Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Rheumatology Fellow, Medicine, Duke University 1993 - 1999
  • Clinical Investigator Pathway, Medicine, Duke University 1991 - 1993
  • Medical Resident, Medicine, Duke University 1989 - 1991
  • M.D., Yale University 1989
• 

  Previous Appointments & Affiliations

  • Associate Professor in Immunology, Immunology, Basic Science Departments 2007 - 2008
  • Associate Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2007 - 2008
  • Assistant Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2000 - 2007
  • Instructor, Temporary in the Department of Medicine, Medicine, Rheumatology and Immunology, Medicine 1999 - 2000
• Expertise
• 

  Global Scholarship

  • Research

    • Kenya (Country) 
    • United Republic of Tanzania (Country) 
• Research
• 

  Selected Grants

  • Nitric Oxide Metabolism in Statin-treated Pediatric SLE awarded by National Institutes of Health 2003 - 2011
  • Prevention of Chronic Lymphocytic Leukemia (CLL) awarded by National Institutes of Health 2007 - 2009
  • Human TNFa-Induced Pre-B Cell Bone Marrow Emigrants awarded by National Institutes of Health 2006 - 2009
  • Inducible NOS as a Treatment Target in CLL awarded by National Institutes of Health 2001 - 2007
  • Hyaluronan mediated nitric oxide production by macrophages awarded by National Institutes of Health 1999 - 2002
  • same awarded by National Institutes of Health 1999 - 2002
  • Immunoregulatory Functions Of The Isoforms Of Cd44 awarded by National Institutes of Health 1993 - 1999
  • Immunoregulatory Functions Of The Isoforms Of Cd44 awarded by National Institutes of Health 1993 - 1998
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Levesque, Marc C., Dipak K. Ghosh, Bethany E. Beasley, Youwei Chen, Alicia D. Volkheimer, Charles W. O’Loughlin, Jon P. Gockerman, Joseph O. Moore, and J Brice Weinberg. “CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant.” Leuk Res 32, no. 7 (July 2008): 1061–70. https://doi.org/10.1016/j.leukres.2007.11.026.
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    • Ashley-Koch, Allison E., Laine Elliott, Melanie E. Kail, Laura M. De Castro, Jude Jonassaint, Terry L. Jackson, Jennifer Price, et al. “Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease.” Blood 111, no. 12 (June 15, 2008): 5721–26. https://doi.org/10.1182/blood-2007-02-074849.
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    • Levesque, Marc C., David W. Hauswirth, Sabrena Mervin-Blake, Carolyn A. Fernandez, Kistie B. Patch, Katie M. Alexander, Sallie Allgood, Patrice D. McNair, Andrew S. Allen, and John S. Sundy. “Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults.” J Allergy Clin Immunol 121, no. 2 (February 2008): 396-402.e3. https://doi.org/10.1016/j.jaci.2007.09.031.
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    • Levesque, Marc C., and E William St Clair. “B cell-directed therapies for autoimmune disease and correlates of disease response and relapse.” J Allergy Clin Immunol 121, no. 1 (January 2008): 13–21. https://doi.org/10.1016/j.jaci.2007.11.030.
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    • Sundy, J. S., D. W. Hauswirth, S. Mervin-Blake, C. A. Fernandez, K. B. Patch, K. M. Alexander, S. Allgood, P. D. McNair, and M. C. Levesque. “Smoking is associated with an age-related decline in exhaled nitric oxide.” Eur Respir J 30, no. 6 (December 2007): 1074–81. https://doi.org/10.1183/09031936.00087807.
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    • Weinberg, J Brice, Alicia D. Volkheimer, Youwei Chen, Bethany E. Beasley, Ning Jiang, Mark C. Lanasa, Daphne Friedman, et al. “Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia.” Am J Hematol 82, no. 12 (December 2007): 1063–70. https://doi.org/10.1002/ajh.20987.
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    • Looney, R John, Betty Diamond, V Michael Holers, Marc C. Levesque, Larry Moreland, Moon H. Nahm, E William St Clair, and E William Autoimmunity Centers of Excellence Immunocompetency Committee. “Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases.” Clin Immunol 123, no. 3 (June 2007): 235–43. https://doi.org/10.1016/j.clim.2007.01.001.
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    • Elliott, Laine, Allison E. Ashley-Koch, Laura De Castro, Jude Jonassaint, Jennifer Price, Kenneth I. Ataga, Marc C. Levesque, et al. “Genetic polymorphisms associated with priapism in sickle cell disease.” Br J Haematol 137, no. 3 (May 2007): 262–67. https://doi.org/10.1111/j.1365-2141.2007.06560.x.
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    • Volkheimer, Alicia D., J Brice Weinberg, Bethany E. Beasley, John F. Whitesides, Jon P. Gockerman, Joseph O. Moore, Garnett Kelsoe, Barbara K. Goodman, and Marc C. Levesque. “Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.” Blood 109, no. 4 (February 15, 2007): 1559–67. https://doi.org/10.1182/blood-2006-05-020644.
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    • Lopansri, Bert K., Nicholas M. Anstey, Gregory J. Stoddard, Esther D. Mwaikambo, Craig S. Boutlis, Emiliana Tjitra, Helena Maniboey, et al. “Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications.” Infect Immun 74, no. 6 (June 2006): 3355–59. https://doi.org/10.1128/IAI.02106-05.
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    • Levesque, Marc C., Youwei Chen, Bethany E. Beasley, Charles W. O’Loughlin, Jon P. Gockerman, Joseph O. Moore, and J Brice Weinberg. “Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.” Leuk Res 30, no. 1 (January 2006): 24–28. https://doi.org/10.1016/j.leukres.2005.05.022.
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    • Levesque, Marc C., and J Brice Weinberg. “The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus.” Curr Mol Med 4, no. 7 (November 2004): 777–86. https://doi.org/10.2174/1566524043359872.
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    • Boutlis, Craig S., Maurine R. Hobbs, Robyn L. Marsh, Mary A. Misukonis, Ariana N. Tkachuk, Moses Lagog, Jennifer Booth, et al. “Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population.” Am J Trop Med Hyg 69, no. 6 (December 2003): 569–73.
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    • Lopansri, Bert K., Nicholas M. Anstey, J Brice Weinberg, Gregory J. Stoddard, Maurine R. Hobbs, Marc C. Levesque, Esther D. Mwaikambo, and Donald L. Granger. “Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production.” Lancet 361, no. 9358 (February 22, 2003): 676–78. https://doi.org/10.1016/S0140-6736(03)12564-0.
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    • Levesque, M. C., M. A. Misukonis, C. W. O’Loughlin, Y. Chen, B. E. Beasley, D. L. Wilson, D. J. Adams, R. Silber, and J. B. Weinberg. “IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells.” Leukemia 17, no. 2 (February 2003): 442–50. https://doi.org/10.1038/sj.leu.2402783.
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    • Oates, Jim C., Marc C. Levesque, Maurine R. Hobbs, Erica Grace Smith, Ivan D. Molano, Grier P. Page, Bruce S. Hill, J Brice Weinberg, Glinda S. Cooper, and Gary S. Gilkeson. “Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.” J Rheumatol 30, no. 1 (January 2003): 60–67.
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    • Hobbs, Maurine R., Venkatachalam Udhayakumar, Marc C. Levesque, Jennifer Booth, Jacquelin M. Roberts, Ariana N. Tkachuk, Ann Pole, et al. “A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children.” Lancet 360, no. 9344 (November 9, 2002): 1468–75. https://doi.org/10.1016/S0140-6736(02)11474-7.
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    • Adams, D. J., M. C. Levesque, J. B. Weinberg, K. L. Smith, J. L. Flowers, J. Moore, O. M. Colvin, and R. Silber. “Nitric oxide enhancement of fludarabine cytotoxicity for B-CLL lymphocytes.” Leukemia 15, no. 12 (December 2001): 1852–59. https://doi.org/10.1038/sj.leu.2402291.
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    • Levesque, M. C., C. W. O’Loughlin, and J. B. Weinberg. “Use of serum-free media to minimize apoptosis of chronic lymphocytic leukemia cells during in vitro culture.” Leukemia 15, no. 8 (August 2001): 1305–7. https://doi.org/10.1038/sj.leu.2402192.
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    • Levesque, M. C., and B. F. Haynes. “Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma.” J Immunol 166, no. 1 (January 1, 2001): 188–96. https://doi.org/10.4049/jimmunol.166.1.188.
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    • Levesque, M. C., D. A. Mackin, J. A. Fleming, and E. W. St Clair. “Serum levels of soluble CD44 in primary Sjögren's syndrome.” J Rheumatol 27, no. 6 (June 2000): 1444–49.
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    • Levesque, M. C., M. R. Hobbs, N. M. Anstey, T. N. Vaughn, J. A. Chancellor, A. Pole, D. J. Perkins, et al. “Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.” J Infect Dis 180, no. 6 (December 1999): 1994–2002. https://doi.org/10.1086/315140.
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    • Levesque, M. C., and B. F. Haynes. “TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44.” Cell Immunol 193, no. 2 (May 1, 1999): 209–18. https://doi.org/10.1006/cimm.1999.1456.
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    • Levesque, M. C., F. E. Ward, D. R. Jeffery, and J. B. Weinberg. “Interferon-beta1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele.” Arthritis Rheum 42, no. 3 (March 1999): 569–73. https://doi.org/10.1002/1529-0131(199904)42:3<569::AID-ANR23>3.0.CO;2-M.
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    • Chang, C. C., C. Y. Lee, E. T. Chang, J. C. Cruz, M. C. Levesque, and T. Y. Chang. “Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner.” J Biol Chem 273, no. 52 (December 25, 1998): 35132–41. https://doi.org/10.1074/jbc.273.52.35132.
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    • Levesque, M. C., C. S. Heinly, L. P. Whichard, and D. D. Patel. “Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium.” Arthritis Rheum 41, no. 12 (December 1998): 2221–29. https://doi.org/10.1002/1529-0131(199812)41:12<2221::AID-ART18>3.0.CO;2-I.
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    • Levesque, M. C., and B. F. Haynes. “Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13.” J Immunol 159, no. 12 (December 15, 1997): 6184–94.
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    • Liu, N. P., W. L. Roberts, L. P. Hale, M. C. Levesque, D. D. Patel, C. L. Lu, and G. J. Jaffe. “Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells.” Invest Ophthalmol Vis Sci 38, no. 10 (September 1997): 2027–37.
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    • Conlon, P. J., C. A. Fischer, M. C. Levesque, S. R. Smith, E. W. St Clair, N. B. Allen, J. A. Fleming, and D. N. Howell. “Clinical, biochemical and pathological predictors of poor response to intravenous cyclophosphamide in patients with proliferative lupus nephritis.” Clin Nephrol 46, no. 3 (September 1996): 170–75.
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    • Telen, M. J., M. Udani, M. K. Washington, M. C. Levesque, E. Lloyd, and N. Rao. “A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding.” J Biol Chem 271, no. 12 (March 22, 1996): 7147–53. https://doi.org/10.1074/jbc.271.12.7147.
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    • Levesque, M. C., and B. F. Haynes. “In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression.” J Immunol 156, no. 4 (February 15, 1996): 1557–65.
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    • Liao, H. X., D. M. Lee, M. C. Levesque, and B. F. Haynes. “N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding.” J Immunol 155, no. 8 (October 15, 1995): 3938–45.
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    • Liao, H. X., M. C. Levesque, K. Patton, B. Bergamo, D. Jones, M. A. Moody, M. J. Telen, and B. F. Haynes. “Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies.” J Immunol 151, no. 11 (December 1, 1993): 6490–99.
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    • Ventimiglia, J. B., M. C. Levesque, and T. Y. Chang. “Preparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine.” Anal Biochem 157, no. 2 (September 1986): 323–30. https://doi.org/10.1016/0003-2697(86)90633-0.
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