Mai ElMallah | Scholars@Duke

Mai ElMallah
Associate Professor of Pediatrics

Our laboratory focuses on the control of breathing and pulmonary mechanics in murine models of several genetic diseases. We are currently focuased on ALS mouse models and the Pompe disease mouse model. We examine the impact of gene therapy and neuromodulation on respiratory insufficiency that results from neuromuscular weakness. As a clinician scientist, my goal is to bring therapy from the bench to the bedside and enhance our research at the bench through observations at the bedside.

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Pulmonary and Sleep Medicine, Pediatrics 2018

Contact Information

mai.elmallah@duke.edu

Background
Education, Training, & Certifications
- Pediatric Pulmonary Fellowship, Pediatrics, University of Florida College of Medicine 2010 - 2012
- Residency, Pediatrics, Baylor College of Medicine 2002 - 2005
- Junior House Officer, Queen Elizabeth Hospital, England 2001 - 2002
- M.B.B.Ch., Queens University Belfast (N. Ireland) 2001
Duke Appointment History
- Instructor in the Department of Pediatrics, Pediatrics, Pulmonary and Sleep Medicine, Pediatrics 2017 - 2018
Expertise
Subject Headings
Research
Selected Grants
- VX16-809-120 awarded by Vertex Pharmaceuticals Inc. 2018 - 2021
- A Phase I Study of the Safety of AAV2/8 LSPhGAA in Late-onset Pompe Disease awarded by National Institutes of Health 2017 - 2020
- Sav005-04 awarded by Savara Inc. 2017 - 2019
- Gene Therapy for Upper Airway and Respiratory Insufficiency in an ALS Mouse Model awarded by National Institutes of Health 2016 - 2019
- Novel Approaches for Correcting Respiratory Insufficiency in Pompe Disease awarded by National Institutes of Health 2014 - 2019
Publications & Artistic Works
Selected Publications
- Book Sections
  - Kalfopoulos, M, Wetmore, K, and ElMallah, MK. "Pathophysiology of alpha-1 antitrypsin lung disease." In Methods in Molecular Biology, 9-19. January 1, 2017. Full Text
  - Wang, W, Bacewicz, A, Ashouri, J, Elmallah, RK, and ElMallah, MK. "Secondhand smoke exposure in children with chronic lung disease." In Nicotine Dependence, Smoking Cessation and Effects of Secondhand Smoke, 87-121. January 1, 2015.
- Conference Papers
  - Zieger, M, Keeler, AM, Flotte, TR, and ElMallah, MK. "AAV9-Mediated Gene Replacement Therapy of Respiratory Insufficiency in Very-Long Chain Acyl-CoA Dehydrogenase Deficiency." 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT). Chicago, IL. May 16, 2018 - May 19, 2018.: CELL PRESS, May 1, 2018. Link to Item
  - Lind, LA, Johnson, KA, McCall, AL, Mueller, C, Brown, RH, Lever, TE, Elmallah, MK, and Nichols, NL. "Impact of Intralingual AAVrh10-miRSOD1 Injection on Respiratory Function in SOD1(G93A) Mice." Experimental Biology Meeting. San Diego, CA. April 21, 2018 - April 25, 2018.: FEDERATION AMER SOC EXP BIOL, April 1, 2018. Link to Item
  - Borel, F, Sun, H, Elmallah, MK, Cox, A, Cardozo, B, Li, W, Hoffman, AM, Flotte, TR, and Mueller, C. "Editing out Five SERPINA1 Paralogs to Create a New Mouse Model of Genetic Emphysema." May 2017. Link to Item
  - Keeler-Klunk, AM, Zieger, M, Bircsak, S, Choudhury, S, Byrne, BJ, Sena-Esteves, M, and ElMallah, MK. "Systemic Delivery of AAVB1-GAA Gene Therapy for Respiratory Pathology in Pompe Disease." May 2017. Link to Item
  - Keeler, AM, Zieger, M, Liu, D, Salemi, J, ZhuGe, R, and ElMallah, MK. "Respiratory And Airway Smooth Muscle Pathology In A Pompe Disease Mouse Model." 2017. Link to Item
  - Lu, P, Liu, D, Bellve, K, Fogarty, K, ElMallah, MK, Lifshitz, L, and ZhuGe, R. "Bitter Tastant 1,10-Phenanthroline Activates Tas2r-Gustducin Signaling To Relax Airways, Resulting In A Decrease In Airway Resistance In Vivo." 2017. Link to Item
  - Borel, F, Cardozo, B, Cox, A, Li, W, Hoffman, A, ElMallah, M, and Mueller, C. "167. Genome Editing to Generate the First Mouse Model of Alpha-One Antitrypsin Deficiency, the Leading Cause of Genetic COPD." May 2016. Full Text
  - Turner, S, Elmallah, M, Hoyt, A, Greer, J, and Fuller, D. "Pretreatment with Ampakine CX717 Enhances Long-Term Facilitation (LTF) of Inspiratory Hypoglossal (XII) Bursting, But Only When Initial Burst Output is Low." April 2016. Link to Item
  - Keeler, AM, Desroshers, KV, Xiong, L, and ElMallah, MK. "Exercise Induced Respiratory Insufficiency In A Murine Model Of Very Long-Chain Acyl-Coa Dehydrogenase Deficiency." 2016. Link to Item
  - Stoica, L, Xiong, L, Kalfopoulos, M, Desroshers, KV, and ElMallah, MK. "Characterization Of Pulmonary Mechanics Of The Sod1g93a Als Mouse Model." 2016. Link to Item
  - ElMallah, M, Stanley, D, and Fuller, D. "Hypoglossal long term facilitation shifts the power spectral density to higher frequencies." April 2015. Link to Item
  - Turner, S, ElMallah, M, Falk, D, Byrne, B, and Fuller, D. "Preferential Neuropathology in Respiratory-Related Motor Nuclei in Pompe Mice." April 2015. Link to Item
  - Fuller, D, Elmallah, MK, Ross, H, Cerreta, A, Corti, M, Smith, B, Poirier, A, Mandel, R, and Byrne, B. "Selective knockout of acid alpha-glucosidase GAA gene expression in the medulla alters breathing." April 2014. Link to Item
  - ElMallah, MK, Pagliardini, S, Turner, SM, Greer, JJ, Byrne, BJ, and Fuller, DD. "Ampakines Enhance Respiratory Motor Output In A Murine Model Of Pompe Disease." 2014. Link to Item
  - Falk, D, Todd, A, Soustek, M, Cloutier, D, ElMallah, M, Fuller, D, and Byrne, B. "P.17.9 AAV9 vector encoding hGAA improves synaptic pathology of the neuromuscular junction in Pompe disease." October 2013. Full Text
  - ElMallah, MK, Sandhu, MS, Lee, K-Z, Baekey, DM, and Fuller, DD. "Apnea Alters the Pattern of Intermittent Hypoxia-Induced Long Term Facilitation in Anesthetized Mice." April 2013. Link to Item
  - Sandhu, MS, Elmallah, MK, Lane, MA, Reier, PJ, Greer, JJ, and Fuller, DD. "Ampakines induce a persistent increase in phrenic motor output in rats with cervical spinal cord injury." April 2013. Link to Item
  - Fuller, D, Elmallah, M, Falk, D, Lawson, LA, Martin, AD, Smith, B, and Byrne, B. "The importance of targeting the central nervous system for treatment of respiratory insufficiency in Pompe disease." February 2013. Full Text
  - Chakravarthy, U, El Mallah, M, and Hart, PM. "Amblyopia: Is visual loss permanent." March 15, 2000. Link to Item
- Journal Articles
  - Borel, F, Sun, H, Zieger, M, Cox, A, Cardozo, B, Li, W, Oliveira, G, Davis, A, Gruntman, A, Flotte, TR, Brodsky, MH, Hoffman, AM, Elmallah, MK, and Mueller, C. "Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema." Proceedings of the National Academy of Sciences 115, no. 11 (March 13, 2018): 2788-2793. Full Text
  - ElMallah, M, Bailey, E, Trivedi, M, Kremer, T, and Rhein, LM. "Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications (vol 46, pg e336, 2017)." PEDIATRIC ANNALS 46, no. 11 (November 2017): E436-E436. Full Text Link to Item
  - Trivedi, M, ElMallah, M, Bailey, E, Kremer, T, and Rhein, LM. "Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications (vol 46 pg e332, 2017)." PEDIATRIC ANNALS 46, no. 11 (November 2017). Full Text Link to Item
  - ElMallah, M, Bailey, E, Trivedi, M, Kremer, T, and Rhein, LM. "Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications." Pediatric annals 46, no. 9 (September 2017): e336-e339. Full Text
  - Trivedi, M, ElMallah, M, Bailey, E, Kremer, T, and Rhein, LM. "Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications." Pediatric annals 46, no. 9 (September 2017): e332-e335. Full Text
  - Keeler, A, ElMallah, M, and Flotte, T. "Gene Therapy 2017: Progress and Future Directions." Clinical and Translational Science 10, no. 4 (July 2017): 242-248. Full Text
  - Keeler, AM, Liu, D, Zieger, M, Xiong, L, Salemi, J, Bellvé, K, Byrne, BJ, Fuller, DD, ZhuGe, R, and ElMallah, MK. "Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 312, no. 6 (June 2017): L873-L881. Full Text
  - Stoica, L, Keeler, AM, Xiong, L, Kalfopoulos, M, Desrochers, K, Brown, RH, Sena-Esteves, M, Flotte, TR, and ElMallah, MK. "Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model." American Journal of Respiratory Cell and Molecular Biology 56, no. 3 (March 2017): 405-408. (Letter) Full Text
  - Turner, SM, ElMallah, MK, Hoyt, AK, Greer, JJ, and Fuller, DD. "Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation." Journal of neurophysiology 116, no. 3 (September 2016): 1232-1238. Full Text
  - Turner, SMF, Hoyt, AK, ElMallah, MK, Falk, DJ, Byrne, BJ, and Fuller, DD. "Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice." Respiratory Physiology & Neurobiology 227 (June 2016): 48-55. Full Text
  - Loring, HS, ElMallah, MK, and Flotte, TR. "Development of rAAV2-CFTR: History of the First rAAV Vector Product to be Used in Humans." Human Gene Therapy Methods 27, no. 2 (April 2016): 49-58. (Review) Full Text
  - Stoica, L, Todeasa, SH, Cabrera, GT, Salameh, JS, ElMallah, MK, Mueller, C, Brown, RH, and Sena-Esteves, M. "Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model." Annals of Neurology 79, no. 4 (April 2016): 687-700. Full Text
  - ElMallah, MK, Stanley, DA, Lee, K-Z, Turner, SMF, Streeter, KA, Baekey, DM, and Fuller, DD. "Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice." Journal of Neurophysiology 115, no. 3 (March 2016): 1372-1380. Full Text
  - Borel, F, Gernoux, G, Cardozo, B, Metterville, JP, Toro Cabrera, GC, Song, L, Su, Q, Gao, GP, Elmallah, MK, Brown, RH, and Mueller, C. "Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates." Human gene therapy 27, no. 1 (January 2016): 19-31. Full Text
  - ElMallah, MK, Pagliardini, S, Turner, SM, Cerreta, AJ, Falk, DJ, Byrne, BJ, Greer, JJ, and Fuller, DD. "Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines." American Journal of Respiratory Cell and Molecular Biology 53, no. 3 (September 2015): 326-335. Full Text
  - Bacewicz, A, Wang, W, Ashouri, J, and ElMallah, MK. "Children with Chronic Lung Disease: Facilitating Smoking Cessation for their Caregivers." Journal of community health 40, no. 3 (June 2015): 409-413. Full Text
  - Falk, DJ, Todd, AG, Lee, S, Soustek, MS, ElMallah, MK, Fuller, DD, Notterpek, L, and Byrne, BJ. "Peripheral nerve and neuromuscular junction pathology in Pompe disease." Human Molecular Genetics 24, no. 3 (February 2015): 625-636. Full Text
  - Halawa, M, Abu-Hasan, MN, and ElMallah, MK. "Hereditary mucoepithelial dysplasia and severe respiratory distress." Respiratory Medicine Case Reports 15 (2015): 27-29. Full Text
  - Abu-Hasan, M, Elmallah, M, Neal, D, and Brookes, J. "Salivary Amylase Level in Bronchoalveolar Fluid as a Marker of Chronic Pulmonary Aspiration in Children." Pediatric allergy, immunology, and pulmonology 27, no. 3 (September 2014): 115-119. Full Text
  - Elmallah, MK, Falk, DJ, Nayak, S, Federico, RA, Sandhu, MS, Poirier, A, Byrne, BJ, and Fuller, DD. "Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice." Molecular Therapy : the Journal of the American Society of Gene Therapy 22, no. 4 (April 2014): 702-712. Full Text
  - Fuller, DD, ElMallah, MK, Smith, BK, Corti, M, Lawson, LA, Falk, DJ, and Byrne, BJ. "The respiratory neuromuscular system in Pompe disease." Respiratory Physiology & Neurobiology 189, no. 2 (November 2013): 241-249. (Review) Full Text
  - Falk, DJ, Mah, CS, Soustek, MS, Lee, K-Z, Elmallah, MK, Cloutier, DA, Fuller, DD, and Byrne, BJ. "Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease." Molecular Therapy : the Journal of the American Society of Gene Therapy 21, no. 9 (September 2013): 1661-1667. Full Text
  - ElMallah, MK, and Hendeles, L. "Delivery of Medications by Metered Dose Inhaler Through a Chamber/Mask to Young Children with Asthma." Pediatric Allergy, Immunology, and Pulmonology 25, no. 4 (December 2012): 236-240. Full Text
  - ElMallah, MK, Falk, DJ, Lane, MA, Conlon, TJ, Lee, K-Z, Shafi, NI, Reier, PJ, Byrne, BJ, and Fuller, DD. "Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9." Human gene therapy methods 23, no. 2 (April 2012): 148-156. Full Text
  - Elmallah, MK, Khan, Y, Hochhaus, G, Shuster, JJ, and Hendeles, L. "Systemic exposure to fluticasone MDI delivered through antistatic chambers." The Journal of Allergy and Clinical Immunology 128, no. 5 (November 2011): 1113-5.e1-3-null. (Letter) Full Text
  - ElMallah, MK, Prabhakaran, S, and Chesrown, SE. "Plastic bronchitis: resolution after heart transplantation." Pediatric pulmonology 46, no. 8 (August 2011): 824-825. Full Text
  - Byrne, BJ, Falk, DJ, Pacak, CA, Nayak, S, Herzog, RW, Elder, ME, Collins, SW, Conlon, TJ, Clement, N, Cleaver, BD, Cloutier, DA, Porvasnik, SL, Islam, S, Elmallah, MK, Martin, A, Smith, BK, Fuller, DD, Lawson, LA, and Mah, CS. "Pompe disease gene therapy." Human Molecular Genetics 20, no. R1 (April 25, 2011): R61-R68. (Review) Full Text
  - Lee, K-Z, Qiu, K, Sandhu, MS, Elmallah, MK, Falk, DJ, Lane, MA, Reier, PJ, Byrne, BJ, and Fuller, DD. "Hypoglossal Neuropathology and Respiratory Activity in Pompe Mice." Frontiers in Physiology 2 (2011). Full Text
  - El Mallah, MK, Sands, AJ, Casey, FA, Craig, BG, and Mulholland, HC. "Transcatheter occlusion of the patent ductus arteriosus: a comparison of two devices." Irish journal of medical science 171, no. 3 (July 2002): 151-154. Full Text
  - El Mallah, MK, Chakravarthy, U, and Hart, PM. "Amblyopia: is visual loss permanent?." The British journal of ophthalmology 84, no. 9 (September 2000): 952-956. Full Text

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles