Skip to main content

Rupalatha Maddala

Assistant Professor of Ophthalmology
Ophthalmology
Box 3802 Med Ctr, 4028 Aeri Building, 2351 Erwin Rd, Durham, NC 27710
2351 Erwin Road, 4028 Aeri Building, Durham, NC 27710

Overview


Dr. Maddala was recently promoted to Associate Professor of Ophthalmology following her
post-doctoral fellowship and research scientist roles in the Rao Laboratory. She has a keen
interest in fundamental biological research. Her research is focused on ocular lens and
glaucoma. Dr. Maddala's post doctorial research demonstrated the essential role of Rho, Rac
and Rap1 GTPases in lens development and function.

During her time as a research scientist, her research discovered that the lens expresses S100A4,
a small molecular calcium binding protein which exhibits a lens fiber cell-specific, discrete
distribution profile, an independent research project that was NIH-funded.

Dr. Maddala’s long term plans include understanding lens and trabecular meshwork (TM)
biology and function as they relate to ocular dysfunction and identification of new therapies to
address unmet needs in ocular disease. She has been invited to present her research at ISER
meetings in Berlin and Montreal, Lens and Cataract meeting of NFER in Hawaii and ARVO
annual conferences. She also enjoys teaching undergraduate, medical and postdoctorial
students.

Current Appointments & Affiliations


Assistant Professor of Ophthalmology · 2021 - Present Ophthalmology, Clinical Science Departments

Recent Publications


Protocol for the Extraction and Characterization of Trabecular Meshwork Cell Cytoskeleton Fraction.

Journal Article Methods Mol Biol · 2025 Among various cellular attributes modulating aqueous humor (AH) outflow through the trabecular pathway and eventually intraocular pressure, the involvement of actomyosin regulated cellular contraction and relaxation, cell-extracellular matrix adhesion and ... Full text Link to item Cite

Ankyrin-B is required for the establishment and maintenance of lens cytoarchitecture, mechanics and clarity.

Journal Article J Cell Sci · December 15, 2024 The transparent ocular lens is essential for vision because it focuses light onto the retina. Despite recognition of the importance of its unique cellular architecture and mechanical properties, the molecular mechanisms governing these attributes remain el ... Full text Link to item Cite

Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension.

Journal Article JCI Insight · December 6, 2024 Ocular hypertension, believed to result partly from increased contractile activity, cell adhesive interactions, and stiffness within the trabecular meshwork (TM), is a major risk factor for glaucoma, a leading cause of blindness. However, the identity of m ... Full text Link to item Cite
View All Publications

Recent Grants


Role of Glypicans in Aqueous Humor Outflow, IOP and Glaucoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Role of the S100 Family of Proteins in Lens Physiology and Cataract

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028

Role of Septin Cytoskeleton in Trabecular Meshwork, IOP and Glaucoma

ResearchPrincipal Investigator · Awarded by BrightFocus Foundation · 2023 - 2025

View All Grants

Education, Training & Certifications


Osmania University (India) · 1999 Ph.D.