Overview
B cell development
Chronic lymphocytic leukemia
Lymphomagenesis and monoclonal B cell lymphocytosis
Familial CLL
Autoimmunity and autoantibody development
Asthma
Endotoxin induced airway disease
Chronic lymphocytic leukemia
Lymphomagenesis and monoclonal B cell lymphocytosis
Familial CLL
Autoimmunity and autoantibody development
Asthma
Endotoxin induced airway disease
Current Appointments & Affiliations
Adjunct Associate Professor in the Department of Medicine
·
2009 - Present
Medicine, Rheumatology and Immunology,
Medicine
Recent Publications
CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant.
Journal Article Leuk Res · July 2008 Nitric oxide synthase (NOS) inhibitors induce chronic lymphocytic leukemia (CLL) cell apoptosis and have potential as CLL therapeutics. We determined the half-maximal concentration (ED(50)) of 22 NOS inhibitors that induced CLL cell death in vitro. There w ... Full text Link to item CiteIdentification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease.
Journal Article Blood · June 15, 2008 Up to 30% of adult patients with sickle cell disease (SCD) will develop pulmonary hypertension (pHTN), a complication associated with significant morbidity and mortality. To identify genetic factors that contribute to risk for pHTN in SCD, we performed ass ... Full text Link to item CiteDeterminants of exhaled nitric oxide levels in healthy, nonsmoking African American adults.
Journal Article J Allergy Clin Immunol · February 2008 Featured Publication BACKGROUND: Asthma is a significant cause of morbidity and mortality for African Americans. Fraction of exhaled nitric oxide (FeNO) levels are increased in patients with asthma, and airway levels of nitric oxide metabolites regulate airway inflammation and ... Full text Link to item CiteRecent Grants
Nitric Oxide Metabolism in Statin-treated Pediatric SLE
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2011Prevention of Chronic Lymphocytic Leukemia (CLL)
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2009Human TNFa-Induced Pre-B Cell Bone Marrow Emigrants
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2009View All Grants
Education, Training & Certifications
Yale University ·
1989
M.D.