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Lisa Wruck

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Durham Center, DUMC #3850, 300 West Morgan Street, Suite 800, Durham, NC 27701
P. O. Box 17969, 300 West Morgan Street, Suite 800, Durham, NC 27715

Overview


Coordinating Centers, Pragmatic Clinical Research, Real World Evidence, Neurocognitive Data, Data Science Workforce Development

Current Appointments & Affiliations


Professor of Biostatistics & Bioinformatics · 2025 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics
Member in the Duke Clinical Research Institute · 2021 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications


The power, potential of real-world data in randomized controlled trials: proceedings from a multistakeholder think tank.

Journal Article Trials · April 11, 2026 Randomized controlled trials (RCTs) remain the gold standard for evaluating medical interventions, but they often face challenges related to patient recruitment, cost, and efficiency. Real-world data (RWD) has emerged as a valuable tool to enhance trial de ... Full text Link to item Cite

Prevalence of pre-stroke and stroke-related vision impairments and their association with mild cognitive impairment and dementia.

Journal Article J Alzheimers Dis · March 2026 BackgroundVision impairment is a risk factor for mild cognitive impairment (MCI) among stroke survivors, but it is unclear if this association is driven by vision impairment present before or due to the stroke, and if similar associations exist with dement ... Full text Link to item Cite

MULTIPLY ROBUST ESTIMATION FOR CAUSAL SURVIVAL ANALYSIS WITH TREATMENT NONCOMPLIANCE

Journal Article Annals of Applied Statistics · March 1, 2026 Comparative effectiveness research frequently addresses a time-to-event outcome and can require unique considerations in the presence of treatment noncompliance. Motivated by the challenges in addressing noncompliance in the ADAPTABLE pragmatic clinical tr ... Full text Cite
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Recent Grants


The Gut Brain Parkinson's Disease Consortium (GBPDC): Coordinating and Data Management Center (CDMC)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

VCID Biomarkers Coordinating Center

ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2022 - 2027

Integrated Biostatistical Training for CVD Research

Inst. Training Prgm or CMEMentor · Awarded by North Carolina State University · 2022 - 2027

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Education


Harvard University, T.H. Chan School of Public Health · 2004 Ph.D.