Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Residency, Internal Medicine, Northwestern University 2017 - 2019
  • Internship, Internal Medicine, Northwestern University 2016 - 2017
  • M.D., Northwestern University, Feinberg School of Medicine 2016
• Research
• 

  External Relationships

  • American Society of Transplantation
  • Cigna
  • North Star Camp for Boys
  • One Lambda ThermoFisher
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Heldman, Madeleine R., Kerstin L. Edlefsen, Gregory Pepper, Siddhartha G. Kapnadak, Robert M. Rakita, Cynthia E. Fisher, and Ajit P. Limaye. “Combined assessment of Epstein-Barr virus viral capsid antigen and Epstein-Barr virus nuclear antigen-1 serology for post-transplant lymphoproliferative disorder risk stratification in adult solid organ transplant recipients.” Transpl Infect Dis 24, no. 6 (December 2022): e13933. https://doi.org/10.1111/tid.13933.
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    • Heldman, Madeleine R., Kaja M. Aagaard, and Joshua A. Hill. “Assessing and restoring adaptive immunity to HSV, VZV, and HHV-6 in solid organ and hematopoietic cell transplant recipients.” Clin Microbiol Infect 28, no. 10 (October 2022): 1345–50. https://doi.org/10.1016/j.cmi.2022.02.001.
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    • Heldman, Madeleine R., Darren J. Wight, Pakorn Aiewsakun, Amr Aswad, Min Fang, Pavitra Roychoudhury, Terry Stevens-Ayers, et al. “Chromosome-Specific Human Herpesvirus 6 Integration and Hematologic Malignancies.” J Virol 96, no. 17 (September 14, 2022): e0093722. https://doi.org/10.1128/jvi.00937-22.
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    • Heldman, Madeleine R., Robert M. Rakita, Erika D. Lease, Cynthia E. Fisher, and Ajit P. Limaye. “Apples to apples: The challenges of studying COVID-19 mortality in solid organ transplant recipients.” Am J Transplant 22, no. 7 (July 2022): 1929–30. https://doi.org/10.1111/ajt.16989.
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    • Heldman, Madeleine R., Olivia S. Kates, Kassem Safa, Camille N. Kotton, Ashrit Multani, Sarah J. Georgia, Julie M. Steinbrink, et al. “Delayed mortality among solid organ transplant recipients hospitalized for COVID-19.” Clin Infect Dis, February 25, 2022. https://doi.org/10.1093/cid/ciac159.
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    • Heldman, Madeleine R., Olivia S. Kates, Kassem Safa, Camille N. Kotton, Sarah J. Georgia, Julie M. Steinbrink, Barbara D. Alexander, et al. “Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic.” Am J Transplant 22, no. 1 (January 2022): 279–88. https://doi.org/10.1111/ajt.16840.
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    • Lindsay, Julian, Jad Othman, Madeleine R. Heldman, and Monica A. Slavin. “Epstein-Barr virus posttransplant lymphoproliferative disorder: update on management and outcomes.” Curr Opin Infect Dis 34, no. 6 (December 1, 2021): 635–45. https://doi.org/10.1097/QCO.0000000000000787.
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    • Heldman, M. R., C. Chandler, J. A. Lieberman, and A. P. Limaye. “Multiple liver lesions in a lung transplant recipient.” American Journal of Transplantation 21, no. 11 (November 1, 2021): 3801–3. https://doi.org/10.1111/ajt.16721.
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    • Heldman, Madeleine R., Cassandra Job, Joyce Maalouf, Jessica Morris, Hu Xie, Chris Davis, Terry Stevens-Ayers, et al. “Association of Inherited Chromosomally Integrated Human Herpesvirus 6 with Neurologic Symptoms and Management after Allogeneic Hematopoietic Cell Transplantation.” Transplant Cell Ther 27, no. 9 (September 2021): 795.e1-795.e8. https://doi.org/10.1016/j.jtct.2021.05.029.
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    • Heldman, Madeleine R., Olivia S. Kates, Cynthia E. Fisher, and Ajit P. Limaye. “Immunosuppression in solid organ transplant recipients with Covid-19: More data, but still complicated.” Transpl Infect Dis 23, no. 4 (August 2021): e13650. https://doi.org/10.1111/tid.13650.
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    • Heldman, Madeleine R., Olivia S. Kates, Kassem Safa, Camille N. Kotton, Sarah J. Georgia, Julie M. Steinbrink, Barbara D. Alexander, et al. “COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.” Am J Transplant 21, no. 8 (August 2021): 2774–84. https://doi.org/10.1111/ajt.16692.
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    • Heldman, Madeleine R., and Ajit P. Limaye. “SARS-CoV-2 Vaccines in Kidney Transplant Recipients: Will They Be Safe and Effective and How Will We Know?” J Am Soc Nephrol 32, no. 5 (May 3, 2021): 1021–24. https://doi.org/10.1681/ASN.2021010023.
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    • Heldman, Madeleine R., Kexin Guo, Brett Nelson, Tenzin Babu, and Michael G. Ison. “Treatment of multidrug-resistant gram-negative bacilli after solid organ transplant: Outcomes and complications.” Transpl Infect Dis 23, no. 1 (February 2021): e13474. https://doi.org/10.1111/tid.13474.
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    • Heldman, Madeleine R., Olivia S. Kates, Brandy M. Haydel, Sander S. Florman, Meenakshi M. Rana, Zohra S. Chaudhry, Mayur S. Ramesh, et al. “Healthcare resource use among solid organ transplant recipients hospitalized with COVID-19.” Clin Transplant 35, no. 2 (February 2021): e14174. https://doi.org/10.1111/ctr.14174.
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    • Heldman, Madeleine R., Stephen Ngo, Peter B. Dorschner, Mia Helfrich, and Michael G. Ison. “Pre- and post-transplant bacterial infections in liver transplant recipients.” Transpl Infect Dis 21, no. 5 (October 2019): e13152. https://doi.org/10.1111/tid.13152.
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    • Joshi, Deepak, Jessica Dyson, Mark Hudson, Josh Levitsky, Madeleine Heldman, and Marianne Samyn. “Paediatric to adult liver transition services: the state of play in the UK.” Clin Med (Lond) 19, no. 5 (September 2019): 425–26. https://doi.org/10.7861/clinmed.2019-0172.
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    • VanWagner, Lisa B., Sarah Uttal, Brittany Lapin, Joshua Lee, Amanda Jichlinski, Tanvi Subramanian, Madeleine Heldman, et al. “Use of Six-Minute Walk Test to Measure Functional Capacity After Liver Transplantation.” Phys Ther 96, no. 9 (September 2016): 1456–67. https://doi.org/10.2522/ptj.20150376.
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    • Heldman, Madeleine R., Min-Woong Sohn, Elisa J. Gordon, Zeeshan Butt, Saeed Mohammed, Estella M. Alonso, and Josh Levitsky. “National survey of adult transplant hepatologists on the pediatric-to-adult care transition after liver transplantation.” Liver Transpl 21, no. 2 (February 2015): 213–23. https://doi.org/10.1002/lt.24044.
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    • Chen, Jin-Qiu, Jih-Hsiang Lee, Michelle A. Herrmann, Kang-Seo Park, Madeleine R. Heldman, Paul K. Goldsmith, Yisong Wang, and Giuseppe Giaccone. “Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer.” Mol Cancer Ther 12, no. 11 (November 2013): 2601–13. https://doi.org/10.1158/1535-7163.MCT-13-0074.
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    • Chen, Jin-Qiu, Madeleine R. Heldman, Michelle A. Herrmann, Noemi Kedei, Wonhee Woo, Peter M. Blumberg, and Paul K. Goldsmith. “Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.” Anal Biochem 442, no. 1 (November 1, 2013): 97–103. https://doi.org/10.1016/j.ab.2013.07.022.
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    • Kedei, Noemi, Nancy E. Lewin, Tamás Géczy, Julia Selezneva, Derek C. Braun, Jinqiu Chen, Michelle A. Herrmann, et al. “Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.” Acs Chem Biol 8, no. 4 (April 19, 2013): 767–77. https://doi.org/10.1021/cb300671s.
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    • Kohn, Ethan A., Yu-an Yang, Zhijun Du, Yoshiko Nagano, Catherine M. H. Van Schyndle, Michelle A. Herrmann, Madeleine Heldman, et al. “Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.” Mol Cancer Res 10, no. 10 (October 2012): 1389–99. https://doi.org/10.1158/1541-7786.MCR-12-0136-T.
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  • Book Sections

    • Ison, M. G., and M. Heldman. “Bacterial infections.” In Hepatic Critical Care, 191–200, 2018. https://doi.org/10.1007/978-3-319-66432-3_15.
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  • Conference Papers

    • Heldman, M. R., O. S. Kates, A. Multani, J. M. Steinbrink, A. V. Lewis, B. D. Alexander, O. E. Beaird, et al. “A Multicenter Prospective Registry Study of Lung Transplant Recipients Hospitalized with COVID-19.” In Journal of Heart and Lung Transplantation, 40:S141–S141, 2021.
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    • Heldman, M., B. Nelson, T. Babu, and M. Ison. “Treatment of Multi-Drug Resistant Gram Negative Infections after Solid Organ Transplant.” In American Journal of Transplantation, 18:888–888, 2018.
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    • Samyn, Marianne, Jessica Dyson, Mark Hudson, Josh Levitsky, Madeleine Heldman, and Deepak Joshi. “A National Audit of Paediatric to Adult Transition Liver Services in the UK.” In Hepatology, 68:315A-316A, 2018.
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    • Heldman, M., E. Gordon, M. Sohn, Z. Butt, S. Mohammad, E. Alonso, and J. Levitsky. “Adult Transplant Hepatologists’ Perceptions of the Transition From Pediatric to Adult Care: A National Survey.” In Transplantation, 98:170–170. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-00519.
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    • Heldman, M., E. Gordon, M. Sohn, Z. Butt, S. Mohammad, E. Alonso, and J. Levitsky. “Adult Transplant Hepatologists' Perceptions of the Transition From Pediatric to Adult Care: A National Survey.” In American Journal of Transplantation, 14:170–170, 2014.
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    • Uttal, Sarah, Lisa B. VanWagner, Brittany Lapin, Amanda Jichlinkski, Joshua Lee, Madeleine Heldman, Brian Poole, et al. “Improved but persistent poor functional performance at 1 year after liver transplantation: Predictors of performance and opportunities for intervention.” In Hepatology, 60:454A-454A. WILEY-BLACKWELL, 2014.
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    • Chen, Jinqiu, Jih-Hsiang Lee, Michelle Herrmann, Kang-Seo Park, Madeleine Heldman, Paul K. Goldsmith, Yisong Wang, and Giuseppe Giaccone. “Abstract 5521: Application of an automated capillary isoelectric-focusing immunoassay to study dynamic oncoprotein phosphorylation in non-small cell lung cancer and for evaluating drug response to targeted therapies.” In Cancer Research, 73:5521–5521. American Association for Cancer Research (AACR), 2013. https://doi.org/10.1158/1538-7445.am2013-5521.
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    • Chen, Jin-Qiu, Jih-hsiang Lee, Michelle Herrmann, Yisong Wang, Kang-seo Park, Madeleine Heldman, Paul Goldsmith, and Giuseppe Giaccone. “A nanofluidic immunoassay system to develop proteomic responsive biomarkers in non-small cell lung cancer.” In Journal of Clinical Oncology, 30:27–27. American Society of Clinical Oncology (ASCO), 2012. https://doi.org/10.1200/jco.2012.30.30_suppl.27.
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    • Chen, Jin-Qiu, Madeleine Heldman, Michelle Herrmann, Noemi Kedei, Peter Blumberg, and Paul Goldsmith. “A fully automated capillary western system for absolute quantitation of endogenous PKC proteins: An approach to correlate protein quantity with function.” In Journal of Clinical Oncology, 30:31–31. American Society of Clinical Oncology (ASCO), 2012. https://doi.org/10.1200/jco.2012.30.30_suppl.31.
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