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Lisa Deneen Hobson-Webb

Professor of Neurology
Neurology, Neuromuscular Disease
Duke Box 3403, Durham, NC 27710
Dept of Medicine, Division of Neurology, Durham, NC 27710

Overview


Trained in neuromuscular medicine, my clinical career has focused on the care of patients with genetically mediated neuromuscular disorders, rare peripheral neuropathies, and immune-mediated nerve and muscle disorders and performing high quality electrodiagnostic testing (nerve conduction studies/electromyography). As a researcher, the core aim of my work is applying high resolution ultrasound in the care of patients with neuromuscular diseases.  My early work focused on peripheral nerve and is now moving toward muscle imaging.  My current research includes muscle ultrasound in late onset Pompe disease and peripheral nerve imaging in acute inflammatory demyelinating radiculoneuropathy.  Since 2016, I have collaborated with Dr. Kathryn Nightingale’s biomedical engineering laboratory on applying shear wave imaging to diseases of the nerve and muscle.   I am interested in clinical trials for neuromuscular disorders and novel technologies for diagnosing and monitoring neuromuscular disease.

Current Appointments & Affiliations


Professor of Neurology · 2023 - Present Neurology, Neuromuscular Disease, Neurology
Vice Chair, Clinical Operations in the Department of Neurology · 2022 - Present Neurology, Clinical Science Departments

Recent Publications


Immune dysregulation in chronic inflammatory demyelinating polyneuropathy.

Journal Article J Neuroimmunol · June 15, 2024 OBJECTIVE: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disorder of the peripheral nerves with an incompletely understood underlying pathophysiology. This investigation focused on defining B and T cell frequencies, T cell funct ... Full text Link to item Cite

Comparative effectiveness of azathioprine and mycophenolate mofetil for myasthenia gravis (PROMISE-MG): a prospective cohort study.

Journal Article The Lancet. Neurology · March 2024 BackgroundMyasthenia gravis is an autoimmune disorder of the neuromuscular junction. Treatment typically includes symptomatic oral cholinesterase inhibitors, immunosuppression, and immunomodulation. In addition to corticosteroids, azathioprine and ... Full text Cite

Rotational 3D shear wave elasticity imaging: Effect of knee flexion on 3D shear wave propagation in in vivo vastus lateralis.

Journal Article Journal of the mechanical behavior of biomedical materials · February 2024 Skeletal muscle is a complex tissue, exhibiting not only direction-dependent material properties (commonly modeled as a transversely isotropic material), but also changes in observed material properties due to factors such as contraction and passive stretc ... Full text Cite
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Recent Grants


Understanding cognitive and neurological pathologies in infantile Pompe disease CNS

Clinical TrialInvestigator · Awarded by Genzyme Corporation · 2022 - 2030

Engineering a Human Skeletal Muscle Tissue Model of LGMD2B

ResearchCollaborator · Awarded by National Institutes of Health · 2023 - 2028

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Education, Training & Certifications


University of Kentucky, College of Medicine · 2001 M.D.