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Lewis M. Siegel

Professor Emeritus of Biochemistry
Biochemistry
Box 90459, Durham, NC 27708-0067
251 Trent, Durham, NC 27708

Current Appointments & Affiliations


Professor Emeritus of Biochemistry · 2010 - Present Biochemistry, Basic Science Departments
Dean Emeritus of the Graduate School · 2010 - Present Graduate School

Recent Publications


Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products.

Journal Article Biochemistry · October 7, 1997 To further understand the six-electron reductions of sulfite and nitrite catalyzed by the Escherichia coli sulfite reductase hemoprotein (SiRHP), we have determined crystallographic structures of the enzyme in complex with the inhibitors phosphate, carbon ... Full text Link to item Cite

Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange.

Journal Article Biochemistry · October 7, 1997 The active center of the Escherichia coli sulfite reductase hemoprotein (SiRHP) is exquisitely designed to catalyze the six-electron reductions of sulfite to sulfide and nitrite to ammonia. Refined high-resolution crystallographic structures of oxidized, t ... Full text Link to item Cite
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Recent Grants


Biological Oxidations In Mitochondria And Microsomes

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1988 - 1990

Mechanism Of Multielectron Reductases

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1989

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Education, Training & Certifications


Johns Hopkins University · 1965 Ph.D.