Skip to main content

Marcia David Palma

Research Associate, Senior
Molecular Genetics and Microbiology

Research Interests


Marcia David-Palma holds a degree in Biochemistry, a Master’s in Applied Microbiology, and a PhD in Biology with a specialization in Molecular Genetics from the Universidade Nova de Lisboa, Portugal. Her doctoral research provided key insights into the life cycle of the biotechnologically relevant basidiomycete Phaffia rhodozyma, uncovering for the first time, the molecular mechanisms driving the life cycle of a primary homothallic basidiomycete. She also explored the ecological relationships between Phaffia species and their tree hosts, leading to the discovery of a biodiversity hotspot in Australasia and the identification of two novel species: P. australis and P. tasmanica.

Currently a Senior Research Associate at Duke University, Dr. David-Palma focuses on the molecular characterization and evolutionary dynamics of reproductive systems in basidiomycete fungi. Her research spans human pathogenic fungi (Cryptococcus and Malassezia), saprobic fungi with unique karyotype variations (Kwoniella), and biotechnologically important species such as Phaffia rhodozyma. She has extensive expertise in genetic transformation, mating tests and whole-genome sequencing of diverse fungi, contributing to the definition of centromeres and the formation of giant chromosomes in Kwoniella species, the elucidation of life cycle regulation in Phaffia rhodozyma, and the study of pathogenic trait evolution in Cryptococcus species.

Selected Grants


Impact of RNAi and unisexual reproduction on Cryptococcus evolution, drug resistance, and pathogenesis

ResearchPostdoctoral Associate · Awarded by National Institute of Allergy and Infectious Diseases · 1997 - 2026

Malassezia and Candida auris: skin microbiome dysbiosis and de-regulation of cutaneous homeostasis

ResearchResearch Associate · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2026

Structure, function, and evolution of the Cryptococcus MAT locus

ResearchPostdoctoral Associate · Awarded by National Institute of Allergy and Infectious Diseases · 2002 - 2025

Fellowships, Gifts, and Supported Research


Comparative genomic analysis reveals karyotype evolution resulting in giant fungal chromosomes · December 2022 - June 2024 Awarded by: CIFAR Catalyst Fund Awarded a CIFAR Catalyst Funds for the project: Comparative genomic analysis reveals karyotype evolution resulting in giant fungal chromosomes.