Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.H.S., Duke University School of Medicine 2006
  • Fellowship - Neonatology, Pediatrics/Jackson Memorial Hospital, University of Miami 1990 - 1993
  • First, Second and Third Year Resident, Pediatrics, Beth Israel Deaconess Medical Center 1987 - 1990
  • Postgraduate, Pediatrics, Universidad de la Republica (Uruguay) 1984 - 1986
  • M.D., Universidad de la Republica (Uruguay) 1984
• 

  Medical Licensure

  • 9900769. North Carolina. 1999
• 

  Duke Appointment History

  • Professor of Pediatrics, Pediatrics, Neonatology, Pediatrics 2017 - 2020
  • Associate Professor of Pediatrics, Pediatrics, Neonatology, Pediatrics 2011 - 2017
  • Assistant Professor of Pediatrics, Pediatrics, Neonatology, Pediatrics 2008 - 2011
  • Medical Instructor in the Department of Pediatrics, Pediatrics, Neonatology, Pediatrics 2007 - 2008
  • Clinical Associate in the Department of Pediatrics, Pediatrics, Clinical Science Departments 2005 - 2007
  • Clinical Associate in the Department of Pediatrics, Pediatrics, Clinical Science Departments 2002 - 2005
  • Clinical Associate in the Department of Pediatrics, Pediatrics, Neonatology, Pediatrics 1999 - 2002
  • Instructor, Temporary in the Department of Pediatrics, Pediatrics, Clinical Science Departments 1999
• Recognition
• 

  Awards & Honors

  • Leonard Tow Humanism in Medicine Award. Duke University School of Medicine. 2018
  • Physician Partner Award. Duke Regional Hospital. 2011
  • Physician's Service Excellence Award. Duke Raleigh Hospital. 2003
  • Premio Moro . Academy of Medicine, Uruguay. 1991
• Research
• 

  Selected Grants

  • Comparison of Two Human Milk Fortifiers in Preterm infants awarded by Abbott Laboratories 2015 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Weimer, Kristin E. D., Hunter Roark, Kimberley Fisher, C Michael Cotten, David A. Kaufman, Margarita Bidegain, and Sallie R. Permar. “Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection.” Am J Perinatol 38, no. 10 (August 2021): 1070–77. https://doi.org/10.1055/s-0040-1701609.
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    • Dworetz, April R., Girija Natarajan, John Langer, Kathy Kinlaw, Jennifer R. James, Margarita Bidegain, Abhik Das, et al. “Withholding or withdrawing life-sustaining treatment in extremely low gestational age neonates.” Arch Dis Child Fetal Neonatal Ed 106, no. 3 (May 2021): 238–43. https://doi.org/10.1136/archdischild-2020-318855.
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    • Travers, Colm P., Waldemar A. Carlo, Scott A. McDonald, Abhik Das, Namasivayam Ambalavanan, Edward F. Bell, Pablo J. Sánchez, et al. “Racial/Ethnic Disparities Among Extremely Preterm Infants in the United States From 2002 to 2016.” Jama Netw Open 3, no. 6 (June 1, 2020): e206757. https://doi.org/10.1001/jamanetworkopen.2020.6757.
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    • Puia-Dumitrescu, Mihai, Rachel G. Greenberg, Noelle Younge, Margarita Bidegain, C Michael Cotten, Martin McCaffrey, Amy Murtha, et al. “Disparities in the use of antenatal corticosteroids among women with hypertension in North Carolina.” J Perinatol 40, no. 3 (March 2020): 456–62. https://doi.org/10.1038/s41372-019-0555-y.
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    • Berube, Megan W., Monica E. Lemmon, Carolyn E. Pizoli, Margarita Bidegain, Veeral N. Tolia, C Michael Cotten, and Rachel G. Greenberg. “Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates.” J Perinatol 40, no. 1 (January 2020): 79–88. https://doi.org/10.1038/s41372-019-0533-4.
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    • Hansen, Adam W., Mullai Murugan, He Li, Michael M. Khayat, Liwen Wang, Jill Rosenfeld, B Kim Andrews, et al. “A Genocentric Approach to Discovery of Mendelian Disorders.” Am J Hum Genet 105, no. 5 (November 7, 2019): 974–86. https://doi.org/10.1016/j.ajhg.2019.09.027.
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    • James, J., D. Munson, S. B. DeMauro, J. C. Langer, A. R. Dworetz, G. Natarajan, M. Bidegain, et al. “Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support (vol 190, pg 118, 2017).” Journal of Pediatrics 207 (April 1, 2019): 270–270.
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    • Helbig, Katherine L., Robert J. Lauerer, Jacqueline C. Bahr, Ivana A. Souza, Candace T. Myers, Betül Uysal, Niklas Schwarz, et al. “De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias.” Am J Hum Genet 104, no. 3 (March 7, 2019): 562. https://doi.org/10.1016/j.ajhg.2019.02.015.
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    • Khan, Tahir N., Kamal Khan, Azita Sadeghpour, Hannah Reynolds, Yezmin Perilla, Marie T. McDonald, William B. Gallentine, et al. “Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.” Am J Hum Genet 104, no. 1 (January 3, 2019): 94–111. https://doi.org/10.1016/j.ajhg.2018.11.017.
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    • Bidegain, Margarita, Tamara I. Herrera, P Brian Smith, and C Michael Cotten. “Correspondence regarding "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy".” Early Hum Dev 128 (January 2019): 104. https://doi.org/10.1016/j.earlhumdev.2018.09.014.
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    • Ku, L. C., C. Simmons, P. B. Smith, R. G. Greenberg, K. Fisher, C. D. Hornik, C Michael Cotten, R. N. Goldberg, and M. Bidegain. “Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit.” J Neonatal Perinatal Med 12, no. 2 (2019): 143–48. https://doi.org/10.3233/NPM-17149.
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    • Autmizguine, Julie, P Brian Smith, Kristi Prather, Catherine Bendel, Girija Natarajan, Margarita Bidegain, David A. Kaufman, et al. “Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants.” J Antimicrob Chemother 73, no. 12 (December 1, 2018): 3482–87. https://doi.org/10.1093/jac/dky353.
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    • Herrera, Tamara I., Laura Edwards, William F. Malcolm, P Brian Smith, Kimberley A. Fisher, Carolyn Pizoli, Kathryn E. Gustafson, et al. “Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy.” Early Hum Dev 125 (October 2018): 1–7. https://doi.org/10.1016/j.earlhumdev.2018.08.003.
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    • James, Jennifer, David Munson, Sara B. DeMauro, John C. Langer, April R. Dworetz, Girija Natarajan, Margarita Bidegain, et al. “Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support.” J Pediatr 190 (November 2017): 118-123.e4. https://doi.org/10.1016/j.jpeds.2017.05.056.
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    • Edwards, L. E., L. B. Hutchison, C. D. Hornik, P. B. Smith, C. M. Cotten, and M. Bidegain. “A case of infant delirium in the neonatal intensive care unit.” J Neonatal Perinatal Med 10, no. 1 (2017): 119–23. https://doi.org/10.3233/NPM-1637.
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    • Lemmon, M. E., M. Bidegain, and R. D. Boss. “Palliative care in neonatal neurology: robust support for infants, families and clinicians.” J Perinatol 36, no. 5 (May 2016): 331–37. https://doi.org/10.1038/jp.2015.188.
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    • Edwards, Laura, Stephen DeMeo, Chi D. Hornik, C Michael Cotten, P Brian Smith, Carolyn Pizoli, Julie M. Hauer, and Margarita Bidegain. “Gabapentin Use in the Neonatal Intensive Care Unit.” J Pediatr 169 (February 2016): 310–12. https://doi.org/10.1016/j.jpeds.2015.10.013.
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    • Neill, Sara, Sarah Haithcock, P Brian Smith, Ronald Goldberg, Margarita Bidegain, David Tanaka, Charlene Carriker, and Jessica E. Ericson. “Sustained Reduction in Bloodstream Infections in Infants at a Large Tertiary Care Neonatal Intensive Care Unit.” Adv Neonatal Care 16, no. 1 (February 2016): 52–59. https://doi.org/10.1097/ANC.0000000000000164.
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    • Pineda, Leslie C., Christoph P. Hornik, Patrick C. Seed, C Michael Cotten, Matthew M. Laughon, Margarita Bidegain, Reese H. Clark, and P. Brian Smith. “Association between positive urine cultures and necrotizing enterocolitis in a large cohort of hospitalized infants.” Early Hum Dev 91, no. 10 (October 2015): 583–86. https://doi.org/10.1016/j.earlhumdev.2015.07.003.
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    • Zimmerman, Kanecia O., Christoph P. Hornik, Lawrence Ku, Kevin Watt, Matthew M. Laughon, Margarita Bidegain, Reese H. Clark, and P Brian Smith. “Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life.” J Pediatr 167, no. 2 (August 2015): 299-304.e3. https://doi.org/10.1016/j.jpeds.2015.04.059.
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    • Bidegain, M., and N. Younge. “Comfort care vs palliative care: Is there a difference in neonates?” Neoreviews 16, no. 6 (June 1, 2015): e333–39. https://doi.org/10.1542/neo.16-6-e333.
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    • Younge, N., P. B. Smith, R. N. Goldberg, D. H. Brandon, C. Simmons, C. M. Cotten, and M. Bidegain. “Impact of a palliative care program on end-of-life care in a neonatal intensive care unit.” J Perinatol 35, no. 3 (March 2015): 218–22. https://doi.org/10.1038/jp.2014.193.
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    • DeMeo, S. D., A. Sherwood, C. D. Hornik, R. N. Goldberg, C. M. Cotten, and M. Bidegain. “Pulmonary artery thrombus in a premature neonate treated with recombinant tissue plasminogen activator.” J Perinatol 34, no. 7 (July 2014): 569–71. https://doi.org/10.1038/jp.2014.34.
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    • Benjamin, Daniel K., Mark L. Hudak, Shahnaz Duara, David A. Randolph, Margarita Bidegain, Gratias T. Mundakel, Girija Natarajan, et al. “Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized clinical trial.” Jama 311, no. 17 (May 7, 2014): 1742–49. https://doi.org/10.1001/jama.2014.2624.
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    • Seigel, Jonathan K., David T. Tanaka, Ronald N. Goldberg, P Brian Smith, C Michael Cotten, and Margarita Bidegain. “Economic impact of human milk on medical charges of extremely low birth weight infants.” Breastfeed Med 9, no. 4 (May 2014): 233–34. https://doi.org/10.1089/bfm.2013.0059.
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    • French, A., C. Thaxton, M. Bidegain, M. Peluso, D. Williford, and K. Briglia. “Perinatal Palliative Care: An Interdisciplinary Team Approach.” Clinical Nurse Specialist 28, no. 2 (March 1, 2014): E39–E39.
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    • Seigel, Jonathan K., P Brian Smith, Patricia L. Ashley, C Michael Cotten, Claudia C. Herbert, Beth A. King, Angela R. Maynor, Sara Neill, James Wynn, and Margarita Bidegain. “Early administration of oropharyngeal colostrum to extremely low birth weight infants.” Breastfeed Med 8, no. 6 (December 2013): 491–95. https://doi.org/10.1089/bfm.2013.0025.
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    • Cohen-Wolkowiez, M., B. Poindexter, and M. Bidegain. “Erratum: Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections (Clinical Infectious Diseases (2012) 55 (1495-502) DOI: 10.1093/cid/cis758).” Clinical Infectious Diseases 56, no. 3 (February 1, 2013): 470. https://doi.org/10.1093/cid/cis997.
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    • Cohen-Wolkowiez, Michael, Brenda Poindexter, Margarita Bidegain, Joern-Hendrik Weitkamp, Robert L. Schelonka, David A. Randolph, Robert M. Ward, et al. “Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections.” Clin Infect Dis 55, no. 11 (December 2012): 1495–1502. https://doi.org/10.1093/cid/cis758.
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    • Smith, P Brian, Michael Cohen-Wolkowiez, Lisa M. Castro, Brenda Poindexter, Margarita Bidegain, Joern-Hendrik Weitkamp, Robert L. Schelonka, et al. “Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections.” Pediatr Infect Dis J 30, no. 10 (October 2011): 844–49. https://doi.org/10.1097/INF.0b013e31822e8b0b.
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    • Dang, C. N., L. I. Katakam, P. B. Smith, C. M. Cotten, R. N. Goldberg, N. Chandler, C. D. Thornburg, and M. Bidegain. “Recombinant activated factor VIIa treatment for refractory hemorrhage in infants.” J Perinatol 31, no. 3 (March 2011): 188–92. https://doi.org/10.1038/jp.2010.85.
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    • Bidegain, Margarita, Rachel Greenberg, Catherine Simmons, Chi Dang, C Michael Cotten, and P Brian Smith. “Vasopressin for refractory hypotension in extremely low birth weight infants.” J Pediatr 157, no. 3 (September 2010): 502–4. https://doi.org/10.1016/j.jpeds.2010.04.038.
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    • Bidegain, M., B. A. Roos, E. L. Hill, G. A. Howard, and W. Balkan. “Calcitonin gene-related peptide (CGRP) in the developing mouse limb.” Endocr Res 21, no. 4 (November 1995): 743–55. https://doi.org/10.1080/07435809509030488.
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  • Conference Papers

    • Ganguly, Samit, Andrea N. Edginton, Jacqueline G. Gerhart, Michael Cohen-Wolkowiez, Rachel G. Greenberg, Daniel Gonzalez, and Daniel Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. “Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants.” In Clinical Pharmacokinetics, 2021. https://doi.org/10.1007/s40262-021-01046-6.
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    • Valdez, Purnima, Elizabeth Thompson, Kathleen Bartlett, Deborah Stroman, Stephanie Baker, Victoria Parente, and Margarita Bidegain. “A Survey of Pediatric Professionals Before and After Racial Equity Training.” In Journal of Developmental and Behavioral Pediatrics, 42:S10–11, 2021.
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    • Ku, Lawrence C., Catherine Simmons, Brian Smith, Rachel Greenberg, Kimberley Fisher, Chi Hornik, C Michael Cotten, Ronald Goldberg, and Margarita Bidegain. “Intranasal Midazolam and Fentanyl for Analgesia and Sedation in Infants in the Neonatal Intensive Care Unit.” In Section on Neonatal Perinatal Medicine Program. American Academy of Pediatrics, 2018. https://doi.org/10.1542/peds.141.1_meetingabstract.532.
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    • Sanchez Varela, A. M., V. Dussel, R. Barfield, M. Bidegain, L. Delima, and E. Dellon. “Perceived Resources and Barriers to Pediatric Palliative Care Among HealthCare Practitioners Attending the V Latin American Palliative Care Association (ALCP) Meeting (755).” In J Pain Symptom Manage, 41:306, 2011. https://doi.org/10.1016/j.jpainsymman.2010.10.234.
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