Scholars@Duke
Louis Robert DiBernardo

Louis Robert DiBernardo

Assistant Professor of Pathology
Pathology
lou.d@duke.edu
Duke Box 3712, Durham, NC 27710
M243 Davison Bldg, Durham, NC 27710

Selected Publications

A machine learning algorithm improves the diagnostic accuracy of the histologic component of antibody mediated rejection (AMR-H) in cardiac transplant endomyocardial biopsies.

Journal Article Cardiovasc Pathol · 2024 BACKGROUND: Pathologic antibody mediated rejection (pAMR) remains a major driver of graft failure in cardiac transplant patients. The endomyocardial biopsy remains the primary diagnostic tool but presents with challenges, particularly in distinguishing the ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria.

Journal Article Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · August 2023 The microbiology, epidemiology, diagnostics, and treatment of infective endocarditis (IE) have changed significantly since the Duke Criteria were published in 1994 and modified in 2000. The International Society for Cardiovascular Infectious Diseases (ISCV ... Full text Cite

Case Report: Nontuberculous mycobacterial infections in children with complete DiGeorge anomaly.

Journal Article Front Immunol · 2023 Children with complete DiGeorge anomaly (cDGA) have congenital athymia, resulting in severe T cell immunodeficiency and susceptibility to a broad range of infections. We report the clinical course, immunologic phenotypes, treatment, and outcomes of three c ... Full text Link to item Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Creutzfeldt-Jakob Disease Mimicking Neurosyphilis: A Complex Presentation, Histopathological Findings, and Special Precautions for Autopsy.

Journal Article Am J Forensic Med Pathol · December 2019 Creutzfeldt-Jakob disease (CJD) is a complex and rapidly fatal prion infection of the central nervous system with characteristic clinical and pathological findings. Herein, we present the case of an 80-year-old man with a 2-month history of rapid cognitive ... Full text Link to item Cite

T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice.

Journal Article Front Immunol · 2018 CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR). CoB ... Full text Link to item Cite

Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.

Journal Article J Card Fail · February 2016 BACKGROUND: Although primary graft dysfunction (PGD) is a leading cause of mortality and morbidity early post-heart transplant, relatively little is known regarding mechanisms involved in PGD development. METHODS AND RESULTS: We examined the relationship b ... Full text Link to item Cite

A Change of Heart

Journal Article · March 21, 2013 Cardiac sarcoidosis can present as ventricular ectopy, sustained ventricular arrhythmias, asymptomatic ventricular dysfunction, heart failure, or sudden death. Although 25% of patients with sarcoidosis have evidence of cardiac involvement autopsy, only 5% ... Full text Cite

Surgical treatment of a cavernous haemangioma of the heart.

Journal Article Eur J Cardiothorac Surg · May 2012 Cardiac haemangioma is an extremely rare, benign vascular tumour. A 42-year-old female patient who was previously very active presented with complaints of exertional chest pain as well as lower extremity oedema. Computed tomography and magnetic resonance i ... Full text Link to item Cite

An acute animal model of aortic stenosis: initial attempts at leaflet modification.

Journal Article J Heart Valve Dis · March 2012 BACKGROUND AND AIM OF THE STUDY: Percutaneous valve insertion is an emerging treatment for aortic stenosis (AS). To date, no large animal model exists that replicates human calcific AS; moreover, the absence of any valve pathology in currently available an ... Link to item Cite

An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.

Journal Article J Cardiovasc Transl Res · October 2011 Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used t ... Full text Link to item Cite

Myocardial scar in sarcoidosis by 12-lead ECG and pathology.

Journal Article Ann Noninvasive Electrocardiol · April 2011 This case demonstrates the use of QRS scoring to quantify myocardial scar in a patient with cardiac sarcoidosis and left bundle branch block who progressively received an implantable defibrillator, cardiac resynchronization therapy (CRT), left ventricular ... Full text Link to item Cite

Readily available tissue-engineered vascular grafts.

Journal Article Sci Transl Med · February 2, 2011 Autologous or synthetic vascular grafts are used routinely for providing access in hemodialysis or for arterial bypass in patients with cardiovascular disease. However, some patients either lack suitable autologous tissue or cannot receive synthetic grafts ... Full text Link to item Cite

Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model.

Journal Article J Thorac Cardiovasc Surg · December 2010 OBJECTIVE: Achieving transmural tissue ablation might be necessary for successful treatment of atrial fibrillation. The purpose of this study was to evaluate the reproducibility of transmural left atrial ablation using a high-intensity focused ultrasound e ... Full text Link to item Cite

Single-port cholecystectomy with the TransEnterix SPIDER: simple and safe.

Journal Article Surg Endosc · April 2010 Featured Publication INTRODUCTION: Single-port or single-incision cholecystectomy with current rigid laparoscopic devices is limited by in-line visualization, restricting the ability to approach the surgical site with proper angles and instrumentation. A single-port access sys ... Full text Link to item Cite

A change of heart.

Journal Article J Hosp Med · February 2009 Full text Link to item Cite

Systolic contraction within aneurysmal rabbit myocardium following transplantation of autologous skeletal myoblasts.

Journal Article J Surg Res · September 2006 Featured Publication OBJECTIVE: Transplantation of autologous skeletal myoblasts (SKMB) into infarcted heart (or cellular cardiomyoplasty, CCM) augments myocardial performance in animal models of myocardial infarction. However, the effect of CCM in the setting of ventricular a ... Full text Link to item Cite

Histopathology and transmurality of acute microwave lesions on the beating human atrium.

Journal Article Interact Cardiovasc Thorac Surg · June 2006 Microwave energy allows thoracoscopic beating-heart ablation for the treatment of atrial fibrillation. However, there is a paucity of data on the histologic effects of microwave energy on the beating human heart. This study aims to histopathologically char ... Full text Link to item Cite

Diagnosis of a solitary cardiac metastasis from ocular melanoma.

Journal Article J Thorac Cardiovasc Surg · December 2005 Full text Link to item Cite

Adjuvant chemotherapy for osteosarcoma may not increase survival after neoadjuvant chemotherapy and surgical resection.

Journal Article J Surg Oncol · November 2001 BACKGROUND AND OBJECTIVES: Osteosarcoma is a primary malignancy of bone. Current therapy includes neoadjuvant chemotherapy, surgery, and postoperative (adjuvant) chemotherapy. Prolonged treatment with chemotherapeutic agents may place patients at increased ... Full text Link to item Cite

Acute functional consequences of left ventriculotomy.

Journal Article Ann Thorac Surg · July 1998 Featured Publication BACKGROUND: Left ventriculotomies are sometimes used during intracardiac congenital defect repair. Acute changes in left ventricular function after longitudinal or apical ventriculotomy were assessed using dynamic pressure-dimensional data. METHODS: Ultras ... Full text Link to item Cite

Low-flow cardiopulmonary bypass produces greater pulmonary dysfunction than circulatory arrest.

Journal Article Ann Thorac Surg · November 1996 Featured Publication BACKGROUND: Deep hypothermic circulatory arrest (DHCA) is used during the repair of congenital heart disease in neonates. However, because of concern about neurologic injury after DHCA, there is increasing use of continuous deep hypothermic low-flow cardio ... Full text Link to item Cite

Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung.

Journal Article J Thorac Cardiovasc Surg · June 1996 Featured Publication Endothelial injury with failure of pulmonary endothelium-dependent vasodilatation has been proposed as a possible cause for the increased pulmonary vascular resistance observed after cardiopulmonary bypass, but the mechanisms underlying this response are n ... Full text Link to item Cite

pH-stat cooling improves cerebral metabolic recovery after circulatory arrest in a piglet model of aortopulmonary collaterals.

Journal Article J Thorac Cardiovasc Surg · January 1996 Cardiopulmonary bypass with deep hypothermic circulatory arrest increases the risk of neurologic injury in patients with aortopulmonary collaterals. Experimental studies have demonstrated that such collaterals decrease the rate of cerebral cooling before a ... Full text Link to item Cite

Effects of aortopulmonary collaterals on cerebral cooling and cerebral metabolic recovery after circulatory arrest.

Journal Article Circulation · November 1, 1995 BACKGROUND: Aortopulmonary collaterals (APC) have been associated with an increased risk of choreoathetosis after deep hypothermic circulatory arrest (DHCA). To study the effects of APC on cerebral hemodynamics and metabolism before and after DHCA, a pigle ... Full text Link to item Cite

Blockade of endothelin-converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest.

Journal Article Surgery · August 1995 BACKGROUND: Pulmonary dysfunction associated with elevated pulmonary vascular resistance is a significant problem after cardiopulmonary bypass (CPB) and circulatory arrest. Mediators of the pulmonary hypertensive response to CPB have not been fully elucida ... Full text Link to item Cite

Modified ultrafiltration improves cerebral metabolic recovery after circulatory arrest.

Journal Article J Thorac Cardiovasc Surg · April 1995 Featured Publication Modified ultrafiltration uses hemofiltration of the patient and bypass circuit after separation from cardiopulmonary bypass to reverse hemodilution and edema. This study investigated the effect of modified ultrafiltration on cerebral metabolic recovery aft ... Full text Link to item Cite