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Maria Anne Schumacher

Nanaline H. Duke Distinguished Professor of Biochemistry
Biochemistry
Box 3711, Durham, NC 27710
243A Nanaline H Duke, Durham, NC 27710

Current Appointments & Affiliations


Nanaline H. Duke Distinguished Professor of Biochemistry · 2017 - Present Biochemistry, Basic Science Departments
Professor of Biochemistry · 2015 - Present Biochemistry, Basic Science Departments

In the News


Published February 10, 2021
Duke Celebrates Women and Girls in Science Day
Published November 19, 2020
Researchers Peer Inside Deadly Pathogen’s Burglary Kit
Published October 21, 2020
Transcription Factors May Inadvertently Lock in DNA Mistakes

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Recent Publications


Allosteric activation mechanism of DriD, a WYL-domain containing transcription regulator.

Journal Article Commun Biol · April 29, 2025 WYL-domain containing transcription factors regulate fundamental processes in bacterial physiology, yet how these proteins sense cellular cues to elicit an allosteric response is not well understood. Here we describe the allosteric activation mechanism of ... Full text Link to item Cite

How c-di-GMP controls progression through the Streptomyces life cycle.

Journal Article Curr Opin Microbiol · August 2024 Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3', 5 ... Full text Link to item Cite

Structure of the E. coli nucleoid-associated protein YejK reveals a novel DNA binding clamp.

Journal Article Nucleic Acids Res · July 8, 2024 Nucleoid-associated proteins (NAPs) play central roles in bacterial chromosome organization and DNA processes. The Escherichia coli YejK protein is a highly abundant, yet poorly understood NAP. YejK proteins are conserved among Gram-negative bacteria but s ... Full text Link to item Cite
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Recent Grants


Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular level

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2027

Cell signaling through O-GlcNAc reader proteins

ResearchCollaborator · Awarded by National Institute of General Medical Sciences · 2016 - 2027

Molecular elucidation of the Francisella tularensis virulence mechanism

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026

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Education, Training & Certifications


Oregon Health and Science University · 1995 Ph.D.