Paul Kelly Marcom | Scholars@Duke

Paul Kelly Marcom
Professor of Medicine

Basic Science:
-Germline and somatic genetic changes in breast cancer.

Translational:
-Identification and management of individuals and families with hereditary cancer risk.
-Communication of cancer risk information to individuals and families.
-Breast cancer prevention.
-Optimizing management of early breast cancer.
-Treatment of metastatic breast cancer

Clinically, Dr. Marcom works as a medical oncologist in the multidisciplinary breast cancer clinic. He participates in clinical trials investigating new chemotherapeutic and biologic treatments.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Medical Oncology, Medicine 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1989

Contact Information

10 Bryan Searle Drive, Room 461 Seeley G. Mudd Building, Durham, NC 27710
Duke Box 3147, Durham, NC 27710
marco001@mc.duke.edu (919) 684-3877

Background
Education, Training, & Certifications
- Fellow in Hematology-Oncology, Medicine, Duke University 1992 - 1995
- Medical Resident, Medicine, Duke University 1989 - 1992
- M.D., Baylor University 1989
Duke Appointment History
- Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2013 - 2017
- Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2010 - 2013
- Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2004 - 2010
- Associate in the Department of Medicine, Medicine, Medical Oncology, Medicine 1997 - 2004
- Instructor, Temporary in the Medicine, Medicine, Medical Oncology, Medicine 1997
Research
Selected Grants
- GMI-1359-210 2019 - 2024
- TBCRC 041 Randomized Phase II Trial to Evaluate Alisertib Alone or Combined with Fulvestrant in Women with Advanced, Hormone-Receptor Positive (HR+) Breast Cancer awarded by Mayo Clinic 2019 - 2023
- TBCRC48 A Phase 2 Study of Olaparib Monotherapy in Metastatic Breast Cancer Patients with Germline or Somatic Mutations in DNA Repair Genes "Olaparib Expanded" awarded by Johns Hopkins University 2018 - 2022
- Targeting tumor-specific apoptosis regulation in advanced ER+ breast cancer awarded by Department of Defense 2019 - 2022
- Kastan Gray Foundation Project 2017 - 2021
- Translational Breast Cancer Research Consortium 2019 Infrastructure (BCRF) awarded by Johns Hopkins University 2019 - 2021
- Translational Breast Cancer Research Consortium 2019 Infrastructure - SGK awarded by Johns Hopkins University 2019 - 2021
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2021
- A RANDOMIZED PHASE II STUDY OF PREOPERATIVE CISPLATIN VS PACLITAXEL IN PATIENTS WITH TRIPLE NEGATIVE BREAST CANCER WITHOUT GERMLINE BRCA MUTATIONS: EVALUATING THE HOMOLOGOUS RECOMBINATION DEFICIENCY (HRB) BIOMARKER awarded by Dana Farber Cancer Institute 2014 - 2021
- TBCRC AURORA US:RETROSPECTIVE TISSUE COLLECTION awarded by Johns Hopkins University 2017 - 2021
- Targeting Dormant Breast Cancer Micrometastases to Prevent Disease Relapse 2019 - 2020
- A phase I/Ib, open label study of LSZ102 single agent and LSZ102 in combination with eitherLEE011 (LSZ102 + LEE011) or BYL719 (LSZ102 + BYL719) in patients with advanced or metastatic ER+ breast cancer who have progressed after endocrine therapy. 2016 - 2020
- Deep learning for prognostication in breast cancer 2018 - 2020
- A RANDOMIZED, MULTICENTER, OPEN-LABEL, PHASE III TRIAL COMPARING TRASTUZUMAB PLUS PERTUZUMAB PLUS A TAXANE FOLLOWING ANTHRACYCLINES VERSUS TRASTUZUMAB EMTANSINE PLUS PERTUZUMAB FOLLOWING ANTHRACYCLINES AS ADJUVANT THERAPY IN PATIENTS 2014 - 2020
- Translational Breast Cancer Research Consortium 2018 Infrastructure (BCRF) awarded by Johns Hopkins University 2018 - 2020
- Translational Breast Cancer Research Consortium 2018 Infrastructure - SGK awarded by Johns Hopkins University 2018 - 2020
- Can contrast dynamics in breast MRI predict genomic intra-tumor heterogeneity 2016 - 2020
- A randomized phase II study of adjuvant Trastuzumab emtansine (T-DM1) vs Paclitaxel in combination with Trastuzumab for stage I HER2-positive breast cancer (ATEMPT Trial) awarded by Dana Farber Cancer Institute 2014 - 2020
- Targeting precursor neural (N)-cadherin to eliminate chemotherapy-resistant triple-negative breast tumor cells awarded by Department of Defense 2017 - 2020
- A Phase 1/2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of VT-464 in Patients with Advanced Breast Cancer. 2016 - 2019
- Translational Breast Cancer Research Consortium-2017 Komen Foundation SGK awarded by Johns Hopkins University 2018 - 2019
- RANDOMIZED PHASE II TRIAL OF NEOADJUVANT CISPLATIN VS. DOXORUBICIN/CYCLOPHOSPHAMIDE (¿AC¿) IN WOMEN WITH NEWLY DIAGNOSED BREAST CANCER AND GERMLINE BRCA MUTATIONS awarded by Johns Hopkins University 2015 - 2019
- TBCRC 031 INFORM (Beth Israel) awarded by Beth Israel Deaconess Medical Center 2015 - 2019
- A Phase III, Randomized, Double-blind Study to Evaluate Pembrolizumab plus Chemotherapy vs Placebo plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy for Triple Negative Breast Cancer (TNBC 2017 - 2018
- A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE) in Patients with Metastatic, GPNMB Over-Expressing, Triple-Negative Breast Cancer (CDX011-04) 2014 - 2018
- A PHASE II RANDOMIZED, DOUBLE-BLIND PLACEBO CONTROLLED STUDY OF LETROZOLE WITH OR WITHOUT BYL719 OR BUPARLISIB, FOR THE NEOADJUVANT TREATMENT OF POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR-POSITIVE HER2-NEGATIVE BREAST CANCER 2013 - 2017
- Commericialization of a computational imaging-based biomarker for prognostication in breast cancer 2016 - 2017
- Targeting nuclear FGF receptor to improve chemotherapy response in triple-negative breast cancer awarded by Department of Defense 2013 - 2016
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Randomized Trial of Optimal Type of Aerobic Training in Breast Cancer awarded by National Institutes of Health 2010 - 2014
- Programs in Clinical Effectiveness of Cancer Pharmacogenomics awarded by National Institutes of Health 2009 - 2012
- Markers of short term breast cancer risk in FNA awarded by National Institutes of Health 1995 - 2008
- Phase II trial of Cetuximab & Carboplatin in Basal-like Breast Cancer awarded by National Institutes of Health 1995 - 2008
- Carolina and Georgia Genetics Network Center awarded by National Institutes of Health 1998 - 2008
- Phase II Trial of Estradiol Therapy for Advanced Breast Cancer awarded by National Institutes of Health 2003 - 2005
- Carolina and Georgia Genetics Network Center awarded by National Institutes of Health 1998 - 2004
External Relationships
- Genentech Roche
- National Comprehensive Cancer Center Network
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Tung, Nadine, Banu Arun, Michele R. Hacker, Erin Hofstatter, Deborah L. Toppmeyer, Steven J. Isakoff, Virginia Borges, et al. “TBCRC 031: Randomized Phase II Study of Neoadjuvant Cisplatin Versus Doxorubicin-Cyclophosphamide in Germline BRCA Carriers With HER2-Negative Breast Cancer (the INFORM trial).” J Clin Oncol 38, no. 14 (May 10, 2020): 1539–48. https://doi.org/10.1200/JCO.19.03292.
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  - Gradishar, William J., Benjamin O. Anderson, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Sarah L. Blair, et al. “Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 18, no. 4 (April 2020): 452–78. https://doi.org/10.6004/jnccn.2020.0016.
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  - Kikuchi, Robin, Gloria Broadwater, Rebecca Shelby, Jessica Robertson, Leah L. Zullig, Bailey Maloney, Claudia Meyer, et al. “Detecting geriatric needs in older patients with breast cancer through use of a brief geriatric screening tool.” J Geriatr Oncol 10, no. 6 (November 2019): 968–72. https://doi.org/10.1016/j.jgo.2019.04.010.
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  - Strickler, John H., Christel N. Rushing, Donna Niedzwiecki, Abigail McLeod, Ivy Altomare, Hope E. Uronis, S David Hsu, et al. “A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer.” Bmc Cancer 19, no. 1 (November 1, 2019): 1032. https://doi.org/10.1186/s12885-019-6234-8.
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  - Fayanju, Oluwadamilola M., Karine Yenokyan, Yi Ren, Benjamin A. Goldstein, Ilona Stashko, Steve Power, Madeline J. Thornton, P Kelly Marcom, and E Shelley Hwang. “The effect of treatment on patient-reported distress after breast cancer diagnosis.” Cancer 125, no. 17 (September 1, 2019): 3040–49. https://doi.org/10.1002/cncr.32174.
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  - Dorfman, Caroline S., Sarah S. Arthur, Gretchen G. Kimmick, Kelly W. Westbrook, Paul Kelly Marcom, Cheyenne Corbett, Sara N. Edmond, and Rebecca A. Shelby. “Partner status moderates the relationships between sexual problems and self-efficacy for managing sexual problems and psychosocial quality-of-life for postmenopausal breast cancer survivors taking adjuvant endocrine therapy.” Menopause 26, no. 8 (August 2019): 823–32. https://doi.org/10.1097/GME.0000000000001337.
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  - Tolaney, Sara M., Hao Guo, Sonia Pernas, William T. Barry, Deborah A. Dillon, Lauren Ritterhouse, Bryan P. Schneider, et al. “Seven-Year Follow-Up Analysis of Adjuvant Paclitaxel and Trastuzumab Trial for Node-Negative, Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.” J Clin Oncol 37, no. 22 (August 1, 2019): 1868–75. https://doi.org/10.1200/JCO.19.00066.
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  - Bellon, Jennifer R., Hao Guo, William T. Barry, Chau T. Dang, Denise A. Yardley, Beverly Moy, P Kelly Marcom, et al. “Local-regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial).” Breast Cancer Res Treat 176, no. 2 (July 2019): 303–10. https://doi.org/10.1007/s10549-019-05238-4.
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  - Mazurowski, Maciej A., Ashirbani Saha, Michael R. Harowicz, Elizabeth Hope Cain, Jeffrey R. Marks, and P Kelly Marcom. “Association of distant recurrence-free survival with algorithmically extracted MRI characteristics in breast cancer.” J Magn Reson Imaging 49, no. 7 (June 2019): e231–40. https://doi.org/10.1002/jmri.26648.
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  - Crosby, Erika J., William Gwin, Kimberly Blackwell, Paul K. Marcom, Serena Chang, Holden T. Maecker, Gloria Broadwater, et al. “Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.” Clin Cancer Res 25, no. 9 (May 1, 2019): 2725–36. https://doi.org/10.1158/1078-0432.CCR-18-3102.
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  - Barroso-Sousa, R., W. T. Barry, H. Guo, D. Dillon, Y. B. Tan, K. Fuhrman, W. Osmani, et al. “The immune profile of small HER2-positive breast cancers: a secondary analysis from the APT trial.” Ann Oncol 30, no. 4 (April 2019): 575–81. https://doi.org/10.1093/annonc/mdz047.
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  - Sitlinger, Andrea, Rebecca A. Shelby, Alyssa N. Van Denburg, Heidi White, Sarah N. Edmond, Paul K. Marcom, Hayden B. Bosworth, Francis J. Keefe, and Gretchen G. Kimmick. “Higher symptom burden is associated with lower function in women taking adjuvant endocrine therapy for breast cancer.” J Geriatr Oncol 10, no. 2 (March 2019): 317–21. https://doi.org/10.1016/j.jgo.2018.11.008.
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  - Cain, Elizabeth Hope, Ashirbani Saha, Michael R. Harowicz, Jeffrey R. Marks, P Kelly Marcom, and Maciej A. Mazurowski. “Multivariate machine learning models for prediction of pathologic response to neoadjuvant therapy in breast cancer using MRI features: a study using an independent validation set.” Breast Cancer Res Treat 173, no. 2 (January 2019): 455–63. https://doi.org/10.1007/s10549-018-4990-9.
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  - Devi, Gayathri R., Holly Hough, Nadine Barrett, Massimo Cristofanilli, Beth Overmoyer, Neil Spector, Naoto T. Ueno, et al. “Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium.” J Cancer 10, no. 15 (2019): 3344–51. https://doi.org/10.7150/jca.31176.
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  - Saha, Ashirbani, Michael R. Harowicz, Elizabeth Hope Cain, Allison H. Hall, Eun-Sil Shelley Hwang, Jeffrey R. Marks, Paul Kelly Marcom, and Maciej A. Mazurowski. “Intra-tumor molecular heterogeneity in breast cancer: definitions of measures and association with distant recurrence-free survival.” Breast Cancer Res Treat 172, no. 1 (November 2018): 123–32. https://doi.org/10.1007/s10549-018-4879-7.
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  - Force, Jeremy, Lynn J. Howie, Sara E. Abbott, Rex Bentley, P Kelly Marcom, Gretchen Kimmick, Kelly Westbrook, et al. “Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype.” Clin Breast Cancer 18, no. 5 (October 2018): 410–17. https://doi.org/10.1016/j.clbc.2018.02.010.
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  - McRee, Autumn J., Paul K. Marcom, Dominic T. Moore, William C. Zamboni, Zachary A. Kornblum, Zhiyuan Hu, Rachel Phipps, et al. “A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer.” Clin Breast Cancer 18, no. 4 (August 2018): 289–97. https://doi.org/10.1016/j.clbc.2017.10.014.
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  - Han, H. S., V. Diéras, M. Robson, M. Palácová, P. K. Marcom, A. Jager, I. Bondarenko, et al. “Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: randomized phase II study.” Ann Oncol 29, no. 1 (January 1, 2018): 154–61. https://doi.org/10.1093/annonc/mdx505.
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  - Harowicz, Michael R., Ashirbani Saha, Lars J. Grimm, P Kelly Marcom, Jeffrey R. Marks, E Shelley Hwang, and Maciej A. Mazurowski. “Can algorithmically assessed MRI features predict which patients with a preoperative diagnosis of ductal carcinoma in situ are upstaged to invasive breast cancer?” J Magn Reson Imaging 46, no. 5 (November 2017): 1332–40. https://doi.org/10.1002/jmri.25655.
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  - Buchanan, Adam H., Corrine I. Voils, Joellen M. Schildkraut, Catherine Fine, Nora K. Horick, P Kelly Marcom, Kristi Wiggins, and Celette Sugg Skinner. “Adherence to Recommended Risk Management among Unaffected Women with a BRCA Mutation.” J Genet Couns 26, no. 1 (February 2017): 79–92. https://doi.org/10.1007/s10897-016-9981-6.
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  - Harowicz, Michael R., Timothy J. Robinson, Michaela A. Dinan, Ashirbani Saha, Jeffrey R. Marks, P Kelly Marcom, and Maciej A. Mazurowski. “Algorithms for prediction of the Oncotype DX recurrence score using clinicopathologic data: a review and comparison using an independent dataset.” Breast Cancer Res Treat 162, no. 1 (February 2017): 1–10. https://doi.org/10.1007/s10549-016-4093-4.
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  - Nelson, Erik R., Shenduo Li, Margaret Kennedy, Sturgis Payne, Kelly Kilibarda, Jeffrey Groth, Michelle Bowie, et al. “Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.” Oncotarget 7, no. 51 (December 20, 2016): 84030–42. https://doi.org/10.18632/oncotarget.12767.
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  - Kamal, Arif, Tian Zhang, Steve Power, and P Kelly Marcom. “Is Advanced Imaging in Early-Stage Breast Cancer Ever Warranted? Reconciling Clinical Judgment With Common Quality Measures.” J Natl Compr Canc Netw 14, no. 8 (August 2016): 993–98. https://doi.org/10.6004/jnccn.2016.0106.
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  - Daly, Mary B., Robert Pilarski, Jennifer E. Axilbund, Michael Berry, Saundra S. Buys, Beth Crawford, Meagan Farmer, et al. “Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015.” J Natl Compr Canc Netw 14, no. 2 (February 2016): 153–62. https://doi.org/10.6004/jnccn.2016.0018.
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  - Buchanan, Adam H., Santanu K. Datta, Celette Sugg Skinner, Gail P. Hollowell, Henry F. Beresford, Thomas Freeland, Benjamin Rogers, John Boling, P Kelly Marcom, and Martha B. Adams. “Randomized Trial of Telegenetics vs. In-Person Cancer Genetic Counseling: Cost, Patient Satisfaction and Attendance.” J Genet Couns 24, no. 6 (December 2015): 961–70. https://doi.org/10.1007/s10897-015-9836-6.
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  - Gradishar, William J., Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, et al. “NCCN Guidelines Insights Breast Cancer, Version 1.2016.” J Natl Compr Canc Netw 13, no. 12 (December 2015): 1475–85. https://doi.org/10.6004/jnccn.2015.0176.
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  - Mazurowski, Maciej A., Lars J. Grimm, Jing Zhang, P Kelly Marcom, Sora C. Yoon, Connie Kim, Sujata V. Ghate, and Karen S. Johnson. “Recurrence-free survival in breast cancer is associated with MRI tumor enhancement dynamics quantified using computer algorithms.” Eur J Radiol 84, no. 11 (November 2015): 2117–22. https://doi.org/10.1016/j.ejrad.2015.07.012.
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  - Kimmick, Gretchen, Sara N. Edmond, Hayden B. Bosworth, Jeffrey Peppercorn, Paul K. Marcom, Kimberly Blackwell, Francis J. Keefe, and Rebecca A. Shelby. “Medication taking behaviors among breast cancer patients on adjuvant endocrine therapy.” Breast 24, no. 5 (October 2015): 630–36. https://doi.org/10.1016/j.breast.2015.06.010.
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  - Sutton, Linda M., Joseph Geradts, Erika P. Hamilton, Kathleen A. Havlin, Gretchen G. Kimmick, P Kelly Marcom, Neil L. Spector, et al. “CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers.” J Natl Compr Canc Netw 13, no. 8 (August 2015): 1005–11. https://doi.org/10.6004/jnccn.2015.0121.
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  - Li, Shenduo, Sturgis Payne, Fang Wang, Peter Claus, Zuowei Su, Jeffrey Groth, Joseph Geradts, et al. “Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance.” Breast Cancer Res 17 (July 4, 2015): 91. https://doi.org/10.1186/s13058-015-0590-3.
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  - Bossuyt, V., E. Provenzano, W. F. Symmans, J. C. Boughey, C. Coles, G. Curigliano, J. M. Dixon, et al. “Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration.” Ann Oncol 26, no. 7 (July 2015): 1280–91. https://doi.org/10.1093/annonc/mdv161.
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  - Silva, Grace O., Xiaping He, Joel S. Parker, Michael L. Gatza, Lisa A. Carey, Jack P. Hou, Stacy L. Moulder, et al. “Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer.” Breast Cancer Res Treat 152, no. 2 (July 2015): 347–56. https://doi.org/10.1007/s10549-015-3476-2.
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  - Ruddy, Kathryn J., Hao Guo, William Barry, Chau T. Dang, Denise A. Yardley, Beverly Moy, P Kelly Marcom, et al. “Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial).” Breast Cancer Res Treat 151, no. 3 (June 2015): 589–96. https://doi.org/10.1007/s10549-015-3426-z.
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  - Gradishar, William J., Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, et al. “Breast Cancer Version 2.2015.” J Natl Compr Canc Netw 13, no. 4 (April 2015): 448–75. https://doi.org/10.6004/jnccn.2015.0060.
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  - Yadav, Budhi S., S. C. Sharma, Tyler P. Robin, Sharon Sams, Anothony D. Elias, Virginia Kaklamani, P. Kelly Marcom, Sara Schaefer, and Gloria J. Morris. “Synchronous primary carcinoma of breast and ovary versus ovarian metastases.” Seminars in Oncology 42, no. 2 (April 2015): e13–24. https://doi.org/10.1053/j.seminoncol.2014.12.020.
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  - Magbanua, Mark Jesus M., Lisa A. Carey, Amy DeLuca, Jimmy Hwang, Janet H. Scott, Mothaffar F. Rimawi, Erica L. Mayer, et al. “Circulating tumor cell analysis in metastatic triple-negative breast cancers.” Clin Cancer Res 21, no. 5 (March 1, 2015): 1098–1105. https://doi.org/10.1158/1078-0432.CCR-14-1948.
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  - Grimm, Lars J., Karen S. Johnson, P Kelly Marcom, Jay A. Baker, and Mary S. Soo. “Can breast cancer molecular subtype help to select patients for preoperative MR imaging?” Radiology 274, no. 2 (February 2015): 352–58. https://doi.org/10.1148/radiol.14140594.
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  - Tolaney, Sara M., William T. Barry, Chau T. Dang, Denise A. Yardley, Beverly Moy, P Kelly Marcom, Kathy S. Albain, et al. “Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer.” N Engl J Med 372, no. 2 (January 8, 2015): 134–41. https://doi.org/10.1056/NEJMoa1406281.
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  - Barry, William T., Charles M. Perou, P Kelly Marcom, Lisa A. Carey, and Joseph G. Ibrahim. “The use of Bayesian hierarchical models for adaptive randomization in biomarker-driven phase II studies.” J Biopharm Stat 25, no. 1 (2015): 66–88. https://doi.org/10.1080/10543406.2014.919933.
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  - Li, S., S. Payne, F. Wang, P. Claus, Z. Su, J. Groth, J. Geradts, et al. “Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance.” Breast Cancer Research, 2015. https://doi.org/10.1186/s13058-015-0590-3.
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  - Shelby, Rebecca A., Sara N. Edmond, Anava A. Wren, Francis J. Keefe, Jeffrey M. Peppercorn, Paul K. Marcom, Kimberly L. Blackwell, and Gretchen G. Kimmick. “Self-efficacy for coping with symptoms moderates the relationship between physical symptoms and well-being in breast cancer survivors taking adjuvant endocrine therapy.” Support Care Cancer 22, no. 10 (October 2014): 2851–59. https://doi.org/10.1007/s00520-014-2269-1.
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  - Daly, Mary B., Robert Pilarski, Jennifer E. Axilbund, Saundra S. Buys, Beth Crawford, Susan Friedman, Judy E. Garber, et al. “Genetic/familial high-risk assessment: breast and ovarian, version 1.2014.” J Natl Compr Canc Netw 12, no. 9 (September 2014): 1326–38. https://doi.org/10.6004/jnccn.2014.0127.
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  - Anders, Carey, Allison M. Deal, Vandana Abramson, Minetta C. Liu, Anna M. Storniolo, John T. Carpenter, Shannon Puhalla, et al. “TBCRC 018: phase II study of iniparib in combination with irinotecan to treat progressive triple negative breast cancer brain metastases.” Breast Cancer Res Treat 146, no. 3 (August 2014): 557–66. https://doi.org/10.1007/s10549-014-3039-y.
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  - Gradishar, William J., Benjamin O. Anderson, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, et al. “Breast cancer version 3.2014.” J Natl Compr Canc Netw 12, no. 4 (April 2014): 542–90. https://doi.org/10.6004/jnccn.2014.0058.
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  - Kamal, Arif H., Steve Power, Gloria Broadwater, Audrey R. Holland, and Paul K. Marcom. “Optimizing the quality of breast cancer biomarker use at Duke Cancer Institute.” J Natl Compr Canc Netw 12 Suppl 1 (February 2014): S21–24. https://doi.org/10.6004/jnccn.2014.0209.
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  - Anders, C., A. M. Deal, V. Abramson, M. C. Liu, A. M. Storniolo, J. T. Carpenter, S. Puhalla, et al. “TBCRC 018: Phase II study of iniparib in combination with irinotecan to treat progressive triple negative breast cancer brain metastases.” Breast Cancer Research and Treatment 146, no. 3 (January 1, 2014): 557–66. https://doi.org/10.1007/s10549-014-3039-y.
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  - Gwin, W. R., and P. K. Marcom. “Ethinylestradiol is beneficial for postmenopausal patients with heavily pre-treated metastatic breast cancer after prior aromatase inhibitor treatment: A prospective study.” Breast Diseases 25, no. 4 (January 1, 2014): 326–27. https://doi.org/10.1016/j.breastdis.2014.10.004.
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  - Hamilton, Erika, Gretchen Kimmick, Judith Hopkins, P Kelly Marcom, Gloria Rocha, Renee Welch, Gloria Broadwater, and Kimberly Blackwell. “Nab-paclitaxel/bevacizumab/carboplatin chemotherapy in first-line triple negative metastatic breast cancer.” Clin Breast Cancer 13, no. 6 (December 2013): 416–20. https://doi.org/10.1016/j.clbc.2013.08.003.
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  - Peppercorn, Jeffrey, Erika Hamilton, Paul Kelly Marcom, Laura Beskow, and Gary H. Lyman. “Pharmacogenetic testing in the face of unclear clinical efficacy: lessons from cytochrome P450 2D6 for tamoxifen.” Cancer 119, no. 20 (October 15, 2013): 3703–9. https://doi.org/10.1002/cncr.28263.
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  - Greenup, Rachel, Adam Buchanan, Wendy Lorizio, Keelia Rhoads, Salina Chan, Tracey Leedom, Robin King, et al. “Prevalence of BRCA mutations among women with triple-negative breast cancer (TNBC) in a genetic counseling cohort.” Ann Surg Oncol 20, no. 10 (October 2013): 3254–58. https://doi.org/10.1245/s10434-013-3205-1.
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  - Jones, Lee W., Diane R. Fels, Miranda West, Jason D. Allen, Gloria Broadwater, William T. Barry, Lee G. Wilke, et al. “Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.” Cancer Prev Res (Phila) 6, no. 9 (September 2013): 925–37. https://doi.org/10.1158/1940-6207.CAPR-12-0416.
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  - Theriault, Richard L., Robert W. Carlson, Craig Allred, Benjamin O. Anderson, Harold J. Burstein, Stephen B. Edge, William B. Farrar, et al. “Breast cancer, version 3.2013: featured updates to the NCCN guidelines.” J Natl Compr Canc Netw 11, no. 7 (July 2013): 753–60. https://doi.org/10.6004/jnccn.2013.0098.
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  - Edmond, Sara N., Rebecca A. Shelby, Gretchen G. Kimmick, Paul K. Marcom, Jeffrey M. Peppercorn, and Francis J. Keefe. “Symptom communication in breast cancer: relationships of holding back and self-efficacy for communication to symptoms and adjustment.” J Psychosoc Oncol 31, no. 6 (2013): 698–711. https://doi.org/10.1080/07347332.2013.835023.
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  - Johnson, Karen S., Rex C. Bentley, P. Kelly Marcom, and Jay A. Baker. “Pseudoangiomatous stromal hyperplasia (PASH) causing massive breast enlargement: MRI findings.” Breast J 18, no. 6 (November 2012): 600–601. https://doi.org/10.1111/tbj.12026.
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  - Vaz-Luis, Ines, Rebecca A. Ottesen, Melissa E. Hughes, P Kelly Marcom, Beverly Moy, Hope S. Rugo, Richard L. Theriault, et al. “Impact of hormone receptor status on patterns of recurrence and clinical outcomes among patients with human epidermal growth factor-2-positive breast cancer in the National Comprehensive Cancer Network: a prospective cohort study.” Breast Cancer Res 14, no. 5 (October 1, 2012): R129. https://doi.org/10.1186/bcr3324.
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  - Strickler, John H., Alexander N. Starodub, Jingquan Jia, Kellen L. Meadows, Andrew B. Nixon, Andrew Dellinger, Michael A. Morse, et al. “Phase I study of bevacizumab, everolimus, and panobinostat (LBH-589) in advanced solid tumors.” Cancer Chemother Pharmacol 70, no. 2 (August 2012): 251–58. https://doi.org/10.1007/s00280-012-1911-1.
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  - Carey, Lisa A., Hope S. Rugo, P Kelly Marcom, Erica L. Mayer, Francisco J. Esteva, Cynthia X. Ma, Minetta C. Liu, et al. “TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer.” J Clin Oncol 30, no. 21 (July 20, 2012): 2615–23. https://doi.org/10.1200/JCO.2010.34.5579.
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  - Carlson, Robert W., D Craig Allred, Benjamin O. Anderson, Harold J. Burstein, Stephen B. Edge, William B. Farrar, Andres Forero, et al. “Metastatic breast cancer, version 1.2012: featured updates to the NCCN guidelines.” J Natl Compr Canc Netw 10, no. 7 (July 1, 2012): 821–29. https://doi.org/10.6004/jnccn.2012.0086.
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  - Hassett, Michael J., Samuel M. Silver, Melissa E. Hughes, Douglas W. Blayney, Stephen B. Edge, James G. Herman, Clifford A. Hudis, et al. “Adoption of gene expression profile testing and association with use of chemotherapy among women with breast cancer.” J Clin Oncol 30, no. 18 (June 20, 2012): 2218–26. https://doi.org/10.1200/JCO.2011.38.5740.
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  - Ellis, Matthew J., Li Ding, Dong Shen, Jingqin Luo, Vera J. Suman, John W. Wallis, Brian A. Van Tine, et al. “Whole-genome analysis informs breast cancer response to aromatase inhibition.” Nature 486, no. 7403 (June 10, 2012): 353–60. https://doi.org/10.1038/nature11143.
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  - Acharya, Chaitanya R., David S. Hsu, Carey K. Anders, Ariel Anguiano, Kelly H. Salter, Kelli S. Walters, Richard C. Redman, et al. “Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13):1574-1587.” Jama 307, no. 5 (February 1, 2012): 453. https://doi.org/10.1001/jama.2012.2.
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  - Salter, K. H., C. R. Acharya, K. S. Walters, R. Redman, A. Anguiano, K. S. Garman, C. K. Anders, et al. “An Integrated Approach to the Prediction of Chemotherapeutic Response in Patients with Breast Cancer.” Plos One 6, no. 9 (December 1, 2011). https://doi.org/10.1371/journal.pone.0001908.
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  - Herold, Christina I., Vijaya Chadaram, Bercedis L. Peterson, P Kelly Marcom, Judith Hopkins, Gretchen G. Kimmick, Justin Favaro, et al. “Phase II trial of dasatinib in patients with metastatic breast cancer using real-time pharmacodynamic tissue biomarkers of Src inhibition to escalate dosing.” Clin Cancer Res 17, no. 18 (September 15, 2011): 6061–70. https://doi.org/10.1158/1078-0432.CCR-11-1071.
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  - Dominici, Laura, Julie Najita, Melissa Hughes, Joyce Niland, Paul Marcom, Yu-Ning Wong, Bradford Carter, et al. “Surgery of the primary tumor does not improve survival in stage IV breast cancer.” Breast Cancer Res Treat 129, no. 2 (September 2011): 459–65. https://doi.org/10.1007/s10549-011-1648-2.
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  - Armstrong, Andrew J., Matthew S. Marengo, Sebastian Oltean, Gabor Kemeny, Rhonda L. Bitting, James D. Turnbull, Christina I. Herold, Paul K. Marcom, Daniel J. George, and Mariano A. Garcia-Blanco. “Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers.” Mol Cancer Res 9, no. 8 (August 2011): 997–1007. https://doi.org/10.1158/1541-7786.MCR-10-0490.
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  - Bild, A. H., J. S. Parker, A. M. Gustafson, C. R. Acharya, K. A. Hoadley, C. Anders, P. K. Marcom, et al. “Correction: An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer.” Breast Cancer Research 13, no. 4 (July 12, 2011). https://doi.org/10.1186/bcr2909.
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  - Ellis, Matthew J., Vera J. Suman, Jeremy Hoog, Li Lin, Jacqueline Snider, Aleix Prat, Joel S. Parker, et al. “Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype--ACOSOG Z1031.” J Clin Oncol 29, no. 17 (June 10, 2011): 2342–49. https://doi.org/10.1200/JCO.2010.31.6950.
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  - Carlson, Robert W., D Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W Bradford Carter, Stephen B. Edge, John K. Erban, et al. “Invasive breast cancer.” J Natl Compr Canc Netw 9, no. 2 (February 2011): 136–222. https://doi.org/10.6004/jnccn.2011.0016.
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  - Il’yasova, Dora, Kelly Kennedy, Ivan Spasojevic, Frances Wang, Adviye A. Tolun, Karel Base, Sarah P. Young, et al. “Individual responses to chemotherapy-induced oxidative stress.” Breast Cancer Res Treat 125, no. 2 (January 2011): 583–89. https://doi.org/10.1007/s10549-010-1158-7.
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  - Moorman, Patricia G., Edwin S. Iversen, P Kelly Marcom, Jeffrey R. Marks, Frances Wang, Frances Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Eunjung Lee, et al. “Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.” Breast Cancer Res Treat 124, no. 2 (November 2010): 441–51. https://doi.org/10.1007/s10549-010-0842-y.
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  - Rumble, Meredith E., Francis J. Keefe, Jack D. Edinger, Glenn Affleck, P Kelly Marcom, and Heather S. Shaw. “Contribution of cancer symptoms, dysfunctional sleep related thoughts, and sleep inhibitory behaviors to the insomnia process in breast cancer survivors: a daily process analysis.” Sleep 33, no. 11 (November 2010): 1501–9. https://doi.org/10.1093/sleep/33.11.1501.
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  - Jones, Lee W., Pamela S. Douglas, Neil D. Eves, P Kelly Marcom, William E. Kraus, James E. Herndon, Brant A. Inman, Jason D. Allen, and Jeffrey Peppercorn. “Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer.” Bmc Cancer 10 (October 6, 2010): 531. https://doi.org/10.1186/1471-2407-10-531.
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  - Carlson, Robert W., D Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W Bradford Carter, Stephen B. Edge, John K. Erban, et al. “Breast cancer: noninvasive and special situations.” J Natl Compr Canc Netw 8, no. 10 (October 2010): 1182–1207. https://doi.org/10.6004/jnccn.2010.0087.
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  - Lipkus, Isaac M., Ellen Peters, Gretchen Kimmick, Vlayka Liotcheva, and Paul Marcom. “Breast cancer patients' treatment expectations after exposure to the decision aid program adjuvant online: the influence of numeracy.” Med Decis Making 30, no. 4 (July 2010): 464–73. https://doi.org/10.1177/0272989X09360371.
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  - Il’yasova, Dora, Ivan Spasojevic, Frances Wang, Adviye A. Tolun, Karel Base, Sarah P. Young, P Kelly Marcom, et al. “Urinary biomarkers of oxidative status in a clinical model of oxidative assault.” Cancer Epidemiol Biomarkers Prev 19, no. 6 (June 2010): 1506–10. https://doi.org/10.1158/1055-9965.EPI-10-0211.
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  - Barry, William T., Dawn N. Kernagis, Holly K. Dressman, Ryan J. Griffis, J’vonne D. Hunter, John A. Olson, Jeff R. Marks, et al. “Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome.” J Clin Oncol 28, no. 13 (May 1, 2010): 2198–2206. https://doi.org/10.1200/JCO.2009.26.7245.
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  - Daly, Mary B., Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, et al. “Genetic/familial high-risk assessment: breast and ovarian.” J Natl Compr Canc Netw 8, no. 5 (May 2010): 562–94. https://doi.org/10.6004/jnccn.2010.0043.
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  - Tebbit, Christopher L., Jun Zhai, Brian R. Untch, Matthew J. Ellis, Holly K. Dressman, Rex C. Bentley, Jay A. Baker, et al. “Novel tumor sampling strategies to enable microarray gene expression signatures in breast cancer: a study to determine feasibility and reproducibility in the context of clinical care.” Breast Cancer Res Treat 118, no. 3 (December 2009): 635–43. https://doi.org/10.1007/s10549-008-0301-1.
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  - Ellis, Matthew J., Feng Gao, Farrokh Dehdashti, Donna B. Jeffe, P Kelly Marcom, Lisa A. Carey, Maura N. Dickler, et al. “Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study.” Jama 302, no. 7 (August 19, 2009): 774–80. https://doi.org/10.1001/jama.2009.1204.
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  - Il’yasova, Dora, Gabriel Mixon, Frances Wang, P Kelly Marcom, Jeffrey Marks, Ivan Spasojevich, Neal Craft, Francisco Arredondo, and Richard DiGiulio. “Markers of oxidative status in a clinical model of oxidative assault: a pilot study in human blood following doxorubicin administration.” Biomarkers 14, no. 5 (August 2009): 321–25. https://doi.org/10.1080/13547500902946757.
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  - Olson, John A., G Thomas Budd, Lisa A. Carey, Lyndsay A. Harris, Laura J. Esserman, Gini F. Fleming, Paul K. Marcom, et al. “Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial.” J Am Coll Surg 208, no. 5 (May 2009): 906–14. https://doi.org/10.1016/j.jamcollsurg.2009.01.035.
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  - Partridge, Ann H., A. C. Wolff, P. K. Marcom, P. A. Kaufman, L. Zhang, R. Gelman, C. Moore, et al. “The impact of sharing results of a randomized breast cancer clinical trial with study participants.” Breast Cancer Res Treat 115, no. 1 (May 2009): 123–29. https://doi.org/10.1007/s10549-008-0057-7.
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  - Carlson, Robert W., D Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W Bradford Carter, Stephen B. Edge, John K. Erban, et al. “Breast cancer. Clinical practice guidelines in oncology.” J Natl Compr Canc Netw 7, no. 2 (February 2009): 122–92. https://doi.org/10.6004/jnccn.2009.0012.
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  - Bild, Andrea H., Joel S. Parker, Adam M. Gustafson, Chaitanya R. Acharya, Katherine A. Hoadley, Carey Anders, P Kelly Marcom, et al. “An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer.” Breast Cancer Res 11, no. 4 (2009): R55. https://doi.org/10.1186/bcr2344.
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  - Buchanan, A. H., C. S. Skinner, B. Calingaert, J. M. Schildkraut, R. H. King, and P. K. Marcom. “Cancer genetic counseling in rural north carolina oncology clinics: Program establishment and patient characteristics.” Community Oncology 6, no. 2 (January 1, 2009): 70–77. https://doi.org/10.1016/S1548-5315(11)70213-3.
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  - Anders, C., P. K. Marcom, B. Peterson, L. Gu, S. Unruhe, R. Welch, P. Lyons, et al. “A pilot study of predictive markers of chemotherapy-related amenorrhea among premenopausal women with early stage breast cancer (Cancer Investigation 26, 3, (286-295)).” Cancer Investigation 26, no. 10 (December 1, 2008): 1068. https://doi.org/10.1080/07357900802660220.
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  - Herold, Christina I., and P Kelly Marcom. “Primary systemic therapy in breast cancer: past lessons and new approaches.” Cancer Invest 26, no. 10 (December 2008): 1052–59. https://doi.org/10.1080/07357900802123260.
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  - Anders, Carey K., David S. Hsu, Gloria Broadwater, Chaitanya R. Acharya, John A. Foekens, Yi Zhang, Yixin Wang, et al. “Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression.” J Clin Oncol 26, no. 20 (July 10, 2008): 3324–30. https://doi.org/10.1200/JCO.2007.14.2471.
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  - Polite, Blase N., Constance Cirrincione, Gini F. Fleming, Donald A. Berry, Andrew Seidman, Hyman Muss, Larry Norton, et al. “Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B.” J Clin Oncol 26, no. 16 (June 1, 2008): 2659–65. https://doi.org/10.1200/JCO.2007.13.9782.
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  - Liu, Minetta C., George D. Demetri, Donald A. Berry, Larry Norton, Gloria Broadwater, Nicholas J. Robert, David Duggan, et al. “Dose-escalation of filgrastim does not improve efficacy: clinical tolerability and long-term follow-up on CALGB study 9141 adjuvant chemotherapy for node-positive breast cancer patients using dose-intensified doxorubicin plus cyclophosphamide followed by paclitaxel.” Cancer Treat Rev 34, no. 3 (May 2008): 223–30. https://doi.org/10.1016/j.ctrv.2007.11.004.
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  - Olson, John A., and Paul K. Marcom. “Benefit or bias? The role of surgery to remove the primary tumor in patients with metastatic breast cancer.” Ann Surg 247, no. 5 (May 2008): 739–40. https://doi.org/10.1097/SLA.0b013e3181706140.
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  - Acharya, Chaitanya R., David S. Hsu, Carey K. Anders, Ariel Anguiano, Kelly H. Salter, Kelli S. Walters, Richard C. Redman, et al. “Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer.” Jama 299, no. 13 (April 2, 2008): 1574–87. https://doi.org/10.1001/jama.299.13.1574.
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  - Salter, Kelly H., Chaitanya R. Acharya, Kelli S. Walters, Richard Redman, Ariel Anguiano, Katherine S. Garman, Carey K. Anders, et al. “An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer.” Plos One 3, no. 4 (April 2, 2008): e1908. https://doi.org/10.1371/journal.pone.0001908.
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  - Anders, Carey, P Kelly Marcom, Bercedis Peterson, Lin Gu, Sue Unruhe, Renee Welch, Peggy Lyons, et al. “A pilot study of predictive markers of chemotherapy-related amenorrhea among premenopausal women with early stage breast cancer.” Cancer Invest 26, no. 3 (April 2008): 286–95. https://doi.org/10.1080/07357900701829777.
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  - Seidman, Andrew D., Donald Berry, Constance Cirrincione, Lyndsay Harris, Hyman Muss, P Kelly Marcom, Grandella Gipson, et al. “Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840.” J Clin Oncol 26, no. 10 (April 1, 2008): 1642–49. https://doi.org/10.1200/JCO.2007.11.6699.
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  - Demark-Wahnefried, Wendy, L Douglas Case, Kimberly Blackwell, P Kelly Marcom, William Kraus, Noreen Aziz, Denise Clutter Snyder, Jeffrey K. Giguere, and Edward Shaw. “Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.” Clin Breast Cancer 8, no. 1 (February 2008): 70–79. https://doi.org/10.3816/CBC.2008.n.005.
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  - Anders, Carey K., Chaitanya R. Acharya, David S. Hsu, Gloria Broadwater, Katherine Garman, John A. Foekens, Yi Zhang, et al. “Age-specific differences in oncogenic pathway deregulation seen in human breast tumors.” Plos One 3, no. 1 (January 2, 2008): e1373. https://doi.org/10.1371/journal.pone.0001373.
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  - Morse, Michael A., Amy Hobeika, Takuya Osada, Donna Niedzwiecki, Paul Kelly Marcom, Kimberly L. Blackwell, Carey Anders, Gayathri R. Devi, H Kim Lyerly, and Timothy M. Clay. “Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2.” J Transl Med 5 (September 6, 2007): 42. https://doi.org/10.1186/1479-5876-5-42.
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  - Burstein, Harold J., Aparna Keshaviah, Ari D. Baron, Ronald D. Hart, Rosemary Lambert-Falls, P Kelly Marcom, Rebecca Gelman, and Eric P. Winer. “Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study.” Cancer 110, no. 5 (September 1, 2007): 965–72. https://doi.org/10.1002/cncr.22885.
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  - Lehman, Constance D., Claudine Isaacs, Mitchell D. Schnall, Etta D. Pisano, Susan M. Ascher, Paul T. Weatherall, David A. Bluemke, et al. “Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study.” Radiology 244, no. 2 (August 2007): 381–88. https://doi.org/10.1148/radiol.2442060461.
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  - Marcom, P. K. “Genetic Nurse Counsellors Can Be An Acceptable and Cost-effective Alternative to Clinical Geneticists for Breast Cancer Risk Genetic Counselling. Evidence From Two Parallel Randomised Controlled Equivalence Trials.” Breast Diseases 18, no. 2 (July 1, 2007): 212. https://doi.org/10.1016/S1043-321X(07)80287-6.
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  - Marcom, P Kelly, Claudine Isaacs, Lyndsay Harris, Zee Wang Wong, Aruna Kommarreddy, Nellie Novielli, Gretchen Mann, Yu Tao, and Matthew J. Ellis. “The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers.” Breast Cancer Res Treat 102, no. 1 (March 2007): 43–49. https://doi.org/10.1007/s10549-006-9307-8.
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  - Bean, Gregory R., Catherine Ibarra Drendall, Vanessa K. Goldenberg, Joseph C. Baker, Michelle M. Troch, Carolyn Paisie, Lee G. Wilke, et al. “Hypermethylation of the breast cancer-associated gene 1 promoter does not predict cytologic atypia or correlate with surrogate end points of breast cancer risk.” Cancer Epidemiol Biomarkers Prev 16, no. 1 (January 2007): 50–56. https://doi.org/10.1158/1055-9965.EPI-06-0598.
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  - Daly, M. B., J. E. Axilbund, E. Bryant, S. Buys, C. Eng, S. Friedman, L. J. Esserman, et al. “Genetic/familial high-risk assessment: Breast and ovarian. Clinical Practice Guidelines in Oncology™.” Jnccn Journal of the National Comprehensive Cancer Network 4, no. 2 (February 1, 2006): 156–76.
  - Daly, Mary B., Jennifer E. Axilbund, Eileen Bryant, Saundra Buys, Charis Eng, Susan Friedman, Laura J. Esserman, et al. “Genetic/familial high-risk assessment: breast and ovarian.” J Natl Compr Canc Netw 4, no. 2 (February 2006): 156–76. https://doi.org/10.6004/jnccn.2006.0016.
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  - Dressman, Holly K., Christopher Hans, Andrea Bild, John A. Olson, Eric Rosen, P Kelly Marcom, Vlayka B. Liotcheva, et al. “Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.” Clin Cancer Res 12, no. 3 Pt 1 (February 1, 2006): 819–26. https://doi.org/10.1158/1078-0432.CCR-05-1447.
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  - Burris, Howard A., Herbert I. Hurwitz, E Claire Dees, Afshin Dowlati, Kimberly L. Blackwell, Bert O’Neil, Paul K. Marcom, et al. “Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas.” J Clin Oncol 23, no. 23 (August 10, 2005): 5305–13. https://doi.org/10.1200/JCO.2005.16.584.
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  - Spector, Neil L., Wenle Xia, Howard Burris, Herbert Hurwitz, E Claire Dees, Afshin Dowlati, Bert O’Neil, et al. “Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies.” J Clin Oncol 23, no. 11 (April 10, 2005): 2502–12. https://doi.org/10.1200/JCO.2005.12.157.
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  - Bean, Gregory R., Victoria Scott, Lisa Yee, Brooke Ratliff-Daniel, Michelle M. Troch, Pearl Seo, Michelle L. Bowie, et al. “Retinoic acid receptor-beta2 promoter methylation in random periareolar fine needle aspiration.” Cancer Epidemiol Biomarkers Prev 14, no. 4 (April 2005): 790–98. https://doi.org/10.1158/1055-9965.EPI-04-0580.
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  - Miller, Kathy D., Linnea I. Chap, Frankie A. Holmes, Melody A. Cobleigh, P Kelly Marcom, Louis Fehrenbacher, Maura Dickler, et al. “Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer.” J Clin Oncol 23, no. 4 (February 1, 2005): 792–99. https://doi.org/10.1200/JCO.2005.05.098.
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  - Gradishar, W. J., L. A. Meza, B. Amin, D. Samid, T. Hill, Y. M. Chen, E. E. Lower, P. K. Marcom, and S. Iqbal. “Capecitabine plus paclitaxel as front-line combination therapy for metastatic breast cancer: A multicenter phase II study.” Women’S Oncology Review 4, no. 4 (December 1, 2004): 283–85. https://doi.org/10.1080/14733400500034472.
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  - Jones, E. L., L. R. Prosnitz, M. W. Dewhirst, P. K. Marcom, P. H. Hardenbergh, L. B. Marks, D. M. Brizel, Z. Vujaskovic, and T. A. Buchholz. “Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer.” Women’S Oncology Review 4, no. 3 (September 1, 2004): 221–22. https://doi.org/10.1080/14733400400012958.
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  - Jones, Ellen L., Leonard R. Prosnitz, Mark W. Dewhirst, P Kelly Marcom, Patricia H. Hardenbergh, Lawrence B. Marks, David M. Brizel, and Zeljko Vujaskovic. “Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer.” Clin Cancer Res 10, no. 13 (July 1, 2004): 4287–93. https://doi.org/10.1158/1078-0432.CCR-04-0133.
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  - Gradishar, William J., Luis A. Meza, Bipinkumar Amin, Dvorit Samid, Todd Hill, Yin-Miao Chen, Elyse E. Lower, and P Kelly Marcom. “Capecitabine plus paclitaxel as front-line combination therapy for metastatic breast cancer: a multicenter phase II study.” J Clin Oncol 22, no. 12 (June 15, 2004): 2321–27. https://doi.org/10.1200/JCO.2004.12.128.
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  - Burstein, Harold J., Lyndsay N. Harris, P Kelly Marcom, Rosemary Lambert-Falls, Kathleen Havlin, Beth Overmoyer, Robert J. Friedlander, et al. “Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm.” J Clin Oncol 21, no. 15 (August 1, 2003): 2889–95. https://doi.org/10.1200/JCO.2003.02.018.
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  - Partridge, Ann H., Harold J. Burstein, Rebecca S. Gelman, P Kelly Marcom, and Eric P. Winer. “Do patients participating in clinical trials want to know study results?” J Natl Cancer Inst 95, no. 6 (March 19, 2003): 491–92. https://doi.org/10.1093/jnci/95.6.491.
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  - Dietze, Eric C., L Elizabeth Caldwell, Kelly Marcom, Steven J. Collins, Lisa Yee, Karen Swisshelm, Katherine B. Hobbs, Gregory R. Bean, and Victoria L. Seewaldt. “Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.” Microsc Res Tech 59, no. 1 (October 1, 2002): 23–40. https://doi.org/10.1002/jemt.10174.
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  - Skinner, Celette Sugg, Joellen M. Schildkraut, Donald Berry, Brian Calingaert, P Kelly Marcom, Jeremy Sugarman, Eric P. Winer, J Dirk Iglehart, P Andrew Futreal, and Barbara K. Rimer. “Pre-counseling education materials for BRCA testing: does tailoring make a difference?” Genet Test 6, no. 2 (2002): 93–105. https://doi.org/10.1089/10906570260199348.
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  - Demark-Wahnefried, W., B. L. Peterson, E. P. Winer, L. Marks, N. Aziz, P. K. Marcom, K. Blackwell, and B. K. Rimer. “Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy.” J Clin Oncol 19, no. 9 (May 1, 2001): 2381–89. https://doi.org/10.1200/JCO.2001.19.9.2381.
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  - Miron, A., J. M. Schildkraut, B. K. Rimer, E. P. Winer, C. Sugg Skinner, P. A. Futreal, D. Culler, et al. “Testing for hereditary breast and ovarian cancer in the southeastern United States.” Ann Surg 231, no. 5 (May 2000): 624–34. https://doi.org/10.1097/00000658-200005000-00002.
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  - Burstein, H. J., M. J. Ramirez, W. P. Petros, K. D. Clarke, M. A. Warmuth, P. K. Marcom, U. A. Matulonis, L. M. Parker, L. N. Harris, and E. P. Winer. “Phase I study of Doxil and vinorelbine in metastatic breast cancer.” Ann Oncol 10, no. 9 (September 1999): 1113–16. https://doi.org/10.1023/a:1008323200102.
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  - Ortel, T. L., L. A. Charles, F. G. Keller, P. K. Marcom, H. N. Oldham, W. H. Kane, and B. G. Macik. “Topical thrombin and acquired coagulation factor inhibitors: clinical spectrum and laboratory diagnosis.” Am J Hematol 45, no. 2 (February 1994): 128–35. https://doi.org/10.1002/ajh.2830450206.
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  - Kirkland, K. B., P. K. Marcom, D. J. Sexton, J. S. Dumler, and D. H. Walker. “Rocky Mountain spotted fever complicated by gangrene: report of six cases and review.” Clin Infect Dis 16, no. 5 (May 1993): 629–34. https://doi.org/10.1093/clind/16.5.629.
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  - Noebels, J. L., P. K. Marcom, and M. H. Jalilian-Tehrani. “Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion.” Nature 352, no. 6334 (August 1, 1991): 431–34. https://doi.org/10.1038/352431a0.
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- Book Sections
  - Marcom, P. K. “Breast Cancer.” In Genomic and Precision Medicine: Primary Care: Third Edition, 181–94, 2017. https://doi.org/10.1016/B978-0-12-800685-6.00010-2.
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- Other Articles
  - Aziz, Hamza, P Kelly Marcom, and E Shelley Hwang. “Implications of HER2-targeted therapy on extent of surgery for early-stage breast cancer.” Ann Surg Oncol, May 2015. https://doi.org/10.1245/s10434-015-4503-6.
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- Conference Papers
  - Mayer, Erica L., Vandana Gupta Abramson, Rachel Catherine Jankowitz, Carla Isadora Falkson, Paul Kelly Marcom, Tiffany A. Traina, Lisa A. Carey, et al. “TBCRC 030: A randomized phase II study of preoperative cisplatin versus paclitaxel in TNBC—Evaluating the homologous recombination deficiency (HRD) biomarker.” In Journal of Clinical Oncology, 37:507–507. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.507.
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  - Irwin, Blair, Gretchen Kimmick, Ivy Altomare, P Kelly Marcom, Kevin Houck, S Yousuf Zafar, and Jeffrey Peppercorn. “Patient experience and attitudes toward addressing the cost of breast cancer care.” In Oncologist, 19:1135–40, 2014. https://doi.org/10.1634/theoncologist.2014-0117.
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  - Madhav, P., S. Cutler, D. Crotty, K. Perez, R. Mckinley, P. Marcom, T. Wong, and M. Tornai. “TU‐C‐332‐04: Pilot Patient Studies Using a Dedicated Dual‐Modality SPECT‐CT System for Breast Imaging.” In Medical Physics, 35:2894, 2008. https://doi.org/10.1118/1.2962498.
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