Mai ElMallah
Associate Professor of Pediatrics
Our laboratory focuses on the control of breathing and pulmonary mechanics in murine models of several genetic diseases. These genetic diseases include Duchenne Muscular Dystrophy, Pompe Disease, ALS, and Spino-cerebellar ataxia Type 7. We also investigate the ability of gene therapy and neuromodulation to treat respiratory insufficiency in neuromuscular diseases. As a clinician-scientist, my goal is to bring therapy from the bench to the bedside and enhance our research at the bench through observations at the bedside.
Current Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Pulmonary and Sleep Medicine, Pediatrics 2022
- Chief, Division of Pulmonary and Sleep Medicine, Pediatrics, Pulmonary and Sleep Medicine, Pediatrics 2021
- Associate Professor in Neurobiology, Neurobiology, Basic Science Departments 2020
- Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2020
Contact Information
- 2301 Erwin Road, Durham, NC 27710
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mai.elmallah@duke.edu
(919) 681-3364
- Background
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Education, Training, & Certifications
- Pediatric Pulmonary Fellowship, Pediatrics, University of Florida, College of Medicine 2010 - 2012
- Residency, Pediatrics, Baylor College of Medicine 2002 - 2005
- Junior House Officer, Queen Elizabeth Hospital (United Kingdom) 2001 - 2002
- M.B.B.S., Queens University Belfast (United Kingdom) 2001
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Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Pulmonary and Sleep Medicine, Pediatrics 2018 - 2021
- Instructor in the Department of Pediatrics, Pediatrics, Pulmonary and Sleep Medicine, Pediatrics 2017 - 2018
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Leadership & Clinical Positions at Duke
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Director, Duke Cystic Fibrosis Center
Director, Pediatric Pulmonary Fellowship
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Director, Duke Cystic Fibrosis Center
- Recognition
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In the News
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AUG 8, 2022
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- Expertise
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Subject Headings
- Research
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Selected Grants
- Stimulating Access to Research in Residency (StARR) - NHLBI awarded by National Institutes of Health 2018 - 2028
- Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
- Stable therapy in Pompe disease through genome editing awarded by National Institutes of Health 2021 - 2026
- Duke Center for Advancement of Child Health (CAtCH). awarded by National Institutes of Health 2021 - 2026
- Respiratory Characterization of DMD Mouse Models awarded by Sarepta Therapeutics, Inc. 2019 - 2024
- Targeted Therapy for Pompe Disease awarded by National Institutes of Health 2019 - 2024
- Novel Adjunctive Therapies for Pompe Disease awarded by National Institutes of Health 2022 - 2023
- Research Training in Allergy and Clinical Immunology awarded by University of North Carolina - Chapel Hill 2000 - 2023
- Epigenome Editing Technologies for Treating Diverse Disease awarded by National Institutes of Health 2019 - 2023
- Respiratory Dysfunction in an Optineurin knock out ALS mouse model awarded by National Institutes of Health 2020 - 2022
- Award for a Pharmacist awarded by Cystic Fibrosis Foundation 2019 - 2022
- Mental Health Screening in Duke Pediatric CF Patients awarded by Cystic Fibrosis Foundation 2018 - 2021
- A Phase III, randomized, double-blind, placebo-controlled study of AeroVanc for the treatment of persistent methicillin-resistant Staphylococcus aureus lung infection in cystic fibrosis patients awarded by Savara Inc. 2017 - 2020
- A Phase I Study of the Safety of AAV2/8 LSPhGAA in Late-onset Pompe Disease awarded by National Institutes of Health 2017 - 2020
- A Post-approval Observational Study to Evaluate the Long-term Effectiveness and Safety of Orkambi in US Patients who Completed Study VX12-809-105 Part A awarded by Vertex Pharmaceuticals Inc. 2018 - 2019
- Cystic Fibrosis Foundation awarded by Cystic Fibrosis Foundation 2018 - 2019
- Gene Therapy for Upper Airway and Respiratory Insufficiency in an ALS Mouse Model awarded by National Institutes of Health 2016 - 2019
- Parker B. Francis Jo Rae Wright Award for Scientific Excellence awarded by Parker B. Francis Foundation 2018 - 2019
- Novel Approaches for Correcting Respiratory Insufficiency in Pompe Disease awarded by National Institutes of Health 2014 - 2019
- A Novel Vector to treat smooth muscle pathology in Pompe Disease
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External Relationships
- NIH
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Leon-Astudillo, Carmen, Caroline U. A. Okorie, Michael Y. McCown, Fei J. Dy, Sandeep Puranik, Moshe Prero, Mai K. ElMallah, Lauren Treat, and Jane E. Gross. “ATS Core Curriculum 2022. Pediatric Pulmonary Medicine: Updates in pediatric neuromuscular disease.” Pediatr Pulmonol, May 5, 2023. https://doi.org/10.1002/ppul.26448.Full Text Link to Item
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Scott, Zeni, Cynthia Zhou, Elisabeth Tracy, Mai K. ElMallah, and Shatha Yousef. “Congenital lobar emphysema in monozygotic twins.” Respir Med Case Rep 43 (2023): 101842. https://doi.org/10.1016/j.rmcr.2023.101842.Full Text Link to Item
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Biswas, Debolina D., Léa El Haddad, Ronit Sethi, Meredith L. Huston, Elias Lai, Mariam M. Abdelbarr, Doreen Z. Mhandire, and Mai K. ElMallah. “Neuro-respiratory pathology in spinocerebellar ataxia.” J Neurol Sci 443 (December 15, 2022): 120493. https://doi.org/10.1016/j.jns.2022.120493.Full Text Link to Item
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Gonzalez, Trevor J., Katherine E. Simon, Leo O. Blondel, Marco M. Fanous, Angela L. Roger, Maribel Santiago Maysonet, Garth W. Devlin, et al. “Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing.” Nat Commun 13, no. 1 (October 10, 2022): 5947. https://doi.org/10.1038/s41467-022-33745-4.Full Text Link to Item
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Roger, Angela L., Ronit Sethi, Meredith L. Huston, Evelyn Scarrow, Joy Bao-Dai, Elias Lai, Debolina D. Biswas, et al. “What's new and what's next for gene therapy in Pompe disease?” Expert Opin Biol Ther 22, no. 9 (September 2022): 1117–35. https://doi.org/10.1080/14712598.2022.2067476.Full Text Link to Item
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Mhandire, Doreen Z., David P. Burns, Angela L. Roger, Ken D. O’Halloran, and Mai K. ElMallah. “Breathing in Duchenne muscular dystrophy: translation to therapy.” J Physiol 600, no. 15 (August 2022): 3465–82. https://doi.org/10.1113/JP281671.Full Text Link to Item
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El Haddad, L., E. Lai, P. Murthy, P. R. Tata, and M. K. ElMallah. “GAA Deficiency Disrupts Distal Airway Cells in Pompe Disease.” Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 36 (May 1, 2022). https://doi.org/10.1096/fasebj.2022.36.S1.L7829.Full Text
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Lu, Ping, Mai K. ElMallah, Zeyu Liu, Chan Wu, Jun Chen, Lawrence M. Lifshitz, and Ronghua ZhuGe. “Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation.” J Cell Physiol 236, no. 9 (September 2021): 6407–23. https://doi.org/10.1002/jcp.30315.Full Text Link to Item
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Fusco, Anna F., Logan A. Pucci, Pawel M. Switonski, Debolina D. Biswas, Angela L. McCall, Amanda F. Kahn, Justin S. Dhindsa, Laura M. Strickland, Albert R. La Spada, and Mai K. ElMallah. “Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7.” Dis Model Mech 14, no. 7 (July 1, 2021). https://doi.org/10.1242/dmm.048893.Full Text Link to Item
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Hunanyan, Arsen S., Boris Kantor, Ram S. Puranam, Courtney Elliott, Angela McCall, Justin Dhindsa, Promila Pagadala, et al. “Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood.” Hum Gene Ther 32, no. 7–8 (April 2021): 405–19. https://doi.org/10.1089/hum.2020.191.Full Text Link to Item
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Crayle, Jesse, Mai Elmallah, John Sleasman, and Richard Bedlack. “Total serum immunoglobulin A in ALS.” Amyotroph Lateral Scler Frontotemporal Degener 22, no. 1–2 (February 2021): 61–65. https://doi.org/10.1080/21678421.2020.1790608.Full Text Link to Item
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McCall, Angela L., Justin S. Dhindsa, Logan A. Pucci, Amanda F. Khan, Anna F. Fusco, Debolina D. Biswas, Laura M. Strickland, Henry C. Tseng, and Mai K. ElMallah. “Corrigendum to "Respiratory pathology in the optn-/- mouse model of amyotrophic lateral sclerosis" [Respir. Physiol. Neurobiol. 282 (2020) 103525].” Respiratory Physiology & Neurobiology 284 (February 2021): 103570. https://doi.org/10.1016/j.resp.2020.103570.Full Text
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McCall, Angela L., Justin S. Dhindsa, Aidan M. Bailey, Logan A. Pucci, Laura M. Strickland, and Mai K. ElMallah. “Glycogen accumulation in smooth muscle of a Pompe disease mouse model.” J Smooth Muscle Res 57, no. 0 (2021): 8–18. https://doi.org/10.1540/jsmr.57.8.Full Text Link to Item
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McCall, Angela L., Justin S. Dhindsa, Logan A. Pucci, Amanda F. Kahn, Anna F. Fusco, Debolina D. Biswas, Laura M. Strickland, Henry C. Tseng, and Mai K. ElMallah. “Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis.” Respir Physiol Neurobiol 282 (November 2020): 103525. https://doi.org/10.1016/j.resp.2020.103525.Full Text Link to Item
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Lind, Lori A., Ellyn M. Andel, Angela L. McCall, Justin S. Dhindsa, Katherine A. Johnson, Olivia E. Stricklin, Christian Mueller, Mai K. ElMallah, Teresa E. Lever, and Nicole L. Nichols. “Intralingual Administration of AAVrh10-miRSOD1 Improves Respiratory But Not Swallowing Function in a Superoxide Dismutase-1 Mouse Model of Amyotrophic Lateral Sclerosis.” Hum Gene Ther 31, no. 15–16 (August 2020): 828–38. https://doi.org/10.1089/hum.2020.065.Full Text Link to Item
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Keeler, Allison M., Marina Zieger, Carson Semple, Logan Pucci, Alessandra Veinbachs, Robert H. Brown, Christian Mueller, and Mai K. ElMallah. “Intralingual and Intrapleural AAV Gene Therapy Prolongs Survival in a SOD1 ALS Mouse Model.” Mol Ther Methods Clin Dev 17 (June 12, 2020): 246–57. https://doi.org/10.1016/j.omtm.2019.12.007.Full Text Link to Item
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Han, Sang-Oh, Songtao Li, Angela McCall, Benjamin Arnson, Jeffrey I. Everitt, Haoyue Zhang, Sarah P. Young, Mai K. ElMallah, and Dwight D. Koeberl. “Comparisons of Infant and Adult Mice Reveal Age Effects for Liver Depot Gene Therapy in Pompe Disease.” Mol Ther Methods Clin Dev 17 (June 12, 2020): 133–42. https://doi.org/10.1016/j.omtm.2019.11.020.Full Text Open Access Copy Link to Item
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Dhindsa, Justin S., Angela L. McCall, Laura M. Strickland, Anna F. Fusco, Amanda F. Kahn, and Mai K. ElMallah. “Motor axonopathies in a mouse model of Duchenne muscular dystrophy.” Sci Rep 10, no. 1 (June 2, 2020): 8967. https://doi.org/10.1038/s41598-020-65824-1.Full Text Open Access Copy Link to Item
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Khan, Aleena A., Laura E. Case, Mrudu Herbert, Stephanie DeArmey, Harrison Jones, Kelly Crisp, Kanecia Zimmerman, Mai K. ElMallah, Sarah P. Young, and Priya S. Kishnani. “Higher dosing of alglucosidase alfa improves outcomes in children with Pompe disease: a clinical study and review of the literature.” Genet Med 22, no. 5 (May 2020): 898–907. https://doi.org/10.1038/s41436-019-0738-0.Full Text Open Access Copy Link to Item
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Fusco, Anna F., Angela L. McCall, Justin S. Dhindsa, Lucy Zheng, Aidan Bailey, Amanda F. Kahn, and Mai K. ElMallah. “The Respiratory Phenotype of Pompe Disease Mouse Models.” Int J Mol Sci 21, no. 6 (March 24, 2020). https://doi.org/10.3390/ijms21062256.Full Text Link to Item
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ElMallah, Mai K., Ankit K. Desai, Erica B. Nading, Stephanie DeArmey, Richard M. Kravitz, and Priya S. Kishnani. “Pulmonary outcome measures in long-term survivors of infantile Pompe disease on enzyme replacement therapy: A case series.” Pediatr Pulmonol 55, no. 3 (March 2020): 674–81. https://doi.org/10.1002/ppul.24621.Full Text Link to Item
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Koupenova, Milka, Eric Mick, Heather A. Corkrey, Anupama Singh, Selim E. Tanriverdi, Olga Vitseva, Daniel Levy, et al. “Pollen-derived RNAs Are Found in the Human Circulation.” Iscience 19 (September 27, 2019): 916–26. https://doi.org/10.1016/j.isci.2019.08.035.Full Text Link to Item
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Zieger, Marina, Allison M. Keeler, Terence R. Flotte, and Mai K. ElMallah. “AAV9 gene replacement therapy for respiratory insufficiency in very-long chain acyl-CoA dehydrogenase deficiency.” J Inherit Metab Dis 42, no. 5 (September 2019): 870–77. https://doi.org/10.1002/jimd.12101.Full Text Link to Item
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McCall, Angela L., and Mai K. ElMallah. “Macroglossia, Motor Neuron Pathology, and Airway Malacia Contribute to Respiratory Insufficiency in Pompe Disease: A Commentary on Molecular Pathways and Respiratory Involvement in Lysosomal Storage Diseases.” Int J Mol Sci 20, no. 3 (February 11, 2019). https://doi.org/10.3390/ijms20030751.Full Text Link to Item
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Fusco, Anna F., Angela L. McCall, Justin S. Dhindsa, Logan A. Pucci, Laura M. Strickland, Amanda F. Kahn, and Mai K. ElMallah. “The Respiratory Phenotype of Rodent Models of Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia.” J Neuroinflamm Neurodegener Dis 3, no. 1 (2019).Link to Item
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Keeler, Allison M., Marina Zieger, Sophia H. Todeasa, Angela L. McCall, Jennifer C. Gifford, Samantha Birsak, Sourav R. Choudhury, Barry J. Byrne, Miguel Sena-Esteves, and Mai K. ElMallah. “Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease.” Hum Gene Ther 30, no. 1 (January 2019): 57–68. https://doi.org/10.1089/hum.2018.016.Full Text Link to Item
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Borel, Florie, Huaming Sun, Marina Zieger, Andrew Cox, Brynn Cardozo, Weiying Li, Gabriella Oliveira, et al. “Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema.” Proc Natl Acad Sci U S A 115, no. 11 (March 13, 2018): 2788–93. https://doi.org/10.1073/pnas.1713689115.Full Text Link to Item
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McCall, Angela L., Jeffrey Salemi, Preeti Bhanap, Laura M. Strickland, and Mai K. Elmallah. “The impact of Pompe disease on smooth muscle: a review.” J Smooth Muscle Res 54, no. 0 (2018): 100–118. https://doi.org/10.1540/jsmr.54.100.Full Text Link to Item
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“Erratum for “Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications”.” Pediatric Annals 46, no. 11 (November 2017). https://doi.org/10.3928/19382359-20171018-05.Full Text
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“Erratum for “Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications”.” Pediatric Annals 46, no. 11 (November 2017). https://doi.org/10.3928/19382359-20171018-04.Full Text
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ElMallah, Mai, Evan Bailey, Michelle Trivedi, Ted Kremer, and Lawrence M. Rhein. “Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications.” Pediatr Ann 46, no. 9 (September 1, 2017): e336–39. https://doi.org/10.3928/19382359-20170815-01.Full Text Link to Item
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Trivedi, Michelle, Mai ElMallah, Evan Bailey, Ted Kremer, and Lawrence M. Rhein. “Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications.” Pediatr Ann 46, no. 9 (September 1, 2017): e332–35. https://doi.org/10.3928/19382359-20170815-03.Full Text Link to Item
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Keeler, A. M., M. K. ElMallah, and T. R. Flotte. “Gene Therapy 2017: Progress and Future Directions.” Clin Transl Sci 10, no. 4 (July 2017): 242–48. https://doi.org/10.1111/cts.12466.Full Text Link to Item
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Keeler, Allison M., Donghai Liu, Marina Zieger, Lang Xiong, Jeffrey Salemi, Karl Bellvé, Barry J. Byrne, David D. Fuller, Ronghua ZhuGe, and Mai K. ElMallah. “Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice.” Am J Physiol Lung Cell Mol Physiol 312, no. 6 (June 1, 2017): L873–81. https://doi.org/10.1152/ajplung.00568.2016.Full Text Link to Item
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Stoica, Lorelei, Allison M. Keeler, Lang Xiong, Michael Kalfopoulos, Kaitlyn Desrochers, Robert H. Brown, Miguel Sena-Esteves, Terence R. Flotte, and Mai K. ElMallah. “Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model.” Am J Respir Cell Mol Biol 56, no. 3 (March 2017): 405–8. https://doi.org/10.1165/rcmb.2016-0258LE.Full Text Link to Item
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Kalfopoulos, Michael, Kaitlyn Wetmore, and Mai ElMallah. “Pathophysiology of Alpha-1 Antitrypsin Lung Disease,” 2017. https://doi.org/10.1007/978-1-4939-7163-3_2.Full Text Link to Item
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Turner, S. M., M. K. ElMallah, A. K. Hoyt, J. J. Greer, and D. D. Fuller. “Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation.” J Neurophysiol 116, no. 3 (September 1, 2016): 1232–38. https://doi.org/10.1152/jn.00210.2016.Full Text Link to Item
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Turner, Sara M. F., Aaron K. Hoyt, Mai K. ElMallah, Darin J. Falk, Barry J. Byrne, and David D. Fuller. “Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice.” Respir Physiol Neurobiol 227 (June 15, 2016): 48–55. https://doi.org/10.1016/j.resp.2016.02.007.Full Text Link to Item
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Loring, Heather S., Mai K. ElMallah, and Terence R. Flotte. “Development of rAAV2-CFTR: History of the First rAAV Vector Product to be Used in Humans.” Hum Gene Ther Methods 27, no. 2 (April 2016): 49–58. https://doi.org/10.1089/hgtb.2015.150.Full Text Link to Item
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Stoica, Lorelei, Sophia H. Todeasa, Gabriela Toro Cabrera, Johnny S. Salameh, Mai K. ElMallah, Christian Mueller, Robert H. Brown, and Miguel Sena-Esteves. “Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.” Ann Neurol 79, no. 4 (April 2016): 687–700. https://doi.org/10.1002/ana.24618.Full Text Link to Item
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ElMallah, Mai K., David A. Stanley, Kun-Ze Lee, Sara M. F. Turner, Kristi A. Streeter, David M. Baekey, and David D. Fuller. “Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.” J Neurophysiol 115, no. 3 (March 2016): 1372–80. https://doi.org/10.1152/jn.00479.2015.Full Text Link to Item
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Borel, Florie, Gwladys Gernoux, Brynn Cardozo, Jake P. Metterville, Gabriela C. Toro Cabrera, Lina Song, Qin Su, et al. “Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates.” Hum Gene Ther 27, no. 1 (January 2016): 19–31. https://doi.org/10.1089/hum.2015.122.Full Text Link to Item
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ElMallah, Mai K., Silvia Pagliardini, Sara M. Turner, Anthony J. Cerreta, Darin J. Falk, Barry J. Byrne, John J. Greer, and David D. Fuller. “Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines.” Am J Respir Cell Mol Biol 53, no. 3 (September 2015): 326–35. https://doi.org/10.1165/rcmb.2014-0374OC.Full Text Link to Item
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Bacewicz, Aleksandra, Wei Wang, Judy Ashouri, and Mai K. ElMallah. “Children with Chronic Lung Disease: Facilitating Smoking Cessation for their Caregivers.” J Community Health 40, no. 3 (June 2015): 409–13. https://doi.org/10.1007/s10900-014-9947-2.Full Text Link to Item
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Halawa, M., M. N. Abu-Hasan, and M. K. ElMallah. “Hereditary mucoepithelial dysplasia and severe respiratory distress.” Respiratory Medicine Case Reports 15 (April 8, 2015): 27–29. https://doi.org/10.1016/j.rmcr.2015.03.004.Full Text
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Falk, Darin J., Adrian Gary Todd, Sooyeon Lee, Meghan S. Soustek, Mai K. ElMallah, David D. Fuller, Lucia Notterpek, and Barry J. Byrne. “Peripheral nerve and neuromuscular junction pathology in Pompe disease.” Hum Mol Genet 24, no. 3 (February 1, 2015): 625–36. https://doi.org/10.1093/hmg/ddu476.Full Text Link to Item
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Abu-Hasan, Mutasim, Mai Elmallah, Dan Neal, and James Brookes. “Salivary Amylase Level in Bronchoalveolar Fluid as a Marker of Chronic Pulmonary Aspiration in Children.” Pediatr Allergy Immunol Pulmonol 27, no. 3 (September 1, 2014): 115–19. https://doi.org/10.1089/ped.2014.0348.Full Text Link to Item
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Elmallah, Mai K., Darin J. Falk, Sushrusha Nayak, Roland A. Federico, Milapjit S. Sandhu, Amy Poirier, Barry J. Byrne, and David D. Fuller. “Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice.” Mol Ther 22, no. 4 (April 2014): 702–12. https://doi.org/10.1038/mt.2013.282.Full Text Link to Item
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Fuller, David D., Mai K. ElMallah, Barbara K. Smith, Manuela Corti, Lee Ann Lawson, Darin J. Falk, and Barry J. Byrne. “The respiratory neuromuscular system in Pompe disease.” Respir Physiol Neurobiol 189, no. 2 (November 1, 2013): 241–49. https://doi.org/10.1016/j.resp.2013.06.007.Full Text Link to Item
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Falk, Darin J., Cathryn S. Mah, Meghan S. Soustek, Kun-Ze Lee, Mai K. Elmallah, Denise A. Cloutier, David D. Fuller, and Barry J. Byrne. “Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease.” Mol Ther 21, no. 9 (September 2013): 1661–67. https://doi.org/10.1038/mt.2013.96.Full Text Link to Item
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Elmallah, M. K., and L. Hendeles. “Delivery of medications by metered dose inhaler through a chamber/mask to young children with asthma.” Pediatric, Allergy, Immunology, and Pulmonology 25, no. 4 (December 1, 2012): 236–39. https://doi.org/10.1089/ped.2012.0197.Full Text
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ElMallah, Mai K., Leslie Hendeles, Robert G. Hamilton, Cindy Capen, and Pamela M. Schuler. “Management of Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis Using Anti-Immunoglobulin E Therapy (Omalizumab).” The Journal of Pediatric Pharmacology and Therapeutics 17, no. 1 (August 1, 2012): 88–92. https://doi.org/10.5863/1551-6776-17.1.88.Full Text
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ElMallah, Mai K., Darin J. Falk, Michael A. Lane, Thomas J. Conlon, Kun-Ze Lee, Nadeem I. Shafi, Paul J. Reier, Barry J. Byrne, and David D. Fuller. “Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9.” Hum Gene Ther Methods 23, no. 2 (April 2012): 148–56. https://doi.org/10.1089/hgtb.2012.009.Full Text Link to Item
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Elmallah, Mai K., Yasmeen Khan, Guenther Hochhaus, Jonathan J. Shuster, and Leslie Hendeles. “Systemic exposure to fluticasone MDI delivered through antistatic chambers.” J Allergy Clin Immunol 128, no. 5 (November 2011): 1113-5.e1-3. https://doi.org/10.1016/j.jaci.2011.06.014.Full Text Link to Item
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ElMallah, Mai K., Sreekala Prabhakaran, and Sarah E. Chesrown. “Plastic bronchitis: resolution after heart transplantation.” Pediatr Pulmonol 46, no. 8 (August 2011): 824–25. https://doi.org/10.1002/ppul.21432.Full Text Link to Item
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Byrne, Barry J., Darin J. Falk, Christina A. Pacak, Sushrusha Nayak, Roland W. Herzog, Melissa E. Elder, Shelley W. Collins, et al. “Pompe disease gene therapy.” Hum Mol Genet 20, no. R1 (April 15, 2011): R61–68. https://doi.org/10.1093/hmg/ddr174.Full Text Link to Item
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Lee, Kun-Ze, Kai Qiu, Milapjit S. Sandhu, Mai K. Elmallah, Darin J. Falk, Michael A. Lane, Paul J. Reier, Barry J. Byrne, and David D. Fuller. “Hypoglossal neuropathology and respiratory activity in pompe mice.” Front Physiol 2 (2011): 31. https://doi.org/10.3389/fphys.2011.00031.Full Text Link to Item
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El Mallah, M. K., A. J. Sands, F. A. Casey, B. G. Craig, and H. C. Mulholland. “Transcatheter occlusion of the patent ductus arteriosus: a comparison of two devices.” Ir J Med Sci 171, no. 3 (2002): 151–54. https://doi.org/10.1007/BF03170504.Full Text Link to Item
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Mallah, M. K., P. M. Hart, M. McClure, M. R. Stevenson, G. Silvestri, S. T. White, and U. Chakravarthy. “Improvements in measures of vision and self-reported visual function after cataract extraction in patients with late-stage age-related maculopathy.” Optom Vis Sci 78, no. 9 (September 2001): 683–88. https://doi.org/10.1097/00006324-200109000-00014.Full Text Link to Item
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El Mallah, M. K., U. Chakravarthy, and P. M. Hart. “Amblyopia: is visual loss permanent?” Br J Ophthalmol 84, no. 9 (September 2000): 952–56. https://doi.org/10.1136/bjo.84.9.952.Full Text Link to Item
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Book Sections
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ElMallah, M. K., M. Kalfopolous, and T. R. Flotte. “Gene therapy.” In Cancer: Prevention, Early Detection, Treatment and Recovery, 531–51, 2019. https://doi.org/10.1002/9781119645214.ch28.Full Text
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Kalfopoulos, Michael, Kaitlyn Wetmore, and Mai K. ElMallah. “Pathophysiology of Alpha-1 Antitrypsin Lung Disease.,” 1639:9–19, 2017. https://doi.org/10.1007/978-1-4939-7163-3_2.Full Text Link to Item
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Wang, W., A. Bacewicz, J. Ashouri, R. K. Elmallah, and M. K. ElMallah. “Secondhand smoke exposure in children with chronic lung disease.” In Nicotine Dependence, Smoking Cessation and Effects of Secondhand Smoke, 87–121, 2015.
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Conference Papers
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Biswas, D. D., L. M. Strickland, J. S. Dhindsa, Y. Shi, R. Sethi, S. Kehoe, E. X. Lai, M. L. Huston, E. R. Scarrow, and M. K. ElMallah. “Accumulation of pathological Ataxin-7 in the medulla leads to hypoglossal (XII) motor unit pathology.” In Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, Vol. 36, 2022. https://doi.org/10.1096/fasebj.2022.36.S1.R2442.Full Text
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Biswas, Debolina, Justin Dhindsa, Laura Strickland, Logan Pucci, and Mai ElMallah. “Phrenic and Hypoglossal motor unit pathology in a Spinocerebellar ataxia type 7 mouse model.” In The Faseb Journal, Vol. 35. Wiley, 2021. https://doi.org/10.1096/fasebj.2021.35.s1.03965.Full Text
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McCall, Angela, Aidan Bailey, Logan Pucci, Justin Dhindsa, Jacqueline Robinson‐Hamm, Charles Gersbach, and Mai ElMallah. “Respiratory Pathology in a Humanized Mouse Model of Duchenne Muscular Dystrophy.” In The Faseb Journal, Vol. 35. Wiley, 2021. https://doi.org/10.1096/fasebj.2021.35.s1.03516.Full Text
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McCall, Angela L., Justin S. Dhinsda, Lucy Zheng, Aidan M. Bailey, Laura M. Strickland, and Mai K. ElMallah. “Glycogen accumulation in smooth muscle in the Pompe disease mouse.” In Molecular Genetics and Metabolism, 132:S70–S70. Elsevier BV, 2021. https://doi.org/10.1016/j.ymgme.2020.12.162.Full Text
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Shi, Melody, Mai Elmallah, and Robert Benjamin. “Elexacaftor/Tezacaftor/Ivacaftor Improves Glycemic Control in Pediatric Patients with Cystic Fibrosis-Related Diabetes.” In Hormone Research in Paediatrics, 94:26–26, 2021.Link to Item
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Fusco, Anna F., Logan Pucci, Angela L. McCall, Justin Dhindsa, Amanda Kahn, Pawel Switonski, Laura Strickland, Albert La Spada, and Mai K. ElMallah. “Respiratory Dysfunction in a Mouse Model of Spinocerebellar Ataxia 7.” In The Faseb Journal, 34:1–1. Wiley, 2020. https://doi.org/10.1096/fasebj.2020.34.s1.05924.Full Text
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McCall, Angela L., Justin S. Dhindsa, Logan A. Pucci, Laura M. Strickland, Amanda F. Kahn, Anna F. Fusco, Henry Tseng, and Mai K. ElMallah. “Motor Neuron Pathology Leads to Respiratory Deficiency in Optn −/− Mice.” In The Faseb Journal, 34:1–1. Wiley, 2020. https://doi.org/10.1096/fasebj.2020.34.s1.09480.Full Text
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Han, Sang-oh, Angela McCall, Benjamin Arnson, Songtao Li, Jeffrey I. Everitt, Mai K. ElMallah, and Dwight D. Koeberl. “Comparisons of infant and adult mice reveal age effects for liver depot gene therapy in Pompe disease.” In Molecular Genetics and Metabolism, 129:S69–70. Elsevier BV, 2020. https://doi.org/10.1016/j.ymgme.2019.11.165.Full Text
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Khan, Aleena A., Laura E. Case, Mrudu Herbert, Stephanie DeArmey, Harrison Jones, Kelly Crisp, Kanecia Zimmerman, Mai K. ElMallah, and Priya S. Kishnani. “Higher dosing of alglucosidase alfa improves outcomes in children with Pompe disease.” In Molecular Genetics and Metabolism, 129:S88–S88. Elsevier BV, 2020. https://doi.org/10.1016/j.ymgme.2019.11.219.Full Text
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Bulaklak, Karen, Joel Bohning, Veronica Gough, Heather Daniels, Angela McCall, Mai ElMallah, and Charles A. Gersbach. “CRISPR-Mediated Gene Correction in a Severe Humanized Mouse Model of Duchenne Muscular Dystrophy.” In Molecular Therapy, 28:218–19, 2020.Link to Item
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Gonzalez, Trevor J., L Patrick Havlik, Marco Fanous, Katherine Simon, Laura Edwards, Jennifer Kwon, V Grace Stafford, et al. “Cross-Species Evolution of Synthetic AAV Strains for Clinical Translation.” In Molecular Therapy, 28:12–13, 2020.Link to Item
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McCall, Angela L., Augusto de Leon, Anna F. Fusco, Aidan Bailey, Marco Fanous, Aravind Asokan, and Mai K. ElMallah. “A Novel Capsid for Smooth Muscle Pathology in Pompe Disease.” In Molecular Therapy, 28:492–492, 2020.Link to Item
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McCall, Angela, Aidan Bailey, Logan Pucci, Justin Dhindsa, Laura Strickland, Jacqueline Robinson-Hamm, Charles Gersbach, and Mai ElMallah. “Respiratory Dysfunction in a novel mouse model of Duchenne Muscular Dystrophy.” In Faseb Journal, Vol. 34, 2020. https://doi.org/10.1096/fasehj.2020.34.s1.05634.Full Text Link to Item
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Becken, B., M. K. ElMallah, M. J. Smith, M. Bruehl, and I. Akinboyo. “STRATEGIES TO IMPROVE RESIDENT EDUCATION ON DIAGNOSIS AND MANAGEMENT OF INFECTIOUS CONCERNS IN PEDIATRIC PATIENTS WITH CYSTIC FIBROSIS.” In Pediatric Pulmonology, 54:S448–S448. WILEY, 2019.Link to Item
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Keeler, Allison M., Marina Zieger, Carson Semple, Ali Veinbachs, Guangping Gao, Robert H. Brown, Christian Mueller, and Mai K. ElMallah. “Respiratory Directed Gene Therapy to Silence SOD1 Prolongs Survival in the SOD1 ALS Mouse.” In Molecular Therapy, 27:422–422. CELL PRESS, 2019.Link to Item
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ElMallah, Mai K., Allison Keeler-Klunk, Marina Zieder, Angela L. McCall, Logan Pucci, Robert H. Brown, and Christian Mueller. “Respiratory directed gene therapy prolongs survival in an ALS mouse model.” In Faseb Journal, Vol. 33. WILEY, 2019.Link to Item
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McCall, Angela L., Laura M. Strickland, Logan Pucci, Justin Dhindsa, Henry Tseng, and Mai K. ElMallah. “Respiratory Deficiency in the Optn(-/-) Mouse, A Novel Model of Amyotrophic Lateral Sclerosis.” In Faseb Journal, Vol. 33. WILEY, 2019.Link to Item
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Strickland, Laura M., Angela L. McCall, Logan Pucci, Justin Dhindsa, Henry L. Tseng, and Mai K. ElMallah. “Chronic Intermittent Hypoxia and Hypercapnia Induces Respiratory Insufficiency in an Amyotrophic Lateral Sclerosis Mouse Model.” In Faseb Journal, Vol. 33. WILEY, 2019.Link to Item
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King, S., J. A. Sank, J. Hildebran, B. McLurkin, and M. K. ElMallah. “A RESPIRATORY THERAPIST-DRIVEN QUALITY IMPROVEMENT INITIATIVE IN THE EFFECTIVE MANAGEMENT OF AIRWAY CLEARANCE FOR THE PEDIATRIC PATIENT WITH CYSTIC FIBROSIS.” In Pediatric Pulmonology, 53:381–82. WILEY, 2018.Link to Item
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Lind, Lori A., Katherine A. Johnson, Angela L. McCall, Christian Mueller, Robert H. Brown, Teresa E. Lever, Mai K. Elmallah, and Nicole L. Nichols. “Impact of Intralingual AAVrh10-miRSOD1 Injection on Respiratory Function in SOD1(G93A) Mice.” In Faseb Journal, Vol. 32. FEDERATION AMER SOC EXP BIOL, 2018.Link to Item
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ElMallah, M. K., A. Keeler, M. Zieger, F. Borel, V. Semple, A. Veinbachs, R. Brown, and C. Mueller. “Respiratory Directed Gene Therapy Prolongs Survival In An Als Mouse Model.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.Link to Item
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Borel, Florie, Huaming Sun, Mai K. Elmallah, Andrew Cox, Brynn Cardozo, Weiying Li, Andrew M. Hoffman, Terence R. Flotte, and Christian Mueller. “Editing out Five SERPINA1 Paralogs to Create a New Mouse Model of Genetic Emphysema.” In Molecular Therapy, 25:117–117. CELL PRESS, 2017.Link to Item
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Keeler-Klunk, Allison M., Marina Zieger, Samantha Bircsak, Sourav Choudhury, Barry J. Byrne, Miguel Sena-Esteves, and Mai K. ElMallah. “Systemic Delivery of AAVB1-GAA Gene Therapy for Respiratory Pathology in Pompe Disease.” In Molecular Therapy, 25:28–29. CELL PRESS, 2017.Link to Item
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Keeler, A. M., M. Zieger, D. Liu, J. Salemi, R. ZhuGe, and M. K. ElMallah. “Respiratory And Airway Smooth Muscle Pathology In A Pompe Disease Mouse Model.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.Link to Item
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Lu, P., D. Liu, K. Bellve, K. Fogarty, M. K. ElMallah, L. Lifshitz, and R. ZhuGe. “Bitter Tastant 1,10-Phenanthroline Activates Tas2r-Gustducin Signaling To Relax Airways, Resulting In A Decrease In Airway Resistance In Vivo.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.Link to Item
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Borel, Florie, Brynn Cardozo, Andrew Cox, Weiying Li, Andrew Hoffman, Mai ElMallah, and Christian Mueller. “167. Genome Editing to Generate the First Mouse Model of Alpha-One Antitrypsin Deficiency, the Leading Cause of Genetic COPD.” In Molecular Therapy, 24:S65–S65. Elsevier BV, 2016. https://doi.org/10.1016/s1525-0016(16)32976-8.Full Text
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Turner, Sara, Mai Elmallah, Aaron Hoyt, John Greer, and David Fuller. “Pretreatment with Ampakine CX717 Enhances Long-Term Facilitation (LTF) of Inspiratory Hypoglossal (XII) Bursting, But Only When Initial Burst Output is Low.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.Link to Item
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Keeler, A. M., K. V. Desroshers, L. Xiong, and M. K. ElMallah. “Exercise Induced Respiratory Insufficiency In A Murine Model Of Very Long-Chain Acyl-Coa Dehydrogenase Deficiency.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.Link to Item
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Stoica, L., L. Xiong, M. Kalfopoulos, K. V. Desroshers, and M. K. ElMallah. “Characterization Of Pulmonary Mechanics Of The Sod1g93a Als Mouse Model.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.Link to Item
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ElMallah, Mai, David Stanley, and David Fuller. “Hypoglossal long term facilitation shifts the power spectral density to higher frequencies.” In Faseb Journal, Vol. 29. FEDERATION AMER SOC EXP BIOL, 2015.Link to Item
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Turner, Sara, Mai ElMallah, Darin Falk, Barry Byrne, and David Fuller. “Preferential Neuropathology in Respiratory-Related Motor Nuclei in Pompe Mice.” In Faseb Journal, Vol. 29. FEDERATION AMER SOC EXP BIOL, 2015.Link to Item
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Fuller, David, Mai Kamal Elmallah, Heather Ross, Anthony Cerreta, Manuela Corti, Barb Smith, Amy Poirier, Ronald Mandel, and Barry Byrne. “Selective knockout of acid alpha-glucosidase GAA gene expression in the medulla alters breathing.” In Faseb Journal, Vol. 28. FEDERATION AMER SOC EXP BIOL, 2014.Link to Item
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ElMallah, M. K., S. Pagliardini, S. M. Turner, J. J. Greer, B. J. Byrne, and D. D. Fuller. “Ampakines Enhance Respiratory Motor Output In A Murine Model Of Pompe Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.Link to Item
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Falk, D. J., A. G. Todd, M. S. Soustek, D. C. Cloutier, M. ElMallah, D. D. Fuller, and B. J. Byrne. “P.17.9 AAV9 vector encoding hGAA improves synaptic pathology of the neuromuscular junction in Pompe disease.” In Neuromuscular Disorders, 23:829–829. Elsevier BV, 2013. https://doi.org/10.1016/j.nmd.2013.06.659.Full Text
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ElMallah, Mai Kamal, Milap S. Sandhu, Kun-Ze Lee, David M. Baekey, and David D. Fuller. “Apnea Alters the Pattern of Intermittent Hypoxia-Induced Long Term Facilitation in Anesthetized Mice.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.Link to Item
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Sandhu, Milap Singh, Mai K. Elmallah, Michael A. Lane, Paul J. Reier, John J. Greer, and David D. Fuller. “Ampakines induce a persistent increase in phrenic motor output in rats with cervical spinal cord injury.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.Link to Item
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Fuller, David, Mai Elmallah, Darin Falk, Lee Ann Lawson, A Daniel Martin, Barbara Smith, and Barry Byrne. “The importance of targeting the central nervous system for treatment of respiratory insufficiency in Pompe disease.” In Molecular Genetics and Metabolism, 108:S41–S41. Elsevier BV, 2013. https://doi.org/10.1016/j.ymgme.2012.11.089.Full Text
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Chakravarthy, U., M. El Mallah, and P. M. Hart. “Amblyopia: Is visual loss permanent.” In Investigative Ophthalmology & Visual Science, 41:S705–S705, 2000.Link to Item
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- Teaching & Mentoring
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Recent Courses
- CELLBIO 493: Research Independent Study 2023
- NEUROBIO 393: Research Independent Study 2023
- NEUROSCI 494: Research Independent Study 2 2023
- BIOLOGY 293: Research Independent Study 2022
- BIOLOGY 493: Research Independent Study 2022
- CELLBIO 493: Research Independent Study 2022
- NEUROSCI 493: Research Independent Study 1 2022
- BIOLOGY 293: Research Independent Study 2021
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