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Lei Ren

Adjunct Professor in the Department of Radiation Oncology
Radiation Oncology
Box 3295 Med Ctr, Durham, NC 27710
04209 Radiation Physics, P.O. Box 3295 DUMC, Durham, NC 27710

Overview


Dr. Ren's research interests include imaging dose reduction using digital tomosynthesis (DTS), cone-beam CT (CBCT) scatter correction, novel DTS/CBCT/MRI image reconstruction methods using prior information and motion modeling, deformable image registration, image synthesis, image augmentation, 4D imaging, development and application of AI in image guided radiation therapy (IGRT).  His clinical expertise focuses on stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) of brain, lung and liver cancer patients.

Current Appointments & Affiliations


Adjunct Professor in the Department of Radiation Oncology · 2021 - Present Radiation Oncology, Clinical Science Departments

Recent Publications


Deep residual network-based projection interpolation and post-processing techniques for thoracic patient CBCT reconstruction.

Journal Article Med Phys · July 2025 BACKGROUND: Projection interpolation can be used to reduce streak artifacts caused by sparse sampling in cone-beam computed tomography (CBCT) image reconstruction. Conventional analytical interpolation methods create additional blur and artifacts at locati ... Full text Link to item Cite

Finite Element Method-Based Hybrid MRI/CBCT Generation to Improve Liver Stereotactic Body Radiation Therapy Targets Localization Accuracy.

Journal Article IEEE Trans Radiat Plasma Med Sci · March 2025 Cone-beam CT (CBCT) is commonly used in treatment imaging, but its limited soft tissue contrast presents challenges for liver tumor localization. As a result, indirect localization methods relying on the liver's boundary are commonly utilized, which have l ... Full text Link to item Cite
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Recent Grants


Developing a workflow for clinical evaluation of a hybrid virtual-MRI/CBCT system for precision image guidance in radiation therapy

ResearchCo-Principal Investigator · Awarded by Varian Medical Systems, Inc. · 2020 - 2023

Hybrid virtual-MRI/CBCT: A new paradigm for image guidance in liver SBRT

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021

A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2020

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Education, Training & Certifications


Duke University · 2009 Ph.D.