Lei Ren | Scholars@Duke

Lei Ren
Associate Professor of Radiation Oncology

Dr. Ren's research interests include imaging dose reduction using digital tomosynthesis (DTS), cone-beam CT (CBCT) scatter correction, novel DTS/CBCT image reconstruction methods using prior information and motion modeling, image guided radiation therapy (IGRT), deformable image registration, patient clinical objective QA methods, stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT).

Current Appointments & Affiliations

Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2015
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017

Contact Information

04209 Radiation Physics, P.O. Box 3295 DUMC, Durham, NC 27710
Box 3295 Med Ctr, Durham, NC 27710
lei.ren@duke.edu (919) 668-0489

Background
Education, Training, & Certifications
- Medical Physics Faculty, Radiation Oncology, Radiation Oncology, Henry Ford Health System 2009 - 2011
- Ph.D., Duke University 2009
Duke Appointment History
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2011 - 2015
Recognition
Awards & Honors
- ASTRO Annual Meeting Basic Science Abstract Award. American Society for Radiation Oncology (ASTRO). 2010
Research
Selected Grants
- A Limited-angle Intra-fractional Verification (LIVE) System for SBRT Treatments awarded by National Institutes of Health 2014 - 2018
- A synchronized moving grid (SMOG) system to improve CBCT for IGRT and ART awarded by Indiana University 2016 - 2017
- A synchronized moving grid system to improve CBCT for IGRT and ART awarded by Georgia Regents University 2013 - 2016
Publications & Artistic Works
Selected Publications
- Book Sections
  - Godfrey, DJ, Ren, L, Wu, Q, and Yin, F. "Tomosynthesis Applications in Radiation Oncology." In Tomosynthesis Imaging. Taylor & Francis, April 19, 2016. (Chapter)
  - Wu, QJ, Godfrey, DJ, Ren, L, Yoo, S, and Yin, F. "On-Board Digital Tomosynthesis: An Emerging New Technology for IGRT." In Image-Guided Radiation Therapy, edited by D Bourland. CRC Press, February 22, 2012. (Chapter)
- Conference Papers
  - Chen, Y, Yin, F-F, Zhang, Y, Zhang, Y, and Ren, L. "Low dose CBCT reconstruction via prior contour based total variation regularization (PCTV): a feasibility study." March 14, 2018. Full Text
  - Wang, C, Harris, W, Yin, F, Chang, Z, Cai, J, and Ren, L. "A Novel Method of Generating Onboard 4D-MRI for Liver SBRT Target Localization Using Prior 4D-MRI Simulation and Onboard Limited Angle kV Acquisition from a Conventional LINAC." October 2017. Full Text
  - Ding, G, Zhang, Y, and Ren, L. "MV and KV Imagingdose Resulting From 4D Target Verification Using the Limited-AngleIntra-Fractional Verification (LIVE) System for SBRT Lung Treatment." June 2017. Link to Item
  - Dubey, A, Iliopoulos, A, Sun, X, Yin, F, and Ren, L. "Iterative Inversion of Deformation Vector Fields with Feedback Control." June 2017. Link to Item
  - Gao, H, Zhang, Y, Ren, L, and Yin, F. "Principal Component Reconstruction (PCR) for Cine CBCT with Motion Learning From 2D Fluoroscopy." June 2017. Link to Item
  - Liu, T, Floros, D, Pitsianis, N, Sun, X, Yin, F, and Ren, L. "Robust Automatic Co-Segmentation of Multiple Medical Images." June 2017. Link to Item
  - Ren, L, Hugo, G, Low, D, and Yang, W. "Multi-Modality 4D Imaging: From Principles to Applications." June 2017. Link to Item
  - Wang, C, Yin, F, Segars, P, Chang, Z, and Ren, L. "Development of a Computerized 4D MRI Phantom for Liver Motion Study." June 2017. Link to Item
  - Zhang, Y, Deng, X, Yin, F, and Ren, L. "Image Acquisition Optimization of a Limited-Angle Intrafraction Verification (LIVE) System for Lung Radiotherapy." June 2017. Link to Item
  - Zhang, Y, Ding, G, Liu, X, Yin, F, and Ren, L. "Clinical Implementation and Evaluation of a Limited-Angle Intrafraction Verification (LIVE) System for Lung Radiotherapy." June 2017. Link to Item
  - Zhang, Y, Meyer, J, Ren, L, Tehrani, JN, and Wang, J. "Liver 4D-CBCT Imaging by a Motion Modeling and Biomechanical Modeling-Guided Reconstruction Technique (MM-Bio-Recon)." June 2017. Link to Item
  - Harris, W, Yin, FF, Wang, C, Chang, Z, Cai, J, Zhang, Y, and Ren, L. "Ultrafast Volumetric Cine Magnetic Resonance Imaging (UVC-MRI) for Real-Time 3-Dimensional Target Localization/Tracking." October 1, 2016. Full Text Link to Item
  - Harris, W, Yin, FF, Wang, C, Chang, Z, Cai, J, Zhang, Y, and Ren, L. "Ultrafast Volumetric Cine Magnetic Resonance Imaging (UVC-MRI) for Real-Time 3-Dimensional Target Localization/Tracking." October 1, 2016. Link to Item
  - Lafata, K, Cai, J, Ren, L, Wu, Q, Hong, JC, Kelsey, CR, and Yin, FF. "Development of a Machine Learning Methodology to Estimate Lung Stereotactic Body Radiation Therapy Dosimetric Endpoints Based on Patient-Specific Anatomic Features." October 1, 2016. Full Text Link to Item
  - Lafata, K, Cai, J, Ren, L, Wu, Q, Hong, JC, Kelsey, CR, and Yin, FF. "Development of a Machine Learning Methodology to Estimate Lung Stereotactic Body Radiation Therapy Dosimetric Endpoints Based on Patient-Specific Anatomic Features." October 1, 2016. Link to Item
  - Zhang, Y, Yin, F, Vergalasova, I, and Ren, L. "Phase-matched DTS Imaging for Lung Tumor Localization." November 2015. Full Text
  - Crockett, E, Oldham, M, and Ren, L. "DVH-Based Comparison of True 3D Measurements to a Delta4 System." June 2015. Full Text Link to Item
  - Gao, R, Wang, H, Zhang, Y, Mao, R, Ren, L, and Yin, F. "Phantom Research On Monochromatic Images Taken by Dual CBCT with Multiple Energy Sets." June 2015. Full Text Link to Item
  - Harris, W, Yin, F, Cai, J, Zhang, Y, and Ren, L. "Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization." June 2015. Full Text Link to Item
  - Harris, W, Zhang, Y, Yin, F, and Ren, L. "Deformable Registration-Based Image Estimation Method for 4D CBCT Using Region-Based PCA." June 2015. Full Text Link to Item
  - Iliopoulos, AS, Pitsianis, N, Sun, X, Yin, FF, and Ren, L. "Rapid Projection Computations for On-Board Digital Tomosynthesis in Radiation Therapy." June 2015. Full Text Link to Item
  - Iliopoulos, AS, Zhang, Y, Pitsianis, N, Sun, X, Yin, FF, and Ren, L. "Multi-Layer Spectral Analysis for Tensor Structure Encoding of 4D Deformation Field Data." June 2015. Full Text Link to Item
  - Mao, R, Zhang, Y, Ren, L, Tian, L, Gao, R, Ge, H, and Yin, F. "Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers." June 2015. Full Text Link to Item
  - Ren, L, Low, D, Descovich, M, and Keall, P. "Real Time Imaging Verification and Tracking for Moving Targets." June 2015. Full Text Link to Item
  - Zawisza, I, Ren, L, and Yin, F. "An Investigation of Respiratory Signal Parameters for Multiple-Step Ahead Prediction of Surrogate Motion." June 2015. Full Text Link to Item
  - Zhang, H, Ren, L, Kong, V, Zhang, Y, Giles, W, and Jin, J. "An Inter-Projection Sensor Fusion (IPSF) Approach to Estimate Missing Projection Signal in Synchronized Moving Grid (SMOG) System." June 2015. Full Text Link to Item
  - Zhang, H, Ren, L, Kong, V, Zhang, Y, Giles, W, and Jin, J. "Improve Cone Beam CT Using a Synchronized Moving Grid, An Inter-Projection Sensor Fusion and a Probability Total Variation Reconstruction." June 2015. Full Text Link to Item
  - Zhang, L, Zhang, Y, Harris, W, Yin, F, and Ren, L. "A Novel Technique for Markerless Self-Sorted 4D-CBCT Using Patient Motion Modeling: A Feasibility Study." June 2015. Full Text Link to Item
  - Zhang, Y, Yin, F, Mao, R, Gao, R, and Ren, L. "FEATURED PRESENTATION: A Dual-Detector Phase-Matched Digital Tomosynthesis (DTS) Imaging Scheme Using Aggregated KV and MV Projections for Intra-Treatment Lung Tumor Tracking." June 2015. Full Text Link to Item
  - Zhang, Y, Yin, F, and Ren, L. "Dosimetric Accuracy of CBCT Images Estimated by a Motion Modeling and Free-Form Deformation Technique for Radiotherapy of Lung Cancer." June 2015. Full Text Link to Item
  - Ren, L, Zhang, Y, and Yin, F. "Dosimetric Evaluation of a Limited-angle Intrafraction Verification (LIVE) System." September 2014. Full Text
  - Zhang, H, Kong, F, Ren, L, and Jin, J-Y. "An Inter-Projection Interpolation (IPI) Approach with Geometric Model Restriction to Reduce Image Dose in Cone Beam CT (CBCT)." September 2014. Full Text
  - Zhang, Y, Yin, F, Pan, T, Vergalasova, I, and Ren, L. "Lung 4D-CBCT Reconstruction Using Prior Information and Limited-Angle Projections: Phantom and Patient Studies." September 2014. Full Text
  - Ren, L, Zhang, Y, and Yin, F. "A Limited-Angle Intrafractional Verification (LIVE) System for Intrafractional Positioning Verification of Lung SBRT Treatment." October 1, 2013. Full Text Link to Item
  - Turner, K, Zhang, Y, Vergalasova, I, Ren, L, Segars, P, Yin, F, and Cai, J. "Breathing Irregularity-Induced Uncertainties in Patient Positioning of Lung SBRT: An Investigation Based on a Digital Human Phantom." October 1, 2013. Full Text Link to Item
  - Yan, S, Bowsher, J, Giles, W, Ren, L, and Yin, F. "A Simulation Study of Treatment Verification Using On-Board Multipinhole SPECT." October 1, 2013. Full Text Link to Item
  - Ren, L, O'Daniel, J, Adamson, J, Yan, H, and Yin, F. "Can Standard Radiation Therapy Quality Assurance (QA) Detect Potential Delivery Errors?." November 1, 2012. Full Text Link to Item
  - Chang, Z, Wu, Q, Adamson, J, Ren, L, Bowsher, J, Yan, H, Thomas, A, and Yin, F. "SU-E-T-74: Assessing Effects of Ion Collection Efficiency in Flattening Filter-Free (FFF) Beams on Three TrueBeam Machines." June 2012. Full Text
  - Chang, Z, Wu, Q, Adamson, J, Ren, L, Bowsher, J, Yan, H, Thomas, A, and Yin, F. "Assessing Effects of Ion Collection Efficiency in Flattening Filter-Free (FFF) Beams On Three TrueBeam Machines." June 2012. Full Text Link to Item
  - Chang, Z, Wu, Q, Adamson, J, Ren, L, Bowsher, J, Yan, H, Thomas, A, and Yin, F. "Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines." June 2012. Full Text Link to Item
  - Huang, C, Ren, L, Kirkpatrick, J, and Wang, Z. "Treatment of Multiple Brain Metastases Using Stereotactic Radiosurgery with Single-Isocenter Volumetric Modulated Arc Therapy: Comparison with Conventional Dynamic Conformal Arc and Static Beam Stereotactic Radiosurgery." June 2012. Full Text Link to Item
  - Jin, J, Ren, L, Kim, J, Kim, S, Movsas, B, Jaffrey, D, and Chetty, I. "TU-A-213CD-11: A Synchronized Moving Grid (SMOG) to Detect and Correct Imaging Lag in Cone Beam Computed Tomography (CBCT): A Simulation Study." June 2012. Full Text
  - Jin, J, Ren, L, Kim, J, Kim, S, Movsas, B, Jaffrey, D, and Chetty, I. "A Synchronized Moving Grid (SMOG) to Detect and Correct Imaging Lag in Cone Beam Computed Tomography (CBCT): A Simulation Study." June 2012. Full Text Link to Item
  - Li, H, Giles, W, Ren, L, Bowsher, J, and Yin, F. "TH-E-218-01: Dual-Energy CBCT Imaging for Metal Artifact Reduction and Contrast Enhancement." June 2012. Full Text
  - Li, H, Giles, W, Ren, L, Bowsher, J, and Yin, F. "Dual-Energy CBCT Imaging for Metal Artifact Reduction and Contrast Enhancement." June 2012. Full Text Link to Item
  - O'Daniel, J, Ren, L, Yan, H, and Yin, F. "SU-E-T-70: A Protocol for Comprehensive Acceptance/Commissioning of Complex 3D QA Devices." June 2012. Full Text
  - O'Daniel, J, Ren, L, Yan, H, and Yin, F. "A Protocol for Comprehensive Acceptance/Commissioning of Complex 3D QA Devices." June 2012. Full Text Link to Item
  - Ren, L, Jin, J, and Yin, F. "TU-A-213CD-02: Contrast-To-Noise Ratio (CNR) Enhancement and Lag Correction in Cone Beam CT (CBCT) Using a Synchronized-MOving-Grid (SMOG) System." June 2012. Full Text
  - Ren, L, Jin, J, and Yin, F. "Contrast-To-Noise Ratio (CNR) Enhancement and Lag Correction in Cone Beam CT (CBCT) Using a Synchronized-MOving-Grid (SMOG) System." June 2012. Full Text Link to Item
  - Zhang, Y, Ren, L, Vergalasova, I, Cai, J, and Yin, F. "TU-A-BRA-09: Phase-Matched Digital Tomosynthesis (DTS) Imaging for Simultaneous Target Verification during Volumetric Modulated Arc Therapy (VMAT) Treatment." June 2012. Full Text
  - Zhang, Y, Ren, L, Vergalasova, I, Cai, J, and Yin, F. "Phase-Matched Digital Tomosynthesis (DTS) Imaging for Simultaneous Target Verification During Volumetric Modulated Arc Therapy (VMAT) Treatment." June 2012. Full Text Link to Item
  - Jin, J, Ren, L, Kim, J, Kim, S, Movsas, B, and Chetty, I. "MO-D-BRC-06: A Multi-Exposure Approach to Improve Image Quality for Linac-Based Cone Beam Computed Tomography (CBCT)." June 2011. Full Text
  - Kim, S, Ren, L, Jin, J, Kim, J, Movsas, B, and Chetty, I. "SU-E-J-21: Verification of a Monte Carlo Model of CBCT Flat Panel Detector Using BEAMnrc/EGSnrc Code." June 2011. Full Text
  - Ren, L, Jin, J, Movsas, B, Yin, F, and Chetty, I. "MO-D-BRC-01: Dosimetric Evaluation of a Novel Cone-Beam CT (CBCT) Estimation Method Using Prior Information for Lung Cancer Patient Treatment." June 2011. Full Text
  - Ren, L, Jin, J, Movsas, B, Yin, F, and Chetty, I. "Dosimetric Evaluation and Optimization of a Novel CBCT Estimation Method for Adaptive Radiation Therapy (ART)." 2011. Full Text Link to Item
  - Jin, J, Ren, L, Kim, J, Movsas, B, and Chetty, I. "TU-C-204B-01: Reduce Patient Dose and Improve Image Quality in CBCT for Image Guided Radiotherapy." June 2010. Full Text
  - Kim, J, Ren, L, Jin, J, Zhong, H, and Chetty, IJ. "SU-DD-A4-03: Cone Beam Computed Tomography Reconstruction on Graphics Processing Units: Flat3D Texture Techniques." June 2010. Full Text
  - Neicu, T, Ren, L, Chetty, I, Pradhan, D, Stricker, H, Movsas, B, and Elshaikh, M. "TU-C-204B-07: A Comparative Study for Daily Localization with 3D Ultrasound, Cone Beam CT, Implanted Prostate Fiducial Markers and Calypso 4D Localization System for Patients Undergoing IGRT for Prostate Cancer." June 2010. Full Text
  - Ren, L, Kim, J, Liu, Q, Movsas, B, Chetty, I, and Jin, J. "SU-GG-J-30: A Novel Scatter Reduction and Correction Method to Improve Cone-Beam CT (CBCT) Image Quality." June 2010. Full Text
  - Bowsher, J, Giles, W, Roper, J, Ren, L, and Yin, F. "SU-FF-J-09: Limited-Angle Imaging for Target Positioning Using Orthogonal Conebeam X-Ray Systems." June 2009. Full Text
  - Yin, F, Wu, Q, Godfrey, D, Ren, L, Yoo, S, Maurer, J, and Yan, H. "TH-A-211A-01: Digital Tomosynthesis for Target Localization." June 2009. Full Text
  - Ren, L, Zhang, J, Thongphiew, D, Wu, Q, Yan, H, Brizel, DM, Lee, WR, Willett, CG, and Yin, F. "Development and Clinical Evaluation of a Novel 3D Digital Tomosynthesis (DTS) Reconstruction Method using a Deformation Field Map." 2009. Full Text Link to Item
  - Ma, J, Wu, Q, Godfrey, D, Yan, H, Ren, L, and Yin, F. "SU-GG-I-53: The Impact of Scan Angles On the Visibility of Anatomy in On-Board Digital Tomosynthesis (DTS) Images for Head and Neck Cancer Patients: A Single-Observer Study." June 2008. Full Text
  - Ren, L, Zhang, J, Thongphiew, D, Godfrey, D, Zhou, S, and Yin, F. "TH-D-351-02: A Novel Digital Tomosynthesis (DTS) Reconstruction Method Using Prior Information and a Deformation Model." June 2008. Full Text
  - Yan, H, Ren, L, Godfrey, D, Yoo, S, and Yin, F. "SU-GG-J-119: Localization Accuracy of Target Verification System Using Digitial Tomosynthesis (DTS)." June 2008. Full Text
  - Yoo, S, Wu, Q, Godfrey, D, Ren, L, and Yin, F. "SU-GG-I-52: Conversion of On-Board Digital TomoSynthesis (DTS) to HU Values." June 2008. Full Text
  - Zhang, J, Ren, L, Zhou, S, and Yin, F. "SU-GG-I-47: A New Limited-Angle CT Reconstruction Method Based On Total-Variation Minimization." June 2008. Full Text
  - Bowsher, JE, Ren, L, and Yin, F. "Limited-angle DTS imaging using CT bone information." 2008. Full Text Link to Item
  - Ren, L, Zhang, J, Thongphiew, D, Wu, Q, Godfrey, DJ, Zhou, S, and Yin, F. "A novel digital tomosynthesis (DTS) reconstruction method using prior information and a deformation model." 2008. Full Text Link to Item
  - Ren, L, Yan, H, Godfrey, D, and Yin, F. "A hybrid multiresolution method for automatic registration between reference and on board digital tomosynthesis." June 2007. Full Text Link to Item
  - Yan, H, Ren, L, Godfrey, D, and Yin, F. "Development of clinical application platform using digital tomosynthesis for target localization." June 2007. Full Text Link to Item
  - Ren, L, Yan, H, Godfrey, D, and Yin, F. "Automatic registration between reference and on-board digital tomosynthesis for target localization of head and neck treatment." 2007. Full Text Link to Item
  - Yan, H, Godfrey, D, Ren, L, Marks, L, Kasibhalta, M, Wu, J, Willet, C, and Yin, F. "Implementation of digital tomosynthesis for on-board target localization of radiotherapy." 2007. Full Text Link to Item
  - Yoo, S, Wu, Q, Godfrey, D, Yan, H, Ren, L, and Yin, F. "Clinical evaluation of digital tomosynthesis in positioning verification based on bony anatomy and soft-tissue for prostate IMRT treatment." 2007. Full Text Link to Item
  - Godfrey, D, Ren, L, Yan, H, Oldham, M, and Yin, F. "TH-C-ValB-04: Evaluation of the Quality of 3D-3D Mutual Information (MI) Shared Between Reference and On-Board DTS Images." June 2006. Full Text
  - Godfrey, D, Ren, L, Yan, H, Oldham, M, and Yin, F. "Evaluation of the quality of 3D-3D mutual information (MI) shared between reference and on-board DTS images." June 2006. Full Text Link to Item
  - Ren, L, Godfrey, D, Wu, J, Yan, H, and Yin, F. "Automatic comparison between reference and on board digital tomosynthesis for target localization." June 2006. Full Text Link to Item
- Journal Articles
  - Bootsma, GJ, Ren, L, Zhang, H, Jin, J-Y, and Jaffray, DA. "Monte Carlo analysis of beam blocking grid design parameters: Scatter estimation and the importance of electron backscatter." Medical physics 45, no. 3 (March 2018): 1059-1070. Full Text
  - Gao, H, Zhang, Y, Ren, L, and Yin, F-F. "Principal component reconstruction (PCR) for cine CBCT with motion learning from 2D fluoroscopy." Medical physics 45, no. 1 (January 2018): 167-177. Full Text
  - Zhang, Y, Deng, X, Yin, F-F, and Ren, L. "Image acquisition optimization of a limited-angle intrafraction verification (LIVE) system for lung radiotherapy." Medical physics 45, no. 1 (January 2018): 340-351. Full Text
  - Harris, W, Yin, F-F, Wang, C, Zhang, Y, Cai, J, and Ren, L. "Accelerating volumetric cine MRI (VC-MRI) using undersampling for real-time 3D target localization/tracking in radiation therapy: a feasibility study." Physics in medicine and biology 63, no. 1 (December 2017): 01NT01-. Full Text
  - Mao, R, Tian, L, Zhang, Y, Ren, L, Gao, R, Yin, F-F, and Ge, H. "Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers." Technology in cancer research & treatment 16, no. 6 (December 2017): 1113-1119. Full Text
  - Sun, WZ, Jiang, MY, Ren, L, Dang, J, You, T, and Yin, F-F. "Respiratory signal prediction based on adaptive boosting and multi-layer perceptron neural network." Physics in medicine and biology 62, no. 17 (August 2017): 6822-6835. Full Text
  - Zhang, Y, Yin, F-F, Zhang, Y, and Ren, L. "Reducing scan angle using adaptive prior knowledge for a limited-angle intrafraction verification (LIVE) system for conformal arc radiotherapy." Physics in medicine and biology 62, no. 9 (May 2017): 3859-3882. Full Text
  - Harris, W, Zhang, Y, Yin, F-F, and Ren, L. "Estimating 4D-CBCT from prior information and extremely limited angle projections using structural PCA and weighted free-form deformation for lung radiotherapy." Medical physics 44, no. 3 (March 2017): 1089-1104. Full Text
  - Wang, C, Yin, F-F, Segars, WP, Chang, Z, and Ren, L. "Development of a Computerized 4-D MRI Phantom for Liver Motion Study." Technology in cancer research & treatment (January 2017): 1533034617723753-. Full Text
  - Zhang, Y, Ren, L, Vergalasova, I, and Yin, F-F. "Clinical Study of Orthogonal-View Phase-Matched Digital Tomosynthesis for Lung Tumor Localization." Technology in cancer research & treatment (January 2017): 1533034617705716-. Full Text
  - Xin-Ye, N, Ren, L, Yan, H, and Yin, F-F. "Sensitivity of 3D Dose Verification to Multileaf Collimator Misalignments in Stereotactic Body Radiation Therapy of Spinal Tumor." Technology in cancer research & treatment 15, no. 6 (December 2016): NP25-NP34. Full Text
  - Harris, W, Yin, FF, Wang, C, Chang, Z, Cai, J, Zhang, Y, and Ren, L. "Ultrafast Volumetric Cine Magnetic Resonance Imaging (UVC-MRI) for Real-Time 3-Dimensional Target Localization/Tracking." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): E626-. Full Text
  - Lafata, K, Cai, J, Ren, L, Wu, Q, Hong, JC, Kelsey, CR, and Yin, FF. "Development of a Machine Learning Methodology to Estimate Lung Stereotactic Body Radiation Therapy Dosimetric Endpoints Based on Patient-Specific Anatomic Features." International journal of radiation oncology, biology, physics 96, no. 2S (October 2016): E420-E421. Full Text
  - Ding, G, Yin, F, and Ren, L. "SU-G-JeP3-06: Lower KV Image Dose Are Expected From a Limited-Angle Intra-Fractional Verification (LIVE) System for SBRT Treatments." Medical physics 43, no. 6 (June 2016): 3671-. Full Text
  - Dubey, A, Iliopoulos, AS, Sun, X, Yin, FF, and Ren, L. "SU-F-J-82: A Rapid Direct Method for Inverting Respiratory Deformation Fields." Medical physics 43, no. 6 (June 2016): 3425-. Full Text
  - Dubey, A, Iliopoulos, AS, Sun, X, Yin, FF, and Ren, L. "SU-F-J-83: Estimation of Deformation Field with Two-Scale Supervoxel Equations." Medical physics 43, no. 6 (June 2016): 3425-. Full Text
  - Harris, W, Ren, L, Cai, J, Zhang, Y, Chang, Z, and Yin, F-F. "A Technique for Generating Volumetric Cine-Magnetic Resonance Imaging." International journal of radiation oncology, biology, physics 95, no. 2 (June 2016): 844-853. Full Text
  - Harris, W, Yin, F, Wang, C, Chang, Z, Cai, J, Zhang, Y, and Ren, L. "TH-EF-BRA-08: A Novel Technique for Estimating Volumetric Cine MRI (VC-MRI) From Multi-Slice Sparsely Sampled Cine Images Using Motion Modeling and Free Form Deformation." Medical physics 43, no. 6 (June 2016): 3898-3899. Full Text
  - Harris, W, Yin, F, Zhang, Y, and Ren, L. "SU-G-JeP3-04: Estimating 4D CBCT from Prior Information and Extremely Limited Angle Projections Using Structural PCA and Weighted Free-Form Deformation." Medical physics 43, no. 6 (June 2016): 3671-. Full Text
  - Iliopoulos, AS, Floros, D, Zhang, Y, Pitsianis, N, Sun, X, Yin, FF, and Ren, L. "SU-F-I-10: Spatially Local Statistics for Adaptive Image Filtering." Medical physics 43, no. 6 (June 2016): 3388-. Full Text
  - Iliopoulos, AS, Pitsianis, N, Sun, X, Yin, FF, and Ren, L. "SU-F-J-138: An Extension of PCA-Based Respiratory Deformation Modeling Via Multi-Linear Decomposition." Medical physics 43, no. 6 (June 2016): 3439-. Full Text
  - Lafata, K, Ren, L, Cai, J, and Yin, F. "SU-G-JeP3-01: A Method to Quantify Lung SBRT Target Localization Accuracy Based On Digitally Reconstructed Fluoroscopy." Medical physics 43, no. 6 (June 2016): 3670-. Full Text
  - Lafata, K, Ren, L, Wu, Q, Kelsey, C, Hong, J, Cai, J, and Yin, F. "SU-D-204-01: A Methodology Based On Machine Learning and Quantum Clustering to Predict Lung SBRT Dosimetric Endpoints From Patient Specific Anatomic Features." Medical physics 43, no. 6 (June 2016): 3332-. Full Text
  - Ren, L, Chen, Y, Zhang, Y, Giles, W, Jin, J, and Yin, F-F. "Scatter Reduction and Correction for Dual-Source Cone-Beam CT Using Prepatient Grids." Technology in cancer research & treatment 15, no. 3 (June 2016): 416-427. Full Text
  - Ren, L. "TH-C-BRC-03: Emerging Linac Based SRS/SBRT Technologies with Modulated Arc Delivery." Medical physics 43, no. 6 (June 2016): 3872-. Full Text
  - Ren, L. "TH-C-BRC-00: Emerging Technologies in SRS/SBRT Delivery." Medical physics 43, no. 6 (June 2016): 3872-. Full Text
  - Wang, C, Yin, F, Harris, W, Cai, J, Chang, Z, and Ren, L. "TU-AB-BRA-09: A Novel Method of Generating Ultrafast Volumetric Cine MRI (VC-MRI) Using Prior 4D-MRI and On-Board Phase-Skipped Encoding Acquisition for Radiotherapy Target Localization." Medical physics 43, no. 6 (June 2016): 3735-. Full Text
  - Zawisza, I, Ren, L, and Yin, F. "SU-G-JeP4-02: An Investigation of Respiratory Surrogate Motion Data Requirements for Multiple-Step Ahead Prediction." Medical physics 43, no. 6 (June 2016): 3681-. Full Text
  - Zhang, L, Zhang, Y, Yin, F, Harris, W, Cai, J, and Ren, L. "TH-EF-BRA-02: A Novel Markerless 4D CBCT Projection Phase Sorting Technique Using Prior Knowledge and Patient Motion Modeling: A Feasibility Study." Medical physics 43, no. 6 (June 2016): 3897-. Full Text
  - Zhang, Y, Yin, F, Zhang, Y, and Ren, L. "WE-DE-BRA-01: SCIENCE COUNCIL JUNIOR INVESTIGATOR COMPETITION WINNER: Acceleration of a Limited-Angle Intrafraction Verification (LIVE) System Using Adaptive Prior Knowledge Based Image Estimation." Medical physics 43, no. 6 (June 2016): 3812-. Full Text
  - Zhang, H, Ren, L, Kong, V, Giles, W, Zhang, Y, and Jin, J-Y. "An interprojection sensor fusion approach to estimate blocked projection signal in synchronized moving grid-based CBCT system." Medical physics 43, no. 1 (January 2016): 268-. Full Text
  - Zhang, Y, Yin, F-F, and Ren, L. "Dosimetric verification of lung cancer treatment using the CBCTs estimated from limited-angle on-board projections." Medical physics 42, no. 8 (August 2015): 4783-4795. Full Text
  - Crockett, E, Oldham, M, and Ren, L. "SU-E-T-341: DVH-Based Comparison of True 3D Measurements to a Delta4 System." Medical physics 42, no. 6 (June 2015): 3411-. Full Text
  - Gao, R, Wang, H, Zhang, Y, Mao, R, Ren, L, and Yin, F. "SU-E-I-40: Phantom Research On Monochromatic Images Taken by Dual CBCT with Multiple Energy Sets." Medical physics 42, no. 6 (June 2015): 3250-. Full Text
  - Harris, W, Yin, F, Cai, J, Zhang, Y, and Ren, L. "WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization." Medical physics 42, no. 6 (June 2015): 3689-. Full Text
  - Harris, W, Zhang, Y, Yin, F, and Ren, L. "TH-CD-303-06: Deformable Registration-Based Image Estimation Method for 4D CBCT Using Region-Based PCA." Medical physics 42, no. 6 (June 2015): 3729-. Full Text
  - Iliopoulos, AS, Pitsianis, N, Sun, X, Yin, FF, and Ren, L. "WE-AB-303-09: Rapid Projection Computations for On-Board Digital Tomosynthesis in Radiation Therapy." Medical physics 42, no. 6 (June 2015): 3658-. Full Text
  - Iliopoulos, AS, Zhang, Y, Pitsianis, N, Sun, X, Yin, FF, and Ren, L. "WE-D-303-06: Multi-Layer Spectral Analysis for Tensor Structure Encoding of 4D Deformation Field Data." Medical physics 42, no. 6 (June 2015): 3669-. Full Text
  - Mao, R, Zhang, Y, Ren, L, Tian, L, Gao, R, Ge, H, and Yin, F. "SU-E-T-293: Dosimetric Analysis of Microscopic Disease in SBRT for Lung Cancers." Medical physics 42, no. 6 (June 2015): 3400-. Full Text
  - Ren, L. "TH-D-BRD-01: X-Ray Based Real Time Imaging Verification." Medical physics 42, no. 6 (June 2015): 3738-. Full Text
  - Zawisza, I, Ren, L, and Yin, F. "TH-AB-303-02: An Investigation of Respiratory Signal Parameters for Multiple-Step Ahead Prediction of Surrogate Motion." Medical physics 42, no. 6 (June 2015): 3711-. Full Text
  - Zhang, H, Ren, L, Kong, V, Zhang, Y, Giles, W, and Jin, J. "WE-EF-207-04: An Inter-Projection Sensor Fusion (IPSF) Approach to Estimate Missing Projection Signal in Synchronized Moving Grid (SMOG) System." Medical physics 42, no. 6 (June 2015): 3681-. Full Text
  - Zhang, H, Ren, L, Kong, V, Zhang, Y, Giles, W, and Jin, J. "WE-EF-207-08: Improve Cone Beam CT Using a Synchronized Moving Grid, An Inter-Projection Sensor Fusion and a Probability Total Variation Reconstruction." Medical physics 42, no. 6 (June 2015): 3682-. Full Text
  - Zhang, L, Zhang, Y, Harris, W, Yin, F, and Ren, L. "SU-E-J-26: A Novel Technique for Markerless Self-Sorted 4D-CBCT Using Patient Motion Modeling: A Feasibility Study." Medical physics 42, no. 6 (June 2015): 3269-. Full Text
  - Zhang, Y, Yin, F, Mao, R, Gao, R, and Ren, L. "WE-AB-303-01: FEATURED PRESENTATION: A Dual-Detector Phase-Matched Digital Tomosynthesis (DTS) Imaging Scheme Using Aggregated KV and MV Projections for Intra-Treatment Lung Tumor Tracking." Medical physics 42, no. 6 (June 2015): 3655-. Full Text
  - Zhang, Y, Yin, F, and Ren, L. "WE-D-303-05: Dosimetric Accuracy of CBCT Images Estimated by a Motion Modeling and Free-Form Deformation Technique for Radiotherapy of Lung Cancer." Medical physics 42, no. 6 (June 2015): 3669-. Full Text
  - Zhang, Y, Yin, F-F, Pan, T, Vergalasova, I, and Ren, L. "Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 115, no. 1 (April 2015): 22-29. Full Text
  - Zhang, Y, Yin, FF, Pan, T, Vergalasova, I, and Ren, L. "Preliminary clinical evaluation of a 4D-CBCT estimation technique using prior information and limited-angle projections." Radiotherapy and Oncology 115, no. 1 (April 1, 2015): 22-29. Full Text
  - Ashmeg, S, Jackson, J, Zhang, Y, Oldham, M, Yin, F, and Ren, L. "SU-E-T-472: A Multi-Dimensional Measurements Comparison to Analyze a 3D Patient Specific QA Tool." Medical physics 41, no. 6 (June 2014): 335-. Full Text
  - Ashmeg, S, Zhang, Y, O' Daniel, J, Yin, F, and Ren, L. "SU-E-T-159: Evaluation of a Patient Specific QA Tool Based On TG119." Medical physics 41, no. 6 (June 2014): 259-. Full Text
  - Chen, Y, Zhang, Y, Giles, W, Jin, J, Yin, F, and Ren, L. "TH-A-18C-05: Scatter Reduction and Correction for Dual-Source CBCT Using the Synchronized Moving Grid (SMOG) System." Medical physics 41, no. 6 (June 2014): 541-. Full Text
  - Harris, W, Zhang, Y, Ren, L, and Yin, F. "SU-E-J-246: A Deformation-Field Map Based Liver 4D CBCT Reconstruction Method Using Gold Nanoparticles as Constraints." Medical physics 41, no. 6 (June 2014): 214-. Full Text
  - Kong, V, Zhang, H, Ren, L, and Jin, J. "SU-E-I-08: An Inpaint-Based Interpolation Technique to Recover Blocked Information for Cone Beam CT with a Synchronized Moving Grid (SMOG)." Medical physics 41, no. 6 (June 2014): 131-. Full Text
  - Ren, L, Zhang, Y, and Yin, F. "SU-E-I-56: Scan Angle Reduction for a Limited-Angle Intrafraction Verification (LIVE) System." Medical physics 41, no. 6 (June 2014): 143-. Full Text
  - Xu, X, Iliopoulos, A, Zhang, Y, Pitsianis, N, Sun, X, Yin, F, and Ren, L. "SU-D-18A-02: Towards Real-Time On-Board Volumetric Image Reconstruction for Intrafraction Target Verification in Radiation Therapy." Medical physics 41, no. 6 (June 2014): 118-. Full Text
  - Zhang, H, Kong, V, Ren, L, and Jin, J. "SU-D-12A-01: An Inter-Projection Interpolation (IPI) Approach for the Synchronized Moving Grid (SMOG) to Reduce Dose in Cone Beam CT." Medical physics 41, no. 6 (June 2014): 123-124. Full Text
  - Zhang, Y, Yin, F, and Ren, L. "WE-G-BRF-03: A Quasi-Cine CBCT Reconstruction Technique for Real-Time On- Board Target Tracking of Lung Cancer Treatment." Medical physics 41, no. 6 (June 2014): 522-. Full Text
  - Zhang, Y, Yin, F, and Ren, L. "SU-D-17A-01: Geometric and Dosimetric Evaluation of a 4D-CBCT Reconstruction Technique Using Prior Knowledge." Medical physics 41, no. 6 (June 2014): 116-. Full Text
  - Ren, L, Zhang, Y, and Yin, F-F. "A limited-angle intrafraction verification (LIVE) system for radiation therapy." Medical physics 41, no. 2 (February 2014): 020701-. Full Text
  - Zhang, Y, Yin, F-F, Segars, WP, and Ren, L. "A technique for estimating 4D-CBCT using prior knowledge and limited-angle projections." Med Phys 40, no. 12 (December 2013): 121701-. Full Text Link to Item
  - Zhang, Y, Ren, L, Ling, CC, and Yin, F-F. "Respiration-phase-matched digital tomosynthesis imaging for moving target verification: a feasibility study." Med Phys 40, no. 7 (July 2013): 071723-. Full Text Link to Item
  - Ren, L, Zhang, Y, Yang, Y, Adamson, J, and Yin, F. "SU-E-T-196: Pretreatment Patient Clinical Objective IMRT Quality Assurance Using a 3D Diode Array." Medical physics 40, no. 6Part13 (June 2013): 249-. Full Text
  - Turner, K, Zhang, Y, Vergalasova, I, Ren, L, Segars, P, Kelsey, C, Yoo, D, Yin, F, and Cai, J. "MO-F-WAB-11: Investigation of CBCT-Based Patient Positioning Accuracy in Lung SBRT: Correlation with Breathing Irregularity." Medical physics 40, no. 6Part24 (June 2013): 412-. Full Text
  - Wu, Q, Chang, Z, Adamson, J, Ren, L, and Yin, F. "SU-E-T-560: A Method to Determine Optimal Dynamic MLC Parameters for Varian Truebeam with Millennium MLC and HDMLC." Medical physics 40, no. 6Part19 (June 2013): 334-. Full Text
  - Zhang, Y, Ren, L, Ling, C, and Yin, F. "WE-A-134-04: Comprehensive Evaluation of a Respiration-Phase-Matched Digital Tomosynthesis (DTS) Imaging Technique for Monitoring Moving Targets." Medical physics 40, no. 6Part28 (June 2013): 469-470. Full Text
  - Zhang, Y, Segars, P, Yin, F, and Ren, L. "TU-G-141-03: An On-Board 4D-CBCT Reconstruction Technique Using Limited-Angle Projections Based On Motion Modeling and Free-Form Deformation (MM-FD)." Medical physics 40, no. 6Part27 (June 2013): 456-. Full Text
  - Zou, G, Ren, L, Kim, J, Jaffray, D, Chetty, I, and Jin, J. "WE-G-141-07: Feasibility of Using a Grid to Detect and Correct the Geometric Variations in Flat-Panel Based Cone Beam CT." Medical physics 40, no. 6Part31 (June 2013): 509-. Full Text
  - Mayyas, E, Chetty, IJ, Chetvertkov, M, Wen, N, Neicu, T, Nurushev, T, Ren, L, Lu, M, Stricker, H, Pradhan, D, Movsas, B, and Elshaikh, MA. "Evaluation of multiple image-based modalities for image-guided radiation therapy (IGRT) of prostate carcinoma: a prospective study." Med Phys 40, no. 4 (April 2013): 041707-. Full Text Link to Item
  - Ren, L, Zhang, Y, and Yin, F. "Phase/Amplitude-matched Digital Tomosynthesis (DTS) Imaging for Moving Target Localization." Practical radiation oncology 3, no. 2 Suppl 1 (April 2013): S20-S21. Full Text
  - Chang, Z, Wu, Q, Adamson, J, Ren, L, Bowsher, J, Yan, H, Thomas, A, and Yin, F-F. "Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines." Med Phys 39, no. 11 (November 2012): 6981-7018. Full Text Link to Item
  - Li, H, Giles, W, Ren, L, Bowsher, J, and Yin, F-F. "Implementation of dual-energy technique for virtual monochromatic and linearly mixed CBCTs." Med Phys 39, no. 10 (October 2012): 6056-6064. Full Text Link to Item
  - Ren, L, Yin, F-F, Chetty, IJ, Jaffray, DA, and Jin, J-Y. "Feasibility study of a synchronized-moving-grid (SMOG) system to improve image quality in cone-beam computed tomography (CBCT)." Med Phys 39, no. 8 (August 2012): 5099-5110. Full Text Link to Item
  - Chang, Z, Wu, Q, Adamson, J, Ren, L, Bowsher, J, Yan, H, Thomas, A, and Yin, F. "SU-E-T-104: Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines." Medical physics 39, no. 6Part11 (June 2012): 3726-. Full Text
  - Huang, C, Ren, L, Kirkpatrick, J, and Wang, Z. "SU-E-T-645: Treatment of Multiple Brain Metastases Using Stereotactic Radiosurgery with Single-Isocenter Volumetric Modulated Arc Therapy: Comparison with Conventional Dynamic Conformal Arc and Static Beam Stereotactic Radiosurgery." Medical physics 39, no. 6Part20 (June 2012): 3854-. Full Text
  - Kim, J, Wen, N, Jin, J-Y, Walls, N, Kim, S, Li, H, Ren, L, Huang, Y, Doemer, A, Faber, K, Kunkel, T, Balawi, A, Garbarino, K, Levin, K, Patel, S, Ajlouni, M, Miller, B, Nurushev, T, Huntzinger, C, Schulz, R, Chetty, IJ, Movsas, B, and Ryu, S. "Clinical commissioning and use of the Novalis Tx linear accelerator for SRS and SBRT. (Published online)" J Appl Clin Med Phys 13, no. 3 (May 10, 2012): 3729-. Link to Item
  - Ren, L, Chetty, IJ, Zhang, J, Jin, J-Y, Wu, QJ, Yan, H, Brizel, DM, Lee, WR, Movsas, B, and Yin, F-F. "Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map." Int J Radiat Oncol Biol Phys 82, no. 5 (April 1, 2012): 1584-1593. Full Text Link to Item
  - Chang, Z, Bowsher, J, Cai, J, Yoo, S, Wang, Z, Adamson, J, Ren, L, and Yin, F-F. "Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: Our 1 year experience." Journal of Applied Clinical Medical Physics 13, no. 4 (2012): 113-140.
  - Chang, Z, Bowsher, J, Cai, J, Yoo, S, Wang, Z, Adamson, J, Ren, L, and Yin, FF. "Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: our 1 year experience." Journal of applied clinical medical physics / American College of Medical Physics 13, no. 4 (2012): 3754-. (Academic Article)
  - Kim, J, Wen, N, Jin, J-Y, Walls, N, Kim, S, Li, H, Ren, L, Huang, Y, Doemer, A, Faber, K, Kunkel, T, Balawi, A, Garbarino, K, Levin, K, Patel, S, Ajlouni, M, Miller, B, Nurushev, T, Huntzinger, C, Schulz, R, Chetty, IJ, Movsas, B, and Ryu, S. "Clinical commissioning and use of the Novalis Tx linear accelerator for SRS and SBRT." Journal of Applied Clinical Medical Physics 13, no. 3 (2012): 124-151.
  - Jin, J-Y, Wen, N, Ren, L, Glide-Hurst, C, and Chetty, IJ. "Advances in treatment techniques: arc-based and other intensity modulated therapies." Cancer J 17, no. 3 (May 2011): 166-176. (Review) Full Text Link to Item
  - Jin, J-Y, Kong, F-M, Liu, D, Ren, L, Li, H, Zhong, H, Movsas, B, and Chetty, IJ. "A TCP model incorporating setup uncertainty and tumor cell density variation in microscopic extension to guide treatment planning." Med Phys 38, no. 1 (January 2011): 439-448. Full Text Link to Item
  - Jin, J-Y, Ren, L, Liu, Q, Kim, J, Wen, N, Guan, H, Movsas, B, and Chetty, IJ. "Combining scatter reduction and correction to improve image quality in cone-beam computed tomography (CBCT)." Med Phys 37, no. 11 (November 2010): 5634-5644. Full Text Link to Item
  - Yoo, S, Wu, QJ, Godfrey, D, Yan, H, Ren, L, Das, S, Lee, WR, and Yin, F-F. "Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy." Int J Radiat Oncol Biol Phys 73, no. 1 (January 1, 2009): 296-305. Full Text Link to Item
  - Ren, L, Zhang, J, Thongphiew, D, Godfrey, DJ, Wu, QJ, Zhou, S-M, and Yin, F-F. "A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map." Medical physics 35, no. 7Part1 (July 2008): 3110-3115. (Letter) Full Text
  - Ren, L, Zhang, J, Thongphiew, D, Godfrey, DJ, Wu, QJ, Zhou, S-M, and Yin, F-F. "A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map." Med Phys 35, no. 7 (July 2008): 3110-3115. (Letter) Full Text Link to Item
  - Ren, L, Godfrey, DJ, Yan, H, Wu, QJ, and Yin, F-F. "Automatic registration between reference and on-board digital tomosynthesis images for positioning verification." Med Phys 35, no. 2 (February 2008): 664-672. Full Text Link to Item
  - Yan, H, Lei, R, Wu, J, Di, F, and Yin, F-F. "Evaluation of Image Enhancement Method on Target Registration Using Cone Beam CT in Radiation Therapy." Clinical medicine. Oncology 2 (January 2008): 289-299.
  - Yan, H, Ren, L, Godfrey, DJ, and Yin, F-F. "Accelerating reconstruction of reference digital tomosynthesis using graphics hardware." Med Phys 34, no. 10 (October 2007): 3768-3776. Full Text Link to Item
  - Godfrey, DJ, Ren, L, Yan, H, Wu, Q, Yoo, S, Oldham, M, and Yin, FF. "Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS)." Med Phys 34, no. 8 (August 2007): 3374-3384. Full Text Link to Item
Teaching & Mentoring
Recent Courses
- MEDPHY 791: Independent Study in Medical Physics 2018
- MEDPHY 791K: Independent Study in Medical Physics 2017

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles

Recent Courses