Lisa Einhorn

Journal Article Anesth Analg · November 1, 2025 BACKGROUND: Posterior spinal fusion (PSF) surgery for correction of idiopathic scoliosis is associated with chronic postsurgical pain (CPSP). In this multicenter study, we describe perioperative multimodal analgesic (MMA) management and characterize postop ... Full text Link to item Cite

Combined Pecto-intercostal Fascial Plane and Rectus Sheath Blocks Versus Local Infiltration for Pain Management Following Pediatric Cardiac Surgery: A Randomized Clinical Trial.

Journal Article Anesth Analg · October 1, 2025 BACKGROUND: Previous studies have shown that regional anesthesia (RA) use versus placebo control is associated with less postsurgical opioid requirements and improved pain scores. This trial compared a novel combination of bilateral pecto-intercostal fasci ... Full text Link to item Cite

Risks and Benefits of Pharmacological Treatment for Pediatric Chronic Non-cancer Pain: When Safety Evidence Lags Behind Prescription Pads.

Journal Article Paediatr Drugs · July 2025 The evidence to support the efficacy and safety of pharmacological treatments for chronic non-cancer pain in children is limited. In practice, clinicians are often required to establish therapeutic plans using data extrapolated from adult studies, which ma ... Full text Link to item Cite

Multisite prospective study of perioperative pain management practices for anterior cruciate ligament reconstruction in adolescents: Society for Pediatric Anesthesia Improvement Network (SPAIN) Project Report

Journal Article Regional Anesthesia & Pain Medicine · June 2025 IntroductionAlthough 200 000 adolescents undergo anterior cruciate ligament reconstruction (ACLR) surgery annually, no benchmarks for pediatric post-ACLR pain management exist ... Full text Cite

National practice patterns for the use of regional anesthesia for pediatric cardiac surgery: An analysis of the Society of Thoracic Surgeons congenital heart surgery database.

Journal Article J Clin Anesth · March 2025 BACKGROUND: Complications associated with suboptimal pain management after pediatric cardiac surgery have increased interest in regional anesthesia (RA). We sought to evaluate national trends and explore the association of RA with postoperative outcomes fo ... Full text Link to item Cite

Factors associated with the use of regional anesthesia for calcaneal osteotomy in pediatric patients: A single-center, retrospective cohort study.

Journal Article Paediatr Anaesth · February 2025 BACKGROUND: Despite known disparities in pediatric perioperative outcomes, few studies have examined factors associated with the use of regional anesthesia for pediatric orthopedic surgery. AIMS: This investigation aimed to determine if minority and develo ... Full text Link to item Cite

Preoperative Psychological Factors, Postoperative Pain Scores, and Development of Posttraumatic Stress Disorder Symptoms After Pediatric Anterior Cruciate Ligament Reconstruction

Journal Article Anesthesia & Analgesia · January 31, 2025 BACKGROUND:Acute orthopedic injuries and subsequent surgical repair can be challenging for children and adolescents and result in posttraumatic stress reactions that can be problematic af ... Full text Cite

Regional Anesthesia and Pain Outcomes After Anterior Cruciate Ligament Reconstruction Surgery in Pediatric Patients: Society of Pediatric Anesthesia Improvement Network

Journal Article Anesthesia and Analgesia · January 1, 2025 BACKGROUND: Optimal perioperative pain management is unknown for adolescent patients undergoing anterior cruciate ligament reconstruction (ACLR). The study aimed to determine the association of nerve blocks with short- and long-term pain outcomes and facto ... Full text Cite

Regional Anesthesia With Fascial Plane Blocks for Pediatric Cardiac Surgery With Sternotomy: A Narrative Review

Journal Article Anesthesia and Analgesia · January 1, 2025 Undertreated pain in children who undergo sternotomy for cardiac surgery can lead to cardiopulmonary complications, the development of chronic pain, and long-term maladaptive stress response. Opioids have dose-dependent side effects that may interfere with ... Full text Cite

Admixture of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Peripheral Nerve Blocks in Adolescents Undergoing Orthopedic Surgery: An Observational Cohort Study.

Journal Article J Clin Med · December 13, 2024 Background/Objectives: In 2021, the Food and Drug Administration approved liposomal bupivacaine injectable suspension for single-dose infiltration in patients ≥ 6 years of age. Liposomal bupivacaine and bupivacaine hydrochloride admixtures may also be admi ... Full text Link to item Cite

Multicenter study of OPRM1 A118G and promoter-region DNA methylation associations with opioid outcomes and chronic postsurgical pain after pediatric musculoskeletal surgery

Journal Article Pain Reports · October 16, 2024 Introduction: Mu opioid receptor gene (OPRM1) variant rs1799971 introduces a CpG site, which may influence DNA methylation (DNAm) and opioid/pain outcomes. Objectives: In this nested analysis, we investigated both OPRM1 A118G genotype and promoter/immediat ... Full text Open Access Cite

Integrating tailored approaches in perioperative care strategies for neurodivergent individuals.

Journal Article EClinicalMedicine · October 2024 Neurodivergent (ND) individuals exhibit variations in communication, behaviors, and cognition, which present both opportunities and challenges in healthcare settings. Anesthesiologists can offer personalized and compassionate care to ND patients throughout ... Full text Open Access Link to item Cite

Impact of a Tranexamic Acid Dosing Practice Guideline in Reducing Blood Product Administration in Pediatric Scoliosis Surgery.

Journal Article AANA J · October 1, 2024 Pediatric patients who undergo spinal corrective surgery often require multiple blood product transfusions. The use of antifibrinolytics, especially tranexamic acid (TXA), to mitigate intraoperative blood loss has increased in popularity. The goal of this ... Link to item Cite

Single-dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double-blind Clinical Trial.

Journal Article Anesthesiology · September 1, 2024 BACKGROUND: More than 500,000 elective tonsillectomies are performed in U.S. children annually. Pain after pediatric tonsillectomy is common, often severe, and undertreated. There is no consensus on the optimal management of perioperative tonsillectomy pai ... Full text Link to item Cite

The Pharmacological Treatment of Neuropathic Pain in Children.

Journal Article Curr Neuropharmacol · 2024 The International Association for the Study of Pain (IASP) defines neuropathic pain as pain caused by a lesion or disease of the somatosensory nervous system. It is characterized as a clinical condition in which diagnostic studies reveal an underlying caus ... Full text Link to item Cite

Chronic Postsurgical Pain in Children and Adolescents: A Call for Action.

Journal Article J Pain Res · 2024 Chronic postsurgical pain (CPSP) affects a significant proportion of children and adolescents after major surgery and is a detriment to both short- and long-term recovery outcomes. While clinical characteristics and psychosocial risk factors for developing ... Full text Link to item Cite

Evaluation of Analgesic Practice Changes Following the Nuss Procedure in Pediatric Patients.

Journal Article J Surg Res · November 2023 INTRODUCTION: Pectus excavatum repair by the Nuss procedure results in severe postoperative pain. Regional blocks and intercostal nerve cryoablation (INC) have emerged as potential strategies to manage analgesia. This study compares pain-related outcomes f ... Full text Link to item Cite

Impact of state legislation and institutional protocols on opioid prescribing practices following pediatric tonsillectomy.

Journal Article Laryngoscope Investig Otolaryngol · June 2023 OBJECTIVES: Tonsillectomy is a common pediatric surgery, and pain is an important consideration in recovery. Due to the opioid epidemic, individual states, medical societies, and institutions have all taken steps to limit postoperative opioids, yet few stu ... Full text Link to item Cite

What we know and what we don't know about the perioperative use of methadone in children and adolescents.

Journal Article Paediatr Anaesth · March 2023 Postoperative pain control is essential to optimizing patient outcomes, improving satisfaction, and allowing patients to resume their baseline functional activities. Methadone, a synthetic mu-opioid agonist, has multiple pharmacologic properties that may b ... Full text Link to item Cite

Opioid and non-opioid analgesic prescribing practices for pediatric adenotonsillectomy in a tertiary care center.

Journal Article Int J Pediatr Otorhinolaryngol · December 2022 IMPORTANCE: The U.S. is in an opioid epidemic with greater than 40,000 deaths annually. Pediatric adenotonsillectomy is one of the most common and painful otolaryngology surgeries performed, often associated with opioid prescriptions. OBJECTIVE: To underst ... Full text Link to item Cite

Analgesic Effects of a Novel Combination of Regional Anesthesia After Pediatric Cardiac Surgery: A Retrospective Cohort Study.

Journal Article J Cardiothorac Vasc Anesth · November 2022 OBJECTIVE: The objective of this study was to determine whether the use of regional anesthesia in children undergoing congenital heart surgery was associated with differences in outcomes when compared to surgeon-delivered local anesthetic wound infiltratio ... Full text Link to item Cite

Children And The Opioid Epidemic: Age-Stratified Exposures And Harms.

Journal Article Health Aff (Millwood) · October 2020 Using North Carolina Medicaid 2016-18 claims data, we found that approximately one in ten adolescents (10.8 percent) filled at least one opioid prescription per year. Dentists, advanced practice providers, and surgeons were common prescribers of opioids to ... Full text Link to item Cite

Successful Combination of Neuraxial and Regional Anesthesia in a Child With Advanced Spinal Muscular Atrophy Type 1 Receiving Maintenance Nusinersen Therapy: A Case Report.

Journal Article A A Pract · April 2020 Spinal muscular atrophy (SMA) is an autosomal recessive condition characterized by degeneration of the anterior horn cells of the spinal cord, which causes progressive muscle atrophy and weakness. SMA type 1 is the most common type and is associated with s ... Full text Link to item Cite

Percutaneous endoscopic gastrostomy vs surgical gastrostomy in infants with congenital heart disease.

Journal Article Paediatr Anaesth · July 2018 BACKGROUND: Infants with congenital heart disease often require feeding tube placement to supplement oral intake. Gastrostomy tubes may be placed by either surgical or percutaneous endoscopic methods, but there is currently no data comparing outcomes of th ... Full text Link to item Cite

Epidemiologic Analysis of Elective Operative Procedures in Infants Less Than 6 Months of Age in the United States.

Journal Article Anesth Analg · November 2017 BACKGROUND: This study uses publicly available data to analyze the total number of elective, potentially deferrable operative procedures involving infants <6 months of age in the United States. We investigated the factors associated with the performance of ... Full text Link to item Cite

The impact of body mass index on the risk of high spinal block in parturients undergoing cesarean delivery: a retrospective cohort study.

Journal Article J Anesth · August 2017 PURPOSE: To investigate the hypothesis that the risk of high spinal block is not increased in obese parturients undergoing cesarean delivery compared to non-obese parturients. METHODS: This is a retrospective study at an academic center. We searched the pe ... Full text Link to item Cite

3-Factor Prothrombin Complex Concentrates in Infants With Refractory Bleeding After Cardiac Surgery.

Journal Article J Cardiothorac Vasc Anesth · December 2016 Full text Link to item Cite

Evaluation of failed and high blocks associated with spinal anesthesia for Cesarean delivery following inadequate labour epidural: a retrospective cohort study.

Journal Article Can J Anaesth · October 2016 PURPOSE: The purpose of this retrospective cohort study was to investigate factors associated with failed and high spinal blocks in patients who received spinal anesthesia for Cesarean delivery following a labour epidural that was inadequate for surgical a ... Full text Link to item Cite

The impact of gestational age and fetal weight on the risk of failure of spinal anesthesia for cesarean delivery.

Journal Article Int J Obstet Anesth · May 2016 BACKGROUND: There are limited data about spinal dosing for cesarean delivery in preterm parturients. We investigated the hypothesis that preterm gestation is associated with an increased incidence of inadequate spinal anesthesia for cesarean delivery compa ... Full text Open Access Link to item Cite

The frequency of hyperkalemia and its significance in chronic kidney disease.

Journal Article Arch Intern Med · June 22, 2009 BACKGROUND: Hyperkalemia is a potential threat to patient safety in chronic kidney disease (CKD). This study determined the incidence of hyperkalemia in CKD and whether it is associated with excess mortality. METHODS: This retrospective analysis of a natio ... Full text Link to item Cite

Frequency of hypoglycemia and its significance in chronic kidney disease.

Journal Article Clin J Am Soc Nephrol · June 2009 BACKGROUND AND OBJECTIVES: This study set out to determine the incidence of hypoglycemia in patients with chronic kidney disease (CKD), with and without diabetes, and the association of hypoglycemia with mortality. DESIGN, SETTING, PARTICIPANTS, & MEASUREM ... Full text Link to item Cite