Majda Hadziahmetovic | Scholars@Duke

Majda Hadziahmetovic
Assistant Professor of Ophthalmology

Majda Hadzihametovic, M.D., received her M.D. from University of Belgrade School of Medicine in 2006, followed by Postdoctoral Fellowship at the University of Pennsylvania, Scheie Eye Institute, from 2007 to 2012. After completing a year of General Surgery training at Drexel University College of Medicine in 2012, she completed Ophthalmology Residency at the same institution from 2013 to 2016, where she served as a chief resident during her final year. After finishing Medical Retina training at Duke, in 2017 she joined the faculty.

Dr. Hadziahmetovic’s is a clinician scientist with present research agenda focused on teleophthalmology. She is particularly interested in employing remote diagnosis in early diagnosis, suitable referral and timely treatment of diabetic retinopathy and age-related macular degeneration using cutting-edge noninvasive optic coherence tomography (OCT) imaging and fundus photography.

Dr. Hadziahmetovic also has a great interest in basic science, especially investigating new mouse models of retinal diseases. Her long term goal is better understanding of disease processes in Age related macular degeneration using different animal models and potential reversal of morphological changes.

Current Appointments & Affiliations

Assistant Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2021

Contact Information

majda.hadziahmetovic@duke.edu

Background
Education, Training, & Certifications
- 3-Year Ophthalmology Residency, Department Of Ophthalmology, Drexel University, College of Medicine 2013 - 2016
- Preliminary Internship, Department Of Surgery, Drexel University, College of Medicine 2012 - 2013
- M.D., University of Belgrade (Serbia) 2006
Previous Appointments & Affiliations
- Assistant Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2020
- Medical Instructor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2017 - 2020
- Clinical Associate in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2016 - 2017
Research
External Relationships
- Protagonist Therapeutics
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ahuja, Abhimanyu S., Mays A. El-Dairi, Majda Hadziahmetovic, and Sidney M. Gospe. “Pellegrini et al-"Reply to: Paracentral Acute Middle Maculopathy as a Manifestation of Giant Cell Arteritis": Response.” J Neuroophthalmol 42, no. 2 (June 1, 2022): e533–34. https://doi.org/10.1097/WNO.0000000000001335.
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  - Lee, Terry, Joshua Amason, Amanda Del Risco, Joon-Bom Kim, Scott W. Cousins, and Majda Hadziahmetovic. “Incidence of Referable Retinal Disease in Diabetic Patients at a Primary Care Practice.” Journal of Vitreoretinal Diseases 6, no. 2 (March 2022): 138–46. https://doi.org/10.1177/24741264211044223.
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  - Gao, Qitong, Dong Wang, Joshua D. Amason, Siyang Yuan, Chenyang Tao, Ricardo Henao, Majda Hadziahmetovic, Lawrence Carin, and Miroslav Pajic. “Gradient Importance Learning for Incomplete Observations,” July 5, 2021.
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  - Ahuja, Abhimanyu S., Mays A. El-Dairi, Majda Hadziahmetovic, and Sidney M. Gospe. “Paracentral Acute Middle Maculopathy as a Manifestation of Giant Cell Arteritis.” J Neuroophthalmol 41, no. 2 (June 1, 2021): e153–56. https://doi.org/10.1097/WNO.0000000000001170.
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  - Gao, Qitong, Ying Xu, Joshua Amason, Anna Loksztejn, Scott Cousins, Miroslav Pajic, and Majda Hadziahmetovic. “Automated Recognition of Retinal Pigment Epithelium Cells on Limited Training Samples Using Neural Networks.” Transl Vis Sci Technol 9, no. 2 (June 2020): 31. https://doi.org/10.1167/tvst.9.2.31.
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  - Hadziahmetovic, Majda, and Goldis Malek. “Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies.” Front Cell Dev Biol 8 (2020): 612812. https://doi.org/10.3389/fcell.2020.612812.
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  - Hadziahmetovic, Majda, Peter Nicholas, Sumeet Jindal, Priyatham S. Mettu, and Scott W. Cousins. “Evaluation of a Remote Diagnosis Imaging Model vs Dilated Eye Examination in Referable Macular Degeneration.” Jama Ophthalmol 137, no. 7 (July 1, 2019): 802–8. https://doi.org/10.1001/jamaophthalmol.2019.1203.
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  - Lange, Jason, Majda Hadziahmetovic, Jingfa Zhang, and Weiye Li. “Region-specific ischemia, neovascularization and macular oedema in treatment-naïve proliferative diabetic retinopathy.” Clin Exp Ophthalmol 46, no. 7 (September 2018): 757–66. https://doi.org/10.1111/ceo.13168.
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  - Sterling, Jacob, Samyuktha Guttha, Ying Song, Delu Song, Majda Hadziahmetovic, and Joshua L. Dunaief. “Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.” Experimental Eye Research 155 (February 2017): 15–23. https://doi.org/10.1016/j.exer.2016.12.008.
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  - Zhao, Liangliang, Majda Hadziahmetovic, Chenguang Wang, Xueying Xu, Ying Song, H. A. Jinnah, Jolanta Wodzinska, et al. “Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.” J Neurochem 135, no. 5 (December 2015): 958–74. https://doi.org/10.1111/jnc.13292.
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  - Song, Delu, Liangliang Zhao, Yafeng Li, Majda Hadziahmetovic, Ying Song, John Connelly, Michael Spino, and Joshua L. Dunaief. “The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.” Invest Ophthalmol Vis Sci 55, no. 7 (June 26, 2014): 4525–32. https://doi.org/10.1167/iovs.14-14568.
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  - Dunaief, Joshua, Majda Hadziahmetovic, Natalie Wolkow, Ying Song, Paul Hahn, Yafeng Li, John Connelly, Michael Spino, Sophie Vaulont, and Marie-Paule Roth. “RETINAL IRON DYSREGULATION IN SYSTEMIC OR CONDITIONAL KNOCKOUT MOUSE MODELS OF HUMAN DISEASE: PROTECTION BY IRON CHELATION.” American Journal of Hematology 88, no. 5 (May 1, 2013): E34–E34.
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  - Hadziahmetovic, Majda, Usha Kumar, Ying Song, Steven Grieco, Delu Song, Yafeng Li, John W. Tobias, and Joshua L. Dunaief. “Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.” Invest Ophthalmol Vis Sci 53, no. 9 (August 7, 2012): 5231–41. https://doi.org/10.1167/iovs.12-10204.
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  - Song, Delu, Ying Song, Majda Hadziahmetovic, Yong Zhong, and Joshua L. Dunaief. “Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina.” Free Radic Biol Med 53, no. 1 (July 1, 2012): 64–71. https://doi.org/10.1016/j.freeradbiomed.2012.04.020.
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  - Wolkow, Natalie, Delu Song, Ying Song, Sally Chu, Majda Hadziahmetovic, Jennifer C. Lee, Jared Iacovelli, Steven Grieco, and Joshua L. Dunaief. “Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.” Am J Pathol 180, no. 4 (April 2012): 1614–24. https://doi.org/10.1016/j.ajpath.2011.12.041.
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  - Hadziahmetovic, Majda, Miroslav Pajic, Steven Grieco, Ying Song, Delu Song, Yafeng Li, Alyssa Cwanger, et al. “The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.” Transl Vis Sci Technol 1, no. 3 (2012): 2. https://doi.org/10.1167/tvst.1.3.2.
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  - Hadziahmetovic, Majda, Miroslav Pajic, Steven Grieco, Ying Song, Delu Song, Yafeng Li, Alyssa Cwanger, et al. “The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.” Transl Vis Sci Technol 1, no. 2 (2012): 7. https://doi.org/10.1167/tvst.1.2.7.
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  - Hadziahmetovic, Majda, Ying Song, Natalie Wolkow, Jared Iacovelli, Leon Kautz, Marie-Paule Roth, and Joshua L. Dunaief. “Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration.” Am J Pathol 179, no. 1 (July 2011): 335–48. https://doi.org/10.1016/j.ajpath.2011.03.033.
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  - Kaneko, Hiroki, Sami Dridi, Valeria Tarallo, Bradley D. Gelfand, Benjamin J. Fowler, Won Gil Cho, Mark E. Kleinman, et al. “DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.” Nature 471, no. 7338 (March 17, 2011): 325–30. https://doi.org/10.1038/nature09830.
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  - Hadziahmetovic, Majda, Ying Song, Natalie Wolkow, Jared Iacovelli, Steven Grieco, Jennifer Lee, Arkady Lyubarsky, et al. “The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.” Invest Ophthalmol Vis Sci 52, no. 2 (February 16, 2011): 959–68. https://doi.org/10.1167/iovs.10-6207.
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  - Hadziahmetovic, Majda, Ying Song, Padmavathi Ponnuru, Jared Iacovelli, Allan Hunter, Nadine Haddad, John Beard, James R. Connor, Sophie Vaulont, and Joshua L. Dunaief. “Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.” Invest Ophthalmol Vis Sci 52, no. 1 (January 5, 2011): 109–18. https://doi.org/10.1167/iovs.10-6113.
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  - Loh, Allison, Majda Hadziahmetovic, and Joshua L. Dunaief. “Iron homeostasis and eye disease.” Biochim Biophys Acta 1790, no. 7 (July 2009): 637–49. https://doi.org/10.1016/j.bbagen.2008.11.001.
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  - Shoham, Akiva, Majda Hadziahmetovic, Joshua L. Dunaief, Marc B. Mydlarski, and Hyman M. Schipper. “Oxidative stress in diseases of the human cornea.” Free Radic Biol Med 45, no. 8 (October 15, 2008): 1047–55. https://doi.org/10.1016/j.freeradbiomed.2008.07.021.
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  - Hadziahmetovic, Majda, Tzvete Dentchev, Ying Song, Nadine Haddad, Xining He, Paul Hahn, Domenico Pratico, et al. “Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.” Invest Ophthalmol Vis Sci 49, no. 6 (June 2008): 2728–36. https://doi.org/10.1167/iovs.07-1472.
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  - Simic, T., M. Pljesa-Ercegovac, A. Savic-Radojevic, M. Hadziahmetovic, and J. Mimic-Oka. “Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney.” Amino Acids 30, no. 4 (June 2006): 495–98. https://doi.org/10.1007/s00726-006-0329-7.
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- Conference Papers
  - Gao, Qitong, Joshua Amason, Scott Cousins, Miroslav Pajic, and Majda Hadziahmetovic. “A deep learning-based automated tool for the identification of referable retinal pathology from multi-modal imaging sources.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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  - Hadziahmetovic, Majda, Joshua Amason, Terry Lee, and Scott Cousins. “Remote diagnosis of referable retinal pathology in diabetic patients visiting primary care clinic.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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  - Hu, Mingzhe, Joshua Amason, Terry Lee, Qitong Gao, Durga Borkar, Miroslav Pajic, and Majda Hadziahmetovic. “Deep learning approach for automated detection of retinal pathology from ultra-widefield retinal images.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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  - Hadziahmetovic, Majda, Qitong Gao, Ying Xu, Joshua Amason, Anna Loksztejn, Scott W. Cousins, and Miroslav Pajic. “Deep Learning Approach for Automated Recognition of Retinal Pigment Epithelium Cell.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.
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  - Hadziahmetovic, Majda, Priyatham S. Mettu, and Scott W. Cousins. “Remote diagnosis of referable macular pathology in high disease prevalence communities.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
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  - Dunaief, Joshua, Ying Song, Delu Song, Bailey Baumann, Milan Theurl, Paul Hahn, Majda Hadziahmetovic, and Natalie Wolkow. “TISSUE-AUTONOMOUS REGULATION OF RETINAL IRON TRANSPORT.” In American Journal of Hematology, 92:E318–E318. WILEY, 2017.
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  - Li, Weiye, Majda Hadziahmetovic, and Jason Lange. “The region-dependent neovascularization and macular layer-specific edema and ischemia in proliferative diabetic retinopathy.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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  - Hadziahmetovic, Majda, Sultan Ahmed Ghuman, and Jessica M. Ackert. “Two-year follow-up on characteristics of patients with primary open angle glaucoma at Drexel Eye Physicians in Philadelphia, a high-risk population.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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  - Hadziahmetovic, Majda, Kelly Williamson, Amanda Y. Lehman, and Jessica M. Ackert. “Higher than Expected Prevalence of Glaucoma in Community Centered Practice.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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  - Song, Delu, Liangliang Zhao, Yafeng Li, Majda Hadziahmetovic, Ying Song, and Joshua L. Dunaief. “The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration in Hepcidin knockout mice.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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  - Williamson, Kelly, Enrique Aradillas Lopez, Majda Hadziahmetovic, and Jessica M. Ackert. “Increased Risk of Ophthalmic Disease in Patients with Complex Regional Pain Syndrome.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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  - Hadziahmetovic, M., Y. Song, S. Grieco, S. Kusko, D. Pratico, and J. L. Dunaief. “Iron Chelator Deferiprone Protects Against Iron Mediated Oxidative Stress and Retinal Degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Song, Y., M. Hadziahmetovic, A. Hunter, J. Iacovelli, N. Haddad, S. Vaulont, and J. L. Dunaief. “Peptide Hormone Hepcidin Regulates Retinal Iron Homeostasis.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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Education, Training, & Certifications

Previous Appointments & Affiliations

External Relationships

Selected Publications

Academic Articles

Conference Papers