Skip to main content

Rupalatha Maddala

Assistant Professor of Ophthalmology
Ophthalmology
Box 3802 Med Ctr, 4028 Aeri Building, 2351 Erwin Rd, Durham, NC 27710
2351 Erwin Road, 4028 Aeri Building, Durham, NC 27710

Overview


Dr. Maddala was recently promoted to Associate Professor of Ophthalmology following her
post-doctoral fellowship and research scientist roles in the Rao Laboratory. She has a keen
interest in fundamental biological research. Her research is focused on ocular lens and
glaucoma. Dr. Maddala's post doctorial research demonstrated the essential role of Rho, Rac
and Rap1 GTPases in lens development and function.

During her time as a research scientist, her research discovered that the lens expresses S100A4,
a small molecular calcium binding protein which exhibits a lens fiber cell-specific, discrete
distribution profile, an independent research project that was NIH-funded.

Dr. Maddala’s long term plans include understanding lens and trabecular meshwork (TM)
biology and function as they relate to ocular dysfunction and identification of new therapies to
address unmet needs in ocular disease. She has been invited to present her research at ISER
meetings in Berlin and Montreal, Lens and Cataract meeting of NFER in Hawaii and ARVO
annual conferences. She also enjoys teaching undergraduate, medical and postdoctorial
students.

Current Duke Appointments & Affiliations


Assistant Professor of Ophthalmology · 2021 - Present Ophthalmology, Clinical Science Departments

Recent Scholarly Works


Dysregulation of Non-Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens.

Journal article J Cell Physiol · June 2026 Non-muscle myosin IIA (NMIIA), a motor protein plays a critical role in regulating cell morphology, adhesion, migration, contractility, and mechanotransduction across various tissues, including the ocular lens. S100A4, a known NMIIA-interacting protein, is ... Full text Link to item Cite

The Human Lens Fiber Cytoskeletome Reveals Neuronal Signatures and the Presence of Chaperonins, Proteasome, Signaling, and Redox Regulators.

Journal article Invest Ophthalmol Vis Sci · May 1, 2026 PURPOSE: Morphogenesis, growth, shape, mechanics, and transparency of the ocular lens critically depend on cytoskeletal networks and cell adhesive interactions. However, the molecular composition of these cellular components of lens fibers remains to be de ... Full text Link to item Cite
View All Scholarly Works

Recent Grants


Role of Glypicans in Aqueous Humor Outflow, IOP and Glaucoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Role of the S100 Family of Proteins in Lens Physiology and Cataract

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028

Role of Septin Cytoskeleton in Trabecular Meshwork, IOP and Glaucoma

ResearchPrincipal Investigator · Awarded by BrightFocus Foundation · 2023 - 2025

View All Grants

Education


Osmania University (India) · 1999 Ph.D.