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Matthew M. Engelhard

Assistant Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Translational Biomedical
2424 Erwin Rd, Durham, NC 27705

Overview


Developing new machine learning methods for multi-modal longitudinal clinical data to support clinical decision-making.

Current Appointments & Affiliations


Assistant Professor of Biostatistics & Bioinformatics · 2022 - Present Biostatistics & Bioinformatics, Division of Translational Biomedical, Biostatistics & Bioinformatics
Assistant Professor in the Department of Electrical and Computer Engineering · 2025 - Present Electrical and Computer Engineering, Pratt School of Engineering

In the News


Published October 1, 2025
New AI Method Excels at Predicting Disease Risk from Clinical Notes
Published September 22, 2025
Duke Team Expands AI Tool to Predict Teen Mental Illness
Published September 5, 2025
Machine Learning Model Improves on Long-Term Diagnosis Prediction

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Recent Publications


Discrete Time Neural Network Models to Address Time-Varying Predictor Importance: An Illustration in Predicting Mortality Over Different Time Horizons.

Journal Article IEEE J Biomed Health Inform · January 2026 Clinical predictive models (CPMs) are crucial for forecasting patient outcomes using available electronic health record (EHR) data. Traditional time-to-event (TTE) models, like the Cox proportional hazards model, assume that hazard ratios remain constant o ... Full text Link to item Cite

Using mixture cure models to address algorithmic bias in diagnostic timing: autism as a test case.

Journal Article JAMIA Open · December 2025 OBJECTIVES: To address algorithmic bias in clinical prediction models related to the timing of diagnosis, we evaluated the efficacy of mixture cure models that integrate time-to-event and binary classification frameworks to predict diagnoses. MATERIALS AND ... Full text Link to item Cite

Machine Learning Risk Prediction for Treated Retinopathy of Prematurity in Infants.

Journal Article Neonatology · November 18, 2025 INTRODUCTION: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. However, current screening guidelines may be overly broad, necessitating better models to detect high-risk infants. METHODS: From a multicenter cohort of 103,701 infa ... Full text Link to item Cite
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Recent Grants


Digital Envirotyping to Develop Understanding of Cigarette smoking and the Environment

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2030

Advancing Identification of Circadian Delay in ADHD Youth: Associations with Clinical Heterogeneity and Cognition

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2029

Leveraging Artificial Intelligence to Predict Mental Health Risk among Youth Presenting to Rural Primary Care Clinics

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2025 - 2029

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Education, Training & Certifications


University of Virginia · 2016 Ph.D.
University of Virginia · 2014 M.D.