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Lei Ren

Adjunct Professor in the Department of Radiation Oncology
Radiation Oncology
Box 3295 Med Ctr, Durham, NC 27710
04209 Radiation Physics, P.O. Box 3295 DUMC, Durham, NC 27710

Overview


Dr. Ren's research interests include imaging dose reduction using digital tomosynthesis (DTS), cone-beam CT (CBCT) scatter correction, novel DTS/CBCT/MRI image reconstruction methods using prior information and motion modeling, deformable image registration, image synthesis, image augmentation, 4D imaging, development and application of AI in image guided radiation therapy (IGRT).  His clinical expertise focuses on stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) of brain, lung and liver cancer patients.

Current Appointments & Affiliations


Adjunct Professor in the Department of Radiation Oncology · 2021 - Present Radiation Oncology, Clinical Science Departments
Member of the Duke Cancer Institute · 2017 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Genomic Determinants Associated with Modes of Progression and Patterns of Failure in Metachronous Oligometastatic Castration-sensitive Prostate Cancer.

Journal Article Eur Urol Oncol · February 2025 BACKGROUND AND OBJECTIVE: Oligometastatic castration-sensitive prostate cancer (omCSPC) represents an early state in the progression of metastatic disease for which patients experience better outcomes in comparison to those with higher disease burden. Desp ... Full text Link to item Cite

Multistage deep learning methods for automating radiographic sharp score prediction in rheumatoid arthritis.

Journal Article Sci Rep · January 27, 2025 The Sharp-van der Heijde score (SvH) is crucial for assessing joint damage in rheumatoid arthritis (RA) through radiographic images. However, manual scoring is time-consuming and subject to variability. This study proposes a multistage deep learning model ... Full text Link to item Cite
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Recent Grants


Developing a workflow for clinical evaluation of a hybrid virtual-MRI/CBCT system for precision image guidance in radiation therapy

ResearchCo-Principal Investigator · Awarded by Varian Medical Systems, Inc. · 2020 - 2023

Hybrid virtual-MRI/CBCT: A new paradigm for image guidance in liver SBRT

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021

A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2020

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Education, Training & Certifications


Duke University · 2009 Ph.D.