Current Appointments & Affiliations
Nanaline H. Duke Distinguished Professor of Biochemistry
·
2017 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2015 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Structural Studies on the M. tuberculosis Nucleoid-associated-Protein, NapA, Indicates DNA Bridging Mechanism.
Journal Article J Mol Biol · October 15, 2025 Nucleoid-associated proteins (NAPs) play central roles in bacterial chromosome organization and DNA processes. Interestingly, Mycobacterium tuberculosis (Mtb) lacks most common NAPs and only recently have NAPs been uncovered in this bacterium. One such pro ... Full text Link to item CiteAuthor Correction: Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
Journal Article Nat Commun · July 3, 2025 Full text Link to item CiteAllosteric activation mechanism of DriD, a WYL-domain containing transcription regulator.
Journal Article Commun Biol · April 29, 2025 WYL-domain containing transcription factors regulate fundamental processes in bacterial physiology, yet how these proteins sense cellular cues to elicit an allosteric response is not well understood. Here we describe the allosteric activation mechanism of ... Full text Link to item CiteRecent Grants
Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular level
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2027Cell signaling through O-GlcNAc reader proteins
ResearchCollaborator · Awarded by National Institute of General Medical Sciences · 2016 - 2027Molecular elucidation of the Francisella tularensis virulence mechanism
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026View All Grants
Education, Training & Certifications
Oregon Health and Science University ·
1995
Ph.D.