Overview
My academic and clinical expertise is in the area of HIV infection in pregnancy. I have participated in the ACTG (Aids Clinical Trial Group as well as PACTG/IMPAACT and the AACTG) since 1988. My specific interest is in complications of medical and surgical treatments for HIV-infected pregnant women. I have served as a principal investigator on ACTG 249 (DDI pharmacokinetics in pregnancy) and AACTG 5084 (Metabolic complications of protease inhibitors in pregnancy). I have a long time affiliation with the Duke Adult and Pediatric infectious disease clinics both for research and for clinical management of mothers and babies. Additionally I have clinical expertise in the care of diabetes in pregnancy, prenatal diagnosis and general high risk pregnancy care. I am an active member of the Division of Maternal Fetal Medicine and fully participate in our research efforts through recruitment of patients to trials within our division. I am involved in the education of medical students and residents.
Current Appointments & Affiliations
Professor of Obstetrics and Gynecology
·
2015 - Present
Obstetrics and Gynecology, Maternal Fetal Medicine,
Obstetrics and Gynecology
Recent Publications
Antiretroviral Therapy at Conception Leads to Lower Peripheral CD49a+ NK Cells and Higher SERPINB2.
Journal Article J Immunol Res · 2025 Problem: Antiretroviral therapy (ART) during pregnancy is essential to prevent vertical HIV transmission and preserve the health of the mother and child. However, ART in pregnancy has been associated with adverse birth outcomes linked to poor placental dev ... Full text Link to item CiteRacial and Rural-Urban Disparities in Maternal Cardiac Disease Care in North Carolina: A Call to Action
Journal Article North Carolina Medical Journal · July 5, 2023 BackgroundCardiac disease is a leading cause of severe maternal morbidity (SMM). We sought to estimate the effects of race and rural-urban status on cardiac-specific severe maternal morbidity (“c ... Full text CiteRacial and Rural-Urban Disparities in Maternal Cardiac Disease Care in North Carolina: A Call to Action.
Conference N C Med J · July 2023 BACKGROUND: Cardiac disease is a leading cause of severe maternal morbidity (SMM). We sought to estimate the effects of race and rural-urban status on cardiac-specific severe maternal morbidity ("cardiac SMM") in North Carolina. METHODS: This retrospective ... Full text Link to item CiteRecent Grants
Pediatric Aids Clinical Trials Unit
ResearchCo-Principal Investigator · Awarded by National Institutes of Health ·Ryan White HIV/AIDS Program Part D Coordinated HIV Services and Access to Research for Women, Infants, Children, and Youth (WICY)
Public ServicePhysician · Awarded by Health Resources and Service Administration · 2010 - 2026HRSA National Cord Blood Inventory
ResearchAdvisor · Awarded by Health Resources and Service Administration · 2006 - 2019View All Grants
Education, Training & Certifications
Duke University ·
1984
M.D.