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Madison Shoaf

Assistant Professor of Neurosurgery
Neurosurgery, Neuro-Oncology

Current Appointments & Affiliations


Assistant Professor of Neurosurgery · 2023 - Present Neurosurgery, Neuro-Oncology, Neurosurgery
Assistant Professor of Medicine · 2023 - Present Medicine, Medical Oncology, Medicine
Assistant Professor in Neurology · 2023 - Present Neurology, Clinical Science Departments

In the News


Published October 10, 2023
Madison Shoaf Joins the Faculty

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Recent Publications


Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration.

Journal Article Cancer Immunol Res · February 3, 2026 Tumor-draining lymph nodes are a pivotal site for antitumor T-cell priming. However, their mechanistic roles in cancer immune surveillance and immunotherapy response remain poorly defined. Intratumor (IT) virotherapy generates antitumor T-cell immunity thr ... Full text Link to item Cite

Impact of Systemic and Radiation Therapy on Survival of Primary Central Nervous System Lymphoma

Journal Article Cancers · February 1, 2025 Introduction: Treatment for primary central nervous system lymphoma (PCNSL) includes high-dose methotrexate (HD-MTX)-based systemic therapy. Multiple regimens exist with no clear standard of care. We evaluated the impact of different therapies on PCNSL out ... Full text Cite

Patterns of Treatment Failure in Primary Central Nervous System Lymphoma.

Journal Article Am J Clin Oncol · July 1, 2024 OBJECTIVES: Progression of PCNSL remains a challenge with salvage therapies, including the risk of substantial morbidity and mortality. We report patterns of first tumor progression to inform opportunities for improvement. METHODS: This is an institutional ... Full text Link to item Cite
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Recent Grants


Randomized Phase 2 (Ph2) clinical trial of Lerapolturev (previously known as PVSRIPO) in recurrent glioblastoma (rGBM)

Clinical TrialCo Investigator · Awarded by Brain Tumor Research Charity · 2024 - 2027

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Education, Training & Certifications


Wake Forest University, School of Medicine · 2016 M.D.
Wake Forest University · 2012 M.S.
Wake Forest University · 2010 B.S.