Lindsay Edwards

Journal Article Am Heart J · January 2026 BACKGROUND: Infants born to women with congenital heart disease (CHD) are at increased risk for adverse outcomes compared with the general population. There are few large, contemporary studies examining the relationship between CHD severity, maternal risk ... Full text Link to item Cite

Enhancing Prediction of Cancer Therapy-Related Cardiomyopathy From Surveillance Echocardiograms: A Children's Oncology Group Study.

Journal Article JACC Adv · December 2025 BACKGROUND: Early echocardiographic indicators of cardiac remodeling may enhance cardiomyopathy risk prediction in childhood cancer survivors (CCS). OBJECTIVES: The objective of the study was to assess whether influential echocardiographic measures can be ... Full text Link to item Cite

Abstract 4368616: Core lab versus computer: Pediatric echocardiogram measurement agreement between expert human and AI readers

Conference Circulation · November 4, 2025 Background: Deep learning algorithms for automated echocardiographic measurements have demonstrated strong performance in adult populations; however, their utility in pediatric echocar ... Full text Cite

Abstract 4366573: Neonatal Resource Utilization following False Positive Prenatal Diagnosis of Coarctation of the Aorta

Conference Circulation · November 4, 2025 Introduction: Prenatal diagnosis of coarctation of the aorta (COA) is challenging and associated with high false positive rates. Postnatal confirmation of the diagnosis is frequently n ... Full text Cite

Advance care planning for adolescents and young adults with congenital heart disease: the adult patient perspective.

Journal Article Cardiol Young · August 2025 INTRODUCTION: Although the importance of advance care planning (ACP) for individuals with adult congenital heart disease (ACHD) has been established, there is no consensus regarding the optimal age to initiate ACP discussions. We asked ACHD patients their ... Full text Link to item Cite

Interpersonal relationships after prenatal diagnosis of congenital heart disease: Social stressors and supports.

Journal Article J Perinatol · July 2025 OBJECTIVE: To identify social stressors and supports for expectant parents after prenatal diagnosis of congenital heart disease (CHD) and inform interventions to reduce distress. METHOD: Parents of children diagnosed prenatally with CHD (N = 37) were purpo ... Full text Link to item Cite

Impact of COVID-19 on Prenatal Diagnosis and Surgical Outcomes of Congenital Heart Disease: Fetal Heart Society and Society of Thoracic Surgeons Collaborative Study.

Journal Article J Am Heart Assoc · May 6, 2025 BACKGROUND: Fetal echocardiography is the mainstay of prenatal diagnosis of congenital heart disease. The COVID-19 pandemic led to shifts in triage of prenatal services. Our objective was to evaluate the impact of COVID-19 restrictions on prenatal diagnosi ... Full text Link to item Cite

Potential role of targeted echocardiography as a screening test for select diagnoses in the paediatric population: bicuspid aortic valve and left ventricular hypertrophy.

Journal Article Cardiol Young · May 2025 OBJECTIVE: We explore the role of targeted echocardiography as a screening tool for bicuspid aortic valve and left ventricular hypertrophy, specifically assessing the risk of missing significant cardiac findings that would otherwise be identified by compre ... Full text Link to item Cite

Suboptimal Imaging on Obstetric Ultrasound Should Prompt Early Referral for Fetal Echocardiography.

Journal Article Pediatr Cardiol · April 2025 Recent studies suggest that suboptimal cardiac imaging on routine obstetric anatomy ultrasound (OB-scan) is not associated with a higher risk for congenital heart disease (CHD) and, therefore, should not be an indication for fetal echocardiography (F-echo) ... Full text Link to item Cite

Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function Including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes.

Journal Article Pediatr Cardiol · March 2025 Despite significant advancements in the care of patients with hypoplastic left heart syndrome (HLHS) morbidity and mortality remain high. Postnatal right ventricular dysfunction and tricuspid regurgitation (TR) are associated with worse outcomes in HLHS. W ... Full text Link to item Cite

Neurodevelopment in Children With Congenital Heart Disease.

Journal Article Pediatr Ann · February 2025 Congenital heart disease (CHD) is the most common birth defect and is associated with significant morbidity and mortality. With advances in medical management and surgical techniques, most individuals with CHD now live into adulthood. Many children and adu ... Full text Link to item Cite

Abstract 4137064: High Incidence of Adverse Neonatal Outcomes of Pregnancy in Women with Congenital Heart Disease

Conference Circulation · November 12, 2024 Background: Neonates born to women with congenital heart disease (CHD) are at high risk for adverse outcomes. We sought to describe these outcomes and maternal/pregnancy risk factors. Full text Cite

Building a machine learning-assisted echocardiography prediction tool for children at risk for cancer therapy-related cardiomyopathy.

Journal Article Cardiooncology · October 9, 2024 BACKGROUND: Despite routine echocardiographic surveillance for childhood cancer survivors, the ability to predict cardiomyopathy risk in individual patients is limited. We explored the feasibility and optimal processes for machine learning-enhanced cardiom ... Full text Link to item Cite

Advances in Diagnosis and Management of Fetal Heart Disease

Journal Article Current Pediatrics Reports · September 1, 2024 Purpose of Review: In this review, we will provide updates on the current state of diagnosis and management of fetal heart disease and highlight the research that is driving the field forward. Recent Findings: The prenatal detection rate for congenital hea ... Full text Cite

Machine Learning for Pediatric Echocardiographic Mitral Regurgitation Detection.

Journal Article J Am Soc Echocardiogr · January 2023 BACKGROUND: Echocardiography-based screening for valvular disease in at-risk asymptomatic children can result in early diagnosis. These screening programs, however, are resource intensive and may not be feasible in many resource-limited settings. Automated ... Full text Link to item Cite

Utility of Screening Fetal Echocardiogram Following Normal Anatomy Ultrasound for In Vitro Fertilization Pregnancies.

Journal Article Pediatr Cardiol · August 2022 In vitro fertilization (IVF) is associated with a higher incidence of congenital heart disease, resulting in universal screening fetal echocardiograms (F-echo) even when cardiac structures on obstetric scan (OB-scan) are normal. Recent studies suggest that ... Full text Link to item Cite

Advance Care Planning Preferences for Adolescents With Cardiac Disease.

Journal Article Pediatrics · February 1, 2022 BACKGROUND AND OBJECTIVES: Adolescents with cardiac disease are at risk for life-changing complications and premature death. The importance of advance care planning (ACP) in adults with congenital heart disease and in pediatric patients with HIV and cancer ... Full text Link to item Cite

Partnering With Stakeholders to Inform the Co-Design of a Psychosocial Intervention for Prenatally Diagnosed Congenital Heart Disease.

Journal Article J Patient Exp · 2022 Input from diverse stakeholders is critical to the process of designing healthcare interventions. This study applied a novel mixed-methods, stakeholder-engaged approach to co-design a psychosocial intervention for mothers expecting a baby with congenital h ... Full text Link to item Cite

Fetal Echocardiographic Parameters and Surgical Outcomes in Congenital Left-Sided Cardiac Lesions.

Journal Article Pediatr Cardiol · August 2019 This study aimed to evaluate fetal echocardiographic parameters associated with neonatal intervention and single-ventricle palliation (SVP) in fetuses with suspected left-sided cardiac lesions. Initial fetal echocardiograms (1/2002-1/2017) were interpreted ... Full text Link to item Cite

Chronic Maternal Hyperoxygenation and Effect on Cerebral and Placental Vasoregulation and Neurodevelopment in Fetuses with Left Heart Hypoplasia.

Journal Article Fetal Diagn Ther · 2019 INTRODUCTION: In a pilot study of chronic maternal hyperoxygenation (CMH) in left heart hypoplasia (LHH), we sought to determine effect estimates of CMH on head size, vascular resistance indices, and neurodevelopment compared to controls. MATERIAL AND METH ... Full text Link to item Cite

Idiopathic congenital right atrial dilation: Fetal presentation.

Journal Article J Clin Ultrasound · October 2018 Full text Link to item Cite

Controversy About a High-Risk and Innovative Fetal Cardiac Intervention.

Journal Article Pediatrics · September 2018 A 20-week-old fetus was diagnosed with critical pulmonary valve stenosis. Given the ultrasound findings, the outcome was difficult to predict. The fetal cardiologists discussed the possibility of a pulmonary valvuloplasty (an experimental procedure) with t ... Full text Link to item Cite

Improving outpatient advance care planning for adults with congenital or pediatric heart disease followed in a pediatric heart failure and transplant clinic.

Journal Article Congenit Heart Dis · May 2018 OBJECTIVE: To improve outpatient advanced care planning (ACP) for adults with congenital/pediatric heart disease followed in a pediatric heart failure (HF) and transplant clinic through quality improvement (QI) methodology. DESIGN: A one-year QI project wa ... Full text Link to item Cite

Atypical Circular Shunt and Diffuse Emphysema in a Fetus with Double-Outlet Right Ventricle and Absent Pulmonary Valve.

Journal Article CASE (Phila) · December 2017 • APVS is usually associated with agenesis of the ductus arteriosus. • APVS is frequently accompanied by dilation of the main and branch pulmonary arteries, often leading to tracheal and bronchial compression with varying degrees of respiratory distress. • ... Full text Link to item Cite

Binding of polyreactive antibodies to self versus foreign antigens.

Journal Article Immunobiology · March 2002 Aside from their ability to bind to multiple antigens, the classic hallmark of polyreactive antibodies is their autoreactivity. Because of their ability to bind a number of common autoantigens, it has long been speculated that polyreactive antibodies are i ... Full text Link to item Cite