Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Rheumatology Fellow, Medicine, Duke University 1993 - 1999
  • Clinical Investigator Pathway, Medicine, Duke University 1991 - 1993
  • Medical Resident, Medicine, Duke University 1989 - 1991
  • M.D., Yale University 1989
• 

  Duke Appointment History

  • Associate Professor in Immunology, Immunology, Basic Science Departments 2007 - 2008
  • Associate Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2007 - 2008
  • Assistant Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2000 - 2007
  • Instructor, Temporary in the Department of Medicine, Medicine, Rheumatology and Immunology, Medicine 1999 - 2000
• Expertise
• 

  Global Scholarship

  • Research

    • Kenya (Country) 
    • United Republic of Tanzania (Country) 
• Research
• 

  Selected Grants

  • Nitric Oxide Metabolism in Statin-treated Pediatric SLE awarded by National Institutes of Health 2003 - 2011
  • Prevention of Chronic Lymphocytic Leukemia (CLL) awarded by National Institutes of Health 2007 - 2009
  • Human TNFa-Induced Pre-B Cell Bone Marrow Emigrants awarded by National Institutes of Health 2006 - 2009
  • Inducible NOS as a Treatment Target in CLL awarded by National Institutes of Health 2001 - 2007
  • Hyaluronan mediated nitric oxide production by macrophages awarded by National Institutes of Health 1999 - 2002
  • Hyaluronan-mediated Nitric Oxide Production by Macrophages awarded by National Institutes of Health 1999 - 2002
  • Immunoregulatory Functions Of The Isoforms Of Cd44 awarded by National Institutes of Health 1993 - 1999
  • Immunoregulatory Functions Of The Isoforms Of Cd44 awarded by National Institutes of Health 1993 - 1998
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Levesque, MC, Ghosh, DK, Beasley, BE, Chen, Y, Volkheimer, AD, O'Loughlin, CW, Gockerman, JP, Moore, JO, and Weinberg, JB. "CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant." Leuk Res 32, no. 7 (July 2008): 1061-1070.  Full Text  Link to Item
    • Ashley-Koch, AE, Elliott, L, Kail, ME, De Castro, LM, Jonassaint, J, Jackson, TL, Price, J, Ataga, KI, Levesque, MC, Weinberg, JB, Orringer, EP, Collins, A, Vance, JM, and Telen, MJ. "Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease." Blood 111, no. 12 (June 15, 2008): 5721-5726.  Full Text  Link to Item
    • Levesque, MC, Hauswirth, DW, Mervin-Blake, S, Fernandez, CA, Patch, KB, Alexander, KM, Allgood, S, McNair, PD, Allen, AS, and Sundy, JS. "Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults." J Allergy Clin Immunol 121, no. 2 (February 2008): 396-402.e3.  Full Text  Link to Item
    • Levesque, MC, and St Clair, EW. "B cell-directed therapies for autoimmune disease and correlates of disease response and relapse." J Allergy Clin Immunol 121, no. 1 (January 2008): 13-21. (Review)  Full Text  Link to Item
    • Sundy, JS, Hauswirth, DW, Mervin-Blake, S, Fernandez, CA, Patch, KB, Alexander, KM, Allgood, S, McNair, PD, and Levesque, MC. "Smoking is associated with an age-related decline in exhaled nitric oxide." Eur Respir J 30, no. 6 (December 2007): 1074-1081.  Full Text  Link to Item
    • Weinberg, JB, Volkheimer, AD, Chen, Y, Beasley, BE, Jiang, N, Lanasa, MC, Friedman, D, Vaccaro, G, Rehder, CW, Decastro, CM, Rizzieri, DA, Diehl, LF, Gockerman, JP, Moore, JO, Goodman, BK, and Levesque, MC. "Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia." Am J Hematol 82, no. 12 (December 2007): 1063-1070.  Full Text  Link to Item
    • Looney, RJ, Diamond, B, Holers, VM, Levesque, MC, Moreland, L, Nahm, MH, St Clair, EW, and Autoimmunity Centers of Excellence Immunocompetency Committee, . "Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases." Clin Immunol 123, no. 3 (June 2007): 235-243. (Review)  Full Text  Link to Item
    • Elliott, L, Ashley-Koch, AE, De Castro, L, Jonassaint, J, Price, J, Ataga, KI, Levesque, MC, Brice Weinberg, J, Eckman, JR, Orringer, EP, Vance, JM, and Telen, MJ. "Genetic polymorphisms associated with priapism in sickle cell disease." Br J Haematol 137, no. 3 (May 2007): 262-267.  Full Text  Link to Item
    • Volkheimer, AD, Weinberg, JB, Beasley, BE, Whitesides, JF, Gockerman, JP, Moore, JO, Kelsoe, G, Goodman, BK, and Levesque, MC. "Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification." Blood 109, no. 4 (February 15, 2007): 1559-1567.  Full Text  Link to Item
    • Lopansri, BK, Anstey, NM, Stoddard, GJ, Mwaikambo, ED, Boutlis, CS, Tjitra, E, Maniboey, H, Hobbs, MR, Levesque, MC, Weinberg, JB, and Granger, DL. "Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications." Infect Immun 74, no. 6 (June 2006): 3355-3359.  Full Text  Link to Item
    • Levesque, MC, Chen, Y, Beasley, BE, O'Loughlin, CW, Gockerman, JP, Moore, JO, and Weinberg, JB. "Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels." Leuk Res 30, no. 1 (January 2006): 24-28.  Full Text  Link to Item
    • Levesque, MC, and Weinberg, JB. "The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus." Curr Mol Med 4, no. 7 (November 2004): 777-786. (Review)  Link to Item
    • Boutlis, CS, Hobbs, MR, Marsh, RL, Misukonis, MA, Tkachuk, AN, Lagog, M, Booth, J, Granger, DL, Bockarie, MJ, Mgone, CS, Levesque, MC, Weinberg, JB, and Anstey, NM. "Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population." Am J Trop Med Hyg 69, no. 6 (December 2003): 569-573.  Link to Item
    • Lopansri, BK, Anstey, NM, Weinberg, JB, Stoddard, GJ, Hobbs, MR, Levesque, MC, Mwaikambo, ED, and Granger, DL. "Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production." Lancet 361, no. 9358 (February 22, 2003): 676-678.  Full Text  Link to Item
    • Levesque, MC, Misukonis, MA, O'Loughlin, CW, Chen, Y, Beasley, BE, Wilson, DL, Adams, DJ, Silber, R, and Weinberg, JB. "IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells." Leukemia 17, no. 2 (February 2003): 442-450.  Full Text  Link to Item
    • Oates, JC, Levesque, MC, Hobbs, MR, Smith, EG, Molano, ID, Page, GP, Hill, BS, Weinberg, JB, Cooper, GS, and Gilkeson, GS. "Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans." J Rheumatol 30, no. 1 (January 2003): 60-67.  Link to Item
    • Hobbs, MR, Udhayakumar, V, Levesque, MC, Booth, J, Roberts, JM, Tkachuk, AN, Pole, A, Coon, H, Kariuki, S, Nahlen, BL, Mwaikambo, ED, Lal, AL, Granger, DL, Anstey, NM, and Weinberg, JB. "A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children." Lancet 360, no. 9344 (November 9, 2002): 1468-1475.  Full Text  Link to Item
    • Adams, DJ, Levesque, MC, Weinberg, JB, Smith, KL, Flowers, JL, Moore, J, Colvin, OM, and Silber, R. "Nitric oxide enhancement of fludarabine cytotoxicity for B-CLL lymphocytes." Leukemia 15, no. 12 (December 2001): 1852-1859.  Link to Item
    • Levesque, MC, O'Loughlin, CW, and Weinberg, JB. "Use of serum-free media to minimize apoptosis of chronic lymphocytic leukemia cells during in vitro culture." Leukemia 15, no. 8 (August 2001): 1305-1307. (Letter)  Link to Item
    • Levesque, MC, and Haynes, BF. "Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma." J Immunol 166, no. 1 (January 1, 2001): 188-196.  Link to Item
    • Levesque, MC, Mackin, DA, Fleming, JA, and St Clair, EW. "Serum levels of soluble CD44 in primary Sjögren's syndrome." J Rheumatol 27, no. 6 (June 2000): 1444-1449.  Link to Item
    • Levesque, MC, Hobbs, MR, Anstey, NM, Vaughn, TN, Chancellor, JA, Pole, A, Perkins, DJ, Misukonis, MA, Chanock, SJ, Granger, DL, and Weinberg, JB. "Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria." J Infect Dis 180, no. 6 (December 1999): 1994-2002.  Full Text  Link to Item
    • Levesque, MC, and Haynes, BF. "TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44." Cell Immunol 193, no. 2 (May 1, 1999): 209-218.  Full Text  Link to Item
    • Levesque, MC, Ward, FE, Jeffery, DR, and Weinberg, JB. "Interferon-beta1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele." Arthritis Rheum 42, no. 3 (March 1999): 569-573. (Review)  Full Text  Link to Item
    • Chang, CC, Lee, CY, Chang, ET, Cruz, JC, Levesque, MC, and Chang, TY. "Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner." J Biol Chem 273, no. 52 (December 25, 1998): 35132-35141.  Link to Item
    • Levesque, MC, Heinly, CS, Whichard, LP, and Patel, DD. "Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium." Arthritis Rheum 41, no. 12 (December 1998): 2221-2229.  Full Text  Link to Item
    • Levesque, MC, and Haynes, BF. "Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13." J Immunol 159, no. 12 (December 15, 1997): 6184-6194.  Link to Item
    • Liu, NP, Roberts, WL, Hale, LP, Levesque, MC, Patel, DD, Lu, CL, and Jaffe, GJ. "Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells." Invest Ophthalmol Vis Sci 38, no. 10 (September 1997): 2027-2037.  Link to Item
    • Conlon, PJ, Fischer, CA, Levesque, MC, Smith, SR, St Clair, EW, Allen, NB, Fleming, JA, and Howell, DN. "Clinical, biochemical and pathological predictors of poor response to intravenous cyclophosphamide in patients with proliferative lupus nephritis." Clin Nephrol 46, no. 3 (September 1996): 170-175.  Link to Item
    • Telen, MJ, Udani, M, Washington, MK, Levesque, MC, Lloyd, E, and Rao, N. "A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding." J Biol Chem 271, no. 12 (March 22, 1996): 7147-7153.  Link to Item
    • Levesque, MC, and Haynes, BF. "In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression." J Immunol 156, no. 4 (February 15, 1996): 1557-1565.  Link to Item
    • Liao, HX, Lee, DM, Levesque, MC, and Haynes, BF. "N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding." J Immunol 155, no. 8 (October 15, 1995): 3938-3945.  Link to Item
    • Liao, HX, Levesque, MC, Patton, K, Bergamo, B, Jones, D, Moody, MA, Telen, MJ, and Haynes, BF. "Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies." J Immunol 151, no. 11 (December 1, 1993): 6490-6499.  Link to Item
    • Ventimiglia, JB, Levesque, MC, and Chang, TY. "Preparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine." Anal Biochem 157, no. 2 (September 1986): 323-330.  Link to Item

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