvard Society Junior Fellows. Harvard Society of Fellows. 2010
Research
Selected Grants
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Genetic analysis of mucin utilization by Akkermansia muciniphila and its impact on host physiology awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Personalizing prebiotic therapies that target human gut microbiota awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics awarded by National Institutes of Health 2016 - 2021
- Predicting prebiotic effects on human microbiota, behavior, and cognition. awarded by Office of Naval Research 2018 - 2021
- Using natural bacterial interactions to control host-associated microbial communities awarded by Arnold and Mabel Beckman Foundation 2015 - 2020
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Personalized Prebiotics to Optimize Microbiota Metabolism and Improve Transplant Outcomes 2018 - 2019
- AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
- Personalizing prebiotic therapies for astronauts' gut microbiota awarded by Baylor College of Medicine 2017 - 2019
- A high througput platform for screening microbial interactions awarded by Burroughs Wellcome Fund 2016 - 2019
- Personalizing prebiotic treatments that manipulate human gut microbiota awarded by University of North Carolina - Chapel Hill 2017 - 2018
- Genetic analysis in an intractable gut microbe awarded by National Institutes of Health 2016 - 2018
- Linking oxygen and bacterial ecology in necrotizing enterocolitis 2015 - 2018
- Quantifying Nitrogen Limitation in the Gut Microbiota awarded by National Science Foundation 2015 - 2017
- HARDAC+:Reproducible HPC for next-generation genomics 2016 - 2017
- Alfred P. Sloan Research Fellowship for Dr. Lawrence David in Computational & Evolutionary Molecular Biology awarded by Alfred P. Sloan Foundation 2014 - 2016
- Automated Library Preparation System for Next-Generation Sequencing 2014 - 2015
- Discovering natural bacterial interactions within the human gut microbiota 2014 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Washburne, A. D., J. D. Silverman, J. T. Morton, D. J. Becker, D. Crowley, S. Mukherjee, L. A. David, and R. K. Plowright. “Phylofactorization: a graph partitioning algorithm to identify phylogenetic scales of ecological data.” Ecological Monographs 89, no. 2 (May 1, 2019). https://doi.org/10.1002/ecm.1353.
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  - Reese, Aspen T., Fátima C. Pereira, Arno Schintlmeister, David Berry, Michael Wagner, Laura P. Hale, Anchi Wu, et al. “Microbial nitrogen limitation in the mammalian large intestine..” Nat Microbiol 3, no. 12 (December 2018): 1441–50. https://doi.org/10.1038/s41564-018-0267-7.
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  - Silverman, Justin D., Heather K. Durand, Rachael J. Bloom, Sayan Mukherjee, and Lawrence A. David. “Correction to: Dynamic linear models guide design and analysis of microbiota studies within artificial human guts..” Microbiome 6, no. 1 (November 27, 2018). https://doi.org/10.1186/s40168-018-0601-6.
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  - Silverman, Justin D., Heather K. Durand, Rachael J. Bloom, Sayan Mukherjee, and Lawrence A. David. “Dynamic linear models guide design and analysis of microbiota studies within artificial human guts..” Microbiome 6, no. 1 (November 12, 2018). https://doi.org/10.1186/s40168-018-0584-3.
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  - Midani, Firas S., Ana A. Weil, Fahima Chowdhury, Yasmin A. Begum, Ashraful I. Khan, Meti D. Debela, Heather K. Durand, et al. “Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection..” J Infect Dis 218, no. 4 (July 13, 2018): 645–53. https://doi.org/10.1093/infdis/jiy192.
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  - Reese, Aspen T., Eugenia H. Cho, Bruce Klitzman, Scott P. Nichols, Natalie A. Wisniewski, Max M. Villa, Heather K. Durand, et al. “Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut..” Elife 7 (June 19, 2018). https://doi.org/10.7554/eLife.35987.
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  - David, Lawrence A. “Toward Personalized Control of Human Gut Bacterial Communities..” Msystems 3, no. 2 (March 2018). https://doi.org/10.1128/mSystems.00165-17.
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  - Reese, Aspen T., Kyrstin Lulow, Lawrence A. David, and Justin P. Wright. “Plant community and soil conditions individually affect soil microbial community assembly in experimental mesocosms..” Ecol Evol 8, no. 2 (January 2018): 1196–1205. https://doi.org/10.1002/ece3.3734.
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  - Silverman, Justin D., Alex D. Washburne, Sayan Mukherjee, and Lawrence A. David. “A phylogenetic transform enhances analysis of compositional microbiota data..” Elife 6 (February 15, 2017). https://doi.org/10.7554/eLife.21887.
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  - Washburne, Alex D., Justin D. Silverman, Jonathan W. Leff, Dominic J. Bennett, John L. Darcy, Sayan Mukherjee, Noah Fierer, and Lawrence A. David. “Phylogenetic factorization of compositional data yields lineage-level associations in microbiome datasets..” Peerj 5 (2017). https://doi.org/10.7717/peerj.2969.
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  - David, Lawrence A., Arne C. Materna, Jonathan Friedman, Maria I. C. Baptista, Matthew C. Blackburn, Allison Perrotta, Susan E. Erdman, and Eric J. Alm. “Erratum to: Host lifestyle affects human microbiota on daily timescales..” Genome Biol 17, no. 1 (May 31, 2016). https://doi.org/10.1186/s13059-016-0988-y.
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  - Boursier, Jérôme, Olaf Mueller, Matthieu Barret, Mariana Machado, Lionel Fizanne, Felix Araujo-Perez, Cynthia D. Guy, et al. “The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota..” Hepatology 63, no. 3 (March 2016): 764–75. https://doi.org/10.1002/hep.28356.
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  - Wong, Sandi, W Zac Stephens, Adam R. Burns, Keaton Stagaman, Lawrence A. David, Brendan J. M. Bohannan, Karen Guillemin, and John F. Rawls. “Ontogenetic Differences in Dietary Fat Influence Microbiota Assembly in the Zebrafish Gut..” Mbio 6, no. 5 (September 29, 2015): e00687–e00615. https://doi.org/10.1128/mBio.00687-15.
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  - David, Lawrence A., Ana Weil, Edward T. Ryan, Stephen B. Calderwood, Jason B. Harris, Fahima Chowdhury, Yasmin Begum, Firdausi Qadri, Regina C. LaRocque, and Peter J. Turnbaugh. “Gut microbial succession follows acute secretory diarrhea in humans..” Mbio 6, no. 3 (May 19, 2015): e00381–e00315. https://doi.org/10.1128/mBio.00381-15.
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  - David, Lawrence A., Corinne F. Maurice, Rachel N. Carmody, David B. Gootenberg, Julie E. Button, Benjamin E. Wolfe, Alisha V. Ling, et al. “Diet rapidly and reproducibly alters the human gut microbiome..” Nature 505, no. 7484 (January 23, 2014): 559–63. https://doi.org/10.1038/nature12820.
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  - David, Lawrence A., Arne C. Materna, Jonathan Friedman, Maria I. Campos-Baptista, Matthew C. Blackburn, Allison Perrotta, Susan E. Erdman, and Eric J. Alm. “Host lifestyle affects human microbiota on daily timescales..” Genome Biol 15, no. 7 (2014). https://doi.org/10.1186/gb-2014-15-7-r89.
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  - Szabo, Gitta, Sarah P. Preheim, Kathryn M. Kauffman, Lawrence A. David, Jesse Shapiro, Eric J. Alm, and Martin F. Polz. “Reproducibility of Vibrionaceae population structure in coastal bacterioplankton..” Isme J 7, no. 3 (March 2013): 509–19. https://doi.org/10.1038/ismej.2012.134.
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  - Smillie, Chris S., Mark B. Smith, Jonathan Friedman, Otto X. Cordero, Lawrence A. David, and Eric J. Alm. “Ecology drives a global network of gene exchange connecting the human microbiome..” Nature 480, no. 7376 (October 30, 2011): 241–44. https://doi.org/10.1038/nature10571.
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  - David, Lawrence A., and Eric J. Alm. “Rapid evolutionary innovation during an Archaean genetic expansion..” Nature 469, no. 7328 (January 6, 2011): 93–96. https://doi.org/10.1038/nature09649.
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  - Preheim, Sarah P., Yan Boucher, Hans Wildschutte, Lawrence A. David, Daniele Veneziano, Eric J. Alm, and Martin F. Polz. “Metapopulation structure of Vibrionaceae among coastal marine invertebrates..” Environ Microbiol 13, no. 1 (January 2011): 265–75. https://doi.org/10.1111/j.1462-2920.2010.02328.x.
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  - Shapiro, B Jesse, Lawrence A. David, Jonathan Friedman, and Eric J. Alm. “Looking for Darwin's footprints in the microbial world..” Trends Microbiol 17, no. 5 (May 2009): 196–204. https://doi.org/10.1016/j.tim.2009.02.002.
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  - Hunt, Dana E., Lawrence A. David, Dirk Gevers, Sarah P. Preheim, Eric J. Alm, and Martin F. Polz. “Resource partitioning and sympatric differentiation among closely related bacterioplankton..” Science 320, no. 5879 (May 23, 2008): 1081–85. https://doi.org/10.1126/science.1157890.
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  - Dubin-Thaler, Benjamin J., Jake M. Hofman, Yunfei Cai, Harry Xenias, Ingrid Spielman, Anna V. Shneidman, Lawrence A. David, Hans-Günther Döbereiner, Chris H. Wiggins, and Michael P. Sheetz. “Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading..” Plos One 3, no. 11 (2008). https://doi.org/10.1371/journal.pone.0003735.
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  - David, Lawrence A., and Chris H. Wiggins. “Benchmarking of dynamic Bayesian networks inferred from stochastic time-series data..” Ann N Y Acad Sci 1115 (December 2007): 90–101. https://doi.org/10.1196/annals.1407.009.
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  - Glenn, C. F., D. K. Chow, L. David, C. A. Cooke, M. S. Gami, W. B. Iser, K. B. Hanselman, I. G. Goldberg, and C. A. Wolkow. “Behavioral Deficits During Early Stages of Aging in Caenorhabditis elegans Result From Locomotory Deficits Possibly Linked to Muscle Frailty.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59, no. 12 (December 1, 2004): 1251–60. https://doi.org/10.1093/gerona/59.12.1251.
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- Conference Papers
  - Zhang, Y., Y. Zhao, L. David, R. Henao, and L. Carin. “Dynamic poisson factor analysis.” In Proceedings Ieee International Conference on Data Mining, Icdm, 1359–64, 2017. https://doi.org/10.1109/ICDM.2016.111.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses