Current Appointments & Affiliations
Nanaline H. Duke Distinguished Professor of Biochemistry
·
2017 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2015 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Allosteric activation mechanism of DriD, a WYL-domain containing transcription regulator.
Journal Article Commun Biol · April 29, 2025 WYL-domain containing transcription factors regulate fundamental processes in bacterial physiology, yet how these proteins sense cellular cues to elicit an allosteric response is not well understood. Here we describe the allosteric activation mechanism of ... Full text Link to item CiteHow c-di-GMP controls progression through the Streptomyces life cycle.
Journal Article Curr Opin Microbiol · August 2024 Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3', 5 ... Full text Link to item CiteStructure of the E. coli nucleoid-associated protein YejK reveals a novel DNA binding clamp.
Journal Article Nucleic Acids Res · July 8, 2024 Nucleoid-associated proteins (NAPs) play central roles in bacterial chromosome organization and DNA processes. The Escherichia coli YejK protein is a highly abundant, yet poorly understood NAP. YejK proteins are conserved among Gram-negative bacteria but s ... Full text Link to item CiteRecent Grants
Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular level
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2027Cell signaling through O-GlcNAc reader proteins
ResearchCollaborator · Awarded by National Institute of General Medical Sciences · 2016 - 2027Molecular elucidation of the Francisella tularensis virulence mechanism
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026View All Grants
Education, Training & Certifications
Oregon Health and Science University ·
1995
Ph.D.