E. Lee Tyrey

Research interests focus on neuroendocrine mechanisms that regulate reproductive function in the female. Using the rat model, stereotaxic brain stimulation, electrolytic lesioning, and microsurgical transection of neural pathways are used to study brain systems that regulate the secretion of gonadotropins and prolactin from the anterior pituitary. Radioimmunoassays are used to monitor serum hormone levels during or after experimental manipulation. Disturbances of pituitary function that are induced by reproductive toxicants are studied with the goal of determining sites and mechanisms that mediate the adverse effects. Current studies address the disruption of reproductive cycles and ovulation by triazine herbicides.