Rupalatha Maddala
Assistant Professor in Ophthalmology
Current Appointments & Affiliations
- Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2019
Contact Information
- 2351 Erwin Road, 4028 Aeri Building, Durham, NC 27710
- Box 3802 Med Ctr, 4028 Aeri Building, 2351 Erwin Rd, Durham, NC 27710
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madda001@mc.duke.edu
(919) 684-0557
- Background
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Education, Training, & Certifications
- Ph.D., Osmania University 1999
- Research
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Selected Grants
- Fiber Cell Membrane Organization-Role in Lens Architecture and Function awarded by National Institutes of Health 2014 - 2019
- Role of S100A4 in Lens Homeostasis and Function awarded by National Institutes of Health 2016 - 2019
- Fiber Cell Cytoskeletal Scaffolds-Role in Lens Architecture and Function awarded by National Institutes of Health 1999 - 2013
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Rasiah, PK, Maddala, R, Bennett, V, and Rao, PV. "Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth." Developmental Biology 446, no. 1 (February 2019): 119-131. Full Text
- Maddala, R, Skiba, NP, and Rao, PV. "Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells." Journal of cellular physiology 232, no. 9 (September 2017): 2447-2460. Full Text
- Maddala, R, and Rao, PV. "Switching of α-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation." Investigative Ophthalmology & Visual Science 58, no. 9 (July 2017): 3445-3455. Full Text
- Meekins, LC, Rosado-Adames, N, Maddala, R, Zhao, JJ, Rao, PV, and Afshari, NA. "Corneal Endothelial Cell Migration and Proliferation Enhanced by Rho Kinase (ROCK) Inhibitors in In Vitro and In Vivo Models." Investigative Ophthalmology & Visual Science 57, no. 15 (December 2016): 6731-6738. Full Text
- Muralidharan, AR, Maddala, R, Skiba, NP, and Rao, PV. "Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells." Investigative Ophthalmology & Visual Science 57, no. 15 (December 2016): 6482-6495. Full Text
- Maddala, R, Walters, M, Brophy, PJ, Bennett, V, and Rao, PV. "Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics." American Journal of Physiology. Cell Physiology 310, no. 2 (January 2016): C115-C126. Full Text
- Rao, PV, and Maddala, R. "Ankyrin-B in lens architecture and biomechanics: Just not tethering but more." Bioarchitecture 6, no. 2 (January 2016): 39-45. Full Text
- Maddala, R, Nagendran, T, Lang, RA, Morozov, A, and Rao, PV. "Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis." Developmental biology 406, no. 1 (October 2015): 74-91. Full Text
- Pattabiraman, PP, Maddala, R, and Rao, PV. "Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling." Journal of Cellular Physiology 229, no. 7 (July 2014): 927-942. Full Text
- Gandham, VD, Maddala, RL, Rao, V, Jin, JY, Epstein, DL, Hall, RP, and Zhang, JY. "Effects of Y27632 on keratinocyte procurement and wound healing." Clinical and Experimental Dermatology 38, no. 7 (October 2013): 782-786. Full Text
- Maddala, R, Nagendran, T, de Ridder, GG, Schey, KL, and Rao, PV. "L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins. (Published online)" PLoS One 8, no. 5 (2013): e64676-. Full Text Link to Item
- Iyer, P, Maddala, R, Pattabiraman, PP, and Rao, PV. "Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow." Investigative Ophthalmology & Visual Science 53, no. 8 (July 26, 2012): 4952-4962. Full Text
- Maddala, R, Chauhan, BK, Walker, C, Zheng, Y, Robinson, ML, Lang, RA, and Rao, PV. "Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival." Dev Biol 360, no. 1 (December 1, 2011): 30-43. Full Text Link to Item
- Maddala, R, Skiba, NP, Lalane, R, Sherman, DL, Brophy, PJ, and Rao, PV. "Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers." Dev Biol 357, no. 1 (September 1, 2011): 179-190. Full Text Link to Item
- Inoue, T, Pecen, P, Maddala, R, Skiba, NP, Pattabiraman, PP, Epstein, DL, and Rao, PV. "Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells." Invest Ophthalmol Vis Sci 51, no. 12 (December 2010): 6461-6471. Full Text Link to Item
- Rao, PV, and Maddala, R. "Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling." Investigative Ophthalmology & Visual Science 50, no. 4 (April 2009): 1769-1777. Full Text
- Zhang, M, Maddala, R, and Rao, PV. "Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork." American Journal of Physiology. Cell Physiology 295, no. 5 (November 2008): C1057-C1070. Full Text
- Rao, PV, Ho, T, Skiba, NP, and Maddala, R. "Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins." Biochemical and Biophysical Research Communications 368, no. 3 (April 2008): 508-514. Full Text
- Maddala, R, Reneker, LW, Pendurthi, B, and Rao, PV. "Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival." Developmental Biology 315, no. 1 (March 2008): 217-231. Full Text
- Maddala, R, Skiba, N, and Vasantha Rao, P. "Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse." Differentiation; Research in Biological Diversity 75, no. 8 (October 2007): 713-725. Full Text
- Sanka, K, Maddala, R, Epstein, DL, and Rao, PV. "Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells." Invest Ophthalmol Vis Sci 48, no. 5 (May 2007): 2105-2114. Full Text Link to Item
- Rao, PV, and Maddala, R. "The role of the lens actin cytoskeleton in fiber cell elongation and differentiation." Semin Cell Dev Biol 17, no. 6 (December 2006): 698-711. (Review) Full Text Link to Item
- Chudgar, SM, Deng, P, Maddala, R, Epstein, DL, and Rao, PV. "Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway." Molecular Vision 12 (September 30, 2006): 1117-1126.
- Maddala, R, and Rao, PV. "α-Crystallin localizes to the leading edges of migrating lens epithelial cells." Experimental Cell Research 306, no. 1 (May 15, 2005): 203-215. Full Text
- Rao, PV, Deng, P, Maddala, R, Epstein, DL, Li, C-Y, and Shimokawa, H. "Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow." Molecular Vision 11 (January 2005): 288-297.
- Maddala, R, Deng, P-F, Costello, JM, Wawrousek, EF, Zigler, JS, and Rao, VP. "Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse." Laboratory Investigation; a Journal of Technical Methods and Pathology 84, no. 6 (June 2004): 679-692. Full Text
- Rao, PV, Maddala, R, John, F, and Zigler, JS. "Expression of nonphagocytic NADPH oxidase system in the ocular lens." Molecular Vision 10 (February 19, 2004): 112-121.
- Maddala, R, Reddy, VN, Epstein, DL, and Rao, V. "Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells." Molecular Vision 9 (July 17, 2003): 329-336.
- Khurana, RN, Maddala, RL, Shimokawa, H, Samuel Zigler, J, Epstein, DL, and Vasantha Rao, P. "Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells." Biochem Biophys Res Commun 294, no. 5 (June 28, 2002): 981-987. Full Text Link to Item
- Maddala, R, Peng, YW, and Rao, PV. "Selective expression of the small GTPase RhoB in the early developing mouse lens." Dev Dyn 222, no. 3 (November 2001): 534-537. Full Text Link to Item
- Maddala, RL, Reddy, VN, and Rao, PV. "Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases." Investigative Ophthalmology & Visual Science 42, no. 11 (October 2001): 2610-2615.
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