Scholars@Duke
Lindsay Edwards

Lindsay Edwards

Assistant Professor of Pediatrics
Pediatrics, Cardiology
Manage Profile
Embed Profile Data

Selected Publications

Advances in Diagnosis and Management of Fetal Heart Disease

Journal Article Current Pediatrics Reports · September 1, 2024 Purpose of Review: In this review, we will provide updates on the current state of diagnosis and management of fetal heart disease and highlight the research that is driving the field forward. Recent Findings: The prenatal detection rate for congenital hea ... Full text Cite

Suboptimal Imaging on Obstetric Ultrasound Should Prompt Early Referral for Fetal Echocardiography.

Journal Article Pediatr Cardiol · June 4, 2024 Recent studies suggest that suboptimal cardiac imaging on routine obstetric anatomy ultrasound (OB-scan) is not associated with a higher risk for congenital heart disease (CHD) and, therefore, should not be an indication for fetal echocardiography (F-echo) ... Full text Link to item Cite

Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function Including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes.

Journal Article Pediatric cardiology · April 2024 Despite significant advancements in the care of patients with hypoplastic left heart syndrome (HLHS) morbidity and mortality remain high. Postnatal right ventricular dysfunction and tricuspid regurgitation (TR) are associated with worse outcomes in HLHS. W ... Full text Cite

Machine Learning for Pediatric Echocardiographic Mitral Regurgitation Detection.

Journal Article J Am Soc Echocardiogr · January 2023 BACKGROUND: Echocardiography-based screening for valvular disease in at-risk asymptomatic children can result in early diagnosis. These screening programs, however, are resource intensive and may not be feasible in many resource-limited settings. Automated ... Full text Link to item Cite

Utility of Screening Fetal Echocardiogram Following Normal Anatomy Ultrasound for In Vitro Fertilization Pregnancies.

Journal Article Pediatr Cardiol · August 2022 In vitro fertilization (IVF) is associated with a higher incidence of congenital heart disease, resulting in universal screening fetal echocardiograms (F-echo) even when cardiac structures on obstetric scan (OB-scan) are normal. Recent studies suggest that ... Full text Link to item Cite

Advance Care Planning Preferences for Adolescents With Cardiac Disease.

Journal Article Pediatrics · February 1, 2022 BACKGROUND AND OBJECTIVES: Adolescents with cardiac disease are at risk for life-changing complications and premature death. The importance of advance care planning (ACP) in adults with congenital heart disease and in pediatric patients with HIV and cancer ... Full text Link to item Cite

Partnering With Stakeholders to Inform the Co-Design of a Psychosocial Intervention for Prenatally Diagnosed Congenital Heart Disease.

Journal Article J Patient Exp · 2022 Input from diverse stakeholders is critical to the process of designing healthcare interventions. This study applied a novel mixed-methods, stakeholder-engaged approach to co-design a psychosocial intervention for mothers expecting a baby with congenital h ... Full text Link to item Cite

Fetal Echocardiographic Parameters and Surgical Outcomes in Congenital Left-Sided Cardiac Lesions.

Journal Article Pediatr Cardiol · August 2019 This study aimed to evaluate fetal echocardiographic parameters associated with neonatal intervention and single-ventricle palliation (SVP) in fetuses with suspected left-sided cardiac lesions. Initial fetal echocardiograms (1/2002-1/2017) were interpreted ... Full text Link to item Cite

Chronic Maternal Hyperoxygenation and Effect on Cerebral and Placental Vasoregulation and Neurodevelopment in Fetuses with Left Heart Hypoplasia.

Journal Article Fetal Diagn Ther · 2019 INTRODUCTION: In a pilot study of chronic maternal hyperoxygenation (CMH) in left heart hypoplasia (LHH), we sought to determine effect estimates of CMH on head size, vascular resistance indices, and neurodevelopment compared to controls. MATERIAL AND METH ... Full text Link to item Cite

Controversy About a High-Risk and Innovative Fetal Cardiac Intervention.

Journal Article Pediatrics · September 2018 A 20-week-old fetus was diagnosed with critical pulmonary valve stenosis. Given the ultrasound findings, the outcome was difficult to predict. The fetal cardiologists discussed the possibility of a pulmonary valvuloplasty (an experimental procedure) with t ... Full text Link to item Cite

Improving outpatient advance care planning for adults with congenital or pediatric heart disease followed in a pediatric heart failure and transplant clinic.

Journal Article Congenit Heart Dis · May 2018 OBJECTIVE: To improve outpatient advanced care planning (ACP) for adults with congenital/pediatric heart disease followed in a pediatric heart failure (HF) and transplant clinic through quality improvement (QI) methodology. DESIGN: A one-year QI project wa ... Full text Link to item Cite

Atypical Circular Shunt and Diffuse Emphysema in a Fetus with Double-Outlet Right Ventricle and Absent Pulmonary Valve.

Journal Article CASE (Phila) · December 2017 • APVS is usually associated with agenesis of the ductus arteriosus. • APVS is frequently accompanied by dilation of the main and branch pulmonary arteries, often leading to tracheal and bronchial compression with varying degrees of respiratory distress. • ... Full text Link to item Cite

Binding of polyreactive antibodies to self versus foreign antigens.

Journal Article Immunobiology · March 2002 Aside from their ability to bind to multiple antigens, the classic hallmark of polyreactive antibodies is their autoreactivity. Because of their ability to bind a number of common autoantigens, it has long been speculated that polyreactive antibodies are i ... Full text Link to item Cite