Current Appointments & Affiliations
Nanaline H. Duke Distinguished Professor of Biochemistry
·
2017 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2015 - Present
Biochemistry,
Basic Science Departments
Recent Publications
How c-di-GMP controls progression through the Streptomyces life cycle.
Journal Article Curr Opin Microbiol · August 2024 Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3', 5 ... Full text Link to item CiteStructure of the E. coli nucleoid-associated protein YejK reveals a novel DNA binding clamp.
Journal Article Nucleic Acids Res · July 8, 2024 Nucleoid-associated proteins (NAPs) play central roles in bacterial chromosome organization and DNA processes. The Escherichia coli YejK protein is a highly abundant, yet poorly understood NAP. YejK proteins are conserved among Gram-negative bacteria but s ... Full text Link to item CiteStructure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site.
Journal Article Nucleic Acids Res · February 9, 2024 Transcription regulators play central roles in orchestrating responses to changing environmental conditions. Recently the Caulobacter crescentus transcription activator DriD, which belongs to the newly defined WYL-domain family, was shown to regulate DNA d ... Full text Link to item CiteRecent Grants
Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular level
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2027Cell signaling through O-GlcNAc reader proteins
ResearchCollaborator · Awarded by National Institute of General Medical Sciences · 2016 - 2027Molecular elucidation of the Francisella tularensis virulence mechanism
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026View All Grants
Education, Training & Certifications
Oregon Health and Science University ·
1995
Ph.D.