Lan Mao
Assistant Professor in Medicine
I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.
II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.
III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.
II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.
III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.
Current Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2021
Contact Information
- 231 Clin Res Lab Bldg, Durham, NC 27710
- Duke Box 3104, Durham, NC 27710
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mao00004@mc.duke.edu
(919) 668-2530
- Background
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Education, Training, & Certifications
- M.D., Beijing Medical University (China) 1979
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Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2006 - 2020
- Assistant Research Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2006
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 1999
- Research
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Selected Grants
- Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration awarded by National Aeronautics and Space Administration 2016 - 2022
- Bioengineering a Living Tissue Conductor awarded by National Institutes of Health 2015 - 2018
- Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by Sanford-Burnham Medical Research Institute 2017
- E3 Ligases and Deubiquitinases in GPCR Down Regulation awarded by National Institutes of Health 2005 - 2016
- Function and Integration of Stem Cell-derived Cardiac Tissue Patch awarded by National Institutes of Health 2010 - 2016
- Identifying Cardiomyopathy Genes in Mice and Drosophila awarded by National Institutes of Health 2006 - 2015
- TREK-1 in fibroblast differentiation and cardiac fibrosis development awarded by American Heart Association 2014 - 2015
- Novel pathways modulating Raf-mediated cardiac hypertrophy awarded by National Institutes of Health 2013 - 2015
- Identification of genetics modifiers of heart disease awarded by National Institutes of Health 2007 - 2011
- Modifier Genes in Heart Failure awarded by National Institutes of Health 2001 - 2007
- Genes that Regulate Target Organ Damage in Hypertension awarded by National Institutes of Health 2001 - 2006
- Developmental Correlates-Membrane/Contractile Protein awarded by National Institutes of Health 2001 - 2006
- Regulation of BAR Function by Localized PI3K Inhibition awarded by National Institutes of Health 1999 - 2004
- Phenotypic Screens for Cardiovascular Mutations in Mice awarded by National Institutes of Health 2000 - 2004
- Beta adrenergic receptor phosphorylation - heart failure awarded by National Institutes of Health 1999 - 2003
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lee, Chang-Lung, Jessica W. Lee, Andrea R. Daniel, Matt Holbrook, Stephanie Hasapis, Ato O. Wright, Jeremy Brownstein, et al. “Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.” Radiother Oncol 157 (April 2021): 155–62. https://doi.org/10.1016/j.radonc.2021.01.023.Full Text Link to Item
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Kim, Jihee, Chad A. Grotegut, James W. Wisler, Lan Mao, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.” Proc Natl Acad Sci U S A 117, no. 22 (June 2, 2020): 12435–43. https://doi.org/10.1073/pnas.1920310117.Full Text Link to Item
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Nielsen, Natalie R., Krsna V. Rangarajan, Lan Mao, Howard A. Rockman, and Kathleen M. Caron. “A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis.” Am J Physiol Heart Circ Physiol 318, no. 4 (April 1, 2020): H895–907. https://doi.org/10.1152/ajpheart.00436.2019.Full Text Link to Item
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Li, Yanzhen, Daniel Song, Lan Mao, Dennis M. Abraham, and Nenad Bursac. “Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure.” Biomaterials 236 (April 2020): 119824. https://doi.org/10.1016/j.biomaterials.2020.119824.Full Text Link to Item
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Yu, Yen-Rei A., Yuryi Malakhau, Chen-Hsin A. Yu, Stefan-Laural J. Phelan, R Ian Cumming, Matthew J. Kan, Lan Mao, Sudarshan Rajagopal, Claude A. Piantadosi, and Michael D. Gunn. “Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension.” J Immunol 204, no. 6 (March 15, 2020): 1474–85. https://doi.org/10.4049/jimmunol.1900239.Full Text Link to Item
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Yu, Samuel Mon-Wei, Pierre-Yves Jean-Charles, Dennis M. Abraham, Suneet Kaur, Clarice Gareri, Lan Mao, Howard A. Rockman, and Sudha K. Shenoy. “The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.” J Biol Chem 294, no. 7 (February 15, 2019): 2500–2518. https://doi.org/10.1074/jbc.RA118.004926.Full Text Link to Item
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Dai, Qunsheng, Creighton E. Likes, Anthony L. Luz, Lan Mao, Jason S. Yeh, Zhengzheng Wei, Maragatha Kuchibhatla, Olga R. Ilkayeva, Timothy R. Koves, and Thomas M. Price. “A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.” J Endocr Soc 3, no. 2 (February 1, 2019): 446–67. https://doi.org/10.1210/js.2018-00219.Full Text Open Access Copy Link to Item
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Kim, Jihee, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.” Skelet Muscle 8, no. 1 (December 27, 2018): 39. https://doi.org/10.1186/s13395-018-0184-8.Full Text Open Access Copy Link to Item
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Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, et al. “The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.” J Clin Invest 128, no. 11 (November 1, 2018): 4843–55. https://doi.org/10.1172/JCI95945.Full Text Link to Item
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Toth, Krisztian, Lauren M. Slosky, Thomas F. Pack, Nikhil M. Urs, Peter Boone, Lan Mao, Dennis Abraham, Marc G. Caron, and Lawrence S. Barak. “Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.” Synapse 72, no. 1 (January 2018). https://doi.org/10.1002/syn.22012.Full Text Link to Item
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Hershberger, Kathleen A., Dennis M. Abraham, Angelical S. Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W. Locasale, and Matthew D. Hirschey. “Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.” J Biol Chem 292, no. 48 (December 1, 2017): 19767–81. https://doi.org/10.1074/jbc.M117.809897.Full Text Link to Item
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Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Dennis Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T. Strachan, Zhu-Shan Zhang, et al. “Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.” Jci Insight 2, no. 17 (September 7, 2017). https://doi.org/10.1172/jci.insight.95998.Full Text Link to Item
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Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.Full Text Link to Item
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Wei, Eric Q., Daniel S. Sinden, Lan Mao, Hailin Zhang, Chuan Wang, and Geoffrey S. Pitt. “Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.” Proc Natl Acad Sci U S A 114, no. 20 (May 16, 2017): E4010–19. https://doi.org/10.1073/pnas.1616393114.Full Text Link to Item
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Abraham, Dennis M., Robert T. Davis, Chad M. Warren, Lan Mao, Beata M. Wolska, R John Solaro, and Howard A. Rockman. “β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.” Proc Natl Acad Sci U S A 113, no. 50 (December 13, 2016): 14426–31. https://doi.org/10.1073/pnas.1609308113.Full Text Link to Item
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Ma, Zhiyuan, Lan Mao, and Sudarshan Rajagopal. “Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension.” J Vis Exp, no. 110 (April 11, 2016). https://doi.org/10.3791/53335.Full Text Link to Item
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Grotegut, Chad A., Lan Mao, Stephanie L. Pierce, Geeta K. Swamy, R Phillips Heine, and Amy P. Murtha. “Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization.” Mol Endocrinol 30, no. 4 (April 2016): 455–68. https://doi.org/10.1210/me.2015-1147.Full Text Link to Item
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Wisler, James W., Emily M. Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard A. Rockman, and Robert J. Lefkowitz. “The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.” Am J Physiol Heart Circ Physiol 309, no. 9 (November 2015): H1516–27. https://doi.org/10.1152/ajpheart.00291.2015.Full Text Link to Item
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Xu, Wenjing, Tomasa Barrientos, Lan Mao, Howard A. Rockman, Anthony A. Sauve, and Nancy C. Andrews. “Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.” Cell Rep 13, no. 3 (October 20, 2015): 533–45. https://doi.org/10.1016/j.celrep.2015.09.023.Full Text Link to Item
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Abraham, Dennis, and Lan Mao. “Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice.” J Vis Exp, no. 103 (September 17, 2015). https://doi.org/10.3791/52942.Full Text Link to Item
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Pironti, Gianluigi, Ryan T. Strachan, Dennis Abraham, Samuel Mon-Wei Yu, Minyong Chen, Wei Chen, Kenji Hanada, Lan Mao, Lewis J. Watson, and Howard A. Rockman. “Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.” Circulation 131, no. 24 (June 16, 2015): 2120–30. https://doi.org/10.1161/CIRCULATIONAHA.115.015687.Full Text Link to Item
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Moding, Everett J., Chang-Lung Lee, Katherine D. Castle, Patrick Oh, Lan Mao, Shan Zha, Hooney D. Min, Yan Ma, Shiva Das, and David G. Kirsch. “Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.” J Clin Invest 124, no. 8 (August 2014): 3325–38. https://doi.org/10.1172/JCI73932.Full Text Link to Item
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Kim, Il-Man, Yongchao Wang, Kyoung-Mi Park, Yaoping Tang, Jian-Peng Teoh, Joseph Vinson, Christopher J. Traynham, et al. “β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.” Circ Res 114, no. 5 (February 28, 2014): 833–44. https://doi.org/10.1161/CIRCRESAHA.114.302766.Full Text Link to Item
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Santacruz, Lucia, Alejandro Hernandez, Jeffrey Nienaber, Rajashree Mishra, Miguel Pinilla, James Burchette, Lan Mao, Howard A. Rockman, and Danny O. Jacobs. “Normal cardiac function in mice with supraphysiological cardiac creatine levels.” Am J Physiol Heart Circ Physiol 306, no. 3 (February 2014): H373–81. https://doi.org/10.1152/ajpheart.00411.2013.Full Text Link to Item
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Ashton, Jeffrey R., Nicholas Befera, Darin Clark, Yi Qi, Lan Mao, Howard A. Rockman, G Allan Johnson, and Cristian T. Badea. “Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.” Contrast Media Mol Imaging 9, no. 2 (2014): 161–68. https://doi.org/10.1002/cmmi.1557.Full Text Link to Item
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Yu, Yen-Rei A., Lan Mao, Claude A. Piantadosi, and Michael D. Gunn. “CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.” Am J Respir Cell Mol Biol 48, no. 5 (May 2013): 647–54. https://doi.org/10.1165/rcmb.2012-0182OC.Full Text Link to Item
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Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.” J Mol Cell Cardiol 54 (January 2013): 101–11. https://doi.org/10.1016/j.yjmcc.2012.10.004.Full Text Link to Item
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Kim, Ki-Seok, Dennis Abraham, Barbara Williams, Jonathan D. Violin, Lan Mao, and Howard A. Rockman. “β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.” Am J Physiol Heart Circ Physiol 303, no. 8 (October 15, 2012): H1001–10. https://doi.org/10.1152/ajpheart.00475.2012.Full Text Link to Item
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Lee, Chang-Lung, Everett J. Moding, Kyle C. Cuneo, Yifan Li, Julie M. Sullivan, Lan Mao, Iman Washington, et al. “p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.” Sci Signal 5, no. 234 (July 24, 2012): ra52. https://doi.org/10.1126/scisignal.2002918.Full Text Link to Item
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Piacentino, Valentino, Carmelo A. Milano, Michael Bolanos, Jacob Schroder, Emily Messina, Adam S. Cockrell, Edward Jones, et al. “X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.” Hum Gene Ther 23, no. 6 (June 2012): 635–46. https://doi.org/10.1089/hum.2011.186.Full Text Link to Item
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Chang, Jae-Hyung, Seung-Yeol Paik, Lan Mao, William Eisner, Patrick J. Flannery, Liming Wang, Yuping Tang, et al. “Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion.” Plos One 7, no. 4 (2012): e33942. https://doi.org/10.1371/journal.pone.0033942.Full Text Link to Item
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Grotegut, Chad A., Liping Feng, Lan Mao, R Phillips Heine, Amy P. Murtha, and Howard A. Rockman. “β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.” Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468–77. https://doi.org/10.1152/ajpendo.00390.2010.Full Text Link to Item
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He, Wei, Lunan Zhang, Aiguo Ni, Zhiping Zhang, Maria Mirotsou, Lan Mao, Richard E. Pratt, and Victor J. Dzau. “Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction.” Proc Natl Acad Sci U S A 107, no. 49 (December 7, 2010): 21110–15. https://doi.org/10.1073/pnas.1004708107.Full Text Link to Item
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Piacentino, Valentino, Michael Bolanos, Jacob Schroder, Emily Messina, Edward Jones, Ava Krol, Nenad Bursac, et al. “X-Linked Inhibitor of Apoptosis Protein (XIAP)-Mediated Attenuation of Apoptosis Using a Novel Cardiac Enhanced Adeno-Associated Viral Vector.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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McNamara, Erin R., Lan Mao, Susan Poulton, Howard A. Rockman, Trinity J. Bivalacqua, Stephen J. Freedland, and Craig F. Donatucci. “889 EFFECT OF EXERCISE ON ERECTILE FUNCTION AFTER BILATERAL NERVE CRUSH INJURY IN A RAT MODEL.” Journal of Urology 183, no. 4S (April 2010). https://doi.org/10.1016/j.juro.2010.02.1645.Full Text
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McNamara, Erin, Lan Mao, Susan Poulton, Trinity Bivalacqua, Stephen J. Freedland, and Craig F. Donatucci. “EFFECT OF EXERCISE ON ERECTILE FUNCTION AFTER BILATERAL NERVE CRUSH INJURY IN A RAT MODEL.” Journal of Sexual Medicine 7 (March 1, 2010): 24–24.Link to Item
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Seth, Malini, Zhu-Shan Zhang, Lan Mao, Victoria Graham, Jarrett Burch, Jonathan Stiber, Leonidas Tsiokas, et al. “TRPC1 channels are critical for hypertrophic signaling in the heart.” Circ Res 105, no. 10 (November 6, 2009): 1023–30. https://doi.org/10.1161/CIRCRESAHA.109.206581.Full Text Link to Item
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Yoo, ByungSu, Anthony Lemaire, Supachoke Mangmool, Matthew J. Wolf, Antonio Curcio, Lan Mao, and Howard A. Rockman. “Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.” Am J Physiol Heart Circ Physiol 297, no. 4 (October 2009): H1377–86. https://doi.org/10.1152/ajpheart.00504.2009.Full Text Link to Item
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Wheeler, Ferrin C., Hao Tang, Odessa A. Marks, Tracy N. Hadnott, Pei-Lun Chu, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Tnni3k modifies disease progression in murine models of cardiomyopathy.” Plos Genet 5, no. 9 (September 2009): e1000647. https://doi.org/10.1371/journal.pgen.1000647.Full Text Link to Item
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Francois, Helene, Natalia Makhanova, Philip Ruiz, Jonathan Ellison, Lan Mao, Howard A. Rockman, and Thomas M. Coffman. “A role for the thromboxane receptor in L-NAME hypertension.” Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096–1102. https://doi.org/10.1152/ajprenal.00369.2007.Full Text Link to Item
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Pandya, Kumar, John Cowhig, Joe Brackhan, Hyung Suk Kim, John Hagaman, Mauricio Rojas, Charles W. Carter, et al. “Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.” Proc Natl Acad Sci U S A 105, no. 35 (September 2, 2008): 13063–68. https://doi.org/10.1073/pnas.0805120105.Full Text Link to Item
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Edwards, Claire, Hong-Qiang Feng, Christopher Reynolds, Lan Mao, and Don C. Rockey. “Effect of the nitric oxide donor V-PYRRO/NO on portal pressure and sinusoidal dynamics in normal and cirrhotic mice.” Am J Physiol Gastrointest Liver Physiol 294, no. 6 (June 2008): G1311–17. https://doi.org/10.1152/ajpgi.00368.2007.Full Text Link to Item
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Zhu, Ming, Agnieszka A. Gach, GongXin Liu, Xiaomei Xu, Chee Chew Lim, Julie X. Zhang, Lan Mao, et al. “Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.” Am J Physiol Heart Circ Physiol 294, no. 3 (March 2008): H1335–47. https://doi.org/10.1152/ajpheart.00584.2007.Full Text Link to Item
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Esposito, Giovanni, Cinzia Perrino, Tohru Ozaki, Hideyuki Takaoka, Nicole Defer, Maria Piera Petretta, Maria Carmen De Angelis, et al. “Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8.” Basic Res Cardiol 103, no. 1 (January 2008): 22–30. https://doi.org/10.1007/s00395-007-0688-6.Full Text Link to Item
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Li, Ping, Richard E. Waters, Shelley I. Redfern, Mei Zhang, Lan Mao, Brian H. Annex, and Zhen Yan. “Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.” Am J Pathol 170, no. 2 (February 2007): 599–608. https://doi.org/10.2353/ajpath.2007.060505.Full Text Link to Item
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Badea, Cristian T., Laurence W. Hedlund, Julie F Boslego Mackel, Lan Mao, Howard A. Rockman, and G Allan Johnson. “Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.” Mol Imaging 6, no. 4 (2007): 261–68.Link to Item
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Curcio, Antonio, Takahisa Noma, Sathyamangla V. Naga Prasad, Matthew J. Wolf, Anthony Lemaire, Cinzia Perrino, Lan Mao, and Howard A. Rockman. “Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.” Am J Physiol Heart Circ Physiol 291, no. 4 (October 2006): H1754–60. https://doi.org/10.1152/ajpheart.01199.2005.Full Text Link to Item
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Gurley, Susan B., Alicia Allred, Thu H. Le, Robert Griffiths, Lan Mao, Nisha Philip, Timothy A. Haystead, et al. “Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.” J Clin Invest 116, no. 8 (August 2006): 2218–25. https://doi.org/10.1172/JCI16980.Full Text Link to Item
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Perrino, Cinzia, Sathyamangla V. Naga Prasad, Lan Mao, Takahisa Noma, Zhen Yan, Hyung-Suk Kim, Oliver Smithies, and Howard A. Rockman. “Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.” J Clin Invest 116, no. 6 (June 2006): 1547–60. https://doi.org/10.1172/JCI25397.Full Text Link to Item
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Francois, H., K. Athirakul, D. Howell, R. Dash, L. Mao, H. S. Kim, H. A. Rockman, G. A. FitzGerald, B. H. Koller, and T. M. Coffman. “NSAIDs and cardiovascular risk - Reply [2].” Cell Metabolism 2, no. 6 (December 1, 2005): 339–40. https://doi.org/10.1016/j.cmet.2005.11.009.Full Text
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Francois, Helene, Krairerk Athirakul, David Howell, Rajesh Dash, Lan Mao, Hyung-Suk Kim, Howard A. Rockman, Garret A. Fitzgerald, Beverly H. Koller, and Thomas M. Coffman. “Prostacyclin protects against elevated blood pressure and cardiac fibrosis.” Cell Metab 2, no. 3 (September 2005): 201–7. https://doi.org/10.1016/j.cmet.2005.08.005.Full Text Link to Item
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Chen, Zhiqiang, Matthew W. Foster, Jian Zhang, Lan Mao, Howard A. Rockman, Toshihiro Kawamoto, Kyoko Kitagawa, Keiichi I. Nakayama, Douglas T. Hess, and Jonathan S. Stamler. “An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.” Proc Natl Acad Sci U S A 102, no. 34 (August 23, 2005): 12159–64. https://doi.org/10.1073/pnas.0503723102.Full Text Link to Item
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Nassar, Rashid, Nadia N. Malouf, Lan Mao, Howard A. Rockman, Annette E. Oakeley, James R. Frye, J René Herlong, Stephen P. Sanders, and Page A. W. Anderson. “cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform.” Am J Physiol Heart Circ Physiol 288, no. 3 (March 2005): H1147–56. https://doi.org/10.1152/ajpheart.00140.2004.Full Text Link to Item
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Skavdahl, Maryanne, Charles Steenbergen, James Clark, Page Myers, Tracy Demianenko, Lan Mao, Howard A. Rockman, Kenneth S. Korach, and Elizabeth Murphy. “Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.” Am J Physiol Heart Circ Physiol 288, no. 2 (February 2005): H469–76. https://doi.org/10.1152/ajpheart.00723.2004.Full Text Link to Item
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Seubert, John, Baichun Yang, J Alyce Bradbury, Joan Graves, Laura M. Degraff, Scott Gabel, Rebecca Gooch, et al. “Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.” Circ Res 95, no. 5 (September 3, 2004): 506–14. https://doi.org/10.1161/01.RES.0000139436.89654.c8.Full Text Link to Item
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Caron, Kathleen M. I., Leighton R. James, Hyung-Suk Kim, Josh Knowles, Rick Uhlir, Lan Mao, John R. Hagaman, Wayne Cascio, Howard Rockman, and Oliver Smithies. “Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.” Proc Natl Acad Sci U S A 101, no. 9 (March 2, 2004): 3106–11. https://doi.org/10.1073/pnas.0307333101.Full Text Link to Item
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Francois, Helene, Krairerk Athirakul, Lan Mao, Howard Rockman, and Thomas M. Coffman. “Role for thromboxane receptors in angiotensin-II-induced hypertension.” Hypertension 43, no. 2 (February 2004): 364–69. https://doi.org/10.1161/01.HYP.0000112225.27560.24.Full Text Link to Item
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Nienaber, Jeffrey J., Hideo Tachibana, Sathyamangla V. Naga Prasad, Giovanni Esposito, Dianqing Wu, Lan Mao, and Howard A. Rockman. “Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure.” J Clin Invest 112, no. 7 (October 2003): 1067–79. https://doi.org/10.1172/JCI18213.Full Text Link to Item
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Most, Patrick, Andrew Remppis, Sven T. Pleger, Eva Löffler, Philipp Ehlermann, Juliane Bernotat, Christiane Kleuss, et al. “Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.” J Biol Chem 278, no. 36 (September 5, 2003): 33809–17. https://doi.org/10.1074/jbc.M301788200.Full Text Link to Item
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Colomer, Josep M., Lan Mao, Howard A. Rockman, and Anthony R. Means. “Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.” Mol Endocrinol 17, no. 2 (February 2003): 183–92. https://doi.org/10.1210/me.2002-0350.Full Text Link to Item
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Takaoka, Hideyuki, Giovanni Esposito, Lan Mao, Hiroyuki Suga, and Howard A. Rockman. “Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy.” Am J Physiol Heart Circ Physiol 282, no. 6 (June 2002): H2190–97. https://doi.org/10.1152/ajpheart.00759.2001.Full Text Link to Item
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Kohout, T. A., H. Takaoka, P. H. McDonald, S. J. Perry, L. Mao, R. J. Lefkowitz, and H. A. Rockman. “Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.” Circulation 104, no. 20 (November 13, 2001): 2485–91. https://doi.org/10.1161/hc4501.098933.Full Text Open Access Copy Link to Item
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Rapacciuolo, A., G. Esposito, K. Caron, L. Mao, S. A. Thomas, and H. A. Rockman. “Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.” J Am Coll Cardiol 38, no. 3 (September 2001): 876–82. https://doi.org/10.1016/s0735-1097(01)01433-4.Full Text Link to Item
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Knowles, J. W., G. Esposito, L. Mao, J. R. Hagaman, J. E. Fox, O. Smithies, H. A. Rockman, and N. Maeda. “Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice.” J Clin Invest 107, no. 8 (April 2001): 975–84. https://doi.org/10.1172/JCI11273.Full Text Link to Item
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Esposito, G., S. V. Prasad, A. Rapacciuolo, L. Mao, W. J. Koch, and H. A. Rockman. “Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.” Circulation 103, no. 10 (March 13, 2001): 1453–58. https://doi.org/10.1161/01.cir.103.10.1453.Full Text Link to Item
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Esposito, G., L. F. Santana, K. Dilly, J. D. Cruz, L. Mao, W. J. Lederer, and H. A. Rockman. “Cellular and functional defects in a mouse model of heart failure.” Am J Physiol Heart Circ Physiol 279, no. 6 (December 2000): H3101–12. https://doi.org/10.1152/ajpheart.2000.279.6.H3101.Full Text Link to Item
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Manning, B. S., K. Shotwell, L. Mao, H. A. Rockman, and W. J. Koch. “Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.” Circulation 102, no. 22 (November 28, 2000): 2751–57. https://doi.org/10.1161/01.cir.102.22.2751.Full Text Link to Item
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Chao, H., L. Mao, A. T. Bruce, and C. E. Walsh. “Sustained expression of human factor VIII in mice using a parvovirus-based vector.” Blood 95, no. 5 (March 1, 2000): 1594–99.Link to Item
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Naga Prasad, S. V., G. Esposito, L. Mao, W. J. Koch, and H. A. Rockman. “Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.” J Biol Chem 275, no. 7 (February 18, 2000): 4693–98. https://doi.org/10.1074/jbc.275.7.4693.Full Text Link to Item
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Ryoke, T., Y. Gu, L. Mao, M. Hongo, R. G. Clark, K. L. Peterson, and J. Ross. “Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition.” Circulation 100, no. 16 (October 19, 1999): 1734–43. https://doi.org/10.1161/01.cir.100.16.1734.Full Text Link to Item
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Hongo, M., E. M. Sentianin, N. Tanaka, L. Mao, M. D. McKirnan, R. G. Clark, W. Won, K. R. Chien, and J. Ross. “Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction.” J Card Fail 4, no. 3 (September 1998): 213–24. https://doi.org/10.1016/s1071-9164(98)80008-0.Full Text Link to Item
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Tanaka, N., T. Ryoke, M. Hongo, L. Mao, H. A. Rockman, R. G. Clark, and J. Ross. “Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice.” Am J Physiol 275, no. 2 (August 1998): H393–99. https://doi.org/10.1152/ajpheart.1998.275.2.H393.Full Text Link to Item
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Palakodeti, V., O. H. Samuel, B. H. Oh, L. A. N. Mao, M. Kongo, K. L. Peterson, and J. Ross. “Force-frequency effect is a powerful determinant of myocardial contractility in the mouse.” American Journal of Physiology Heart and Circulatory Physiology 42, no. 3 (December 1, 1997).
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Palakodeti, V., S. Oh, B. H. Oh, L. Mao, M. Hongo, K. L. Peterson, and J. Ross. “Force-frequency effect is a powerful determinant of myocardial contractility in the mouse.” Am J Physiol 273, no. 3 Pt 2 (September 1997): H1283–90. https://doi.org/10.1152/ajpheart.1997.273.3.H1283.Full Text Link to Item
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Tanaka, N., L. Mao, F. A. DeLano, E. M. Sentianin, K. R. Chien, G. W. Schmid-Schönbein, and J. Ross. “Left ventricular volumes and function in the embryonic mouse heart.” Am J Physiol 273, no. 3 Pt 2 (September 1997): H1368–76. https://doi.org/10.1152/ajpheart.1997.273.3.H1368.Full Text Link to Item
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Ryu, K. H., N. Tanaka, N. Dalton, L. Mao, H. A. Rockman, C. A. Milano, and J. Ross. “Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation.” J Card Fail 3, no. 1 (March 1997): 27–39. https://doi.org/10.1016/s1071-9164(97)90006-3.Full Text Link to Item
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Tanaka, N., N. Dalton, L. Mao, H. A. Rockman, K. L. Peterson, K. R. Gottshall, J. J. Hunter, K. R. Chien, and J. Ross. “Transthoracic echocardiography in models of cardiac disease in the mouse.” Circulation 94, no. 5 (September 1, 1996): 1109–17. https://doi.org/10.1161/01.cir.94.5.1109.Full Text Link to Item
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Rockman, H. A., R. A. Hamilton, L. R. Jones, C. A. Milano, L. Mao, and R. J. Lefkowitz. “Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.” J Clin Invest 97, no. 7 (April 1, 1996): 1618–23. https://doi.org/10.1172/JCI118587.Full Text Open Access Copy Link to Item
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Eising, G. P., L. Mao, G. W. Schmid-Schonbein, R. L. Engler, and J. Ross. “Effects of induced tolerance to bacterial lipopolysaccharide on myocardial infarct size in rats.” Cardiovasc Res 31, no. 1 (January 1996): 73–81.Link to Item
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Rockman, H. A., S. P. Wachhorst, L. Mao, and J. Ross. “ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice.” Am J Physiol 266, no. 6 Pt 2 (June 1994): H2468–75. https://doi.org/10.1152/ajpheart.1994.266.6.H2468.Full Text Link to Item
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Ono, S., V. Bhargava, L. Mao, G. Hagan, H. A. Rockman, and J. Ross. “In vivo assessment of left ventricular remodelling after myocardial infarction by digital video contrast angiography in the rat.” Cardiovasc Res 28, no. 3 (March 1994): 349–57. https://doi.org/10.1093/cvr/28.3.349.Full Text Link to Item
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Conference Papers
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Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Lan Mao, Reddy Perra Kommadi, Zhushan Zhang, Jonathan Stiber, Dawn Bowles, et al. “Beta(1)-Adrenergic Receptor-induced Cardiac Contractility is dependent on MDM2-mediated GRK2 Turnover.” In Circulation Research, 119:E162–63. LIPPINCOTT WILLIAMS & WILKINS, 2016.Link to Item
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Torok, Rachel D., Dennis M. Abraham, Clarice Gareri, Lan Mao, and Howard A. Rockman. “TWIK-Related Acid-Sensitive K+ Channels Affect the Development of Aortic Root Aneurysms in Mice.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.Link to Item
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Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Matthew J. Wolf, and Howard A. Rockman. “TREK-1 Modulates Fibrosis & Diastolic Dysfunction Through Activation of Stress-Activated Kinases.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.Link to Item
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Keenan, Jeffrey E., Hagir Sulliman, Allison Ulrich, Lan Mao, and Claude A. Piantadosi. “Cardiomyocyte-Specific Ablation of Nuclear Respiratory Factor 1 in the Mouse Leads to Dysregulation of Mitochondrial Biogenesis, Apoptosis, and Heart Failure.” In Circulation Research, Vol. 115. LIPPINCOTT WILLIAMS & WILKINS, 2014.Link to Item
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Wisler, James, Emily Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard Rockman, and Robert Lefkowitz. “NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME.” In Journal of the American College of Cardiology, 63:A2148–A2148. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)62151-3.Full Text
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Grotegut, Chad, Lan Mao, R Phillips Heine, Amy Murtha, and Howard Rockman. “748: Mice lacking G protein-coupled receptor kinase 6 (GRK6) exhibit an enhanced uterine contractile phenotype resulting in stillbirth.” In American Journal of Obstetrics and Gynecology, 210:S367–68. Elsevier BV, 2014. https://doi.org/10.1016/j.ajog.2013.10.781.Full Text
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Kim, Il-Man, Yongchao Wang, Kyoung-mi Park, Christopher J. Traynham, Lan Mao, Walter J. Koch, and Howard A. Rockman. “beta-arrestin1-Biased beta 1-adrenergic Receptor Signaling Regulates MicroRNA Processing.” In Circulation Research, Vol. 113. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Wang, Yongchao, Corey L. Neal, Weili Zou, Lan Mao, Barbara Williams, and Il-man Kim. “beta-arrestin1 Stimulates the Processing of a Subset of MicroRNAs.” In Circulation Research, 111:E385–E385. LIPPINCOTT WILLIAMS & WILKINS, 2012.Link to Item
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Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of Cardiac Troponin I-Interacting Kinase, a Cardiac-Specific MAPKKK, Promotes Cardiac Dysfunction.” In Circulation Research, Vol. 111. LIPPINCOTT WILLIAMS & WILKINS, 2012.Link to Item
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Grotegut, Chad, Lan Mao, Amy Murtha, and Howard Rockman. “G Protein-Coupled Receptor Kinase 6 (GRK6) Knock-Out Mice Exhibit Enhanced Uterine Contractility in Response to Oxytocin Infusion.” In Reproductive Sciences, 19:195A-195A. SAGE PUBLICATIONS INC, 2012.Link to Item
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Hernandez, Alejandro, Miguel Pinilla, Jeffrey Nienaber, Lan Mao, Howard Rockman, Lucia Santacruz, and Danny O. Jacobs. “Increased intracellular creatine content is not harmful to the mouse heart.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.Link to Item
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Derout, Jorge Espinoza, Maria Mirotsou, Zhiping Zhang, Xiyou Zhou, Lan Mao, Richard E. Pratt, Jeffery D. Molkentin, Paul Rosenberg, and Victor J. Dzau. “Impaired Cardiac Function and Heart Failure in Transgenic Mice With Cardiac Specific Overexpression of Hasf, a Novel Stem Cell Paracrine Factor.” In Circulation, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2010.Link to Item
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Mangmool, Supachoke, Weili Zou, Lan Mao, and Howard A. Rockman. “beta-Arrestin-Dependent Activation of Ca2+/Calmodulin-Dependent Kinase II Following beta(1)-Adrenergic Receptor Activation.” In Circulation, 120:S1147–S1147. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Yoo, ByungSu, Kriti Rakesh, Lan Mao, and Howard A. Rockman. “Mechanical Stretch Activates beta-arrestin-mediated Signaling of the AT1 Receptor.” In Circulation, 120:S866–S866. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Gupta, Manveen K., Afshan Hussain, Lan Mao, and Sathyamangla V Naga Prasad. “Regulation of Novel Micrornas Identified in End-stage Human Heart Failure.” In Circulation, 120:S857–58. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Seth, Malini, Zhu-Shan Zhang, Lan Mao, Jarrett Burch, Victoria Graham, Howard A. Rockman, Lutz Birnbaumer, and Paul Rosenberg. “Transient receptor potential channel C1 deficiency protects the murine heart from pressure overload.” In Circulation, 116:5–5. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
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